Reduced glutathione protects human hepatocytes from palmitate-mediated injury by suppressing endoplasmic reticulum stress response

Hepato-Gastroenterology

Volumn 58, Issue 110-111, 2011, Pages 1670-1679

  Ning, Bo ^a   Bai, Mingjun ^a   Shen, Wei ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Endoplasmic reticulum stress; Hepatocytes; Lipid peroxidation; Palmitate; Reduced glutathione

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 4; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE; MALONALDEHYDE; MESSENGER RNA; PALMITIC ACID;

APOPTOSIS; ARTICLE; CELL VIABILITY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; LIVER PROTECTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 83355167052     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge10845     Document Type: Article

References (31)

1. Duvnjak M, Lerotić I, Barsić N, et al.: Pathogenesis and management issues for non-alcoholic fatty liver disease. World J Gastroenterol 2007; 13(34):4539-50. (Pubitemid 47455230)
2. Mehta K, Van Thiel DH, Shah N, et al.: Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants. Nutr Rev 2002; 60(9):289-93. (Pubitemid 35025794)
3. Sorrentino P, Tarantino G, Conca P, et al.: Silent non-alcoholic fatty liver disease: a clinical histological study. J Hepatol 2004; 41:751-757. (Pubitemid 39434304)
4. Jansen PL: Non-alcoholic steatohepatitis. Eur J Gastroenterol Hepatol 2004; 16: 1079-1085.
5. Choudhury J, Sanyal AJ: Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease. Clin liver Dis 2004; 8: 575-594. (Pubitemid 39141144)
6. Cheng Ji: Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J Gastroenterol Hepatol 2008; 23(Suppl 1): S16-S24.
7. Lin AM, Chao PL, Fang SF, et al.: Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain. Toxicol Appl Pharmacol 2007; 224(2):138-46. (Pubitemid 47494512)
8. Nemsadze K, Sanikidze T, Ratiani L, et al.: Mechanisms of lead-induced poisoning. Georgian Med News 2009; (172-173):92-6.
9. Martin HL, Teismann P: Glutathione-a review on its role and significance in Parkinson's disease. FASEB J 2009; 23(10):3263-72.
10. Spector AA, Fletcher JE, Ashbrook JD: Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants. Biochemistry 1971; 10:3226-3232.
11. Baker MA, Cerniglia GJ, Zaman A: Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem 1990; 190(2):360-5. (Pubitemid 20371981)
12. Liedtke AJ, Mahar CQ, Ytrehus K, et al.: Estimates of free-radical production in rat and swine hearts: method and application of measuring malondialdehyde levels in fresh and frozen myocardium. Basic Res Cardiol 1984; 79(5):513-8. (Pubitemid 14049071)
13. Ji C, Kaplowitz N: Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003; 124:1488-1499. (Pubitemid 36531821)
14. Li J, Xia X, Ke Y, et al.: Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways. Biochim Biophys Acta 2007; 1770(8):1169-80. (Pubitemid 47009016)
15. Derick Han, Naoko Hanawa, Behnam Saberi, et al.: Mechanisms of Liver Injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol 2006; 291:G1-G7.
16. Wei Y, Wang D, Topczewski F, et al.: Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 2006; 291(2):E275-81. (Pubitemid 44035286)
17. Xu, C, Bailly-Maitre B, Reed, J. C: Endoplasmic reticulum stress: cell life and death decisions. J. Clin. Invest 2005; 115:2656-2664. (Pubitemid 41434389)
18. McCullough, K. D, Martindale, J. L, Klotz, L. O, et al.: Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol 2001; 21:1249-1259. (Pubitemid 32114973)
19. Zinszner, H, Kuroda, M, Wang, X, et al.: CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 1998; 12:982-995. (Pubitemid 28204605)
20. Karpinski BA, Morle GD, Huggenvik J, et al.: Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc Natl Acad Sci U S A 1992; 89:4820-4824.
21. Tsujimoto A, Nyunoya H, Morita T, et al.: Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. J Virol 1991; 65:1420-1426.
22. Brindle PK, Montminy MR: The CREB family of transcription activators. Curr Opin Genet Dev 1992; 2:199-204.
23. Hai T, Wolfgang CD, Marsee DK, et al.: ATF3 and stress responses. Gene Expr 1999; 7:321-335. (Pubitemid 29372076)
24. Meyer TE, Habener JF: Cyclic adenosine 3′,5′-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr Rev 1993; 14:269-290. (Pubitemid 23168051)
25. Sassone-Corsi P: Goals for signal transduction pathways: linking up with transcriptional regulation. Embo J 1994; 13:4717-4728.
26. Ziff EB: Transcription factors: a new family gathers at the cAMP response site. Trends Genet 1990; 6:69-72.
27. Shi Y, Vattem KM, Sood R, et al.: Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PERK, involved in translational control. Mol Cell Biol 1998; 18:7499-7509. (Pubitemid 28533068)
28. Marciniak SJ, Yun CY, Oyadomari S, et al.: CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 2004; 18:3066-3077. (Pubitemid 39658175)
29. Harding HP, Zhang Y, Zeng H, et al.: An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003; 11:619-633. (Pubitemid 36385118)
30. Pahl HL, Baeuerle PA: The ER-overload response: activation of NF-kappa B. Trends Biochem Sci 1997; 22:63-67.
31. Puri P, Mirshahi F, Cheung O, et al.: Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008; 134(2):568-76. (Pubitemid 351173040)