Ventilatory responses to specific CNS hypoxia in sleeping dogs

Journal of Applied Physiology

Volumn 88, Issue 5, 2000, Pages 1840-1852

  Curran, Aidan K ^a   Rodman, Joshua R ^a   Eastwood, Peter R ^a   Henderson, Kathleen S ^a   Dempsey, Jerome A ^a   Smith, Curtis A ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b NONE   (United States)

Author keywords

Carotid body; Chemoreceptors; Hypocapnia; Hypoxic depression

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN HYPOXIA; BREATHING RATE; CAROTID BODY; CHEMORECEPTOR REFLEX; CHEMOSENSITIVITY; CONTROLLED STUDY; DOG; FEMALE; HYPERVENTILATION; HYPOCAPNIA; LUNG VENTILATION; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RESPIRATION CONTROL;

EID: 0034111928     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.5.1840     Document Type: Article

References (52)

1. CO2 responses to hypoxia in awake goats. J Appl Physiol 80: 176-181, 1996.
2. Badr MS, Skatrud JB, and Dempsey JA. Determinants of poststimulus potentiation in humans during NREM sleep. J Appl Physiol 73: 1958-1971, 1992.
3. Bisgard GE and Neubauer JA. Peripheral and central effects of hypoxia. In: Regulation of Breathing (2nd ed.), edited by Dempsey JA and Pack AI. New York: Dekker, 1994, p. 617-668.
4. Bouverot P and Bureau M. Ventilatory acclimatization and CSF acid-base balance in carotid chemodenervated dogs at 3,550 m. Pflügers Arch 361: 17-23, 1975.
5. Bouverot P, Candas V, and Libert JP. Role of the arterial chemoreceptors in ventilatory adaptation to hypoxia of awake dogs and rabbits. Respir Physiol 17: 209-219, 1973.
6. Bowes G, Townsend ER, Kozar LF, Bromley SM, and Phillipson EA. Effect of carotid body denervation on arousal response to hypoxia in sleeping dogs. J Appl Physiol 51: 40-45, 1981.
7. Daly M de Burgh. Interactions between respiration and circulation. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 2, chapt. 16, p. 529-594.
8. Davenport HW, Brewer G, Chambers AH, and Goldschmidt S. The respiratory responses to anoxemia of unanesthetized dogs with chronically denervated aortic and carotid chemoreceptors and their causes. Am J Physiol 148: 406-416, 1947.
9. Davies RO, Nishino T, and Lahiri S. Sympathectomy does not alter the response of carotid chemoreceptors to hypoxemia during carboxyhemoglobinemia or anemia. Neurosci Lett 21: 159-164, 1981.
10. Dillon GH and Waldrop TG. In vitro responses of caudal hypothalamic neurons to hypoxia and hypercapnia. Neuroscience 51: 941-950, 1992.
11. Engwall MJA, Smith CA, Dempsey JA, and Bisgard GE. Ventilatory afterdischarge and central respiratory drive interactions in the awake goat. J Appl Physiol 76: 416-423, 1994.
12. Evans HE. Miller's Anatomy of the Dog. Philadelphia, PA: Saunders, 1993.
13. Forster HV, Bisgard GE, Rasmussen B, Onn JA, Buss DD, and Manohar M. Ventilatory control in peripheral chemoreceptor-denervated ponies during chronic hypoxemia. J Appl Physiol 41: 878-885, 1976.
14. Georgopoulos D, Bshouty Z, Younes M, and Anthonisen NR. Hypoxic exposure and activation of the afterdischarge mechanism in conscious humans. J Appl Physiol 69: 1159-1164, 1990.
15. Goiny M, Lagercrantz H, Srinivasan M, Ungerstedt U, and Yamamoto H. Hypoxia-mediated in vivo release of dopamine in nucleus tractus solitarii of rabbits. J Appl Physiol 70: 2395-2400, 1991.
16. Hatcher JD, Chiu LK, and Jennings DB. Anaemia as a stimulus to aortic and carotid chemoreceptors in the cat. J Appl Physiol 44: 696-702, 1978.
17. Horn EM and Waldrop TG. Oxygen-sensing neurons in the caudal hypothalamus and their role in cardiorespiratory control. Respir Physiol 110: 219-228, 1997.
18. 2 during hypoxemia. J Appl Physiol 63: 1567-1571, 1987.
19. Jiang C and Haddad GG. A direct mechanism for sensing low oxygen levels by central neurons. Proc Natl Acad Sci USA 91: 7198-7201, 1994.
20. Krasney JA, Magno MG, Levitzky MG, Koehler RC, and Davies DG. Cardiovascular responses to arterial hypoxia in awake sinoaortic-denervated dogs. J Appl Physiol 35: 733-738, 1973.
21. Lahiri S. Efferent inhibition of carotid body chemoreception in chronically hypoxic cats. Am J Physiol Regulatory Integrative Comp Physiol 245: R678-R683, 1983.
22. Lahiri S, Edelman NH, Cherniack NS, and Fishman AP. Role of carotid chemoreflex in respiratory acclimatization to hypoxemia in goat and sheep. Respir Physiol 46: 367-382, 1981.
23. Lee MC, Reid LA, and Ramsay DJ. Blood flows in the maxillocarotid anastomoses and internal carotid artery of conscious dogs. Anat Rec 215: 192-197, 1986.
24. 2 and hypoxia after sustained hypoxia in awake cats. J Appl Physiol 76: 2262-2266, 1994.
