Dietary supplementation with watermelon (Citrullus Ianatus) juice enhances arginine availability and modifies hyperglycemia, hyperlipidemia and oxidative stress in diabetic rats

Australian Journal of Basic and Applied Sciences

Volumn 5, Issue 6, 2011, Pages 1284-1295

  Abd El Razek, Fatma H ^a   Sadeek, Eman A ^a  

^a Ain Shams University   (Egypt)

Author keywords

Arginine; Diabetic rats; Hyperglycemia; Hyperlipidemia; Oxidative stress; Watermelon juice

Indexed keywords

EID: 83355168074     PISSN: 19918178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (82)

1. Avramoglu, R.K., H. Basciano and K. Adeli, 2006. Lipid and lipoprotein dysregulation in insulin resistant states. Clinica Chimica Acta., 368(1-2): 1-19.
2. Bassit, R.A., R. Curi, L.F.B.P. Costa Rosa, 2008. Creatine supplementation reduces plasma levels of proinflammatory cytokines and PGE2 after a half-ironman competition. Amino Acids, 35: 425-431.
3. Block, R.J., E.L. Durrum and G. Zweig, 1958. Annual of paper chromatography and paper electrophoresis, 2 nd ed. Academic.
4. Bottini, N., T. Vang, F. Cucca and T. Mustelin, 2006. Role of PTPN22 in type 1 diabetic and other autoimmune diseases. Seminars in Immunology, 18: 207-213.
5. Bueno, P., J. Varela, G. Gimenez-Gallego and L.A. del Rõo, 1995. Peroxisomal copper, zinc superoxide dismutase: characterization of the isoenzyme from watermelon cotyledons. Plant Physiology 108: 1151-1160.
6. Caldefie-Chezet, F., C. Moinard, R. Minet-Quinard, F. Gachon, L. Cynober and M. Vasson, 2001 Dexamethasone treatment induces long-lasting hyperleptinemia and anorexia in old rats. Metabolism, 50: 1054-1058.
7. Carrol, N.V., R.W. Longley and J.H. Roe, 1956. The determination of glycogenin liver and museles by use of anthrone reagent. J. Biol. Chem., 220: 583-593.
8. Chareoansiri, R. and R. Kongkachuichai, 2009. Sugar profiles and soluble and insoluble dietary fiber contents of fruits in Thailand markets. Int J. Food Sci. Nutr., 60 Suppl 4: 126-39.
9. Collins, JK., G. Wu, P. Perkins-Veazie, K. Spears, P.L. Claypool and R.A. Baker, 2007. Clevidence BA. Watermelon consumption increases plasma arginine concentrations in adults. Nutrition, 23: 261-6.
10. Collins, J.K., B.H. Arjmandi, P.L. Claypool, V.P. Perkins, R.A. Baker and B.A. Celvidence, 2004. Lycopene from two food sources does not affect antioxidant or cholesterol status of middle-aged adults. Nutr.J., 15: 3-15.
11. Cooke, J.P., 2003. Proc. Natl. Acad. Sci. USA 100: 768-770.
12. Creager, M.A., T.F. Luscher, F. cosentno and J.A. Beckman, 2003. Diabetes and vascular disease: pathopysiology, clinical consequences, and medical therapy. part 1. Circulation, 108: 1527-1532.
13. Draper, H.H. and M. Hadley, 1990. Malondialdehyde determination as of lipid peroxidation method in enzymology, 186: 421.
14. Edmonds, MS. and D.H. Baker, 1987. Failure of excess dietary lysine to antagonize arginine in young pigs. J. Nutr., 117: 1396-1401.
15. Evans, R.W., J.D. Fernstrom, J. Thompson, S.M. Morris and L.H. Kuller, 2004. Biochemical responses of healthy subjects during dietary supplementation with L-arginine. J Nutr Biochem., 15: 534-9.
16. Fossati, P. and L. Prencipe, 1982. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem., 28: 2077-2080.
17. Fox, G.R. and B.B. Vigro, 1986. "Relevance of hyperglycemia to dieldrin toxicity in suckling and adult rats". Toxicol., 38: 315-326. Bull. High. Inst. Pub. Heath., 13: 9-17.
18. Friedewald, W.T., R.T. Levy and D.S. Fredrickson, 1972. Estimation of the concentration of HDLchoesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem., 18: 499.
19. Fu, W.J., T.E. Haynes, R. Kohli, J. Hu, W. Shi, T.E. Spencer, R.J. Carroll, C.J. Meininger, G. Wu, 2005. Dietary L-arginine supplementation reduces fat. mass in Zucker diabetic fatty rats. J Nutr., 135: 714-21.
