Mechanism of transport enhancement of LHRH through porcine epidermis by terpenes and iontophoresis: Permeability and lipid extraction studies

Pharmaceutical Research

Volumn 15, Issue 12, 1998, Pages 1857-1862

  Bhatia, Kuljit S ^a,b   Singh, Jagdish ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

^b Bertek Inc   (United States)

Author keywords

Fourier transform infrared spectroscopy; Lipid extraction; Luteinizing hormone releasing hormone; Porcine epidermis; Terpenes

Indexed keywords

ALCOHOL; CARVONE; CINEOLE; GONADORELIN; LIMONENE; MEMBRANE LIPID; TERPENE DERIVATIVE; THYMOL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG PENETRATION; DRUG TRANSPORT; EPIDERMIS; INFRARED SPECTROSCOPY; IONTOPHORESIS; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; STRATUM CORNEUM; SWINE;

ADMINISTRATION, CUTANEOUS; ANIMALS; BIOLOGICAL TRANSPORT; DRUG DELIVERY SYSTEMS; ELECTRIC STIMULATION; EPIDERMIS; ETHANOL; GONADOTROPIN-RELEASING HORMONE; IONTOPHORESIS; LIPIDS; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SWINE; TERPENES;

EID: 0032443395     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011906022903     Document Type: Article

References (25)

1. T. M. Sweeny and D. T. Downing. Role of the lipids in the epidermal barrier to water diffusion. J. Invest. Dermatol. 55:135-140 (1970).
2. K. S. Bhatia, S. Gao, and J. Singh. Effect of penetration enhancers and iontophoresis on the FT-IR spectroscopy and LHRH permeability. J. Contr. Rel. 47:81-89 (1997).
3. K. S. Bhatia, S. Gao, T. P. Freeman, and J. Singh. Effect of penetration enhancers and iontophoresis of the ultrastructure and Cholecystokinin-8 permeability through porcine skin. J. Pharm. Sci. 86:1011-1015 (1997).
4. A. C. Williams and B. W. Barry. Terpenes and the lipid-protein-partitioning theory of skin penetration enhancement. Pharm. Res. 8:17-24 (1991).
5. C. Y. Goates, and K. Knutson. Enhanced permeation of polar compounds through human epidermis. I. Permeability and membrane structural change in the presence of short-chain alcohols. Biochim. Biophys. Acta 1195:169-179 (1994).
6. D. B. Bommannan, R. O. Potts, and R. H. Guy. Examination of the effect of ethanol on human corneum in vivo using infrared spectroscopy. J. Contr. Rel. 16:299-304 (1991).
7. R. J. Santen. Therapeutic applications of luteininzing hormone releasing hormone and its analogs. Culter, G. B. Jr., Moderator, Ann. Intern. Med. 102:643-657 (1985).
8. A. M. Kligman and E. Christophers. Preparation of isolated sheets of human stratum corneum. Arch Dermatol. 88:702-705 (1963).
9. M. H. Heit, P. L. Williams, F. L. Jayes, S. K. Chang, and J. E. Riviere. Transdermal iontophoretic peptide delivery: in vitro and in vivo studies with lutenizing hormone releasing hormone. J. Pharma. Sci. 82:240-243 (1993).
10. M. A. Yamane, A. C. Williams, and B. W. Barry. Effects of terpenes and oleic acids as skin penetration enhancers towards 5-fluorouracil as assessed with time; permeation, partitioning and differential scanning calorimetry. Int. J. Pharm. 116:237-251 (1995).
11. W. L. Hayton and T. Chen. Correction of perfusate concentration for sample removal. J. Pharm. Sci. 71:820-821 (1982).
12. S. Gao and J. Singh. Mechanism of transdermal transport of 5-fluorouracil by terpenes: carvone, 1,8-cineole, and thymol. Int. J. Pharm. 154:67-77 (1997).
13. S. Gao and J. Singh. In vitro percutaneous absorption enhancement of a lipophilic drug tamoxifen by terpenes. J. Contr. Rel. 51: 193-199 (1998).
14. P. A. Cornwell and B. W. Barry. The route of penetration of ions and 5-fluorouracil across human skin and the mechanisms of action of terpene skin penetration enhancers. Int. J. Pharm. 94:189-194 (1993).
15. R. C. Wester and H. I. Maibach. In vivo animal models for percutaneous absorption. In: R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Marcel Dekker, New York, 1989, pp. 221-238.
16. N. A. Monteiro-Riviere. Ultrastructural evaluation of porcine integument. In: Tumblesom ME (ed), Swine in biomedical research, Plenum Press, New York, 1986, pp. 641-655.
17. K. S. Bhatia and J. Singh. Pig ear skin as a model for predicting percutaneous absorption in man. Pharm. Sci. 2:275-276 (1996).
18. R. L. Chan, M. L. Henzl, M. E. LePage, J. LaFargne, C. A. Nerenberg, S. Anik, and M. D. Chaplin. Absorption and metabolism of nafarelin, a potent agonist of gonadotropin-releasing hormone. Clin. Pharmacol. Ther. 44:275-282 (1988).
19. S. M. Sims, W. I. Higuchi, and V. Srinivasan. Skin alteration and convective solvent flow effects during iontophoresis. I. Neutral solute transport across human skin. Int. J. Pharm. 69:109-121 (1991).
20. Y. Wang, L. Allen, L. C. Li, and Y. H. Tu. Iontophoresis of hydrocortisone across hairless mouse skin: Investigation of skin alteration. J. Pharm. Sci. 82:1140-1144 (1993).
21. R. J. Scheuplein, I. H. Blank, G. J. Bruner, and D. J. MacFarlane Percutaneous absorption of steroids. J. Invest. Dermatol. 52:63-70 (1969).
22. N. G. Tuner, K. Yogeshwar, and R. H. Guy. The effect of current on skin barrier function in vivo: Recovery kinetics post-iontophoresis. Pharm. Res. 14:1252-1257 (1997).
23. G. M. Golden, D. B. Guzek, R. R. Harris, J. E. McKie, and R. O. Potts. Lipid thermotropic transitions in human stratum corneum. J. Invest. Dermatol. 86:255-259 (1986).
24. T. Kurihara-Bergstrom, K. Knutson, L. DeNoble, and C. Goates. Percutaneous absorption enhancement of an ionic molecule by ethanol-water systems in human skin. Pharm. Res. 7:762-766 (1990).
25. T. Osigo, M. Iwaki, and T. Paku. Effects of various enhancers on transdermal penetration of indomethacin and urea, and relationship between penetration parameters and enhancement factors. J. Pharm. Sci. 84:482-488 (1995).