Microfabricated particulate drug-delivery systems

Biotechnology Journal

Volumn 6, Issue 12, 2011, Pages 1477-1487

  Pan, Jing ^a   Chan, Sui Yung ^a   Lee, Won Gu ^b   Kang, Lifeng ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Kyung Hee University   (South Korea)

Author keywords

Engineered drug delivery; Particle shape; Particle size

Indexed keywords

CONTROLLED RELEASE; CONVENTIONAL TECHNIQUES; DRUG-DELIVERY SYSTEMS; MICRO-FABRICATION TECHNIQUES; MICROFABRICATED; NANO PARTICULATES; PARTICLE SHAPE; SIZE AND SHAPE;

BIOLOGICAL MATERIALS; DRUG DELIVERY; NANOPARTICLES; PARTICLE SIZE; SCAFFOLDS; SCAFFOLDS (BIOLOGY);

MICROFABRICATION;

BUPIVACAINE; CISPLATIN; DENDRIMER; DOXORUBICIN; LIPOSOME; NANOPARTICLE; PACLITAXEL; TRANSFERRIN;

BIOPRINTING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FILM STRETCHING; FLOW FOCUSING MICROFLUIDIC DEVICE; FLOW LITHOGRAPHY; HYDROGEL; MICELLE; MICROFLUIDICS; MICROTECHNOLOGY; NANOENCAPSULATION; NANOFABRICATION; PANCREAS TUMOR; PARTICLE REPLICATION IN NON WETTING TEMPLATE; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW; STEP AND FLASH IMPRINT LITHOGRAPHY; STOMACH TUMOR; SURFACE PROPERTY;

BIOTECHNOLOGY; DRUG DELIVERY SYSTEMS; MICROTECHNOLOGY; NANOTECHNOLOGY; PARTICLE SIZE;

EID: 83455211903     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201100237     Document Type: Review

References (99)

