Application of baculovirus-insect cell expression system for human therapy

Current Pharmaceutical Biotechnology

Volumn 12, Issue 11, 2011, Pages 1840-1849

  Rychlowska, Malgorzata ^a   Gromadzka, Beata ^a   Bieńkowska Szewczyk, Krystyna ^a   Szewczyk, Boguslaw ^a  

^a UNIVERSITY OF GDA SK   (Poland)

Author keywords

Baculovirus; Gene delivery; Gene therapy; Glycosylation; Insect cells; Therapeutic proteins; Virus like particles (VLP)

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; APOPTIN; BACULOVIRUS VECTOR; DIPHTHERIA TOXIN; GENOMIC DNA; HYBRID PROTEIN; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT PROTEIN; VIRUS DNA; VIRUS LIKE PARTICLE VACCINE; WART VIRUS VACCINE;

BACULOVIRUS; BACULOVIRUS EXPRESSION SYSTEM; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM DISEASE; DNA TRANSPOSITION; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE SILENCING; HOMOLOGOUS RECOMBINATION; HUMAN; HUMORAL IMMUNITY; NONHUMAN; OPEN READING FRAME; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REPLICON; RESTRICTION SITE; REVIEW; RNA INTERFERENCE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS CAPSID; VIRUS GENE; VIRUS GENOME; VIRUS REPLICATION;

EID: 83455259994     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920111798377012     Document Type: Review

References (160)

1. Jehle, J.A.; Blissard, G.W.; Bonning, B.C.; Cory, J.S.; Herniou, E.A.; Rohrmann, G.F.; Theilmann, D.A.; Thiem, S.M.; Vlak, J.M. On the classification and nomenclature of baculoviruses: a proposal for revision. Arch. Virol., 2006, 151, 1257-1266.
2. Boyce, F.M.; Bucher, N.L.R. Baculovirus-mediated gene transfer into mammalian cells. Proc. Natl. Acad. Sci. USA, 1996, 93, 2348-2352.
3. Kost, T.A.; Condreay, J.P.; Jarvis, D.L. Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nat. Biotechnol., 2005, 23, 567-575.
4. Braunage, S.C.; Russell, W.K.; Rosas-Acosta, G.; Russell, D.H., Summers, M.D. Determination of protein composition of the occlusion- derived virus of Autographa californica nucleopolyhedrovirus. Proc. Natl. Acad. Sci. USA, 2003, 100, 9797-9802.
5. Rohrmann, G.F. Baculovirus structural proteins. J. Gen. Virol., 1992, 73, 749-761.
6. Kelly, B.J.; King, L.A.; Possee R.D. Introduction to Baculovirus Molecular Biology. Methods Mol. Biol., 2007, 388, 25-53.
7. van Oers, M.M. Vaccines for viral and parasitic diseases produced with baculovirus vectors. Adv. Virus Res., 2006, 68, 193-253.
8. Summers, M.D.; Smith, G.E. A manual of methods for baculovirus vectors and insect cell culture procedures. Texas Agricultural Experimental Station Bulletin, 1987, 1555, 1-57.
9. Kitts, P.A.; Ayres, M.D.; Possee, R.D. Linearization of baculovirus DNA enhances the recovery of recombinant virus expression vectors. Nucl. Acids Res., 1990, 18, 5667-5672.
10. Kitts, P.A.; Possee, R.D. A method for producing recombinant baculovirus expression vectors at high frequency. Biotechniques, 1993, 14, 810-817.
11. Luckov, V.A.; Lee, S.C.; Barry, G.F.; Olins, P.O. Efficient generation of infectious recombinant baculviruses by site-specific transposon- mediated insertion of foreign genes into a baculovirus genome propagated in Escherischia coli. J. Virol., 1993, 67, 4566-4579.
12. Berger, I.; Fitzgerald D.J.; Richmond, T.J. Baculovirus expression system for heterologous multiprotein complexes. Nat. Biotechnol., 2004, 22, 1583-1587.
13. Granados, R.R.; Guoxun, L.; Dersksen, A.C.G.; McKenna, K.A. A new insect cell line from Trichoplusia ni (BTI-Tn-5B1-4) susceptible to Trichoplusia ni single nuclear polyhedrosis virus. J. Invertebr. Pathol., 1994, 64, 260-266.
14. Tomiya, N.; Narang, S.; Lee, Y.C.; Betenbaugh, M.J. Comparing N-glycan processing in mammalian cell lines to native and engineered lepidopteran insect cell lines. Glycoconjugate J., 2004, 21, 343-360.
15. Harrison, R.L.; Jarvis, D.L. Protein N-glycosylation in the baculovirus- insect cell expression system and engineering of insect cells to produce "mammalianized" recombinant glycoproteins. Adv. Virus Res., 2006, 68, 159-191.
16. Douris, V.; Swevers, L.; Labropoulou, V.; Andronopoulou, E.; Georgoussi, Z.; Iatrou, K. Stably transformed insect cell lines: tools for expression of secreted and membrane-anchored proteins and high-throughput screening platforms for drug and insecticide discovery. Adv. Virus Res., 2006, 68, 113-156.
17. Farrell, P.J.F.; Swevers, L.; Iatrou, K. In: Comprehensive molecular insect science; L.I. Gilbert, K. Iatrou, S.S. Gill, Ed.; Elsevier: San Diego Calif., 2005; Vol. 4, pp. 475-507.
