Peripheral chemoreflex and baroreflex interactions in cardiovascular regulation in humans

Journal of Physiology

Volumn 552, Issue 1, 2003, Pages 295-302

  Halliwill, John R ^c   Morgan, Barbara J ^a   Charkoudian, Nisha ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b DEPARTMENT OF UROLOGY   (United States)

^c UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTERIAL OXYGEN SATURATION; ARTERIAL PRESSURE; ARTICLE; BREATHING RATE; CARDIOVASCULAR FUNCTION; CHEMORECEPTOR; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; FEMALE; HEART MUSCLE ISCHEMIA; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; MALE; NERVE CONDUCTION; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SYMPATHETIC NERVE; VASOCONSTRICTION; ADRENERGIC TRANSMISSION; BREATHING PATTERN; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RESPONSE; HYPERPNEA; HYPOXIA; MEAN ARTERIAL PRESSURE; MUSCLE SYMPATHETIC NERVE ACTIVITY; TIDAL VOLUME;

ADULT; ANOXIA; BAROREFLEX; CARBON DIOXIDE; CARDIOVASCULAR PHYSIOLOGIC PHENOMENA; CHEMORECEPTORS; FEMALE; HEART RATE; HUMANS; MALE; RESPIRATORY MECHANICS; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION;

EID: 0142125297     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.050708     Document Type: Article

References (38)