1. Vicent, M. J., Duncan, R., Polymer conjugates: Nanosized medicines for treating cancer. Trends Biotechnol. 2006, 24, 39-47.
2. Moghimi, S. M., Hunter, A. C., Murray, J. C., Nanomedicine: Current status and future prospects. FASEB J. 2005, 19, 311-330.
3. Barenholz, Y., Liposome application: Problems and prospects. Curr. Opin. Colloid Interface Sci. 2001, 6, 66-77.
4. Kwon, G. S., Kataoka, K., Block copolymer micelles as long-circulating drug vehicles. Adv. Drug Delivery Rev. 1995, 16, 295-309.
5. Lee, C. C., MacKay, J. A., Frechet, J. M., Szoka, F. C., Designing dendrimers for biological applications. Nat. Biotechnol. 2005, 23, 1517-1526.
6. Torchilin, V. P., Targeted polymeric micelles for delivery of poorly soluble drugs. Cell. Mol. Life Sci. 2004, 61, 2549-2559.
7. Duncan, R., The dawning era of polymer therapeutics. Nat. Rev. Drug Discovery 2003, 2, 347-360.
8. Allen, T. M., Cullis, P. R., Drug delivery systems: Entering the mainstream. Science 2004, 303, 1818-1822.
9. Bawarski, W. E., Chidlowsky, E., Bharali, D. J., Mousa, S. A., Emerging nanopharmaceuticals. Nanomedicine 2008, 4, 273-282.
10. Wei, L., Lin, J., Cai, C., Fang, Z., Fu, W., Drug-carrier/hydrogel scaffold for controlled growth of cells. Eur. J. Pharm. Biopham 2011, 78, 346-354.
11. Zhu, C. T., Xu, Y. Q., Shi, J., Li, J., Ding, J., Liposome combined porous beta-TCP scaffold: Preparation, characterization, and anti-biofilm activity. Drug Delivery 2010, 17, 391-398.
12. Zhao, X., Kim, J., Cezar, C. A., Huebsch, N. et al., Active scaffolds for on-demand drug and cell delivery. Proc. Natl. Acad. Sci. USA 2011, 108, 67-72.
13. Mourino, V., Boccaccini, A. R., Bone tissue engineering therapeutics: Controlled drug delivery in three-dimensional scaffolds. J. R. Soc. Interface 2010, 7, 209-227.
14. Riley, S. (Ed.), Innovation in Drug Delivery: The future of nanotechnology and non-invasive protein delivery. Business Insights 2006, pp. 25-26.
15. Euliss, L. E., DuPont, J. A., Gratton, S., DeSimone, J., Imparting size, shape, and composition control of materials for nanomedicine. Chem. Soc. Rev. 2006, 35, 1095-1104.
16. Langer, R., Drug delivery and targeting. Nature 1998, 392, 5-10.
17. Patil, Y. B., Toti, U. S., Khdair, A., Ma, L., Panyam, J., Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery. Biomaterials 2009, 30, 859-866.
18. Brandl, F., Kastner, F., Gschwind, R. M., Blunk, T. et al., Hydrogel-based drug delivery systems: Comparison of drug diffusivity and release kinetics. J. Controlled Release 2010, 142, 221-228.
19. Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C. et al., Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2007, 2, 751-760.
20. Jain, S., Kaur, A., Puri, R., Utreja, P. et al., Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery. Eur. J. Med. Chem. 2010, 45, 4997-5005.
21. Kopecek, J., Polymer chemistry: Swell gels. Nature 2002, 417, 388-391.
22. LaVan, D. A., McGuire, T., Langer, R., Small-scale systems for in vivo drug delivery. Nat. Biotechnol. 2003, 21, 1184-1191.
23. Sahiner, N., Godbey, W., McPherson, G., John, V., Microgel, nanogel and hydrogel-hydrogel semi-IPN composites for biomedical applications: Synthesis and characterization. Colloid Polym. Sci. 2006, 284, 1121-1129.
24. Oh, J. K., Drumright, R., Siegwart, D. J., Matyjaszewski, K., The development of microgels/nanogels for drug delivery applications. Prog. Polym. Sci. 2008, 33, 448-477.
25. Kabanov, A. V., Vinogradov, S. V., Nanogels as pharmaceutical carriers: Finite networks of infinite capabilities. Angew. Chem. Int. Ed. 2009, 48, 5418-5429.
26. Geckil, H., Xu, F., Zhang, X., Moon, S., Demirci, U., Engineering hydrogels as extracellular matrix mimics. Nanomedicine (Lond) 2010, 5, 469-484.
27. Huang, G. Y., Zhou, L. H., Zhang, Q. C., Chen, Y. M. et al., Microfluidic hydrogels for tissue engineering. Biofabrication 2011, 3, 012001.
