Animal models for spinal fusion

Spine Journal

Volumn 5, Issue 6 SUPPL., 2005, Pages S209-S216

  Drespe, Inneke H ^a   Polzhofer, Gert K ^a   Turner, A Simon ^b   Grauer, Jonathan N ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Animal models; Bone graft; Bone morphogenetic protein; Spinal fusion

Indexed keywords

BIOMATERIAL; BONE MORPHOGENETIC PROTEIN;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOGRAFT; BIOMECHANICS; BONE MATRIX; CAT; CATTLE; CERAMICS; CERVICAL SPINE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOG; GOAT; HISTOPATHOLOGY; LUMBAR SPINE; NONHUMAN; PALPATION; PRIMATE; PRIORITY JOURNAL; RABBIT; RADIOGRAPHY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEEP; SPINE FUSION; SWINE; TREATMENT OUTCOME; VALIDATION PROCESS;

EID: 28244475065     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2005.02.013     Document Type: Article

References (129)

1. E.M. Younger M.W. Chapman Morbidity at bone graft donor sites J Orthop Trauma 3 1989 192-195
2. K.M. Malloy A.S. Hilibrand Autograft versus allograft in degenerative cervical disease Clin Orthop 394 2002 27-38
3. F. Albee An experimental study of bone growth and the spinal bone transplant JAMA 60 1913 1044
4. J.H. Schimandle S.D. Boden Spine update. The use of animal models to study spinal fusion Spine 19 1994 1998-2006
5. D.J. Sucato D. Hedequist H. Zhang et al. Recombinant human bone morphogenetic protein-2 enhances anterior spinal fusion in a thoracoscopically instrumented animal model J Bone Joint Surg Am 86-A 2004 752-762
6. P.O. Newton S.S. Lee A.T. Mahar et al. Thoracoscopic multilevel anterior instrumented fusion in a goat model Spine 28 2003 1614-1620
7. T.A. Jahng T.S. Fu B.W. Cunningham et al. Endoscopic instrumented posterolateral lumbar fusion with Healos and recombinant human growth/ differentiation factor-5 Neurosurgery 54 2004 171-180 discussion 80-1
8. M.A. Feiertag S.D. Boden J.H. Schimandle et al. A rabbit model for nonunion of lumbar intertransverse process spine arthrodesis Spine 21 1996 27-31
9. T.C. Patel J.S. Erulkar J.N. Grauer et al. Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion Spine 26 2001 1656-1661
10. D.H. Silcox 3rd S.D. Boden J.H. Schimandle et al. Reversing the inhibitory effect of nicotine on spinal fusion using an osteoinductive protein extract Spine 23 1998 291-296
11. S.D. Boden L. Titus G. Hair et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1) Spine 23 1998 2486-2492
12. Q. Cui Z. Ming Xiao G. Balian et al. Comparison of lumbar spine fusion using mixed and cloned marrow cells Spine 26 2001 2305-2310
13. R.J. Dumont H. Dayoub J.Z. Li et al. Ex vivo bone morphogenetic protein-9 gene therapy using human mesenchymal stem cells induces spinal fusion in rodents Neurosurgery 51 2002 1239-1244
14. H.S. Kim M. Viggeswarapu S.D. Boden et al. Overcoming the immune response to permit ex vivo gene therapy for spine fusion with human type 5 adenoviral delivery of the LIM mineralization protein-1 cDNA Spine 28 2003 219-226
15. S.D. Boden J.H. Schimandle W.C. Hutton An experimental lumbar intertransverse process spinal fusion model: Radiographic, histologic, and biomechanical healing characteristics Spine 20 1995 412-420
16. J.H. Schimandle S.D. Boden W.C. Hutton Experimental spinal fusion with recombinant human bone morphogenetic protein-2 Spine 20 1995 1326-1337
17. M.A. Morone S.D. Boden Experimental posterolateral lumbar spinal fusion with a demineralized bone matrix gel Spine 23 1998 159-167
18. J.N. Grauer T.C. Patel J.S. Erulkar et al. 2000 Young Investigator Research Award winner. Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion Spine 26 2001 127-133