20. Gualano, B., R.B. Novaes, G.G. Artioli, et al., 2008. Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training. Amino Acids 34: 245-250.
21. Hamasu, K., T. Haraguchi, Y. Kabuki, et al. 2008. L-Proline is a sedative regulator of acute stress in the brain of neonatal chicks. Amino Acids. doi:10.1007/s00726-008-0164-0.
22. Hayashi, T., A.R. Packiasamy, Juliet., H. Matsui-Hirai, A. Miyazaki, A. Fukatsu, J. Funami, A. Iguchi and L.J. Ignarro, 2005. L-citrulline and L-arginine supplementation retards the progression of high-cholesteroldiet-induced atherosclerosis in rabbits. 102(38): 13681-13686.
23. He, Q. H, X.F. Kong, G. Wu, et al, 2008. Metabolomic analysis of the response of growing pigs to dietary L-arginine supplementation. Amino Acids. doi:10.1007/s00726-008-0192-9.
24. He, Q., X. Kong, G. Wu, P. Ren, H. Tang, F. Hao, R. Huang, T. Li, B. Tan and P. Li, 2007. Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation. Amino Acids, 37(1): 199-208.
25. Hsu, JM. and S.T. Ding, 2003. Effect of polyunsaturated fatty acids on the expression of transcription factor adipocyte determination and differentiation-dependent factor 1 and of lipogenic and fatty acid oxidation enzymes in porcine differentiating adipocyte. Br J Nutr., 90: 507-513.
26. Hu, C.A., S. Khalil, S. Zhaorigetu. and et al, 2008a. Human D1-pyrroline-5-carboxylate synthase: function and regulation. Amino Acids, 35: 665-672.
27. Hu, C.A., D.B. Williams, S. Zhaorigetu and et al., 2008b. Functional genomics and SNP analysis of human genes encoding proline metabolic enzymes. Amino Acids, 35: 655-664.
28. Jobgen, W.S., S.K. Fried, W.J. Fu, C.J. Meininger and G. Wu, 2006. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. J. Nutr., Biochem., 17: 571-88.
29. Jobgen, W., C. J. Meininger, S.C. Jobge, P. Li, M.J. Lee, S.B. Smith, T.E. Spencer, S.K. Fried and G. Wu, 2009. Dietary L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats1-3, J. of Nutr., 139(2): 230-237.
30. Leroith, D. and D.O. Smith, 2005. Monitoring glycemic control: the cornerstone of diabetes care. Clin. Therap.,1489-1499.
31. Lopes-Virella, M.F., P. Stone, S.H. Ellis and J.A. Colwell, 1977. Cholesterol determination in high-density lipoproteins separated by three different methods, Clin. Chem., 23: 882-890.
32. Lucotti, P., E. Setola, L.D. Monti, E. Galluccio, S. Costa, E. Sandoli, et al., 2006. Beneficial effect of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulinresistant type 2 diabetic patients. Am J Physiol.291: E906-12.
33. Lutz, T.A., A. Estermann, S. Haag and E. Scharrer, 2001. Depolarization of the cell membrane by metformin. Bioch. Et Biophy. Acta (BBA(Biomembranes, 1513: 176-184.
34. Ma, X., Y. Lin, Z. Jiang, C. Zheng, G. Zhou, D. Yu, T. Cao, J. Wang and F. Chen, 2010. Dietary arginine supplementation enhances antioxidative capacity and improves meat quality of finishing pigs. Amino Acids., 38: 95-102.
35. Malaisse, W.J., 2004. Amino acid-mediated insulin secretion. In: Metabolic and Therapeutic Aspects of Amino Acids in Clin. Nutr. (2nd ed.), edited by Cynober L. Boca Raton, FL: CRC., p: 321-336.
36. Marini, J.C., I.C. Didelija, L. Castillo and B. Lee, 2010. Plasma Arginine and Ornithine Are the Main Citrulline Precursors in Mice Infused with Arginine-Free Diets. J. Nutr., 140(8): 1432-1437.
37. McKnight, J.R., M.C. Satterfield, W.S. Jobgen, S.B. Smith, T.E. Spencer, C.J. Meininger, C.J. McNeal and G. Wu, 2010. Beneficial effects of l-arginine on reducing obesity: potential mechanisms and important implications for human health. Amino Acids, 39(2): 349-357.