18. Condreay, J.P.; Ames, R.S.; Hassan, N.J.; Kost, T.A.; Merrihew, R.V.; Mossakowska, D.E.; Pountney, D.J.; Romanos, M.A. Baculoviruses and mammalian cell-based assays for drug screening. Adv. Virus Res., 2006, 68, 255-286.
19. Kost, T.A.; Condreay, J.P.; Ames, R.S. Baculovirus gene delivery: a flexible assay development tool. Curr. Gene Ther., 2010, 10, 168-173.
20. Condreay, J.P.; Watson, C.A. Pharmacological applications of baculovirus - mediated protein expression in mammalian cells. Curr. Prot. Pharmacol., 2010, 49, 6.11.1-6.11.12.
21. Cox, M.M. Progress on baculovirus-derived influenza vaccines. Curr. Op. Mol. Therapeutics, 2008, 10, 56-61.
22. Yao, Q.; Bu, Z.; Vzorov, A.; Yang, C.; Compans, R.W. Virus-like particle and DNA-based candidate AIDS vaccines. Vaccine, 2003, 21, 638-643.
23. Shrestha, M.P.; Scott, R.M.; Joshi, D.M.; Mammen, M.P. Jr; Thapa, G.B.; Thapa, N.; Myint, K.S.; Fourneau, M.; Kuschner, R.A.; Shrestha, S.K.; David, M.P.; Seriwatana, J.; Vaughn, D.W.; Safary, A.; Endy, T.P.; Innis, B.L. Safety and efficacy of a recombinant hepatitis E vaccine. N. Engl. J. Med., 2007, 356, 895-903.
24. Zhou, Z.; Post, P.; Chubet, R.; Holtz, K.; McPherson, C.; Petric, M.; Cox, M. A recombinant baculovirus expressed S glycoprotein vaccine elicits high titers of SARS-associated coronavirus (SARSCoV) neutralizing antibodies in mice. Vaccine, 2006, 24, 3624-3631.
25. Mlambo, G.; Kumar, N.; Yoshida, S. Functional immunogenicity of baculovirus expressing Pfs25, a human malaria transmissionblocking vaccine candidate antigen. Vaccine, 2010, 28, 7025-7029.
26. Blagborough, A.M.; Yoshida, S.; Sattabongkot, J.; Tsuboi, T.; Sinden, R.E. Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission. Vaccine, 2010, 28, 6014-6020.
27. Xiang, J.; Wunschmann, S.; George, S.L.; Klinzman, D.; Schmidt, W.N.; LaBrecque, D.R.; Stapleton, J.T. Recombinant hepatitis C virus-like particles expressed by baculovirus: Ulility in cell-binding and antibody detection assays. J. Med. Virol., 2002, 68, 537-543.
28. Buonaguro, L.; Tornesello, M.L.; Tagliamonte, M.; Gallo, R.C.; Wang, L.X.; Kamin-Lewis, R.; Abdelwahab, S.; Lewis, G.K.; Buonaguro, F.M. Baculovirus - derived Human Immunodeficiency Virus Type 1 virus-like particles activate dendritic cells and induce ex vivo T-cell responses. J. Virol., 2006, 80, 9134-9143.
29. Ludwig, Ch.; Wagner, R. Virus-like particles - universal molecular toolboxes. Curr. Opin. Biotechnol., 2007, 18, 537-545.
30. Grgacic, E.V.L.; Anderson, D.A. Virus-like particles: Passport to immune recognition. Methods, 2006, 40, 60-65.
31. Vieira, H.L.A.; Estevao, C.; Roldao, A.; Peixoto, C.C.; Sousa, M.F.Q.; Cruz, P.E.; Carrondo, M.J.T.; Alves, P.M. Triple layered rotavirus VLP production: Kinetics of vector replication, mRNA stability and recombinant protein production. J. Biotechnol., 2005, 120, 72-82.
32. Thomsen, D.R.; Roof, L.L.; Homa, F.L. Assembly of herpes simplex virus (HSV) intermediate capsids in insect cells infrcted with recombinant baculoviruses expressing HSV capsid proteins. J.Virol., 1994, 68, 2442-2457.
33. Baumert, T.F.; Ito, S.; Wong, D.T.; Liang, T.J. Hepatitis C virus structural proteins assemble into viruslike particles in insect cells. J. Virol., 1998, 72, 3827-3836.
34. Delchambre, M.; Gheysen, D.; Thines, D.; Thiriart, C.; Jacobs, E.; Verdin, E.; Horth, M.; Burny, A.; Bex, F. The GAG precursor of simian immunodeficiency virus assembles into virus-like particles. EMBO J., 1989, 8, 2653-2660.
35. th international symposium on retroviral nucleocapsid. Retrovirology, 2008, 5, doi: 10.1186/1742-4690-5-21.
36. Chang, C.Y.; Chang, Y.F.; Wang, S.M.; Tseng, Y.T.; Huang, K.J.; Wang, C.T. HIV-1 matrix protein repositioning in nucleocapsid region fails to confer virus-like particle assembly. Virology, 2008, 378, 97-104.
37. Gomez-Puertas, P.; Albo, C.; Perez-Pastrana, E.; Vivo, A.; Portela, A. Influenza virus matrix protein is the major driving force in virus budding. J. Virol., 2000, 74, 11538-11547.