19. M. Kanayama B.W. Cunningham J.C. Sefter et al. Does spinal instrumentation influence the healing process of posterolateral spinal fusion? An in vivo animal model Spine 24 1999 1058-1065
20. S.D. Boden G.J. Martin Jr. W.C. Horton et al. Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage J Spinal Disord 11 1998 95-101
21. H.G. Baramki T. Steffen P. Lander et al. The efficacy of interconnected porous hydroxyapatite in achieving posterolateral lumbar fusion in sheep Spine 25 2000 1053-1060
22. J.S. Fischgrund S.B. James M.C. Chabot et al. Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model J Spinal Disord 10 1997 467-472
23. E.H. Holliger R.H. Trawick S.D. Boden et al. Morphology of the lumbar intertransverse process fusion mass in the rabbit model: A comparison between two bone graft materials - rhBMP-2 and autograft J Spinal Disord 9 1996 125-128
24. J.M.A. Yee H.W. Bae D. Friess et al. Augmentation of rabbit posterolateral spondylodesis using a novel demineralized bone matrix-hyaluronan putty Spine 28 2003 2435-2440
25. A. Minamide T. Tamaki M. Yoshida et al. The use of sintered bone in spinal surgery Eur Spine J 10 Suppl. 2 2001 S185-S188
26. J.S. Erulkar J.N. Grauer T.C. Patel et al. Flexibility analysis of posterolateral fusions in a New Zealand white rabbit model Spine 26 2001 1125-1130
27. H.S. Sandhu L.E. Kanim J.M. Kabo et al. Evaluation of rhBMP-2 with an OPLA carrier in a canine posterolateral (transverse process) spinal fusion model Spine 20 1995 2669-2682
28. J.C. Cheng X. Guo L.P. Law et al. How does recombinant human bone morphogenetic protein-4 enhance posterior spinal fusion? Spine 27 2002 467-474
29. M.A. Morone S.D. Boden G. Hair et al. The Marshall R. Urist Young Investigator Award. Gene expression during autograft lumbar spine fusion and the effect of bone morphogenetic protein 2 Clin Orthop 12 1998 252-265
30. H. Suzuki K. Takahashi M. Yamagata et al. Spatial and temporal collagen gene expression in lumbar intertransverse fusion in the rabbit J Bone Joint Surg Br 83 2001 760-766
31. H.S. Sandhu S.N. Khan Animal models for preclinical assessment of bone morphogenetic proteins in the spine Spine 27 2002 S32-S38
32. A. Minamide M. Kawakami H. Hashizume et al. Evaluation of carriers of bone morphogenetic protein for spinal fusion Spine 26 2001 933-939
33. H.S. Sandhu S.N. Khan D.Y. Suh Demineralized bone matrix, bone morphogenetic proteins, and animal models of spine fusion: An overview Eur Spine J 10 Suppl. 2 2001 S122-S131
34. S.N. Khan H.S. Sandhu J.M. Lane et al. Bone morphogenetic proteins: relevance in spine surgery Orthop Clin North Am 33 2002 447-463
35. K.D. Riew N.M. Wright S. Cheng et al. Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model Calcif Tissue Int 63 1998 357-360
36. J.C. Wang L.E. Kanim S. Yoo et al. Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats J Bone Joint Surg Am 85-A 2003 905-911
37. S. Yang L.W. Wang Biomechanical comparison of the stable efficacy of two anterior plating systems Clin Biomech (Bristol, Avon) 18 2003 S59-S66
38. M. Takahata Y. Kotani K. Abumi et al. Bone ingrowth fixation of artificial intervertebral disc consisting of bioceramic-coated three-dimensional fabric Spine 28 2003 637-644
39. J.R. Dimar 2nd W.A. Ante Y.P. Zhang et al. The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat Spine 21 1996 1870-1876
40. K.D. Riew J. Long J. Rhee et al. Time-dependent inhibitory effects of indomethacin on spinal fusion J Bone Joint Surg Am 85-A 2003 632-634
41. K.J. Wing C.G. Fisher J.X. O'Connell et al. Stopping nicotine exposure before surgery: The effect on spinal fusion in a rabbit model Spine 25 2000 30-34
42. Grauer JN, Bomback DA, Lugo R, et al. Posterolateral lumbar fusions in athymic rats: Characterization of a model. Spine J 2004;4:281-6.