38. Mendez, J.D. and F. Balderas, 2001. Regulation of hyperglycemia and dyslipidemia by exogenous Larginine in diabetic rats. Biochimie., 83: 453-458.
39. Mendez, J.D., R.H. Hernandez, G. Targher, L. Bertolini, G. Zoppini, L. Zenari and G. Falezza, 2005. LArginine and polyamine administration protect beta-cells against alloxan diabetogenic effect Increased plasma markets of inflammation and endothelial. J. Nutr., 137: 2680-2685.
40. Mendez, J. D and R.D.H. Hernandez, 2005. L-arginine and polyamine administration protect B-cells against alloxan diabetogenic effect in sprague-dawley rats. Biomedicine and pharmacotherapy 59: 283-289.
41. Micol, V., H. Larson, B. Edeas, T. Ikeda, 2007. Watermelon extract stimulates antioxidant enzymes and improves glycemic and lipid metabolism. AGRO FOOD INDUSTRY HI TECH, 18(1): 22-26.
42. Miguez, I., G. Marino, B. Rodrguez and C. Taboada, 2004. Effect of dietary L-arginine supplementation on serum lipids and intestinal enzyme activities in diabetic rats.J. Physiol. Biochem., 60(1): 31-38.
43. Morris, S.M. and J.r. 2002. Regulation of enzymes of the urea cycle and arginine metabolism. Annu Rev. Nutr.,22: 87-105.
44. Nakata, M. and T. Yada, 2003. Nitric oxide-mediated insulin secretion in response to citrulline in islet beta-cells. Pancreas 27: 209-213.
45. Osowska, S., T. Duchemann 1 S. Walrand,2 A. Paillard,1 Y. Boirie,2 L. Cynober,1,3 and C. Moinard1, 2006. Citrulline modulates muscle protein metabolism in old malnourished rats. Am J Physiol Endocrinol Metab., 291: E582-E586.
46. Penelope, P.V., C. Julie, H. Donald and M. Niels, 2006. Research Project: physiological and genetic basis of postharvest quality and phytonutrient content of fruits and vegetables title: ripening changes in mini watermelon fruit. Cucurbitaceae, September 17-21, Asheville, North Carolina. p: 578-584.
47. Penelope, P.V., C. Julie, W. Guoyao and C. Beverly, 2008. Research project: physiological and genetic basis of postharvest quality and phytonutrient content of fruits and vegetables Title: Watermelon, phytochemicals and health. Proceedings of the United States-Japan Cooperative Program in Natural Resources. 37th Annual Meeting, August24-28, Chicago, Illinois. p: 138-139.
48. Perkins-Veazie, P. and J.K. Collins, 2006. Carotenoid changes of intact watermelons after storage J Agric Food Chem., 54(916): 5868-74.
49. Peschke, E., H. Ebelt, H.J. Bromme and D. Peschke, 2000. Classical and new diabetogens: Comparison of their effect on isolated rat pancreatic islets in vitro, Cell Mol. Life Sci., 57(1): 158-164.
50. Petrovic, V., B. Buzadzic, A. Korac, et al., 2008. Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role of L-arginine/NO-producing pathway. J Exp Biol., 211: 114-120.
51. Phang, J.M., S.P. Donald, J. Pandhare, Y.M. Liu, 2008. The metabolism of proline, a stress substrate, modulates carcinogenic pathways. Amino Acids, 35: 681-690.
52. Richmond, W., 1973. Preparation and properties of a cholesterol oxidase from nocardia Sp. and its application to the enzymatic assay of total cholesterol in serum. Clin. Chem., 19: 1350-1356.
53. Reeves, R.G., F.H. Nielson and G.C. Fahey,1993. AIN-93 purified diets for laboratory rodents:.J. Nutr., 123 (1): 1939-1951.
54. Rider, J.E., A. Hacker, C.A. Mackintosh and et al., 2007. Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide. Amino Acids, 33: 231-240.
55. Rimando, A.M. and P.M. Perkins, 2005. Determination of Citrulline in watermelon rind. J. Chromatogr.A.,17: 1078(1-2): 196-200.
56. Santhanam, A.V. and M. Dikshit, 2001. Eur. J. Pharmacol, 431: 61-69.
57. Solomonson, L.P., B.R. Flam, L.C. Pendleton, B.L. Goodwin, and D.C. Eichler, 2003. J. Exp. Biol., 206: 2083-2087.