38. Banerjee, M.; Speir, J.A.; Kwan, M.H.; Huang, R.; Aryanpur, P.P.; Bothner, B.; Johnson, J.E. Structure and function of a genetically engineered mimic of a nonenveloped virus entry intermediate. J. Virol., 2010, 84, 4737-4746.
39. Sapp, M.; Volpers, C.; Muller, M.; Streeck, E. Organization of the major and minor capsid proteins in human papillomavirus type 33 virus-like particles. J. Gen. Virol., 1995, 76, 2407-2412.
40. Chang, C.Y.; Fung, W.C.; Ou, P.C.; Chao, S.Y.; Li, M.; Wang, Y.L.; Huang,T.Y.; Tsai, T.R. Self-assembly of the JC virus major capsid protein, VP1, expressed in insect cells. J.Gen. Virol., 1997, 78, 1435-1439.
41. Martin-Serrano, J.; Zang, T.; Bieniasz, D. HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress. Nat. Med., 2001, 7, 1313-1319.
42. Gromadzka, B.; Szewczyk, B.; Konopa, G.; Fitzner, A.; Kesy, A. Recombinant VP60 in the form of Virion-like particles as a potential vaccine against rabbit hemorrhagic disease virus. Acta Biochim. Pol., 2006, 53, 371-376.
43. Noad, R.; Roy, P. Virus-Like Particles as immunogens. Trends Microbiol., 2003, 11, 438-444.
44. Chung, Y.C.; Huang, J.H.; Lai, C.W.; Sheng, H.C.; Shih, S.R.; Ho, M.S.; Hu, Y.C. Expression, purification and characterization of enterovirus- 71 virus-like particles. World J. Gastroenterol., 2006, 12, 921-927.
45. Hansman, G.S.; Oka, T.; Takeda, N. Sapovirus-like particles derived from polyprotein. Virus Res., 2008, 137, 261-265.
46. Rose, R.C.; Bonnez, W.; Reichman, R.C.; Garcea, R.L. Expression of human papillomavirus type 11 L1 protein in insect cells: in vivo and in vitro assembly of virus-like particles. J. Virol., 1993, 67, 1936-1944.
47. Senger, T.; Schadlich, L.; Gissmann, L.; Muller, M. Enhanced papillomavirus-like particles production in insect cells. Virology, 2009, 388, 344-353.
48. Saliki, J.T.; Mizak, B.; Flore, H.P.; Getting, R.R.; Burand, J.P.; Carmichael, L.E.; Wood, H.A.; Parrish, C.R. Canine parvovirus empty capsids produced by expressinon in a baculovirus vector: use in analysis of viral properties and immunization of dogs. J. Gen. Virol., 1992, 73, 369-374.
49. Meghrous, J.; Mahmoud, W.; Jacob, D.; Chubet, R.; Cox, M.; Kamen, A.A. Development of a simple and high-yielding fed-batch process for the production of influenza vaccines. Vaccine, 2010, 28, 309-316.
50. Fooks, A.R.; Stephenson J.R.; Warner, A.; Dowsett, A.B.; Rima, B.K.; Wilkinson, G.W.G. Measles virus nucleocapsid protein expression in insect cells assembles into nucleocapsid - like structure. J. Gen. Virol., 1993, 74, 1439-1444.
51. Doan, L.X.; Li, M.; Chen, C.; Yao,Q. Virus-like particles as HIV-1 vaccine. Rev. Medical Virol., 2004, 15, 75-88.
52. Roingeard, P.; Hourioux, C.; Blanchard, E.; Brand, D.; Ait- Goughoulte, M. Hepatitis C virus ultrastructure and morphogenesis. Biol. Cell, 2004, 96, 103-108.
53. Jourdan, N.; Godeke, J.G.; Penaud, M.; Mottola, G.; Sorrentino,A.; Rottier, P.J.M.; Bonatti, S. Assembly of HCV E1 and E2 glycoproteins into coronavirus VLPs. Arch. Virology, 2006, 151, 2085-2094.
54. Goldman, C.; Stolte, N.; Nisslein, T.; Hunsmann, W.L.; Petry, H. Packaging of small molecules into VP1- virus-like particles of the human polyomavirus JC virus. J. Virol. Methods, 2000, 90, 85-90.
55. Ramqvist, T.; Andreasson, K.; Dalianis, T. Vaccination, immune and gene therapy based on virus like particles against viral infections and cancer. Expert Opin. Biol. Ther., 2007, 7, 997-1007.
56. Evans, T.G.; Bonnez, W.; Rose, R.C.; Koenig, S.; Demeter, L.; Suzich, J.A.; O'Brien D.; Campbell, M.; White, W.I.; Balsley, J.; Reichman, R.C. A Phase 1 study of a recombinant viruslike particle vaccine against human papillomavirus type 11 in healthy adult volunteers. J. Infect. Dis., 2001, 183, 1485-1493.
57. Harro, C.D.; Pang, Y.Y.; Roden, R.B.; Hildesheim, A.; Wang, Z.; Reynolds, M.J.; Mast, T.C.; Robinson, R.; Murphy, B.R.; Karron, R.A.; Dillner, J.; Schiller, J.T.; Lowy, D.R. Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. J. Natl. Cancer. Inst., 2001, 93, 284-292.
58. Franco, E.L.; Harper, D.M. Vaccination against human papillomavirus infection: a new paradigm in cervical cancer control. Vaccine, 2005, 23, 2388-2394.