43. M.L. Salamon P.L. Althausen M.C. Gupta et al. The effects of BMP-7 in a rat posterolateral intertransverse process fusion model J Spinal Disord Tech 16 2003 90-95
44. 3ceramic implantation] Nippon Seikeigeka Gakkai Zasshi 58 1984 205-217
45. T.S. Lindholm P. Ragni T.C. Lindholm Response of bone marrow stroma cells to demineralized cortical bone matrix in experimental spinal fusion in rabbits Clin Orthop 230 1988 296-302
46. T.N. Karaismailoglu Y. Tomak A. Andac et al. [Comparison of autograft, coralline graft, and xenograft in promoting posterior spinal fusion] Acta Orthop Traumatol Turc 36 2002 147-154
47. K.S. Tho S. Krishnamoorthy Use of coral grafts in anterior interbody fusion of the rabbit spine Ann Acad Med Singapore 25 1996 824-827
48. D.H. Silcox 3rd T. Daftari S.D. Boden et al. The effect of nicotine on spinal fusion Spine 20 1995 1549-1553
49. G.J. Martin Jr. S.D. Boden L. Titus Recombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusion Spine 24 1999 2188-2193
50. J. Long S. Lewis T. Kuklo et al. The effect of cyclooxygenase-2 inhibitors on spinal fusion J Bone Joint Surg Am 84-A 2002 1763-1768
51. R.S. Jackson M.A. Asher R.G. Lark Analysis of posterior spinal wiring in a validated rabbit model Clin Orthop 373 2000 285-294
52. L.G. Jenis D. Wheeler S.J. Parazin et al. The effect of osteogenic protein-1 in instrumented and noninstrumented posterolateral fusion in rabbits Spine J 2 2002 173-178
53. J.N. Grauer J.S. Erulkar T.C. Patel et al. Biomechanical evaluation of the New Zealand white rabbit lumbar spine: A physiologic characterization Eur Spine J 9 2000 250-255
54. M. Turgut M. Erkus N. Tavus The effect of fibrin adhesive (Tisseel) on interbody allograft fusion: An experimental study with cats Acta Neurochir (Wien) 141 1999 273-278
55. S.D. Cook J.E. Dalton E.H. Tan et al. In vivo evaluation of anterior cervical fusions with hydroxylapatite graft material Spine 19 1994 1856-1866
56. W.Z. Bi J.F. Wang S.B. Lu [Anterior lumbar interbody fusion of canine with allograft cortical ring plus autogenous cancellus] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 15 2001 366-369
57. S.E. Emery M.S. Brazinski A. Koka et al. The biological and biomechanical effects of irradiation on anterior spinal bone grafts in a canine model J Bone Joint Surg Am 76 1994 540-548
58. D.A. Fuller S. Stevenson S.E. Emery The effects of internal fixation on calcium carbonate: Ceramic anterior spinal fusion in dogs Spine 21 1996 2131-2136
59. P.C. McAfee J.J. Regan I.D. Farey et al. The biomechanical and histomorphometric properties of anterior lumbar fusions: A canine model J Spinal Disord 1 1988 101-110
60. T. Shima J.T. Keller M.M. Alvira et al. Anterior cervical discectomy and interbody fusion: An experimental study using a synthetic tricalcium phosphate J Neurosurg 51 1979 533-538
61. O. Shirado T.A. Zdeblick P.C. McAfee et al. Quantitative histologic study of the influence of anterior spinal instrumentation and biodegradable polymer on lumbar interbody fusion after corpectomy. A canine model Spine 17 1992 795-803
62. G.J. Wang S.I. Reger Z.H. Shao Comparative strength of anterior spinal fixation with bone graft or polymethylmethacrylate: Experimental operations and observations on dogs Clin Orthop 188 1984 303-308
63. R. Whitehill S.F. Stowers R.E. Fechner et al. Posterior cervical fusions using cerclage wires, methylmethacrylate cement and autogenous bone graft: An experimental study of a canine model Spine 12 1987 12-22
64. R. Whitehill S. Reger N. Weatherup et al. A biomechanical analysis of posterior cervical fusions using polymethylmethacrylate as an instantaneous fusion mass Spine 8 1983 368-372
65. R. Whitehill J.C. Barry The evolution of stability in cervical spinal constructs using either autogenous bone graft or methylmethacrylate cement: A follow-up report on a canine in vivo model Spine 10 1985 32-41