1. O2 despite rapid changes in ventilation. J Appl Physiol 88, 1597-1600.
2. A,CO2 and ventilation on the setting and sensitivity of the baroreceptor-cardiac-depressor reflex in man. J Physiol 234, 112-114P.
3. Bowes G, Townsend ER, Kozar LF, Bromley SM & Phillipson EA (1981). Effect of carotid body denervation on arousal response to hypoxia in sleeping dogs. J Appl Physiol 51, 40-45.
4. Bruce EN & Cherniack NS (1987). Central chemoreceptors. J Appl Physiol 62, 389-402.
5. Dinenno FA, Joyner MJ & Halliwill JR (2003). Failure of systemic hypoxia to blunt α-adrenergic vasoconstriction in the human forearm. J Physiol 549, 985-994.
6. Ebert TJ & Cowley AW Jr (1992). Baroreflex modulation of sympathetic outflow during physiological increases of vasopressin in humans. Am J Physiol 262, H1372-1378.
7. Eckberg DL, Bastow H III & Scruby AE (1982). Modulation of human sinus node function by systemic hypoxia. J Appl Physiol 52, 570-577.
8. Eckberg DL & Sleight P (1992). Human Baroreflexes in Health and Disease. Oxford University Press, New York.
9. Fitzgerald RS & Lahiri S (1986). Reflex responses to chemoreceptor stimulation. In Handbook of Physiology, section 3, The Respiratory System, vol. II, Control of Breathing, ed. Cherniack NS & Widdicombe JG, pp. 313-362. American Physiological Society, Bethesda, MD, USA.
10. Gupta PD & Singh M (1987). Tachycardia of carotid chemoreceptors originates in apneic asphyxia in dogs. Am J Physiol 253, H591-597.
11. Halliwill JR (2000). Segregated signal averaging of sympathetic baroreflex responses in humans. J Appl Physiol 88, 767-773.
12. Halliwill JR & Minson CT (2002). Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans. J Appl Physiol 93, 857-864.
13. Heistad DD, Abboud FM, Mark AL & Schmid PG (1974). Interaction of baroreceptor and chemoreceptor reflexes. Modulation of the chemoreceptor reflex by changes in baroreceptor activity. J Clin Invest 53, 1226-1236.
14. Heistad DD, Abboud FM, Mark AL & Schmid PG (1975). Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation. J Appl Physiol 39, 411-416.
15. Iriki M, Dorward P & Korner PI (1977). Baroreflex 'resetting' by arterial hypoxia in the renal and cardiac sympathetic nerves of the rabbit. Pflugers Arch 370, 1-7.
16. Korner PI (1979). Central nervous control of autonomic cardiovascular function. In Handbook of Physiology, section 2, The Cardiovascular System, vol. I, The Heart, ed. Berne RM, Sperelakis N & Geiger SR, pp. 691-739. American Physiological Society, Bethesda, MD, USA.
17. Loewy AD (1990). Central autonomic pathways. In Central Regulation of Autonomic Function. ed. Loewy AD & Spyer KM, pp. 88-103. Oxford University Press, New York.
18. Malpas SC, Bendle RD, Head GA & Ricketts JH (1996). Frequency and amplitude of sympathetic discharges by baroreflexes during hypoxia in conscious rabbits. Am J Physiol 271, H2563-2574.
19. Mancia G (1975). Influence of carotid baroreceptors on vascular responses to carotid chemoreceptor stimulation in the dog. Circ Res 36, 270-276.
20. Minson CT, Halliwill JR, Young TM & Joyner MJ (2000a). Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101, 862-868.
21. Minson CT, Halliwill JR, Young TM & Joyner MJ (2000b). Sympathetic activity and baroreflex sensitivity in young women taking oral contraceptives. Circulation 102, 1473-1476.
22. Miura M & Reis DJ (1972). The role of the solitary and paramedian reticular nuclei in mediating cardiovascular reflex responses from carotid baro- and chemoreceptors. J Physiol 223, 525-548.
23. Pelletier CL & Shepherd JT (1975). Effect of hypoxia on vascular responses to the carotid baroreflex. Am J Physiol 228, 331-336.
24. Raven PB, Potts JT & Shi X (1997). Baroreflex regulation of blood pressure during dynamic exercise. Exerc Sports Sci Rev 25, 365-389.
25. Rowell LB (1993). Human Cardiovascular Control. Oxford University Press, New York.
26. Rowell LB, Johnson DG, Chase PB, Comess KA & Seals DR (1989). Hypoxemia raises muscle sympathetic activity but not norepinephrine in resting humans. J Appl Physiol 66, 1736-1743.
27. Rudas L, Crossman AA, Morillo CA, Halliwill JR, Tahvanainen KUO, Kuusela TA & Eckberg DL (1999). Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine. Am J Physiol 276, H1691-1698.
28. Rutherford JD & Vatner SF (1978). Integrated carotid chemoreceptor and pulmonary inflation reflex control of peripheral vasoreactivity in conscious dogs. Circ Res 43, 200-208.
29. Sagawa S, Torii R, Nagaya K, Wada F, Endo Y & Shiraki K (1997). Carotid baroreflex control of heart rate during acute exposure to simulated altitudes of 3800 m and 4300 m. Am J Physiol 273, R1219-1223.
30. Saito M, Mano T, Iwase S, Koga K, Abe H & Yamazaki Y (1988). Responses in muscle sympathetic activity to acute hypoxia in humans. J Appl Physiol 65, 1548-1552.
31. Seals DR, Suwarno NO & Dempsey JA (1990). Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 67, 130-141.
32. Seals DR, Suwarno NO, Joyner ML Iber C, Copeland JG & Dempsey JA (1993). Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circ Res 72, 440-454.
33. Somers VK, Mark AL & Abboud FM (1991). Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 87, 1953-1957.
34. Somers VK, Mark AL, Zavala DC & Abboud FM (1989). Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol 67, 2095-2100.
35. St Croix CM, Morgan BJ, Wetter TJ & Dempsey JA (2000). Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans. J Physiol 529, 493-504.
36. Sundlöf G & Wallin BG (1977). The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol 272, 383-397.
37. Victor RG, Secher NH, Lyson T & Mitchell JH (1995). Central command increases sympathetic nerve activity during intense intermittent isometric exercise in humans. Circ Res 76, 127-131.
38. Weisbrod CJ, Minson CT, Joyner MJ & Halliwill JR (2001). Effects of regional phentolamine on hypoxic vasodilatation in healthy humans. J Physiol 537, 613-621.