28. Haley, B., Frenkel, E., Nanoparticles for drug delivery in cancer treatment. Urol. Oncol. 2008, 26, 57-64.
29. Chatterjee, S., Banerjee, D. K., Preparation, isolation, and characterization of liposomes containing natural and synthetic lipids. in: Basu S. C., Basu M. (Eds.), Liposome Methods and Protocols, Humana Press, 2002, pp. 3-16.
30. Klibanov, A. L., Maruyama, K., Torchilin, V. P., Huang, L., Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 1990, 268, 235-237.
31. Cao, Z., Tong, R., Mishra, A., Xu, W. et al., Reversible cell-specific drug delivery with aptamer-functionalized liposomes. Angew. Chem. Int. Ed. 2009, 48, 6494-6498.
32. Singh, R., Lillard, J. W. Jr., Nanoparticle-based targeted drug delivery. Exp. Mol. Pathol. 2009, 86, 215-223.
33. Kazunori, K., Glenn S, K., Masayuki, Y., Teruo, O. et al., Block copolymer micelles as vehicles for drug delivery. J. Controlled Release 1993, 24, 119-132.
34. Masayuki, Y., Mizue, M., Noriko, Y., Teruo, O. et al., Polymer micelles as novel drug carrier: Adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. J. Controlled Release 1990, 11, 269-278.
35. Yokoyama, M., Okano, T., Sakurai, Y., Ekimoto, H. et al., Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res. 1991, 51, 3229-3236.
36. Haag, R., Supramolecular drug-delivery systems based on polymeric core-shell architectures. Angew. Chem. Int. Ed. 2004, 43, 278-282.
37. Kedar, U., Phutane, P., Shidhaye, S., Kadam, V., Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine 2010, 6, 714-729.
38. Cai, S., Vijayan, K., Cheng, D., Lima, E. M. et al., Micelles of different morphologies-advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharm. Res. 2007, 24, 2099-2109.
39. Patri, A. K., Majoros, I. J., Baker, J. R., Dendritic polymer macromolecular carriers for drug delivery. Curr. Opin. Chem. Biol. 2002, 6, 466-471.
40. Pridgen, E. M., Langer, R., Farokhzad, O. C., Biodegradable, polymeric nanoparticle delivery systems for cancer therapy. Nanomedicine (Lond) 2007, 2, 669-680.
41. Baker, J. R., Dendrimer-based nanoparticles for cancer therapy. in: Gewirtz, A. M. et al. (Ed.), Hematology, American Society of Hematology 2009, pp. 708-719.
42. Kolhe, P., Khandare, J., Pillai, O., Kannan, S. et al., Preparation, cellular transport, and activity of polyamidoamine-based dendritic nanodevices with a high drug payload. Biomaterials 2006, 27, 660-669.
43. Kurtoglu, Y. E., Navath, R. S., Wang, B., Kannan, S. et al., Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery. Biomaterials 2009, 30, 2112-2121.
44. Luo, D., Haverstick, K., Belcheva, N., Han, E. et al., Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible, high-efficiency DNA delivery. Macromolecules 2002, 35, 3456-3462.
45. Zhu, S., Hong, M., Tang, G., Qian, L. et al., Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: The effects of PEGylation degree and drug conjugation style. Biomaterials 2010, 31, 1360-1371.
46. Gratton, S. E., Pohlhaus, P. D., Lee, J., Guo, J. et al., Nanofabricated particles for engineered drug therapies: A preliminary biodistribution study of PRINT nanoparticles. J. Controlled Release 2007, 121, 10-18.
47. Stolnik, S., Illum, L., Davis, S. S., Long circulating microparticulate drug carriers. Adv. Drug Delivery Rev. 1995, 16, 195-214.
48. Panyam, J., Dali, M. M., Sahoo, S. K., Ma, W. et al., Polymer degradation and in vitro release of a model protein from poly(D, L-lactide-co-glycolide) nano- and microparticles. J. Controlled Release 2003, 92, 173-187.
49. Dunne, M., Corrigan, I., Ramtoola, Z., Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles. Biomaterials 2000, 21, 1659-1668.
50. Shinde Patil, V. R., Campbell, C. J., Yun, Y. H., Slack, S. M. et al., Particle diameter influences adhesion under flow. Biophys. J. 2001, 80, 1733-1743.