66. R. Whitehill S.I. Reger E. Fox et al. The use of methylmethacrylate cement as an instantaneous fusion mass in posterior cervical fusions: A canine in vivo experimental model Spine 9 1984 246-252
67. S.D. Cook J.E. Dalton A.B. Prewett et al. In vivo evaluation of demineralized bone matrix as a bone graft substitute for posterior spinal fusion Spine 20 1995 877-886
68. N. Kahanovitz S.P. Arnoczky J. Nemzek et al. The effect of electromagnetic pulsing on posterior lumbar spinal fusions in dogs Spine 19 1994 705-709
69. H.C. Kioschos M.A. Asher R.G. Lark et al. Overpowering the crankshaft mechanism: The effect of posterior spinal fusion with and without stiff transpedicular fixation on anterior spinal column growth in immature canines Spine 21 1996 1168-1173
70. M.S. Moon I.Y. Ok K.Y. Ha The effect of posterior spinal fixation with acrylic cement on the vertebral growth plate and intervertebral disc in dogs Int Orthop 10 1986 69-73
71. G.F. Muschler B. Huber T. Ullman et al. Evaluation of bone-grafting materials in a new canine segmental spinal fusion model J Orthop Res 11 1993 514-524
72. G.F. Muschler S. Negami A. Hyodo et al. Evaluation of collagen ceramic composite graft materials in a spinal fusion model Clin Orthop 328 1996 250-260
73. C.G. Paramore C. Lauryssen M.J. Rauzzino et al. The safety of OP-1 for lumbar fusion with decompression: A canine study Neurosurgery 44 1999 1151-1155; discussion 5-6
74. I.D. Farey P.C. McAfee K.R. Gurr et al. Quantitative histologic study of the influence of spinal instrumentation on lumbar fusions: A canine model J Orthop Res 7 1989 709-722
75. J. Takahashi N. Saito S. Ebara et al. Anterior thoracic spinal fusion in dogs by injection of recombinant human bone morphogenetic protein-2 and a synthetic polymer J Spinal Disord Tech 16 2003 137-143
76. D.W. Cahill G.J. Martin Jr. M.V. Hajjar et al. Suitability of bioresorbable cages for anterior cervical fusion J Neurosurg 98 2003 195-201
77. J.M. Toth H.S. An T.H. Lim et al. Evaluation of porous biphasic calcium phosphate ceramics for anterior cervical interbody fusion in a caprine model Spine 20 1995 2203-2210
78. T.A. Zdeblick M.E. Cooke D. Wilson et al. Anterior cervical discectomy, fusion, and plating: A comparative animal study Spine 18 1993 1974-1983
79. C.E. Johnston 2nd R.B. Ashman A.M. Baird et al. Effect of spinal construct stiffness on early fusion mass incorporation: Experimental study Spine 15 1990 908-912
80. P. Anderson J. Rouleau V. Bryan et al. Wear analysis of the Bryan Cervical Disc prothesis Spine 28 2003 186-194
81. J.W. Brantigan P.C. McAfee B.W. Cunningham et al. Interbody lumbar fusion using a carbon fiber cage implant versus allograft bone: An investigational study in the Spanish goat Spine 19 1994 1436-1444
82. M. van Dijk T.H. Smit M.F. Arnoe et al. The use of poly-L-lactic acid in lumbar interbody cages: Design and biomechanical evaluation in vitro Eur Spine J 12 2003 34-40
83. D.J. Sucato R.D. Welch B. Pierce et al. Thoracoscopic discectomy and fusion in an animal model: Safe and effective when segmental blood vessels are spared Spine 27 2002 880-886
84. R.F. McLain S.A. Yerby T.A. Moseley Comparative morphometry of L4 vertebrae: Comparison of large animal models for the human lumbar spine Spine 27 2002 E200-E206
85. J.M. Toth M. Wang J.L. Scifert et al. Evaluation of 70/30 D,L-PLa for use as a resorbable interbody fusion cage Orthopedics 25 2002 s1131-s1140
86. T.R. Blattert G. Delling P.S. Dalal et al. Successful transpedicular lumbar interbody fusion by means of a composite of osteogenic protein-1 (rhBMP-7) and hydroxyapatite carrier: A comparison with autograft and hydroxyapatite in the sheep spine Spine 27 2002 2697-2705
87. B.W. Cunningham M. Kanayama L.M. Parker et al. Osteogenic protein versus autologous interbody arthrodesis in the sheep thoracic spine: A comparative endoscopic study using the Bagby and Kuslich interbody fusion device Spine 24 1999 509-518