59. Harper, D.M.; Franco, E.L.; Wheeler, C.; Ferris, D.G.; Jenkins, D.; Schuind, A.; Zahaf, T.; Innis, B.; Naud, P.; De Carvalho, N.S.; Roteli- Martins, C.M.; Teixeira, J.; Blatter, M.M.; Korn, A.P.; Quint, W.; Dubin, G. Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet, 2004, 364, 1757-1765.
60. Harper, D.M.; Franco, E.L.; Wheeler, C.M.; Moscicki, A.B.; Romanowski, B.; Roteli-Martins, C.M.; Jenkins, D.; Schuind, A.; Costa Clemens, S.A.; Dubin, G. Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial. Lancet, 2006, 367, 1247-1255.
61. Bräutigam, S.; Snezhkov, E.; Bishop, D.H. Formation of poliovirus- like particles by recombinant baculoviruses expressing the individual VP0, VP3, and VP1 proteins by comparison to particles derived from the expressed poliovirus polyprotein. Virology, 1993, 192, 512-524.
62. Schirmbeck, R.; Böhm, W.; Reimann, J. Virus-like particles induce MHC class I-restricted T-cell responses. Lessons learned from the hepatitis B small surface antigen. Intervirology, 1996, 39, 111-119.
63. Jeong, S.H.; Qiao, M.; Nascimbeni, M.; Hu, Z.; Rehermann, B.; Murthy, K.; Liang, T.J. Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates. J. Virol., 2004, 78, 6995-7003.
64. Gheysen, D.; Jacobs, E.; de Foresta, F.; Thiriart, C.; Francotte, M.; Thines, D.; De Wilde, M. Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cells. Cell, 1989, 59, 103-112.
65. Paliard, X.; Liu, Y.; Wagner, R.; Wolf, H.; Baenziger, J.; Walker, C.M. Priming of strong, broad, and long-lived HIV type 1 p55gagspecific CD8+ cytotoxic T cells after administration of a virus-like particle vaccine in rhesus macaques. AIDS Res. Hum. Retrovirus., 2000, 16, 273-282.
66. Wagner, R.; Deml, L.; Notka, F.; Wolf, H.; Schirmbeck, R.; Reimann, J.; Teeuwsen, V.; Heeney, J. Safety and immunogenicity of recombinant human immunodeficiency virus-like particles in rodents and rhesus macaques. Intervirology, 1996, 39, 93-103.
67. Mortola, E.; Roy, P. Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system. FEBS Lett., 2004, 6, 174-178.
68. Ho, Y.; Lin, P.H.; Liu, C.Y.; Lee, S.P.; Chao, Y.C. Assembly of human severe acute respiratory syndrome coronavirus-like particles. Biochem. Biophys. Res. Commun., 2004, 318, 833-838.
69. Latham, T.; Galarza, J.M. Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins. J. Virol., 2001, 75, 6154-6165.
70. Galarza, J.M.; Latham, T.; Cupo, A. Virus-like particle (VLP) vaccine conferred complete protection against a lethal influenza virus challenge. Viral Immunol., 2005, 18, 244-251.
71. Pushko, P.; Tumpey, T.M.; Bu, F.; Knell, J.; Robinson, R.; Smith, G. Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice. Vaccine, 2005, 23, 5751-5759.
72. Bright, R.A.; Carter, D.M.; Crevar, C.J.; Toapanta, F.R.; Steckbeck, J.D.; Cole, K.S.; Kumar, N.M.; Pushko, P.; Smith, G.; Tumpey, T.M.; Ross, T.M. Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle. PLoS ONE, 2008, 3, e1501.
73. Sun, Y.; Carrion Jr., R.; Ye, L.; Wen, Z.; Ro Y-T.; Brasky, K.; Ticer, A.E.; Schwegler, E.E.; Patterson, J.L.; Compans R.W.; Yang, C. Protection against lethal challenge by Ebola virus-like particles produced in insect cells. Virology, 2009, 383, 12-21.
74. De Turiso, L.; Cortés, J.A.; Martínez, E.; Ruiz De Ybáñez, C.; Simarro, R.; Vela, I.; Casal, C. Recombinant vaccine for canine parvovirus in dogs. J. Virol., 1992, 66, 2748-2753.
75. Martinez, C.; Dalsgaard, K.; López de Turiso, J.A.; Cortés, E.; Vela, C.; Casal, J.I. Production of porcine parvovirus empty capsids with high immunogenic activity. Vaccine, 1992, 10, 684-690.
76. Antonis, A.F.; Bruschke, C.J.; Rueda, P.; Maranga, L.; Casal, J.I.; Vela, C.; Hilgers, L.A.; Belt, P.B.; Weerdmeester, K.; Carrondo, M.J.; Langeveld, J.P. A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure. Vaccine, 2006, 24, 5481-5490.
77. Kocha, G.; van Roozelaara, D.J.; Verschuerenb, C.A.J.; van der Ebb A.J.; Notebornb, M.H.M. Immunogenic and protective properties of chicken anaemia virus proteins expressed by baculovirus. Vaccine, 1995, 13, 763-770.
78. Noteborn, M.H.M.; Verschueren, C.A.J.; Koch, G.; Van der Eb, A.J. Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope. J. Gen. Virol., 1998, 79, 3073-3077.
79. Yao, Q.; Vuong, V.; Li M.; Compans, R.W. Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity. Vaccine, 2002, 20, 2537-2545.
