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Volumn 16, Issue 1-2, 2011, Pages 25-36

Myeloid leukemia in down syndrome

Author keywords

Acute megakaryoblastic leukemia (AMKL); GATA 1; Transient myeloproliferative disorder (TMD); Trisomy 21

Indexed keywords

ANTHRACYCLINE; BLEOMYCIN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; MELPHALAN; MITOXANTRONE; PIRARUBICIN; TRANSCRIPTION FACTOR GATA 1; VINCRISTINE;

EID: 83255185464     PISSN: 08939675     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevOncog.v16.i1-2.40     Document Type: Review
Times cited : (88)

References (89)
  • 1
    • 0342905433 scopus 로고    scopus 로고
    • Risks of leukaemia and solid tumours in individuals with Down's syndrome
    • Jan 15
    • Hasle H, Clemmensen IH, Mikkelsen M. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet. 2000 Jan 15;355(9199):165-9.
    • (2000) Lancet , vol.355 , Issue.9199 , pp. 165-169
    • Hasle, H.1    Clemmensen, I.H.2    Mikkelsen, M.3
  • 2
    • 33644872564 scopus 로고    scopus 로고
    • Cancer incidence of persons with Down syndrome in Finland: A population-based study
    • Apr 1
    • Patja K, Pukkala E, Sund R, Iivanainen M, Kaski M. Cancer incidence of persons with Down syndrome in Finland: a population-based study. Int J Cancer. 2006 Apr 1;118(7):1769-72.
    • (2006) Int J Cancer , vol.118 , Issue.7 , pp. 1769-1772
    • Patja, K.1    Pukkala, E.2    Sund, R.3    Iivanainen, M.4    Kaski, M.5
  • 5
    • 0033780541 scopus 로고    scopus 로고
    • The management of neoplastic disorders of haematopoiesis in children with Down's syndrome
    • Sep
    • Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Br J Haematol. 2000 Sep;110(3):512-24.
    • (2000) Br J Haematol , vol.110 , Issue.3 , pp. 512-524
    • Lange, B.1
  • 9
    • 34548851944 scopus 로고    scopus 로고
    • Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome
    • Sep 15
    • Pine SR, Guo Q, Yin C, Jayabose S, Druschel CM, Sandoval C. Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome. Blood. 2007 Sep 15;110(6):2128-31.
    • (2007) Blood , vol.110 , Issue.6 , pp. 2128-2131
    • Pine, S.R.1    Guo, Q.2    Yin, C.3    Jayabose, S.4    Druschel, C.M.5    Sandoval, C.6
  • 10
    • 33745076542 scopus 로고    scopus 로고
    • A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481
    • Jun 15
    • Massey GV, Zipursky A, Chang MN, Doyle JJ, Nasim S, Taub JW, Ravindranath Y, Dahl G, Weinstein HJ. A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481. Blood. 2006 Jun 15;107(12):4606-13.
    • (2006) Blood , vol.107 , Issue.12 , pp. 4606-4613
    • Massey, G.V.1    Zipursky, A.2    Chang, M.N.3    Doyle, J.J.4    Nasim, S.5    Taub, J.W.6    Ravindranath, Y.7    Dahl, G.8    Weinstein, H.J.9
  • 13
    • 10044233051 scopus 로고    scopus 로고
    • Transient leukemia in newborns with Down syndrome
    • Jan
    • Massey GV. Transient leukemia in newborns with Down syndrome. Pediatr Blood Cancer. 2005 Jan;44(1):29-32.
    • (2005) Pediatr Blood Cancer , vol.44 , Issue.1 , pp. 29-32
    • Massey, G.V.1
  • 14
    • 0026766319 scopus 로고
    • Leukemia in Down syndrome: A review
    • Apr-Jun
    • Zipursky A, Poon A, Doyle J. Leukemia in Down syndrome: a review. Pediatr Hematol Oncol. 1992 Apr-Jun;9(2):139-49.
    • (1992) Pediatr Hematol Oncol , vol.9 , Issue.2 , pp. 139-149
    • Zipursky, A.1    Poon, A.2    Doyle, J.3
  • 15
    • 16744366910 scopus 로고    scopus 로고
    • Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children's Cancer Group Studies 2861 and 2891
    • Jan 15
    • Lange BJ, Kobrinsky N, Barnard DR, Arthur DC, Buckley JD, Howells WB, Gold S, Sanders J, Neudorf S, Smith FO, Woods WG. Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children's Cancer Group Studies 2861 and 2891. Blood. 1998 Jan 15;91(2):608-15.