58. Tan, BE., Y.L. Yin, Z.Q. Liu, X.G. Li, H.J. Xu, X.F. Kong, R.L. Huang, W.J. Tang, I. Shinzato, et al., 2008. Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs. Amino Acids, doi:10.1007/s00726-008-0148-0.
59. Tedesco, T.A., S.A. Benford, R.C. MD1, M.D.1. Foster, L.A. Barness MD I, 1984. Free Amino Acids in Citrullus vulgaris (Watermelon). Pediatrics, 73(6): 879.
60. Trinder, P., 1969. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Clin. biochem., 6: 24.
61. Unakami, S., T. Komoda and Y. Sakagishi, 1990. Translocation of intestinal alkaline phsphatase in streptozotocin induced diabetic rats. Int. Biochem., 22: 1325-1331.
62. Wang, J.J., L.X. Chen, P. Li, et al., 2008b. Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation. J Nutr., 138: 1025-1032.
63. Wascher, T.C., K. Posch, S. Wallner, 1997. Vascular effects of Larginine: anything beyond a substrate for the NO-synthase? Biochem Biophys Res Commun., 234: 35-38.
64. Waugh, W. H., C.W. Daeschner, B.A. Files, M.E. McConnell and S.E. Strandjord, 2001. Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase twvo results (J Natl Med Assoc., 93: 363-371.
65. West, M.B., K.V. Ramanab, K. Kaiserovaa, S.K. Srivastavab and A. Bhatnagara, 2008. L-Arginine prevents metabolic effects of high glucose in diabetic mice. FEBS Letters, 582: 2609-2614.
66. Wells, B.J., A.G. Mainous and C.J. Everett, 2005. Association between diatry arginine and C-reactive protein. Nutrition, 21: 125-30.
67. Wenger, c., et al., 1984. Alkaline phsphatase. Kaplan A et al. Clin Chem The C.V. Mosby Co. St Louis. Toronto. Princeton, 1094-1098.
68. Wu, G., J.K. Collins, P. Perkins-Veazie, M. Siddiq, K.D. Dolan, K.A. Kelly4, C.L. Heaps and C.J. Meininger, 2007. Dietary Supplementation with Watermelon Pomace Juice Enhances Arginine Availability and Ameliorates the Metabolic Syndrome in Zucker Diabetic Fatty Rats1. J. Nutr. 137:2680-2685.
69. Wu, G., 1997. Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs. Am J Physiol Gastrointest Liver Physiol 272:G1.
70. Wu, G., F.W. Bazer, S. Datta, et al., 2008a. Proline metabolism in the conceptus: Implications for fetal growth and development. Amino Acids, 35: 691-702.
71. Wu, G., F.W. Bazer, T.A. Davis, et al., 2008b. Arginine metabolism and nutrition in growth, health and disease. Amino Acids. 10.1007/s00726-008-0210-y.
72. Wu, G., Y.Z. Fang, S. Yang, et al., 2004a. Glutathione metabolism and its implications for health. J Nutr 134: 489-492.
73. Wu, G., C.J. Meininger, 2008. Nitric oxide and vascular insulin resistance. BioFactors (in press).
74. Wu, G., S.M. Morris, 1998. Arginine metabolism: nitric oxide and beyond. Biochem J., 336: 1-17.
75. Wu, G., S.M. Morris, 2004. Arginine metabolism:in mammals. In:Cynober LA. editor. Metabolic and therapeutic aspects of amino acids in clinical nutrition. Boca Raton, FL: CRC Press; pp: 153-167.
76. Wu, G.Y., D.A. Knabe, S.W. Kim, 2004a. Arginine nutrition in neonatal pigs. J Nutr., 134: 2783s-90.
77. Wu, G., 1998. Intestinal mucosal amino acid catabolism. J Nutr., 128: 1249-52.
78. Wu, G., 1995. Urea synthesis in enterocytes of developing pigs. Biochem J., 312: 717-23.
79. Wu, G., T.A. Davis, S.W. Kim, P. Li, J. Rhoads, M.C. Satterfield, S.B. Smith, T.E. Spencer and Y. Yin, 2008. Arginine metabolism and nutrition in growth, health and disease. Amino Acids, 37(1): 153-168.
80. Wu, G., T.L. Ott, D.A. Knabe and F.W. Bazer, 1999. Amino acid composition of the fetel pig. J. Nutr, 129: 1031-8.
81. Yang, N., Zhao Zhu., Yang, Chen, Cui and C. Jiang, 2008. Anti-diabetic effects of polysaccharides from Opunta monacantha cladoe in normal and streptozotocin-induced diabetic rats. Innovative Food Sci. & Emerging Tecnologies, 9: 570-574.
82. Yao, K., Y.L. Yin, W.Y. Chu, et al., 2008. Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs. J Nutr., 138: 867-872.