Cloning and characterization of chicken fat mass and obesity associated (Fto) gene: Fasting affects Fto expression

Domestic Animal Endocrinology

Volumn 42, Issue 1, 2012, Pages 1-10

  Tiwari, A ^a   Krzysik Walker, S M ^a   Ramachandran, R ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Adipose tissue; Age; Body growth; Energy homeostasis; Liver; Skeletal muscle

Indexed keywords

DIOXYGENASE; RNA;

ADIPOSE TISSUE; AGE; AMINO ACID SEQUENCE; ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CHICKEN; DIET RESTRICTION; EATING; GENETICS; IMMUNOBLOTTING; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT;

ADIPOSE TISSUE; AGE FACTORS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHICKENS; CLONING, MOLECULAR; DIOXYGENASES; EATING; FASTING; IMMUNOBLOTTING; MOLECULAR SEQUENCE DATA; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SEQUENCE ALIGNMENT;

AVES; CHLOROPHYTA; GALLUS GALLUS; MAMMALIA; RODENTIA;

EID: 83355169589     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2011.08.001     Document Type: Article

References (31)

1. Frayling T.M., Timpson N.J., Weedon M.N., et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 316:889-894.
2. Dina C., Meyre D., Gallina S., et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007, 39:724-726.
3. Ewens K.G., Jones M.R., Ankener W., et al. Fto and mc4r gene variants are associated with obesity in polycystic ovary syndrome. PLoS ONE 2011, 6:e16390.
4. Scott L.J., Mohlke K.L., Bonnycastle L.L., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007, 316:1341-1345.
5. Peters T., Ausmeier K., Rüther U. Cloning of fatso (fto), a novel gene deleted by the fused toes (ft) mouse mutation. Mamm Genome 1999, 10:983-986.
6. Church C., Lee S., Bagg E.A., et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 2009, 5;:e1000599.
7. Fischer J., Emmerling C., Ruther U. On the history of fto. Obes Facts 2008, 1:43-44.
8. Gerken T., Girard C.A., Tung Y.C., et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007, 318:1469-1472.
9. Clifton I.J., McDonough M.A., Ehrismann D., Kershaw N.J., Granatino N., Schofield C.J. Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. J Inorg Biochem 2006, 100:644-669.
10. Jia G., Yang C.G., Yang S., et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett 2008, 582:3313-3319.
11. Wu Q., Saunders R.A., Szkudlarek-Mikho M., Serna Ide L., Chin K.V. The obesity-associated FTO gene is a transcriptional coactivator. Biochem Biophys Res Commun 2010, 401:390-395.
12. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., Schwartz M.W. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
13. Lein E.S., Hawrylycz MJ N., Ayres M., Bensinger A., et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 2007, 445:168-176.
14. Fischer J., Koch L., Emmerling C., et al. Inactivation of the FTO gene protects from obesity. Nature 2009, 458:894-898.
15. Tung Y.C., Ayuso E., Shan X., et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS ONE 2010, 5:e8771.
16. Church C., Moir L., McMurray F., et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 2010, 42:1086-1092.
17. Wåhlén K., Sjölin E., Hoffstedt J. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res 2008, 49:607-611.
18. Tews D., Fischer-Posovszky P., Wabitsch M. Regulation of FTO and FTM expression during human preadipocyte differentiation. Horm Metab Res 2011, 43:17-21.
19. Scheuermann G.N., Bilgili S.F., Hess J.B., Mulvaney D.R. Breast muscle development in commercial broiler chickens. Poult Sci 2003, 82:1648-1658.
20. Hood R.L. The cellular basis for growth of the abdominal fat pad in broiler-type chickens. Poult Sci 1982, 61:117-121.
21. Maddineni S., Metzger S., Ocón O., Hendricks G., Ramachandran R. Adiponectin gene is expressed in multiple tissues in the chicken: Food deprivation influences adiponectin messenger ribonucleic acid expression. Endocrinology 2005, 146:4250-4256.
22. Ramachandran R., Ocón-Grove O.M., Metzger S.L. Molecular cloning and tissue expression of chicken adipor1 and adipor2 complementary deoxyribonucleic acids. Domest Anim Endocrinol 2007, 33:19-31.
23. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta c(t)) method. Methods 2001, 25:402-408.
24. Krzysik-Walker S.M., Ocón-Grove O.M., Maddineni S.R., Hendricks G.L., Ramachandran R. Is visfatin an adipokine or myokine?. Evidence for greater visfatin expression in skeletal muscle than visceral fat in chickens. Endocrinology 2008, 149:1543-1550.
25. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
26. Aravind L., Koonin E.V. The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol 2001, 2. RESEARCH0007.
27. Valegård K., van Scheltinga A.C., Lloyd M.D., et al. Structure of a cephalosporin synthase. Nature 1998, 394:805-809.
28. Poritsanos N.J., Lew P.S., Mizuno T.M. Relationship between blood glucose levels and hepatic Fto mRNA expression in mice. Biochem Biophys Res Commun 2010, 400:713-717.
29. Leveille G.A., Romsos D.R., Yeh Y., O'Hea E.K. Lipid biosynthesis in the chick. A consideration of site of synthesis, influence of diet and possible regulatory mechanisms. Poult Sci 1975, 54:1075-1093.
30. Bravard A., Lefai E., Meugnier E., et al. FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes 2010, 60:258-268.
31. Yuan L., Ni Y., Barth S., Wang Y., Grossmann R., Zhao R. Layer and broiler chicks exhibit similar hypothalamic expression of orexigenic neuropeptides but distinct expression of genes related to energy homeostasis and obesity. Brain Res 2009, 1273:18-28.