Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: Effects of linking chain length, chirality and polyfluorination

Pharmaceutical Research

Volumn 26, Issue 4, 2009, Pages 811-821

  Novotný, Jakub ^a   Kovaříková, Petra ^b   Novotný, Michal ^a   Janůšová, Barbora ^a   Hrabálek, Alexandr ^a   Vávrová, Kateřina ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Biodegradability; Permeation enhancers; Reversibility; Structure activity relationships; Transdermal drug delivery

Indexed keywords

ADEFOVIR; DODECYL 2 (DIMETHYLAMINO)PROPANOATE; DODECYL 3 (DIMETHYLAMINO)PROPANOATE; DODECYL 4 (DIMETHYLAMINO)BUTANOATE; DODECYL 5 (DIMETHYLAMINO)PENTANOATE; DODECYL 6 (DIMETHYLAMINO)HEXANOATE; DODECYL 8 (DIMETHYLAMINO)OCTANOATE; ESTER DERIVATIVE; ESTERASE; FLUOROCARBON; HYDROCARBON; HYDROCORTISONE; INDOMETACIN; NITROGEN; PENETRATION ENHANCING AGENT; PERFLUORODECYL 2 (DIMETHYLAMINO)PROPANOATE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; CHIRALITY; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTRIC RESISTANCE; FLUORINATION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADENINE; ADMINISTRATION, CUTANEOUS; ALANINE; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; ELECTRIC IMPEDANCE; ESTERASES; HALOGENATION; HEXANOIC ACIDS; HYDROCORTISONE; HYDROLYSIS; INDOMETHACIN; ISOMERISM; METHYLAMINES; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS; SKIN; SKIN ABSORPTION; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; THEOPHYLLINE; TIME FACTORS;

EID: 61449262804     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9780-3     Document Type: Article

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