Relationship between magnesium and clinical biomarkers on inhibition of vascular calcification

American Journal of Nephrology

Volumn 35, Issue 1, 2012, Pages 31-39

  Salem, Silvia ^a   Bruck, Heike ^b   Bahlmann, Ferdinand H ^c   Peter, Mirjam ^d   Passlick Deetjen, Jutta ^e   Kretschmer, Axel ^f   Steppan, Sonja ^d   Volsek, Michaela ^b   Kribben, Andreas ^b   Nierhaus, Marc ^a   Jankowski, Vera ^a   Zidek, Walter ^a   Jankowski, Joachim ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d FRESENIUS MEDICAL CARE   (Germany)

^e HEINRICH HEINE UNIVERSITY   (Germany)

^f BAYER PHARMA AG   (Germany)

Author keywords

CKD patients; Dialysis; Inhibition; Vascular calcification

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; CALCIUM; GLYCEROL 2 PHOSPHATE; MAGNESIUM; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL STIFFNESS; ARTERIOSCLEROSIS; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL CALCIFICATION; CARDIOVASCULAR RISK; CAROTID ARTERY; CHRONIC KIDNEY DISEASE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; HEART PROTECTION; KIDNEY FAILURE; MAGNESIUM BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PULSE WAVE; QUANTITATIVE ANALYSIS; RAT; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE; VASCULAR RING;

ANIMALS; AORTA; ARTERIOSCLEROSIS; BIOLOGICAL MARKERS; BLOOD PRESSURE; CALCIUM; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MAGNESIUM; MALE; MIDDLE AGED; RATS; RATS, INBRED WKY; RISK FACTORS; VASCULAR CALCIFICATION;

EID: 83455172867     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000334742     Document Type: Article

References (43)