80. Yamshchikov, G.V.; Ritter, G.D.; Vey, M.; Compans, R.W. Assembly of SIV virus-like particles containing envelope proteins using a baculovirus expression system. Virology, 1995, 214, 50-58.
81. Fausch, S.C.; Da Silva, D.M.; Kast W.M. Differential uptake and cross-presentation of human papillomavirus virus-like particles by dendritic cells and langerhans cells. Cancer Res., 2003, 63, 3478-3482.
82. Sedlik, C.; Saron, M.-F.; Sarraseca, J.; Casal, I.; Leclerc, C. Recombinant parvovirus-like particles as an antigen carrier: A novel nonreplicative exogenous antigen to elicit protective antiviral cytotoxicT cells. Proc. Natl. Acad. Sci. USA, 1997, 94, 7503-7508.
83. Fausch, S.C.; Da Silva, D.M.; Kast, W.M. Heterologous papillomavirus virus-like particles and human papillomavirus virus-like particle immune complexes activate human Langerhans cells. Vaccine, 2005, 23, 1720-1729.
84. Lo-Man, R.; Rueda, P.; Sedlik, C.; Deriaud, E.; Casal, I.; Leclerc, C. A recombinant virus-like particle system derived from parvovirus as an efficient antigen carrier to elicit a polarized Th1 immune response without adjuvant. Eur. J. Immunol., 1998, 28, 1401-1407.
85. Lowy, D.R.; Schiller, J.T. Prophylactic human papillomavirus vaccines. J. Clin. Invest., 2006, 116, 1167-1173.
86. Walboomers, J.M.; Jacobs, M.V.; Manos, M.M., Bosch, F.X.; Kummer, J.A.; Shah, K.V.; Snijders, P.J.; Peto, J.; Meijer, C.J.; Muñoz, N. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol., 1999, 189, 12-19.
87. Snijders, P.J.; Steenbergen, R.D.; Heideman, D.A.; Meijer, C.J. HPV-mediated cervical carcinogenesis: concepts and clinical implications. J. Pathol., 2006, 208, 152-164.
88. Volkman, L.E.; Goldsmith, P.A. Generalized immunoassay for Autographa californica nuclear polyhedrosis virus infectivity in vitro. Appl. Environ. Microbiol., 1983, 45, 1085-1093.
89. Tjia, S.T.; zu Altenschildesche, G.M.; Doerfler, W. Autographa californica nuclear polyhedrosis virus (AcNPV) DNA does not persist in mass cultures of mammalian cells. Virology, 1983, 125, 107-117.
90. Duisit, G.; Saleun, S.; Douthe, S.; Barsoum, J.; Chadeuf, G.; Moullier, P. Baculovirus vector requires electrostatic interactions including heparan sulfate for efficient gene transfer in mammalian cells. J. Gene. Med., 1999, 1, 93-102.
91. Tani, H.; Nishijima, M.; Ushijima, H.; Miyamura, T.; Matsuura, Y. Characterization of cell-surface determinants important for baculovirus infection. Virology, 2001, 279, 343-353.
92. Oomens, A.G.P.; Wertz, G.W. The baculovirus GP64 protein mediates highly stable infectivity of a human respiratory syncytial virus lacking its homologous transmembrane glycoproteins. J. Virol., 2004, 78, 124-135.
93. Kadlec, J.; Loureiro, S.; Abrescia, N.G.A.; Stuart, D.I.; Jones, I.M. The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines. Nat. Struct. Mol. Biol., 2008, 15, 1024-1030.
94. Zhou, J.; Blissard, G.W. Identification of a GP64 subdomain snvolved in receptor binding by budded virions of the baculovirus autographica californica multicapsid nucleopolyhedrovirus. J. Virol., 2008, 82, 4449-4460.
95. Hofmann, C.; Sandig, V.; Jennings, G.; Rudolph, M.; Schlag, P.; Strauss, M. Efficient gene transfer into human hepatocytes by baculovirus vectors. Proc. Natl. Acad. Sci. USA, 1995, 92, 10099-10103.
96. Shoji, I.; Aizaki, H.; Tani, H.; Ishii, K.; Chiba, T.; Saito, I.; Miyamura, T.; Matsuura, Y. Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. J. Gen. Virol., 1997, 78, 2657-2664.
97. Gao, R.; McCormick, C.J.; Arthur, M.J.; Ruddell, R.; Oakley, F.; Smart, D.E.; Murphy, F.R.; Harris, M.P.; Mann, D.A. High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors. Liver, 2002, 22, 15-22.
98. Cheng, T.; Xu, C.Y.; Wang, Y.B.; Chen, M.; Wu, T.; Zhang, J.; Xia, N.S. A rapid and efficient method to express target genes in mammalian cells by baculovirus. World J. Gastroenterol., 2004, 10, 1612-1618.
99. Liang, C.Y.; Wang, H.Z.; Li, T.X.; Hu, Z.H.; Chen, X.W. High efficiency gene transfer into mammalian kidney cells using baculovirus vectors. Arch. Virol., 2004, 149, 51-60.
100. Yates, F.; Daley, G.Q. Progress and prospects: gene transfer into embryonic stem cells. Gene Ther., 2006, 13, 1431-1439.
101. Zeng, J.; Du, J.; Zhao, Y.; Palanisamy, N.; Wang, S. Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells. Stem Cells, 2007, 25, 1055-1061.
