Aberrant expression and clinical correlation of Notch signaling molecules in breast cancer of Chinese population

Asia-Pacific Journal of Clinical Oncology

Volumn 7, Issue 4, 2011, Pages 385-391

  Ma, Daoxin ^a   Dong, Xuebin ^a,b   Zang, Shaolei ^a   Ma, Rong ^a   Zhao, Ping ^a,c   Guo, Dongmei ^a   Dai, Jianjian ^a   Chen, Feng ^a   Ye, Jingjing ^a   Ji, Chunyan ^a  

^a SHANDONG UNIVERSITY   (China)

^b JINAN CENTRAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Breast cancer; Clinical correlation; Gene expression; Notch

Indexed keywords

BIOLOGICAL MARKER; ESTROGEN RECEPTOR; JAGGED1; LIGAND; MESSENGER RNA; NOTCH RECEPTOR; PROGESTERONE RECEPTOR;

ARTICLE; BREAST CANCER; CANCER PATIENT; CANCER STAGING; CHINESE; CLINICAL STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; LUNG CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SAMPLE;

BREAST NEOPLASMS; CHINA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; NEOPLASM STAGING; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

EID: 83355171577     PISSN: 17437555     EISSN: 17437563     Source Type: Journal    
DOI: 10.1111/j.1743-7563.2011.01433.x     Document Type: Article

References (25)

1. Kopan R. Notch: a membrane-bound transcription factor. J Cell Sci 2002; 115: 1095-7.
2. Lai EC. Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep 2002; 3: 840-5.
3. Sullivan DC, Bicknell R. New molecular pathways in angiogenesis. Br J Cancer 2003; 89: 228-31.
4. Liu Z, Shirakawa T, Li Y etal. Regulation of Notch 1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol 2003; 23: 14-25.
5. Mailhos C, Lewis J, Ish-Horowicz D, Modlich U, Harris A, Bicknell R. Delta4, an endothelial specific Notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 2001; 69: 135-44.
6. Lindner V, Booth C, Igor P, Small D, Maciag T, Liaw L. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Am J Pathol 2001; 159: 875-83.
7. Dang TP, Gazdar AF, Virmani AK etal. Chromosome 19 translocation, overexpression of Notch3, and human lung cancer. J Natl Cancer Inst 2000; 92: 1355-7.
8. Leethanakul C, Patel V, Gillespie J etal. Distinct pattern of expression of differentiation and growth related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene 2000; 19: 3220-4.
9. Rae FK, Stephenson SA, Nicol DL, Clements JA. Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display. Int J Cancer 2000; 88: 726-32.
10. Suzuki T, Aoki D, Susumu N, Udagawa Y, Nozawa S. Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Int J Oncol 2000; 17: 1131-9.
11. Hendrix MJ, Seftor RE, Seftor EA etal. Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determination. Cancer Res 2002; 62: 665-8.
12. Weijzen S, Rizzo P, Braid M etal. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 2002; 8: 979-86.
13. Soriano J, Uyttendaele H, Kitajewski J, Montesano R. Expression of an activated Notch4 (int-3) oncoprotein disrupts morphogenesis and induces an invasive phenotype in mammary epithelial cells in vitro. Int J Cancer 2000; 86: 652-9.
14. Callahan R, Raafat A. Notch signalling in mammary gland tumourigenesis. J Mammary Gland Biol Neoplasia 2001; 6: 23-36.
15. Parr C, Watkins G, Jiang WG. The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. Int J Mol Med 2004; 14: 779-86.
16. Brendan CD, Anna MM, Hui ZH. High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol 2007; 20: 685-93.
17. Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 2003; 3: 756-67.
18. Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006; 107: 2223-33.
19. Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 2005; 65: 8530-7.
20. Stylianou S, Clarke RB, Brennan K. Aberrant activation of notch signaling in human breast cancer. Cancer Res 2006; 66: 1517-25.
21. Farnie G, Clarke RB. Novel cell culture technique for primary ductal carcinoma in situ: role of notch and epidermal growth factor receptor signaling pathways. J Natl Cancer Inst 2007; 99: 616-27.
22. Nickoloff BJ, Osborne BA, Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene 2003; 22: 6598-608.
23. Nickoloff BJ, Qin JZ, Chaturvedi V, Denning MF, Bonish B, Miele L. Jagged-1 mediated activation of Notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ 2002; 22: 842-55.
24. Siziopikou K, Jang MS, Miao H, Miele L. Notch signaling in ductal carcinoma in situ of the breast. Proc Am Assoc Cancer Res 2002; 43: 4.
25. Chen Y, Fischer WH, Gill GN. Regulation of the ERBB-2 promoter by RBPJ kappa and NOTCH. J Biol Chem 1997; 272: 14110-4.