25. Long WQ, Giesbrecht GG, and Anthonisen NR. Ventilatory response to moderate hypoxia in awake chemodenervated cats. J Appl Physiol 74: 805-810, 1993.
26. McQueen DS, Evrard Y, Gordon BH, and Campbell DB. Ganglioglomerular nerves influence responsiveness of cat carotid chemoreceptors to almitrine. J Auton Nerv Syst 27: 57-66, 1989.
27. 2 sensitivity of cat phrenic neurogram during hypoxic respiratory depression. J Appl Physiol 65: 736-743, 1988.
28. Melton JE, Yu QP, Neubauer JA, and Edelman NH. Modulation of respiratory responses to carotid sinus nerve stimulation by brain hypoxia. J Appl Physiol 73: 2166-2171, 1992.
29. Miller MJ and Tenney SM. Hypoxia-induced tachypnea in carotid-deafferented cats. Respir Physiol 23: 31-39, 1975.
30. Mitchell RA and McCloskey DI. Chemoreceptor responses to sympathetic stimulation and changes in blood pressure. Respir Physiol 20: 297-302, 1974.
31. Neubauer JA, Melton JE, and Edelman NH. Modulation of respiration during brain hypoxia. J Appl Physiol 68: 441-451, 1990.
32. Neubauer JA, Santiago TV, Posner MA, and Edelman NH. Ventral medullary pH and ventilatory responses to hyperperfusion and hypoxia. J Appl Physiol 58: 1659-1968, 1985.
33. Neubauer JA, Simone A, and Edelman NH. Role of brain lactic acidosis in hypoxic depression of respiration. J Appl Physiol 65: 1324-3131, 1988.
34. Nolan PC, Dillon GH, and Waldrop TG. Central hypoxic chemoreceptors in the ventrolateral medulla and caudal hypothalamus. Adv Exp Med Biol 393: 261-266, 1995.
35. Olson EB Jr, Vidruk EH, and Dempsey JA. Carotid body excision significantly changes ventilatory control in awake rats. J Appl Physiol 64: 666-671, 1988.
36. O'Regan RG. Responses of carotid body chemosensory activity and blood flow to stimulation of sympathetic nerves in the cat. J Physiol (Lond) 315: 81-98, 1981.
37. Orem J, Netick A, and Dement WC. Breathing during sleep and wakefulness in the cat. Respir Physiol 30: 265-289, 1977.
38. Ou LC, St. John WM, and Tenney SM. The contribution of central mechanisms rostral to the pens in high-altitude ventilatory acclimatization. Respir Physiol 54: 343-351, 1983.
39. Pan LG, Forster HV, Martino P, Strecker PJ, Beales J, Serra A, Lowry TF, Forster MM, and Forster AL. Important role of carotid afferents in control of breathing. J Appl Physiol 85: 1299-1306, 1998.
40. Phillipson EA and Bowes G. Control of breathing during sleep. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 2, chapt. 19, p. 649-689.
41. Prabhakar NR and Kou YR. Inhibitory sympathetic action on the carotid body responses to sustained hypoxia. Respir Physiol 95: 67-79, 1994.
42. Reis DJ, Golanov EV, Ruggiero DA, and Sun MK. Sympatho-excitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulations. J Hypertens Suppl 12: S159-S180, 1994.
43. Ryan ML, Bisgard GE, Pizarro J, and Hedrick MS. Effects of carotid body sympathetic denervation on ventilatory acclimatization to hypoxia in the goat. Respir Physiol 99: 215-224, 1995.
44. Shima T, Ishikawa S, Sasaki U, Miyazaki M, and Hibino H. Quantitative measurement of the basilar arterial flow in the dog - electromagnetic flowmeter study of the extra- and intracranial arterial occlusion. No Shinkei Geka 4: 451-457, 1976.
45. Smith CA, Bisgard GE, Nielsen AM, Daristotle L, Kressin NA, Forster HV, and Dempsey JA. Carotid bodies are required for ventilatory acclimatization to chronic hypoxia. J Appl Physiol 60: 1003-1010, 1986.
46. Smith CA, Engwall MJA, Dempsey JA, and Bisgard GE. Effects of specific carotid body and brain hypoxia on respiratory muscle control in the awake goat. J Physiol (Lond) 460: 623-640, 1993.
47. Smith CA, Saupe KW, Henderson KS, and Dempsey JA. Ventilatory effects of specific carotid body hypocapnia in dogs during wakefulness and sleep. J Appl Physiol 79: 689-699, 1995.
48. Sun MK and Reis DJ. Central neural mechanisms mediating excitation of sympathetic neurons by hypoxia. Prog Neurobiol 44: 197-219, 1994.
49. Sun MK and Reis DJ. Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats. Am J Physiol Regulatory Integrative Comp Physiol 266: R245-R256, 1994.
50. Tenney SM and Ou LC. Ventilatory response of decorticate and decerebrate cats to hypoxia and CO2. Respir Physiol 29: 81-92, 1976.
51. Van Seek JH, Berkenbosch A, de Goede J, and Olievier CN. Effects of brain stem hypoxaemia on the regulation of breathing. Respir Physiol 57: 171-188, 1984.
52. Xu F, Sato M, Spellman MJ Jr, Mitchell RA, and Severinghaus JW. Topography of cat medullary ventral surface hypoxic acidification. J Appl Physiol 73: 2631-2637, 1992.