88. C.F. Huntington W.D. Murrell R.R. Betz et al. Comparison of thoracoscopic and open thoracic discectomy in a live ovine model for anterior spinal fusion Spine 23 1998 1699-1702
89. C.M. Cain P.G. Langston P.F. Weston et al. Assessment of spinal cord blood flow and function in sheep after anterolateral cervical interbody fusion in the presence of cord damage Spine 19 1994 511-519
90. F. Kandziora R. Pflugmacher J. Schafer et al. Biomechanical comparison of cervical spine interbody fusion cages Spine 26 2001 1850-1857
91. E.J. Lee Y.C. Hung M.Y. Lee et al. Kinematics of cervical spine discectomy with and without bone grafting: Quantitative evaluation of late fusion in a sheep model Neurosurgery 44 1999 139-146
92. J.M. Spivak D. Chen F.J. Kummer The effect of locking fixation screws on the stability of anterior cervical plating Spine 24 1999 334-338
93. H.S. Sandhu S. Turner J.M. Kabo et al. Distractive properties of a threaded interbody fusion device: An in vivo model Spine 21 1996 1201-1210
94. H.S. Sandhu J.M. Toth A.D. Diwan et al. Histologic evaluation of the efficacy of rhBMP-2 compared with autograft bone in sheep spinal anterior interbody fusion Spine 27 2002 567-575
95. O. Paar S. Andereya G. Staatz et al. [Value of human recombinant osteogenetic proteins as bone replacement materials in lumbar spondylodesis. Results of an animal experiment study] Unfallchirurg 104 2001 700-709
96. B.W. Cunningham Y. Kotani P.S. McNulty Video-assisted thoracoscopic surgery versus open thoracotomy for anterior thoracic spinal fusion: A comparative radiographic, biomechanical, and histologic analysis in a sheep model Spine 23 1998 1333-1340
97. Y. Kotani B.W. Cunningham A. Cappuccino et al. The effects of spinal fixation and destabilization on the biomechanical and histologic properties of spinal ligaments: An in vivo study Spine 23 1998 672-682
98. T.R. Blattert G. Delling A. Weckbach [Pediculoscopic assisted transpedicular spongioplasty for interbody fusion of the lumbar spine. An animal experiment study of the sheep model] Unfallchirurg 105 2002 680-687
99. T.R. Blattert G. Delling A. Weckbach Evaluation of an injectable calcium phosphate cement as an autograft substitute for transpedicular lumbar interbody fusion: A controlled, prospective study in the sheep model Eur Spine J 12 2003 216-223
100. M.R. Foster M.J. Allen J.E. Schoonmaker et al. Characterization of a developing lumbar arthrodesis in a sheep model with quantitative instability Spine J 2 2002 244-250
101. M. Kanayama B.W. Cunningham J.C. Weis et al. The effects of rigid spinal instrumentation and solid bony fusion on spinal kinematics: A posterolateral spinal arthrodesis model Spine 23 1998 767-773
102. H.J. Wilke A. Kettler L.E. Claes Are sheep spines a valid biomechanical model for human spines? Spine 22 1997 2365-2374
103. A. Olinger G. Pistorius W. Lindemann et al. Effectiveness of a hands-on training course for laparoscopic spine surgery in a porcine model Surg Endosc 13 1999 118-122
104. M. Muhlbauer J. Ferguson U. Losert et al. Experimental laparoscopic and thoracoscopic discectomy and instrumented spinal fusion: A feasibility study using a porcine model Minim Invasive Neurosurg 41 1998 1-4
105. A. Olinger B. Vollmar U. Hildebrandt et al. Experimental development and validation of a technique for lumboendoscopic anterior fusion of lumbar spine fractures: Comparison of endoscopic and open surgery in a live porcine model Surg Endosc 14 2000 844-848
106. H. Li X. Zou M. Laursen et al. The influence of intervertebral disc tissue on anterior spinal interbody fusion: An experimental study on pigs Eur Spine J 11 2002 476-481
107. T. Takahashi T. Tominaga T. Yoshimoto et al. Biomechanical evaluation of hydroxyapatite intervertebral graft and anterior cervical plating in a porcine cadaveric model Biomed Mater Eng 7 1997 121-127