51. Lamprecht, A., Schafer, U., Lehr, C. M., Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm. Res. 2001, 18, 788-793.
52. Moghimi, S. M., Hunter, A. C., Murray, J. C., Long-circulating and target-specific nanoparticles: Theory to practice. Pharmacol. Rev. 2001, 53, 283-318.
53. Ilium, L., Davis, S. S., Wilson, C. G., Thomas, N. W. et al., Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape. Int. J. Pharm. 1982, 12, 135-146.
54. Veiseh, O., Gunn, J. W., Zhang, M., Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv. Drug Delivery Rev. 2010, 62, 284-304.
55. Tabata, Y., Ikada, Y., Phagocytosis of polymer microspheres by macrophages. in: Abe, A., Benoit, H., Cantow, H.-J., Corradini, P. et al. (Eds.), New Polymer Materials, Springer, Heidelberg, 1990, pp. 107-141.
56. Petros, R. A., DeSimone, J. M., Strategies in the design of nanoparticles for therapeutic applications. Nat. Rev. Drug Discovery 2010, 9, 615-627.
57. Rejman, J., Oberle, V., Zuhorn, I. S., Hoekstra, D., Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 2004, 377, 159-169.
58. May, R. C., Machesky, L. M., Phagocytosis and the actin cytoskeleton. J. Cell. Sci. 2001, 114, 1061-1077.
59. Champion, J. A., Katare, Y. K., Mitragotri, S., Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers. J. Controlled Release 2007, 121, 3-9.
60. Geng, Y., Dalhaimer, P., Cai, S., Tsai, R. et al., Shape effects of filaments versus spherical particles in flow and drug delivery. Nat. Nanotechnol. 2007, 2, 249-255.
61. Nishiyama, N., Nanomedicine: Nanocarriers shape up for long life. Nat. Nanotechnol. 2007, 2, 203-204.
62. Hsieh, D. S., Rhine, W. D., Langer, R., Zero-order controlled-release polymer matrices for micro- and macromolecules. J. Pharm. Sci. 1983, 72, 17-22.
63. Gratton, S. E., Ropp, P. A., Pohlhaus, P. D., Luft, J. C. et al., The effect of particle design on cellular internalization pathways. Proc. Natl. Acad. Sci. USA 2008, 105, 11613-11618.
64. Xu, Q., Hashimoto, M., Dang, T. T., Hoare, T. et al., Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small 2009, 5, 1575-1581.
65. Champion, J. A., Katare, Y. K., Mitragotri, S., Making polymeric micro- and nanoparticles of complex shapes. Proc. Natl. Acad. Sci. USA 2007, 104, 11901-11904.
66. Rolland, J. P., Maynor, B. W., Euliss, L. E., Exner, A. E. et al., Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials. J. Am. Chem. Soc. 2005, 127, 10096-10100.
67. Rolland, J. P., Hagberg, E. C., Denison, G. M., Carter, K. R. et al., High-resolution soft lithography: Enabling materials for nanotechnologies. Angew. Chem. Int. Ed. 2004, 43, 5796-5799.
68. Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X. et al., Soft lithography in biology and biochemistry. Annu. Rev. Biomed. Eng. 2001, 3, 335-373.
69. Xia, Y. N., Whitesides, G. M., Soft lithography. Annu. Rev. Mater. Sci. 1998, 28, 153-184.
70. Petros, R. A., Ropp, P. A., DeSimone, J. M., Reductively labile PRINT particles for the delivery of doxorubicin to HeLa cells. J. Am. Chem. Soc. 2008, 130, 5008-5009.
71. Glangchai, L. C., Caldorera-Moore, M., Shi, L., Roy, K., Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles. J. Controlled Release 2008, 125, 263-272.
72. Reddy, S. T., Rehor, A., Schmoekel, H. G., Hubbell, J. A. et al., In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles. J. Controlled Release 2006, 112, 26-34.
73. Doshi, N., Prabhakarpandian, B., Rea-Ramsey, A., Pant, K. et al., Flow and adhesion of drug carriers in blood vessels depend on their shape: A study using model synthetic microvascular networks. J. Controlled Release 2010, 146, 196-200.
74. Doshi, N., Mitragotri, S., Needle-shaped polymeric particles induce transient disruption of cell membranes. J. R. Soc. Interface 2010, 7Suppl4, S403-410.
75. Doshi, N., Mitragotri, S., Macrophages recognize size and shape of their targets. PLoS ONE 2010, 5, e10051.