102. Sandig, V.; Hofmann, C.; Steinert, S.; Jennings, G.; Schlag, P.; Strauss, M. Gene transfer into hepatocytes and human liver tissue by baculovirus vectors. Hum. Gene Ther., 1996, 7, 1937-1945.
103. Hofmann, C.; Lehnert, W.; Strauss, M. The baculovirus vector system for gene delivery into hepatocytes. Gene Ther. Mol. Biol., 1998, 1, 231-239.
104. Kost, T.A.; Condreay, J.P.; Ames, R.S.; Rees, S.; Romanos, M.A. Implementation of BacMam virus gene delivery technology in a drug discovery setting. Drug Discov. Today, 2007, 12, 396-403.
105. van Loo, N. D.; Fortunati, E.; Ehlert, E.; Rabelink, M.; Grosveld, F.; Scholte, B.J. Baculovirus infection of nondividing mammalian cells: mechanisms of entry and nuclear transport of capsids. J. Virol., 2001, 75, 961-970.
106. Laakkonen, J.P.; Kaikkonen, M.U.; Ronkainen, P.H.; Ihalainen, T.O.; Niskanen, E.A.; Hakkinen, M.; Salminen, M.; Kulomaa, M.S.; Ylä-Herttuala, S.; Airenne, K.J.; Vinhinen-Ranta, M. Baculovirus- mediated immediate-early gene expression and nuclear reorganization in human cells. Cell. Microbiol., 2008, 10, 667-681.
107. Lee, H.P.; Chen, Y.L.; Shen, H.C.; Lo, W.H.; Hu, Y.C. Baculovirus transduction of rat articular chondrocytes: roles of cell cycle. J. Gene Med., 2007, 9, 33-43.
108. Spenger, A.; Ernst, W.; Condreay, J.P.; Kost, T.A.; Grabherr, R. Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. Protein Exper. Purif., 2004, 38, 17-23.
109. Park, S.W.; Lee, H.K.; Kim, T.G.; Yoon, S.K.; Paik, S.Y. Hepatocyte- specific gene expression by baculovirus pseudotyped with vesicular stomatitis virus envelope glycoprotein. Biochem. Biophys. Res. Commun., 2001, 289, 444-450.
110. Li, Y.; Wang, X.; Guo, H.; Wang, S. Axonal transport of recombinant baculovirus vectors. Mol. Ther., 2004, 10, 1121-1129.
111. Li, Y.; Yang, Y.; Wang, S. Neuronal gene transfer by baculovirusderived vectors accommodating a neurone-specific promoter. Exp. Physiol., 2005, 90, 39-44.
112. Boublik, Y.; Di Bonito, P.; Jones, I.M. Eukaryotic virus display: Engineering the major surface glycoprotein of the Autographa californica nuclear polyhedrosis virus (AcNPV) for the presentation of foreign proteins on the virus surface. Biotechnology, 1995, 13, 1079-1084.
113. Grabherr, R.; Ernst, W.; Dobblhof-Dier, O.; Katinger H., S.M. Expression of foreign proteins on the surface of Autographa californica nuclear polyhedrosis virus. Biotechniques, 1997, 22, 730-735.
114. Ojala, K.; Mottershead, D.G.; Suokko, A.; Oker-Blom, C. Specific binding of baculoviruses displaying gp64 fusion proteins to mammalian cells. Biochem. Biophys. Res. Commun., 2001, 284, 777-784.
115. Spenger, A.; Grabherr, R.; Tollner, L.; Katinger, H.; Ernst, W. Altering the surface properties of baculovirus Autographa californica NPV by insertional mutagenesis of the envelope protein gp64. Eur. J. Biochem., 2002, 269, 4458-4467.
116. Barsoum, J.; Brown, R.; McKee, M.; Boyce, F.M. Efficient transduction of mammalian cells by a recombinant baculovirus having the vesicular stomatitis virus G glycoprotein. Hum. Gene Ther., 1997, 8, 2011-2018.
117. Pieroni, L.; Maione, D.; La Monica, N. In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors. Hum. Gene Ther., 2001, 12, 871-881.
118. Burns, J.C.; Friedmann, T.; Driever, W.; Burrascano, M.; Yee, J.K. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc. Natl. Acad. Sci. USA, 1993, 90, 8033-8037.
119. Kaikkonen, M.U.; Raty, J.K.; Airenne, K.J.; Wirth, T.; Heikura, T.; Yla-Herttuala, S. Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo. Gene Ther., 2006, 13, 304-312.
120. Yang, D.G.; Chung, Y.C.; Lai, Y.K.; Lai, C.W.; Liu, H.J.; Hu, Y.C. Avian influenza virus hemagglutinin display on baculovirus envelope: cytoplasmic domain affects virus properties and vaccine potential. Mol. Ther., 2007, 15, 989-996.
121. Raty, J.K.; Airenne, K.J.; Marttila, A.T.; Marjomaki, V.; Hytonen, V.P.; Lehtolainen, P.; Laitinen, O.H.; Mahonen, A.J.; Kulomaa, M.S.; Yla-Herttuala, S. Enhanced gene delivery by avidindisplaying baculovirus. Mol. Ther., 2004, 9, 282-291.
122. Makela, A.R.; Matilainen, H.; White, D.J.; Ruoslahti, E.; Oker- Blom, C. Enhanced baculovirus-mediated transduction of human cancer cells by tumor-homing peptides. J. Virol., 2006, 80, 6603-6611.