    • (1998) Blood , vol.91 , Issue.2 , pp. 608-615
    • Lange, B.J.1    Kobrinsky, N.2    Barnard, D.R.3    Arthur, D.C.4    Buckley, J.D.5    Howells, W.B.6    Gold, S.7    Sanders, J.8    Neudorf, S.9    Smith, F.O.10    Woods, W.G.11
  • 16
    • 18944404989 scopus 로고    scopus 로고
    • AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity
    • Aug
    • Creutzig U, Reinhardt D, Diekamp S, Dworzak M, Stary J, Zimmermann M. AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity. Leukemia. 2005 Aug;19(8):1355-60.
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1355-1360
    • Creutzig, U.1    Reinhardt, D.2    Diekamp, S.3    Dworzak, M.4    Stary, J.5    Zimmermann, M.6
  • 17
    • 0024370632 scopus 로고
    • Florid radiological appearance of megakaryoblastic leukaemia-an aid to earlier diagnosis
    • Moody A, Simpson E, Shaw D. Florid radiological appearance of megakaryoblastic leukaemia-an aid to earlier diagnosis. Pediatr Radiol. 1989;19(6-7):486-8.
    • (1989) Pediatr Radiol , vol.19 , Issue.6-7 , pp. 486-488
    • Moody, A.1    Simpson, E.2    Shaw, D.3
  • 18
    • 0030862211 scopus 로고    scopus 로고
    • Generalised bone disease with abundant periosteal reaction in megakaryocytic leukaemia
    • Nov
    • Kozlowski K, Halimun E. Generalised bone disease with abundant periosteal reaction in megakaryocytic leukaemia. Eur J Pediatr. 1997 Nov;156(11):845-7.
    • (1997) Eur J Pediatr , vol.156 , Issue.11 , pp. 845-847
    • Kozlowski, K.1    Halimun, E.2
  • 19
    • 33644905562 scopus 로고    scopus 로고
    • Treatment for myeloid leukaemia of Down syndrome: Population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials
    • Mar
    • Rao A, Hills RK, Stiller C, Gibson BE, de Graaf SS, Hann IM, O'Marcaigh A, Wheatley K, Webb DK. Treatment for myeloid leukaemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials. Br J Haematol. 2006 Mar;132(5):576-83.
    • (2006) Br J Haematol , vol.132 , Issue.5 , pp. 576-583
    • Rao, A.1    Hills, R.K.2    Stiller, C.3    Gibson, B.E.4    de Graaf, S.S.5    Hann, I.M.6    O'Marcaigh, A.7    Wheatley, K.8    Webb, D.K.9
  • 21
    • 0020054464 scopus 로고
    • Leukaemia of platelet precursors: Diverse features in four cases
    • May
    • Bevan D RM, Greaves M. Leukaemia of platelet precursors: diverse features in four cases. Br J Haematol. 1982 May;51(1):147-64.
    • (1982) Br J Haematol , vol.51 , Issue.1 , pp. 147-164
    • Bevan, D.R.M.1    Greaves, M.2
  • 24
    • 18944363334 scopus 로고    scopus 로고
    • Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts
    • May-Jun
    • Langebrake C, Creutzig U, Reinhardt D. Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts. Klin Padiatr. 2005 May-Jun;217(3):126-34.
    • (2005) Klin Padiatr , vol.217 , Issue.3 , pp. 126-134
    • Langebrake, C.1    Creutzig, U.2    Reinhardt, D.3
  • 25
    • 0029153163 scopus 로고
    • Acute leukemia and the transient myeloproliferative disorder associated with Down syndrome: Morphologic, immunophenotypic and cytogenetic manifestations
    • Sep
    • Litz CE, Davies S, Brunning RD, Kueck B, Parkin JL, Gajl Peczalska K, Arthur DC. Acute leukemia and the transient myeloproliferative disorder associated with Down syndrome: morphologic, immunophenotypic and cytogenetic manifestations. Leukemia. 1995 Sep;9(9):1432-9.