108. K. Suzuki J. Mochida M. Chiba et al. Posterior stabilization of degenerative lumbar spondylolisthesis with a Leeds-Keio artificial ligament: A biomechanical analysis in a porcine vertebral model Spine 24 1999 26-31
109. G.S. Gurwitz J.M. Dawson M.J. McNamara et al. Biomechanical analysis of three surgical approaches for lumbar burst fractures using short-segment instrumentation Spine 18 1993 977-982
110. T. Asazuma I.A. Stokes M.S. Moreland et al. Intersegmental spinal flexibility with lumbosacral instrumentation: An in vitro biomechanical investigation Spine 15 1990 1153-1158
111. S. Ebara M. Kamimura H. Itoh et al. A new system for the anterior restoration and fixation of thoracic spinal deformities using an endoscopic approach Spine 25 2000 876-883
112. M.R. Grubb B.L. Currier J.S. Shih et al. Biomechanical evaluation of anterior cervical spine stabilization Spine 23 1998 886-892
113. A.J. Rapoff A.J. Ghanayem T.A. Zdeblick Biomechanical comparison of posterior lumbar interbody fusion cages Spine 22 1997 2375-2379
114. R. Placzek L. Birken M. Morlock et al. [Effect of various cylinder diameters of implants for lumbar inter-corporeal spinal fusion on compressive strength on the FSU model] Biomed Tech (Berl) 43 1998 253-256
115. J. Zhao Y. Hai N.R. Ordway et al. Posterior lumbar interbody fusion using posterolateral placement of a single cylindrical threaded cage Spine 25 2000 425-430
116. K.B. Fricka A.T. Mahar P.O. Newton Biomechanical analysis of anterior scoliosis instrumentation: Differences between single and dual rod systems with and without interbody structural support Spine 27 2002 702-706
117. H.J. Wilke S.T. Krischak K.H. Wenger et al. Load-displacement properties of the thoracolumbar calf spine: Experimental results and comparison to known human data Eur Spine J 6 1997 129-137
118. R.J. Nasca R.D. Montgomery S.M. Moeini Intervertebral spacer as an adjunct to anterior lumbar fusion. Part II. Six-month implantation in baboons J Spinal Disord 11 1998 136-141
119. B.P. Hecht J.S. Fischgrund H.N. Herkowitz et al. The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model Spine 24 1999 629-636
120. T. Akamaru D. Suh S.D. Boden et al. Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion Spine 28 2003 429-434
121. S.D. Boden G.J. Martin Jr. M.A. Morone et al. Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate Spine 24 1999 1179-1185
122. D.Y. Suh S.D. Boden J. Louis-Ugbo et al. Delivery of recombinant human bone morphogenetic protein-2 using a compression-resistant matrix in posterolateral spine fusion in the rabbit and in the non-human primate Spine 27 2002 353-360
123. T.A. Zdeblick A.J. Ghanayem A.J. Rapoff et al. Cervical interbody fusion cages: An animal model with and without bone morphogenetic protein Spine 23 1998 758-765
124. T.A. Zdeblick D. Wilson M.E. Cooke et al. Anterior cervical discectomy and fusion: A comparison of techniques in an animal model Spine 17 1992 S418-S426
125. T.A. Zdeblick M.E. Cooke D.N. Kunz et al. Anterior cervical discectomy and fusion using a porous hydroxyapatite bone graft substitute Spine 19 1994 2348-2357
126. U. Hildebrandt G. Pistorius A. Olinger et al. First experience with laparoscopic spine fusion in an experimental model in the pig Surg Endosc 10 1996 143-146
127. J.M. Spivak S. Bharam D. Chen et al. Internal fixation of cervical trauma following corpectomy and reconstruction. The effects of posterior element injury Bull Hosp Jt Dis 59 2000 47-51
128. Bomback DA, Grauer JN, Lugo R, et al., Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model. Spine 2004;29:1612-7.
129. P.D. Sawin C.A. Dickman N.R. Crawford et al. The effects of dexamethasone on bone fusion in an experimental model of posterolateral lumbar spinal arthrodesis J Neurosurg 94 2001 76-81