1. Coronel F, Cigarran S, Herrero JA: Morbidity and mortality in diabetic patients on peritoneal dialysis. Twenty-five years of experience at a single centre (in Spanish). Nefrologia 2010; 30: 626-632.
2. Keith DS, Nichols GA, Gullion CM, Brown JB, Smith DH: Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 2004; 164: 659-663. (Pubitemid 38392981)
3. Yilmaz MI, Stenvinkel P, Sonmez A, Saglam M, Yaman H, Kilic S, Eyileten T, Caglar K, Oguz Y, Vural A, Cakar M, Altun B, Yenicesu M, Carrero JJ: Vascular health, systemic inflammation and progressive reduction in kidney function; clinical determinants and impact on cardiovascular outcomes. Nephrol Dial Transplant 2011; 26: 3537-3543.
4. Vanholder R, Baurmeister U, Brunet P, Cohen G, Glorieux G, Jankowski J: A bench to bedside view of uremic toxins. J Am Soc Nephrol 2008; 19: 863-870.
5. Awan Z, Alwaili K, Alshahrani A, Langsetmo L, Goltzman D, Genest J: Calcium homeostasis and skeletal integrity in individuals with familial hypercholesterolemia and aortic calcification. Clin Chem 2010; 56: 1599-1607.
6. Scholze A, Jankowski V, Henning L, Haass W, Wittstock A, Suvd-Erdene S, Zidek W, Tepel M, Jankowski J: Phenylacetic acid and arterial vascular properties in patients with chronic kidney disease stage 5 on hemodialysis therapy. Nephron Clin Pract 2007; 107:c1-6. (Pubitemid 47360944)
7. Liviakis L, Pogue B, Paramsothy P, Bourne A, Gill EA: Carotid intima-media thickness for the practicing lipidologist. J Clin Lipidol 2010; 4: 24-35.
8. Rennenberg RJ, Schurgers LJ, Kroon AA, Stehouwer CD: Arterial calcifications. J Cell Mol Med 2010; 14: 2203-2210.
9. Panizo S, Cardus A, Encinas M, Parisi E, Valcheva P, Lopez-Ongil S, Coll B, Fernandez E, Valdivielso JM: Rankl increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathway. Circ Res 2009; 104: 1041-1048.
10. Montezano AC, Zimmerman D, Yusuf H, Burger D, Chignalia AZ, Wadhera V, van Leeuwen FN, Touyz RM: Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension 2010; 56: 453-462.
11. Quercioli A, Luciano Viviani G, Dallegri F, Mach F, Montecucco F: Receptor activator of nuclear factor- κ B ligand/osteoprotegerin pathway is a promising target to reduce atherosclerotic plaque calcification. Crit Pathw Cardiol 2010; 9: 227-230.
12. Mizobuchi M, Towler D, Slatopolsky E: Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol 2009; 20: 1453-1464.
13. Maziere C, Savitsky V, Galmiche A, Gomila C, Massy Z, Maziere JC: Oxidized low density lipoprotein inhibits phosphate signaling and phosphate-induced mineralization in osteoblasts. Involvement of oxidative stress. Biochim Biophys Acta 2010; 1802: 1013-1019.
14. Lomashvili KA, Cobbs S, Hennigar RA, Hardcastle KI, O'Neill WC: Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin. J Am Soc Nephrol 2004; 15: 1392-1401. (Pubitemid 38679664)
15. Zeidan A, Nordstrom I, Dreja K, Malmqvist U, Hellstrand P: Stretch-dependent modulation of contractility and growth in smooth muscle of rat portal vein. Circ Res 2000; 87: 228-234. (Pubitemid 30626431)
16. Wang JL, Shaw NS, Yeh HY, Kao MD: Magnesium status and association with diabetes in the Taiwanese elderly. Asia Pac J Clin Nutr 2005; 14: 263-269.
17. Bauer M, Mohlenkamp S, Lehmann N, Schmermund A, Roggenbuck U, Moebus S, Stang A, Mann K, Jockel KH, Erbel R: The effect of age and risk factors on coronary and carotid artery atherosclerotic burden in males - results of the Heinz Nixdorf Recall Study. Atherosclerosis 2009; 205: 595-602.
18. Nurnberger J, Michalski R, Turk TR, Opazo Saez A, Witzke O, Kribben A: Can arterial stiffness parameters be measured in the sitting position? Hypertens Res 2011; 34: 202-208.
19. Baulmann J, Schillings U, Rickert S, Uen S, Dusing R, Illyes M, Cziraki A, Nickering G, Mengden T: A new oscillometric method for assessment of arterial stiffness: comparison with tonometric and piezo-electronic methods. J Hypertens 2008; 26: 523-528. (Pubitemid 351317262)
20. Mirza MA, Hansen T, Johansson L, Ahlstrom H, Larsson A, Lind L, Larsson TE: Relationship between circulating FGF-23 and total body atherosclerosis in the community. Nephrol Dial Transplant 2009; 24: 3125-3131.
21. Johnson RC, Leopold JA, Loscalzo J: Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 2006; 99: 1044-1059. (Pubitemid 44729928)
22. Hasegawa H, Nagano N, Urakawa I, Yamazaki Y, Iijima K, Fujita T, Yamashita T, Fukumoto S, Shimada T: Direct evidence for a causative role of FGF-23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. Kidney Int 2010; 78: 975-980.
