Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: Influence of pH, ion-pairing and skin species

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 3, 2008, Pages 901-907

  Vávrová, Kateřina ^a   Lorencová, Kateřina ^a   Novotný, Jakub ^a   Holý, Antonín ^b   Hrabálek, Alexandr ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Acyclic nucleoside phosphonates; Adefovir; Antiviral; Permeation enhancer; Transdermal drug delivery

Indexed keywords

ADEFOVIR; DODECYL 6 (DIMETHYLAMINO)HEXANOATE; MYRISTIC ACID ISOPROPYL ESTER; PENETRATION ENHANCING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DERMIS; DIFFUSION COEFFICIENT; DRUG ABSORPTION; DRUG BLOOD LEVEL; EPIDERMIS; FEMALE; HUMAN; HUMAN TISSUE; NONHUMAN; PH; SKIN CONDUCTANCE; STRATUM CORNEUM; SWINE; THERMODYNAMICS;

ADENINE; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DIFFUSION CHAMBERS, CULTURE; FEMALE; HEXANOIC ACIDS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; METHYLAMINES; PERMEABILITY; PHOSPHONIC ACIDS; SKIN; SKIN ABSORPTION; SPECIES SPECIFICITY; SWINE; VEHICLES;

EID: 54949094659     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.07.002     Document Type: Article

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