123. Makela, A.R.; Enback, J.; Laakkonen, J.P.; Vihinen-Ranta, M.; Laakkonen, P.; Oker-Blom, C. Tumor targeting of baculovirus displaying a lymphatic homing peptide. J. Gene Med., 2008, 10, 1019-1031.
124. Kukkonen, S.P.; Airenne, K.J.; Marjomaki, V.; Laitinen, O.H.; Lehtolainen, P.; Kankaanpaa, P.; Mahonen, A.J.; Raty, J.K.; Nordlund, H.R.; Oker-Blom, C.; Kulomaa, M.S.; Yla-Herttuala, S. Baculovirus capsid display: a novel tool for transduction imaging. Mol. Ther., 2003, 8, 853-862.
125. Makela, A.; Oker-Blom, C. Baculovirus display: a multifunctional technology for gene delivery and eukaryotic library development. Adv. Virus Res., 2006, 68, 91-112.
126. Makela, A.R.; Oker-Blom, C. The baculovirus display technology - an evolving instrument for molecular screening and drug delivery. Comb. Chem. High Throughput Screen., 2008, 11, 86-98.
127. Wang, L.; Shan, L.; Yin, J.; Zhao, M.; Su, D.; Zhong, J. The activation of lytic replication of Epstein-Barr virus by baculovirusmediated gene transduction. Arch. Virol., 2006, 151, 2047-2053.
128. Andersson, M.; Warolen, M.; Nilsson, J.; Selander, M.; Sterky, C.; Bergdahl, K.; Sorving, C.; James, S.R.; Doverskog, M. Baculovirus- mediated gene transfer and recombinant protein expression do not interfere with insulin dependent phosphorylation of PKB/Akt in human SHSY-5Y and C3A cells. BMC Cell Biol., 2007, 8, 6.
129. Song, S.U.; Boyce, F.M. Combination treatment for osteosarcoma with baculoviral vector mediated gene therapy (p53) and chemotherapy (adriamycin). Exp. Mol. Med., 2001, 33, 46-53.
130. Yap, C.C.; Ishii, K.; Aoki, Y.; Aizaki, H.; Tani, H.; Shimizu, H.; Ueno, Y.; Miyamura, T.; Matsuura, Y. A hybrid baculovirus-T7 RNA polymerase system for recovery of an infectious virus from cDNA. Virology, 1997, 231, 192-200.
131. Sung, L.Y.; Lo, W.H.; Chiu, H.Y.; Chen, H.C.; Chung, C.K.; Lee, H.P.; Hu, Y.C. Modulation of chondrocyte phenotype via baculovirus- mediated growth factor expression. Biomaterials, 2007, 28, 3437-3447.
132. Pan, Y.; Fang, L.; Fan, H.; Luo, R.; Zhao, Q.; Chen, H.; Xiao, S. Antitumor effects of a recombinant pseudotype baculovirus expressing Apoptin in vitro and in vivo. Int. J. Cancer, 2010, 126, 2741-2751.
133. Grabowska, A.K.; Lipińska, A.D.; Rohde, J.; Szewczyk, B.; Bienkowska- Szewczyk, K.; Rziha, H.J. New baculovirus recombinants expressing Pseudorabies virus (PRV) glycoproteins protect mice against lethal challenge infection. Vaccine, 2009, 27, 3584-3591.
134. Wilson, J.M. Gendicine: the first commercial gene therapy product. Hum. Gene Ther., 2005, 16, 1014-1015.
135. Condreay, J.P.; Witherspoon, S.M.; Clay, W.C.; Kost, T.A. Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. Proc. Natl. Acad. Sci. USA, 1999, 96, 127-132.
136. Merrihew, R.V.; Clay, W.C.; Condreay, J.P.; Witherspoon, S.M.; Dallas, W.S.; Kost, T.A. Chromosomal integration of transduced recombinant baculovirus DNA in mammalian cells. J. Virol., 2001, 75, 903-909.
137. [Airenne, K.J.; Mahonen, A.J.; Laitinen, O.H.; Yla-Herttuala, S. In: Gene and Cell Therapy. Therapeutic Mechanisms and Strategies; Templeton, N.S., Ed.; CRC Press Taylor & Francis Group, 2008, 3rd ed., pp. 263-292.
138. Georgopoulos, L.J.; Elgue, G.; Sanchez, J.; Dussupt, V.; Magotti, P.; Lambris, J.D.; Tötterman, T.H.; Maitland, N.J.; Nilsson, B. Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood. Mol. Immunol., 2009, 46, 2911-2917.
139. Hofmann, C.; Strauss, M. Baculovirus-mediated gene transfer in the presence of human serum or blood facilitated by inhibition of the complement system. Gene Ther., 1998, 5, 531-536.
140. Hofmann, C.; Huser, A.; Lehnert, W.; Strauss, M. Protection of baculovirus-vectors against complement-mediated inactivation by recombinant soluble complement receptor type 1. Biol. Chem., 1999, 380, 393-395.
141. Tani, H.; Limn, C.K.; Yap, C.C.; Onishi, M.; Nozaki, M.; Nishimune, Y.; Okahashi, N.; Kitagawa, Y.; Watanabe, R.; Mochizuki, R.; Moriishi, K.; Matsuura, Y. In vitro and in vivo gene delivery by recombinant baculoviruses. J. Virol., 2003, 77, 9799-9808.