23. Helvig CF, Cuerrier D, Hosfield CM, Ireland B, Kharebov AZ, Kim JW, Ramjit NJ, Ryder K, Tabash SP, Herzenberg AM, Epps TM, Petkovich M: Dysregulation of renal vitamin D metabolism in the uremic rat. Kidney Int 2010; 78: 463-472.
24. Chen NX, Moe SM: Vascular calcification in chronic kidney disease. Semin Nephrol 2004; 24: 61-68. (Pubitemid 38141846)
25. Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, Sirkis R, Naveh-Many T, Silver J: The parathyroid is a target organ for FGF-23 in rats. J Clin Invest 2007; 117: 4003-4008. (Pubitemid 350224109)
26. Massy ZA, Mentaverri R, Mozar A, Brazier M, Kamel S: The pathophysiology of vascular calcification: are osteoclast-like cells the missing link? Diabetes Metab 2008; 34(suppl 1):S16-S20.
27. Poggio P, Grau JB, Field BC, Sainger R, Seefried WF, Rizzolio F, Ferrari G: Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with calcific aortic stenosis and controls. J Cell Physiol;226: 2139-2149.
28. Nitschke Y, Weissen-Plenz G, Terkeltaub R, Rutsch F: Npp1 promotes atherosclerosis in ApoE knockout mice. J Cell Mol Med 2011; 15: 2273-2283.
29. Li H, Liu Y, Zhang Q, Jing Y, Chen S, Song Z, Yan J, Li Y, Wu X, Zhang X, Zhang Y, Case J, Yu M, Ingram DA, Yang FC: Ras-dependent paracrine secretion of osteopontin by Nf1+/- osteoblasts promote osteoclast activation in a neurofibromatosis type I murine model. Pediatr Res 2009; 65: 613-618.
30. Sage AP, Lu J, Tintut Y, Demer LL: Hyperphosphatemia- induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro. Kidney Int 2011; 79: 414-422.
31. Rubin MF, Rosas SE, Chirinos JA, Townsend RR: Surrogate markers of cardiovascular disease in CKD: what's under the hood? Am J Kidney Dis 2011; 57: 488-497.
32. Ekart R, Hojs R, Hojs-Fabjan T, Balon BP: Predictive value of carotid intima media thickness in hemodialysis patients. Artif Organs 2005; 29: 615-619. (Pubitemid 41602838)
33. Shoji T, Maekawa K, Emoto M, Okuno S, Yamakawa T, Ishimura E, Inaba M, Nishizawa Y: Arterial stiffness predicts cardiovascular death independent of arterial thickness in a cohort of hemodialysis patients. Atherosclerosis 2010; 210: 145-149.
34. Gorgels TG, Waarsing JH, de Wolf A, ten Brink JB, Loves WJ, Bergen AA: Dietary magnesium, not calcium, prevents vascular calcification in a mouse model for pseudo xanthoma elasticum. J Mol Med (Berl) 2010; 88: 467-475.
35. Sontia B, Montezano AC, Paravicini T, Tabet F, Touyz RM: Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. Hypertension 2008; 51: 915-921. (Pubitemid 351654704)
36. Espeland MA, Craven TE, Riley WA, Corson J, Romont A, Furberg CD: Reliability of longitudinal ultrasonographic measurements of carotid intimal-medial thicknesses. Asymptomatic carotid artery progression study research group. Stroke 1996; 27: 480-485. (Pubitemid 26081446)
37. Ekart R, Hojs R, Pecovnik-Balon B, Bevc S, Dvorsak B: Blood pressure measurements and carotid intima media thickness in hemodialysis patients. Ther Apher Dial 2009; 13: 288-293.
38. Savage T, Clarke AL, Giles M, Tomson CR, Raine AE: Calcified plaque is common in the carotid and femoral arteries of dialysis patients without clinical vascular disease. Nephrol Dial Transplant 1998; 13: 2004-2012. (Pubitemid 28356766)
39. Gross ML, Meyer HP, Ziebart H, Rieger P, Wenzel U, Amann K, Berger I, Adamczak M, Schirmacher P, Ritz E: Calcification of coronary intima and media: immunohistochemistry, backscatter imaging, and x-ray analysis in renal and nonrenal patients. Clin J Am Soc Nephrol 2007; 2: 121-134.
40. Koleganova N, Piecha G, Ritz E, Schirmacher P, Muller A, Meyer HP, Gross ML: Arterial calcification in patients with chronic kidney disease. Nephrol Dial Transplant 2009; 24: 2488-2496.
41. Okamoto K, Inaba M, Furumitsu Y, Ban A, Mori N, Yukioka K, Imanishi Y, Nishizawa Y: Beneficial effect of risedronate on arterial thickening and stiffening with a reciprocal relationship to its effect on bone mass in female osteoporosis patients: a longitudinal study. Life Sci 2010; 87: 686-691.
42. Okura T, Watanabe S, Kurata M, Manabe S, Koresawa M, Irita J, Enomoto D, Miyoshi K, Fukuoka T, Higaki J: Relationship between cardio-ankle vascular index (CAVI) and carotid atherosclerosis in patients with essential hypertension. Hypertens Res 2007; 30: 335-340. (Pubitemid 46779981)
43. Spiegel DM, Farmer B: Long-term effects of magnesium carbonate on coronary artery calcification and bone mineral density in hemodialysis patients: a pilot study. Hemodial Int 2009; 13: 453-459.