    • (1995) Leukemia , vol.9 , Issue.9 , pp. 1432-1439
    • Litz, C.E.1    Davies, S.2    Brunning, R.D.3    Kueck, B.4    Parkin, J.L.5    Peczalska, K.G.6    Arthur, D.C.7
  • 28
    • 79953739378 scopus 로고    scopus 로고
    • Fet-aletal/et-al-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21
    • Apr
    • Papageorgiou EA, Karagrigoriou A, Tsaliki E, Velissariou V, Carter NP, Patsalis PC. Fet-aletal/et-al-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21. Nat Med. 2011 Apr;17(4):510-3.
    • (2011) Nat Med , vol.17 , Issue.4 , pp. 510-513
    • Papageorgiou, E.A.1    Karagrigoriou, A.2    Tsaliki, E.3    Velissariou, V.4    Carter, N.P.5    Patsalis, P.C.6
  • 29
    • 79955045041 scopus 로고    scopus 로고
    • Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down syndrome screening
    • Pennings JL, Rodenburg W, Imholz S, Koster MP, van Oostrom CT, Breit TM, Schielen PC, de Vries A. Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down syndrome screening. PLoS One. 2011;6(4):e18866.
    • (2011) PLoS One , vol.6 , Issue.4
    • Pennings, J.L.1    Rodenburg, W.2    Imholz, S.3    Koster, M.P.4    van Oostrom, C.T.5    Breit, T.M.6    Schielen, P.C.7    de Vries, A.8
  • 30
    • 0142089730 scopus 로고    scopus 로고
    • Increased age at diagnosis has a significantly negative effect on outcome in children with Down syndrome and acute myeloid leukemia: A report from the Children's Cancer Group Study 2891
    • Sep 15
    • Gamis AS, Woods WG, Alonzo TA, Buxton A, Lange B, Barnard DR, Gold S, Smith FO. Increased age at diagnosis has a significantly negative effect on outcome in children with Down syndrome and acute myeloid leukemia: a report from the Children's Cancer Group Study 2891. J Clin Oncol. 2003 Sep 15;21(18):3415-22.
    • (2003) J Clin Oncol , vol.21 , Issue.18 , pp. 3415-3422
    • Gamis, A.S.1    Woods, W.G.2    Alonzo, T.A.3    Buxton, A.4    Lange, B.5    Barnard, D.R.6    Gold, S.7    Smith, F.O.8
  • 32
    • 0038142390 scopus 로고    scopus 로고
    • Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis
    • Jun 1
    • Mundschau G, Gurbuxani S, Gamis AS, Greene ME, Arceci RJ, Crispino JD. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood. 2003 Jun 1;101(11):4298-300.
    • (2003) Blood , vol.101 , Issue.11 , pp. 4298-4300
    • Mundschau, G.1    Gurbuxani, S.2    Gamis, A.S.3    Greene, M.E.4    Arceci, R.J.5    Crispino, J.D.6
  • 33
    • 0038142350 scopus 로고    scopus 로고
    • GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome
    • Jun 1
    • Hitzler JK, Cheung J, Li Y, Scherer SW, Zipursky A. GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. Blood. 2003 Jun 1;101(11):4301-4.
    • (2003) Blood , vol.101 , Issue.11 , pp. 4301-4304
    • Hitzler, J.K.1    Cheung, J.2    Li, Y.3    Scherer, S.W.4    Zipursky, A.5
  • 35
    • 0029040851 scopus 로고
    • Expression of erythroid-specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome
    • Jul
    • Ito E, Kasai M, Hayashi Y, Toki T, Arai K, Yokoyama S, Kato K, Tachibana N, Yamamoto M, Yokoyama M. Expression of erythroid-specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome. Br J Haematol. 1995 Jul;90(3):607-14.
    • (1995) Br J Haematol , vol.90 , Issue.3 , pp. 607-614
    • Ito, E.1    Kasai, M.2    Hayashi, Y.3    Toki, T.4    Arai, K.5    Yokoyama, S.6    Kato, K.7    Tachibana, N.8    Yamamoto, M.9    Yokoyama, M.10
  • 37
    • 0346966816 scopus 로고    scopus 로고
    • Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome
    • Jan 1
    • Shimada A, Xu G, Toki T, Kimura H, Hayashi Y, Ito E. Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome. Blood. 2004 Jan 1;103(1):366.
    • (2004) Blood , vol.103 , Issue.1 , pp. 366
    • Shimada, A.1    Xu, G.2    Toki, T.3    Kimura, H.4    Hayashi, Y.5    Ito, E.6
  • 39
    • 20044381309 scopus 로고    scopus 로고
    • Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
    • Jun
    • Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005 Jun;37(6):613-9.