142. Hoare, J.; Waddington, S.; Thomas, H.C.; Coutelle, C.; McGarvey, M.J. Complement inhibition rescued mice allowing observation of transgene expression following intraportal delivery of baculovirus in mice. J. Gene Med., 2005, 7, 325-333.
143. Huser, A.; Rudolph, M.; Hofmann, C. Incorporation of decayaccelerating factor into the baculovirus envelope generates complement- resistant gene transfer vectors. Nat. Biotechnol., 2001, 19, 451-455.
144. Kim, Y.K.; Park, I.K.; Jiang, H.L.; Choi, J.Y.; Je, Y.H.; Jin, H.; Kim, H.W.; Cho, M.H.; Cho, C.S. Regulation of transduction efficiency by pegylation of baculovirus vector in vitro and in vivo. J. Biotechnol., 2006, 125, 104-109.
145. Kim, Y.K.; Choi, J.Y.; Yoo, M.K.; Jiang, H.L.; Arote, R.; Je, Y.H.; Cho, M.H.; Cho C.S. Receptor-mediated gene delivery by folate- PEG-baculovirus in vitro. J. Biotechnol., 2007, 131, 353-361.
146. Sarkis, C.; Serguera, C.; Petres, S.; Buchet, D.; Ridet, J.L.; Edelman, L.; Mallet, J. Efficient transduction of neural cells in vitro and in vivo by a baculovirus-derived vector. Proc. Natl. Acad. Sci. USA, 2000, 97, 14638-14643.
147. Lehtolainen, P.; Tyynela, K.; Kannasto, J.; Airenne, K.J.; Yla-Herttuala, S. Baculoviruses exhibit restricted cell type specificity in rat brain: a comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo. Gene Ther., 2002, 9, 1693-1699.
148. Wang, X.; Wang, C.; Zeng, J.; Xu, X.; Hwang, P.Y.; Yee, W.C.; Ng, Y.K.; Wang, S. Gene transfer fto dorsal root ganglia by intrathecal injection: effects on regeneration of peripheral nerves. Mol. Ther., 2005, 12, 314-320.
149. Liu, X.; Li, K.; Song, J.; Liang, C.; Wang, X.; Chen, X. Efficient and stable gene expression in rabbit intervertebral disc cells transduced with a recombinant baculovirus vector. Spine, 2006, 31, 732-735.
150. Kinnunen, K.; Kalesnykas, G.; Mähönen, A.J.; Laidinen, S.; Holma, L.; Heikura, T.; Airenne, K.; Uusitalo, H.; Ylä-Herttuala, S. Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye. J. Gene Med., 2009, 11, 382-389.
151. Wang, C.Y.; Li, F.; Yang, Y.; Guo, H.Y.; Wu, C.X.; Wang, S. Recombinant baculovirus containing the diphtheria toxin A gene for malignant glioma therapy. Cancer Res., 2006, 66, 5798-5806.
152. Huang, W.; Tian, X.L.; Wu, Y.L.; Zhong, J.; Yu, L.F.; Hu, S.P.; Li, B. Suppression of gastric cancer growth by baculovirus vectormediated transfer of normal epithelial cell specific-1 gene. World J. Gastroenterol., 2008, 14, 5810-5815.
153. Nicholson, L.J.; Philippe, M.; Paine, A.J.; Mann, D.A.; Dolphin, C.T. RNA interference mediated in human primary cells via recombinant baculoviral vectors. Mol. Ther., 2005, 11, 638-644.
154. Suzuki, H.; Saitoh, H.; Suzuki, T.; Takaku, H. Baculovirusmediated bispecific short-hairpin small-interfering RNAs have remarkable ability to cope with both influenza viruses A and B. Oligonucleotides, 2009, 19, 307-316.
155. Isom, H.C.; Starkey, J.L.; Chiari, E. Recombinant baculovirus expressing anti-HBsAg shRNA inhibits HBV cccDNA amplification in HepG2 cells. FASEB J., 2007, 21, A1137a., 867.11; (Meeting Abstract Supplement) A1137.
156. Suzuki, H.; Matsumoto, N.; Suzuki, T.; Chang, M.; Takaku, H. Stable replication of the EBNA1/OriP-mediated baculovirus vector and its application to anti-HCV gene therapy. Virology J., 2009, 6,156.
157. Murges, D.; Kremer, A.; Knebel-Morsdorf, D. Baculovirus transactivator IE1 is functional in mammalian cells. J. Gen. Virol., 1997, 78, 1507-1510.
158. Dai, X.; Willis, L.G.; Huijskens, I.; Palli, S.R.; Theilmann, D.A. The acidic activation domains of the baculovirus transactivators IE1 and IE0 are functional for transcriptional activation in both insect and mammalian cells. J. Gen. Virol., 2004, 85, 573-582.
159. Fujita, R.; Matsuyama, T.; Yamagishi, J.; Sahara, K.; Asano, S.; Bando, H. Expression of Autographa californica multiple nucleopolyhedrovirus genes in mammalian cells and upregulation of the host {beta}-actin gene. J. Virol., 2006, 80, 2390-2395.
160. Kenoutis, C.; Efrose, R.C.; Swevers, L.; Lavdas, A.A.; Gaitanou, M.; Matsas, R.; Iatrou, K. Baculovirus-mediated gene delivery into mammalian cells does not alter their transcriptional and differentiating potential but is accompanied by early viral gene expression. J. Virol., 2006, 80, 4135-4146.