76. Dendukuri, D., Pregibon, D. C., Collins, J., Hatton, T. A. et al., Continuous-flow lithography for high-throughput microparticle synthesis. Nat. Mater. 2006, 5, 365-369.
77. Dendukuri, D., Gu, S. S., Pregibon, D. C., Hatton, T. A. et al., Stop-flow lithography in a microfluidic device. Lab Chip 2007, 7, 818-828.
78. Panda, P., Ali, S., Lo, E., Chung, B. G. et al., Stop-flow lithography to generate cell-laden microgel particles. Lab Chip 2008, 8, 1056-1061.
79. Khademhosseini, A., Langer, R., Microengineered hydrogels for tissue engineering. Biomaterials 2007, 28, 5087-5092.
80. Burdick, J. A., Chung, C., Jia, X., Randolph, M. A. et al., Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules 2005, 6, 386-391.
81. Khademhosseini, A., Bettinger, C., Karp, J. M., Yeh, J. et al., Interplay of biomaterials and micro-scale technologies for advancing biomedical applications. J. Biomater. Sci. Polym. Ed. 2006, 17, 1221-1240.
82. Bruining, M. J., Edelbroek-Hoogendoorn, P. S., Blaauwgeers, H. G., Mooy, C. M. et al., New biodegradable networks of poly(N-vinylpyrrolidinone) designed for controlled nonburst degradation in the vitreous body. J. Biomed. Mater. Res. 1999, 47, 189-197.
83. Bong, K. W., Bong, K. T., Pregibon, D. C., Doyle, P. S., Hydrodynamic focusing lithography. Angew. Chem. Int. Ed. 2010, 49, 87-90.
84. Ganan-Calvo, A. M., Gordillo, J. M., Perfectly monodisperse microbubbling by capillary flow focusing. Phys. Rev. Lett. 2001, 87. 274501.
85. Anna, S. L., Bontoux, N., Stone, H. A., Formation of dispersions using "flow focusing" in microchannels. Appl. Phys. Lett. 2003, 82, 364-366.
86. Ward, T., Faivre, M., Abkarian, M., Stone, H. A., Microfluidic flow focusing: Drop size and scaling in pressure versus flow-rate-driven pumping. Electrophoresis 2005, 26, 3716-3724.
87. De Geest, B. G., Urbanski, J. P., Thorsen, T., Demeester, J. et al., Synthesis of monodisperse biodegradable microgels in microfluidic devices. Langmuir 2005, 21, 10275-10279.
88. Griffith, L. G., Swartz, M. A., Capturing complex 3D tissue physiology in vitro. Nat. Rev. Mol. Cell Biol. 2006, 7, 211-224.
89. Tsuda, Y., Morimoto, Y., Takeuchi, S., Monodisperse cell-encapsulating peptide microgel beads for 3D cell culture. Langmuir 2010, 26, 2645-2649.
90. McDonald, J. C., Duffy, D. C., Anderson, J. R., Chiu, D. T. et al., Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 2000, 21, 27-40.
91. Guillotin, B., Guillemot, F., Cell patterning technologies for organotypic tissue fabrication. Trends Biotechnol. 2011, 29, 183-190.
92. Jakab, K., Norotte, C., Marga, F., Murphy, K. et al., Tissue engineering by self-assembly and bio-printing of living cells. Biofabrication 2010, 2, 022001.
93. Xu, F., Moon, S. J., Emre, A. E., Turali, E. S. et al., A droplet-based building block approach for bladder smooth muscle cell (SMC) proliferation. Biofabrication 2010, 2, 014105.
94. Tan, C. P., Cipriany, B. R., Lin, D. M., Craighead, H. G., Nanoscale resolution, multicomponent biomolecular arrays generated by aligned printing with parylene peel-off. Nano. Lett. 2010, 10, 719-725.
95. Tan, C. P., Craighead, H. G., Surface engineering and patterning using parylene for biological applications. Materials 2010, 3, 1803-1832.
96. Barron, J. A., Wu, P., Ladouceur, H. D., Ringeisen, B. R., Biological laser printing: A novel technique for creating heterogeneous 3-dimensional cell patterns. Biomed. Microdevices 2004, 6, 139-147.
97. Millman, J. R., Bhatt, K. H., Prevo, B. G., Velev, O. D., Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors. Nat. Mater. 2005, 4, 98-102.
98. Bhaskar, S., Hitt, J., Chang, S. W., Lahann, J., Multicompartmental microcylinders. Angew. Chem. Int. Ed. 2009, 48, 4589-4593.
99. Roh, K. H., Martin, D. C., Lahann, J., Biphasic Janus particles with nanoscale anisotropy. Nat. Mater. 2005, 4, 759-763.