    • (2005) Nat Genet , vol.37 , Issue.6 , pp. 613-619
    • Li, Z.1    Godinho, F.J.2    Klusmann, J.H.3    Garriga-Canut, M.4    Yu, C.5    Orkin, S.H.6
  • 40
    • 69849088569 scopus 로고    scopus 로고
    • Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant
    • Sep
    • Shimizu R, Kobayashi E, Engel JD, Yamamoto M. Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant. Genes Cells. 2009 Sep;14(9):1119-31.
    • (2009) Genes Cells , vol.14 , Issue.9 , pp. 1119-1131
    • Shimizu, R.1    Kobayashi, E.2    Engel, J.D.3    Yamamoto, M.4
  • 41
    • 58149380865 scopus 로고    scopus 로고
    • Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations
    • Dec 1
    • Tunstall-Pedoe O, Roy A, Karadimitris A, de la Fuente J, Fisk NM, Bennett P, Norton A, Vyas P, Roberts I. Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations. Blood. 2008 Dec 1;112(12):4507-11.
    • (2008) Blood , vol.112 , Issue.12 , pp. 4507-4511
    • Tunstall-Pedoe, O.1    Roy, A.2    Karadimitris, A.3    de la Fuente, J.4    Fisk, N.M.5    Bennett, P.6    Norton, A.7    Vyas, P.8    Roberts, I.9
  • 48
    • 65349165222 scopus 로고    scopus 로고
    • ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
    • Apr 2
    • Stankiewicz MJ, Crispino JD. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood. 2009 Apr 2;113(14):3337-47.
    • (2009) Blood , vol.113 , Issue.14 , pp. 3337-3347
    • Stankiewicz, M.J.1    Crispino, J.D.2
  • 50
    • 38349119730 scopus 로고    scopus 로고
    • Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome
    • Jan 15
    • Kirsammer G, Jilani S, Liu H, Davis E, Gurbuxani S, Le Beau MM, Crispino JD. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood. 2008 Jan 15;111(2):767-75.
    • (2008) Blood , vol.111 , Issue.2 , pp. 767-775
    • Kirsammer, G.1    Jilani, S.2    Liu, H.3    Davis, E.4    Gurbuxani, S.5    le Beau, M.M.6    Crispino, J.D.7
  • 58
    • 0242558935 scopus 로고    scopus 로고
    • Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down's syndrome
    • Nov
    • Hirose Y, Kudo K, Kiyoi H, Hayashi Y, Naoe T, Kojima S. Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down's syndrome. Leukemia. 2003 Nov;17(11):2250-2.
    • (2003) Leukemia , vol.17 , Issue.11 , pp. 2250-2252
    • Hirose, Y.1    Kudo, K.2    Kiyoi, H.3    Hayashi, Y.4    Naoe, T.5    Kojima, S.6
  • 59
    • 25444497962 scopus 로고    scopus 로고
    • GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1
    • Oct
    • Kuhl C, Atzberger A, Iborra F, Nieswandt B, Porcher C, Vyas P. GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1. Mol Cell Biol. 2005 Oct;25(19):8592-606.
    • (2005) Mol Cell Biol , vol.25 , Issue.19 , pp. 8592-8606
    • Kuhl, C.1    Atzberger, A.2    Iborra, F.3    Nieswandt, B.4    Porcher, C.5    Vyas, P.6
  • 60
    • 23044499360 scopus 로고    scopus 로고
    • Differential requirements for the activation domain and FOGinteraction surface of GATA-1 in megakaryocyte gene expression and development
    • Aug 15
    • Muntean AG, Crispino JD. Differential requirements for the activation domain and FOGinteraction surface of GATA-1 in megakaryocyte gene expression and development. Blood. 2005 Aug 15;106(4):1223-31.
    • (2005) Blood , vol.106 , Issue.4 , pp. 1223-1231
    • Muntean, A.G.1    Crispino, J.D.2
  • 61
    • 70350492497 scopus 로고    scopus 로고
    • Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
    • Sep 24
    • Cabelof DC, Patel HV, Chen Q, van Remmen H, Matherly LH, Ge Y, Taub JW. Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome. Blood. 2009 Sep 24;114(13):2753-63.
    • (2009) Blood , vol.114 , Issue.13 , pp. 2753-2763
    • Cabelof, D.C.1    Patel, H.V.2    Chen, Q.3    van Remmen, H.4    Matherly, L.H.5    Ge, Y.6    Taub, J.W.7
  • 64
    • 0030926006 scopus 로고    scopus 로고
    • A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development
    • Jul 1
    • Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 1;16(13):3965-73.
