Beneficial effect of probiotics in IBD: Are peptidogycan and NOD2 the molecular key effectors?

Gut Microbes

Volumn 2, Issue 5, 2011, Pages 280-286

  Fernandez, Elise Macho ^a   Pot, Bruno ^a   Grangette, Corinne ^a  

^a UNIV LILLE   (France)

Author keywords

Dendritic cells; IBD; Lactobacilli; NOD2; Peptidoglycan; Probiotics; Regulatory T cells

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 10; PEPTIDOGLYCAN; PROBIOTIC AGENT;

ARTICLE; BACTERIAL STRAIN; BIFIDOBACTERIACEAE; CD4+ T LYMPHOCYTE; COLITIS; ENTERITIS; HELICOBACTER HEPATICUS; HUMAN; IMMUNOREGULATION; LACTOBACILLUS; LACTOBACILLUS PLANTARUM; LACTOBACILLUS SALIVARIUS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

EID: 83255192440     PISSN: 19490976     EISSN: 19490984     Source Type: Journal    
DOI: 10.4161/gmic.2.5.18255     Document Type: Article

References (33)

1. Spor A, Koren O, Ley R. Unravelling the effects of the environment and host genotype on the gut microbiome. Nat Rev Microbiol 2011; 9:279-290. PMID:21407244; DOI:10.1038/nrmicro2540
2. O'Flaherty S, Saulnier DM, Pot B, Versalovic J. How can probiotics and prebiotics impact mucosal immunity? Gut Microbes 2010; 1:293-300. PMID:21327037; DOI:10.4161/gmic.1.5.12924
3. Christensen HR, Frokiaer H, Pestka JJ. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 2002; 168:171-178. PMID:11751960
4. Foligne B, Nutten S, Grangette C, Dennin V, Goudercourt D, Poiret S, et al. Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria. World J Gastroenterol 2007; 13:236-43. PMID:17226902
5. Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, et al. Tolllike receptor 9 signaling mediates the antiinf lammatory effects of probiotics in murine experimental colitis. Gastroenterology 2004; 126:520-528. PMID:14762789; DOI:10.1053/j.gastro. 2003.11.019
6. Ménard S, Candalh C, Bambou JC, Terpend K, Cerf-Bensussan N, Heyman M. Lactic acid bacteria secrete metabolites retaining anti-inf lammatory properties after intestinal transport. Gut 2004; 53:821-828. PMID:15138208; DOI:10.1136/gut.2003.026252
7. Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA 2008; 105:16731-16736. PMID:18936492; DOI:10.1073/pnas.0804812105
8. Grangette C, Nutten S, Palumbo E, Morath S, Hermann C, Dewulf J, et al. Enhanced anti-inflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids. Proc Natl Acad Sci USA 2005; 102:10321-10326. PMID:15985548; DOI:10.1073/pnas.0504084102
9. Foligne B, Zoumpopoulou G, Dewulf J, Ben Younes A, Chareyre F, Sirard JC, et al. A key role of dendritic cells in probiotic functionality. PLoS ONE 2007; 2:313. PMID:17375199; DOI:10.1371/journal.pone.0000313
10. Fernandez EM, Valenti VI, Rockel C, Hermann C, Pot B, Boneca IG, et al. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Gut 2011; 60:1050-1059. PMID:21471573; DOI:10.1136/gut.2010.232918
11. Vollmer W, Joris B, Charlier P, Foster S. Bacterial peptidoglycan (murein) hydrolases. FEMS Microbiol Rev 2008; 32:259-286. PMID:18266855; DOI:10.11 11/j.1574-6976.2007.00099. x
12. Girardin SE, Travassos LH, Herve M, Blanot D, Boneca IG, Philpott DJ, et al. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 2003; 278:41702-41708. PMID:12871942; DOI:10.1074/jbc.M307198200
13. Mohamadzadeh M, Pfeiler EA, Brown JB, Zadeh M, Gramarossa M, Managlia E, et al. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci USA 2011; 108:4623-4630. PMID:21282652;DOI:10.1073/pnas.1005066107
14. Sashihara T, Sueki N, Ikegami S. An analysis of the effectiveness of heat-killed lactic acid bacteria in alleviating allergic diseases. J Dairy Sci 2006; 89:2846-2855. PMID:16840600; DOI:10.3168/jds.S0022-0302(06)72557-7
15. Shida K, Kiyoshima-Shibata J, Nagaoka M, Watanabe K, Nanno M. Induction of interleukin-12 by Lactobacillus strains having a rigid cell wall resistant to intracellular digestion. J Dairy Sci 2006; 89:3306-3317. PMID:16899663; DOI:10.3168/jds.S0022-0302(06)72367-0
16. Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, et al. Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters. J Biol Chem 2010; 285:20147-20154. PMID:20406817; DOI:10.1074/jbc.M110.115584
17. Vavricka SR, Musch MW, Chang JE, Nakagawa Y, Phanvijhitsiri K, Waypa TS, et al. HPepT1 transports muramyl dipeptide, activating NFkappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology 2004; 127:1401-1409. PMID:15521010; DOI:10.1053/j.gastro.2004.07.024
18. Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1- mediated tripeptide KPV uptake reduces intestinal inf lammation. Gastroenterology 2008; 134:166-178. PMID:18061177; DOI:10.1053/j.gastro.2007.10.026
19. Chen HQ, Yang J, Zhang M, Zhou YK, Shen TY, Chu ZX, et al. Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice. Am J Physiol Gastrointest Liver Physiol 2010; 299:1287-1297. PMID:20884889;DOI:10.1152/ajpgi.00196.2010
20. Blander JM. Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors. Ann Rheum Dis 2008; 67:44-49. PMID:19022813;DOI:10.1136/ard.2008.097964
21. Boirivant M, Strober W. The mechanism of action of probiotics. Curr Opin Gastroenterol 2007; 23:679-692. PMID:17906447; DOI:10.1097/MOG.0b013e3282f0cffc
22. Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol 2005; 174:3237-3246. PMID:15749854
23. O'Mahony C, Scully P, O'Mahony D, Murphy S, O'Brien F, Lyons A, et al. Commensal-induced regulatory T cells mediate protection against pathogenstimulated NFkappaB activation. PLoS Pathog 2008; 4:1000112. PMID:18670628; DOI:10.1371/journal.ppat.1000112
24. Kwon HK, Lee CG, So JS, Chae CS, Hwang JS, Sahoo A, et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci USA 2010; 107:2159-2164. PMID:20080669; DOI:10.1073/pnas.0904055107
25. + regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007; 204:1757-1764. PMID:17620361; DOI:10.1084/jem.20070590
26. Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005; 6:507-514. PMID:15821737; DOI:10.1038/ni1192
27. Petrof EO, Kojima K, Ropeleski MJ, Musch MW, Tao Y, De Simone C, et al. Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology 2004; 127:1474-1487. PMID:15521016; DOI:10.1053/j.gastro.2004.09.001
28. Neish AS, Gewirtz AT, Zeng H, Young AN, Hobert ME, Karmali V, et al. Prokaryotic regulation of epithelial responses by inhibition of IkappaBalpha ubiquitination. Science 2000; 289:1560-1563. PMID:10968793; DOI:10.1126/science.289.5484.1560
29. Kelly D, Campbell JI, King TP, Grant G, Jansson EA, Coutts AG, et al. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclearcytoplasmic shuttling of PPARgamma and RelA. Nat Immunol 2004; 5:104-112. PMID:14691478; DOI:10.1038/ni1018
30. Watanabe T, Kitani A, Murray PJ, Strober W. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 2004; 5:800-808. PMID:15220916; DOI:10.1038/ni1092
31. Hedl M, Li J, Cho JH, Abraham C. Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci USA 2007; 104:19440-19445. PMID:18032608; DOI:10.1073/pnas.0706097104
32. Kullberg BJ, Ferwerda G, de Jong DJ, Drenth JP, Joosten LA, Van der Meer JW, et al. Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli. Immunology 2008; 123:600-605. PMID:18028374; DOI:10.1111 /j.1365-2567.2007.02735. x
33. Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008; 453:620-625. PMID:18509436; DOI:10.1038/nature07008