The human WW45 protein enhances MST1-mediated apoptosis in vivo

International Journal of Molecular Medicine

Volumn 23, Issue 3, 2009, Pages 357-362

  Luo, Xuelai ^a   Li, Zhaoming ^a   Yan, Qun ^a   Li, Xiaolan ^a   Tao, Deding ^a   Wang, Jing ^b   Leng, Yan ^a   Gardner, Kevin ^c   Judge, Susan I V ^d   Li, Qingdi Quentin ^c   Hu, Junbo ^a   Gong, Jianping ^a  

^a Tongji Hospital   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c NATIONAL CANCER INSTITUTE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; hWW45; Mammalian sterile 20 like kinase 1

Indexed keywords

BINDING PROTEIN; MAMMALIAN STERILE 20 LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; PROTEIN WW45; RNA; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; SAV1 PROTEIN, HUMAN; STK4 PROTEIN, HUMAN; STK4 PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GENE FUNCTION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; TWO HYBRID SYSTEM; ANIMAL; BIOSYNTHESIS; CELL STRAIN 3T3; GENETICS; HELA CELL; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CELL NUCLEUS; CYTOPLASM; HELA CELLS; HUMANS; MICE; NIH 3T3 CELLS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 64249116807     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000139     Document Type: Article

References (26)

1. Creasy CL and Chernoff J: Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem 270: 21695-21700, 1995.
2. Taylor LK, Wang CR and Erikson RL: Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc Natl Acad Sci USA 93: 10099-10104, 1996.
3. Dan T, Watanabe NM and Kusumi A: The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol 11: 220-230, 2001.
4. Creasy CL, Ambrose D and Chernoff J: The Ste20-like protein kinase MST dimerizes and contains an inhibitory domain. J Biol Chem 271: 21049-21053, 1996.
5. Ura S, Masuyama N and Graves JD: Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. Proc Natl Acad Sci USA 98: 10148-10153, 2001.
6. Graves JD, Draves KE and Gotohi Y: Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase MST1 during CD95/Fas-induced apoptosis. J Biol Chem 276: 14909-14915, 2001.
7. Kakeya H, Onose R and Osada H: Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res 58: 4888-4894, 1998.
8. Lee KK, Murakawa M and Nishida E: Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene 16: 3029-3037, 1998.
9. Reszka AA, Halasy-Nagy JM and Masarachia PJ: Bisphosphonates act directly on the osteoclast to induce caspase cleavage of MST1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. J Biol Chem 274: 34967-34973, 1999.
10. Watabe M, Kakeya H and Osada H: Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis. Oncogene 18: 5211-5220, 1999.
11. Watabe M, Kakeya H, Onose R and Osada H: Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis. J Biol Chem 275: 8766-8771, 2000.
12. Lu ML, Sato M and Cao B: UV irradiation-induced apoptosis leads to activation of a 36-kDa myelin basic protein kinase in HL-60 cells. Proc Natl Acad Sci USA 93: 8977-8982, 1996.
13. Lin Y, Khokhlatchev A and Figeys D: Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem 277: 47991-48001, 2002.
14. Cheung WL, Ajiro K and Samejima K: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113: 507-517, 2003.
15. Ura S, Masuyama N and Graves JD: MST1-JNK promotes apoptosis via caspase-dependent and -independent pathways. Genes Cells 6: 519-530, 2001.
16. Glantschnig H, Rodan GA and Reszka AA: Mapping of MST1 kinase sites of phosphorylation, activation and autophosphorylation. J Biol Chem 277: 42987-42996, 2002.
17. Tapon N, Harvey KF and Bell DW: Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110: 467-478, 2002.
18. Wu S, Huang J and Dong J: Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114: 445-456, 2003.
19. Harvey KF, Pfleger CM and Hariharan IK: The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114: 457-467, 2003.
20. Hay BA and Guo M: Coupling cell growth, proliferation, and death. Hippo weighs in. Dev Cell 5: 361-363, 2003.
21. Lehtinen MK, Yuan K and Boag PR: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125: 987-1001, 2006.
22. Feng Y, Hu J, Li QQ and Gong J: Subcellular localization of caspase-3 activation correlates with changes in apoptotic morphology in MOLT-4 leukemia cells exposed to X-ray irradiation. Int J Oncol 27: 699-704, 2005.
23. Valverde P: Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene. Biochem Biophys Res Comm 276: 990-998, 2000.
24. Callus BA, Verhagen AM and Vaux DL: Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J 273: 4264-4276, 2006.
25. Sudol M, Chen HI, Bougeret C, Einbond A and Bork P: Characterization of a novel protein-binding module-the WW domain. FEBS Lett 369: 67-71, 1995.
26. Ingham RJ, Colwill K and Howard C: WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol 25: 7092-7106, 2005.