    • (1997) EMBO J , vol.16 , Issue.13 , pp. 3965-3973
    • Shivdasani, R.A.1    Fujiwara, Y.2    McDevitt, M.A.3    Orkin, S.H.4
  • 66
    • 0033991491 scopus 로고    scopus 로고
    • The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome
    • Jan 1
    • Malkin D, Brown EJ, Zipursky A. The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome. Cancer Genet Cytogenet. 2000 Jan 1;116(1):1-5.
    • (2000) Cancer Genet Cytogenet , vol.116 , Issue.1 , pp. 1-5
    • Malkin, D.1    Brown, E.J.2    Zipursky, A.3
  • 67
    • 33745208430 scopus 로고    scopus 로고
    • Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5
    • Jul
    • Kanezaki R, Toki T, Xu G, Narayanan R, Ito E. Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5. Tohoku J Exp Med. 2006 Jul;209(3):169-80.
    • (2006) Tohoku J Exp Med , vol.209 , Issue.3 , pp. 169-180
    • Kanezaki, R.1    Toki, T.2    Xu, G.3    Narayanan, R.4    Ito, E.5
  • 69
    • 33847202261 scopus 로고    scopus 로고
    • JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults
    • Mar
    • Kiyoi H, Yamaji S, Kojima S, Naoe T. JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. Leukemia. 2007 Mar;21(3):574-6.
    • (2007) Leukemia , vol.21 , Issue.3 , pp. 574-576
    • Kiyoi, H.1    Yamaji, S.2    Kojima, S.3    Naoe, T.4
  • 74
    • 77952400247 scopus 로고    scopus 로고
    • Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells
    • Apr 27
    • Chou S, Lodish HF. Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7799-804.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.17 , pp. 7799-7804
    • Chou, S.1    Lodish, H.F.2
  • 75
    • 77955870488 scopus 로고    scopus 로고
    • Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis
    • Aug 1
    • Klusmann JH, Godinho FJ, Heitmann K, Maroz A, Koch ML, Reinhardt D, Orkin SH, Li Z. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev. 2010 Aug 1;24(15):1659-72.
    • (2010) Genes Dev , vol.24 , Issue.15 , pp. 1659-1672
    • Klusmann, J.H.1    Godinho, F.J.2    Heitmann, K.3    Maroz, A.4    Koch, M.L.5    Reinhardt, D.6    Orkin, S.H.7    Li, Z.8
  • 76
    • 0029417023 scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
    • Dec 21-28
    • Busciglio J, Yankner BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature. 1995 Dec 21-28;378(6559):776-9.
    • (1995) Nature , vol.378 , Issue.6559 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 77
    • 0036156452 scopus 로고    scopus 로고
    • Telomerase and the benign and malignant megakaryoblastic leukemias of Down syndrome
    • Jan
    • Holt SE, Brown EJ, Zipursky A. Telomerase and the benign and malignant megakaryoblastic leukemias of Down syndrome. J Pediatr Hematol Oncol. 2002 Jan;24(1):14-7.
    • (2002) J Pediatr Hematol Oncol , vol.24 , Issue.1 , pp. 14-17
    • Holt, S.E.1    Brown, E.J.2    Zipursky, A.3
  • 78
    • 0026808789 scopus 로고
    • Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: Experience on Pediatric Oncology Group AML Study 8498
    • Nov 1
    • Ravindranath Y, Abella E, Krischer JP, Wiley J, Inoue S, Harris M, Chauvenet A, Alvarado CS, Dubowy R, and Ritchey AK. Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498. Blood. 1992 Nov 1;80(9):2210-4.
    • (1992) Blood , vol.80 , Issue.9 , pp. 2210-2214
    • Ravindranath, Y.1    Abella, E.2    Krischer, J.P.3    Wiley, J.4    Inoue, S.5    Harris, M.6    Chauvenet, A.7    Alvarado, C.S.8    Dubowy, R.9    Ritchey, A.K.10
  • 79
    • 0011294902 scopus 로고
    • AML in Down syndrome; repsonse and toxicity with high-dose Ara-C
    • Ravindranath Y AE, Krischer S. AML in Down syndrome; repsonse and toxicity with high-dose Ara-C. Proc ASCO 1993;12:323a.
    • (1993) Proc ASCO , vol.12
    • