Simvastatin improves spinal fusion in rats

Acta Orthopaedica et Traumatologica Turcica

Volumn 45, Issue 4, 2011, Pages 270-275

  Bostan, Bora ^a   Güneş, Taner ^a   Aşçi, Murat ^a   Şen, Cengiz ^b   Keleştemur, Mehmet Halidun ^c   Erdem, Mehmet ^d   Köseoǧlu, Reşit Doǧan ^e   Erkorkmaz, Ünal ^e  

^a Gaziosmanpafla University   (Turkey)

^b BEZMIALEM VAKIF UNIVERSITY   (Turkey)

^c MELIKSAH UNIVERSITY   (Turkey)

^d DR LUTFI KIRDAR KARTAL TRAINING AND RESEARCH HOSPITAL   (Turkey)

^e GAZIOSMANPASA UNIVERSITY   (Turkey)

Author keywords

Bmp; Pseudoarthrosis; Simvastatin; Spinal fusion; Statin

Indexed keywords

BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN;

ANIMAL; ARTICLE; BONE DEVELOPMENT; DRUG EFFECT; LUMBAR VERTEBRA; MALE; METABOLISM; METHODOLOGY; ORAL DRUG ADMINISTRATION; PSEUDARTHROSIS; RAT; SPINE FUSION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LUMBAR VERTEBRAE; MALE; OSTEOGENESIS; PSEUDARTHROSIS; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SPINAL FUSION;

EID: 83255186931     PISSN: 1017995X     EISSN: None     Source Type: Journal    
DOI: 10.3944/AOTT.2011.2526     Document Type: Article

References (32)

1. Garrett IR, Gutierrez G, Mundy GR. Statins and bone formation. Curr Pharm 2001;7:715-36.
2. Deedwania PC, Hunninghake DB, Bays HE, Jones PH, Cain VA, Blasetto JW; STELLAR Study Group. Effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on atherogenic dyslipidemia in patients with characteristics of the metabolic syndrome. Am J Cardiol 2005;95:360-6.
3. Oxlund H, Andreassen TT. Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation. Bone 2004;34:609-18.
4. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G. Stimulation of bone formation in vitro and in rodents by statins. Science 1999;286:1946-9.
5. Wong RW, Rabie AB. Early healing pattern of statininduced osteogenesis. Br J Oral Maxillofac Surg 2005;43:46-50.
6. Drespe IH, Polzhofer GK, Turner AS, Grauer JN. Animal models for spinal fusion. Spine J 2005;5:209-16.
7. Dimar JR 2nd, Ante WA, Zhang YP, Glassman SD. The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat. Spine 1996;21:1870-6.
8. Lenke LG, Bridwell KH, Bullis D, Betz RR, Baldus C, Schoenecker PL. Results of in situ fusion for isthmic spondylolisthesis. J Spinal Disord 1992;5:433-42.
9. Huddlestone PM, Steckelberg JM, Hansen AD, Rouse MS, Bolander ME, Pater R. Ciprofloxacin inhibition of experimental fracture healing. J Bone Joint Surg Am 2000;82:161-73.
10. Moazzaz P, Gupta MC, Gilotra MM, Gilotra MN, Maitra S, Theerajunyaporn T, et al. Estrogen-dependent actions of bone morphogenetic protein-7 on spine fusion in rats. Spine 2005;30:1706-11.
11. Salamon ML, Althausen PL, Gupta MC, Laubach J. The effects of BMP-7 in a rat posterolateral intertransverse process fusion model. J Spinal Disord Tech 2003;16:90-5.
12. Guizzardi S, Di Silvestre M, Scandroglio R, Rugerri A, Savini R. Implants of heterologous demineralized bone matrix for induction of posterior spinal fusion in rats. Spine 1992;17:701-7.
13. Patel TC, Erulkar JS, Grauer JN, Toriano NW, Panjabi MM, Friedlaender GE. Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion. Spine 2001;26:1656-61.
14. Maeda T, Kawane T, Horiuchi N. Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology 2003;144:681-92.
15. Edwards CJ, Spector TD. Statins as modulators of bone formation. Arthritis Res 2002;4:151-3.
16. Gonyeau MJ. Statins and osteoporosis: a clinical review. Pharmacotherapy 2005;25:228-43.
17. Gotto AM Jr, LaRosa JC. The benefits of statin therapy--what questions remain? Clin Cardiol 2005;28:499-503.
18. Barter P, Gotto AM, LaRosa JC, Maroni J, Szarek M, Grundy SM, et al. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med 2007;357:1301-10.
19. Ohno T, Shigetomi M, Ihara K, Matsunaga T, Hashimoto T, Kawano H, et al. Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats. Transplantation 2003;76:869-71.
20. Lee YP, Jo M, Luna M, Chien B, Lieberman JR, Wang JC. The efficacy of different commercially available demineralized bone matrix substances in an athymic rat model. J Spinal Disord Tech 2005;18:439-44.
21. Huang-Brown KM, Guhad FA. Chocolate, an effective means of oral drug delivery in rats. Lab Anim (NY) 2002;31:34-6.
22. Bauer DC, Mundy GR, Jamal SA, Black DM, Cauley JA, Ensrud KE, et al. Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials. Arch Intern Med 2004;164:146-52.
23. Skoglund B, Forslund C, Aspenberg P. Simvastatin improves fracture healing in mice. J Bone Miner Res 2002;17:2004-8.
24. Wong RW, Rabie AB. Statin collagen grafts used to repair defects in the parietal bone of rabbits. Br J Oral Maxillofac Surg 2003;41:244-88.
25. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, et al. Stimulation of bone formation in vitro and in rodents by statins. Science 1999;286:1946-9.
26. Wong RW, Rabie BM. Histologic and ultrastructural study on statin graft in rabbit skulls. J Oral Maxillofac Surg 2005;63:1515-21.
27. Skoglund B, Aspenberg P. Locally applied simvastatin improves fracture healing in mice. BMC Musculoskeletal Disorders 2007;8:1-6.
28. Patil S, Holt G, Raby N, McLennan AN, Smith K, O'Kane S, et al. Prospective, double blind, randomized, controlled trial of simvastatin in human fracture healing. J Orthop Res 2009;27:281-5.
29. Stein D, Lee Y, Schmid MJ, Killpack B, Genrich MA, Narayana N, et al. Local simvastatin effects on mandibular bone growth and inflammation. J Periodontol 2005;76:1861-70.
30. Ma B, Clarke SA, Brooks RA, Rushton N. The effect of simvastatin on bone formation and ceramic resorption in a peri-implant defect model. Acta Biomater 2008;4:149-55.
31. Yee AJ, Bae HW, Friess D, Roth SM, Whyne C, Robbin M, et al. The use of simvastatin in rabbit posterolateral lumbar intertransverse process spine fusion. Spine J 2006;6:391-6.
32. Yee AJ, Bae HW, Friess D, Robbin M, Johnstone B, Yoo JU. Accuracy and interobserver agreement for determinations of rabbit posterolateral spinal fusion. Spine 2004;29:1308-13.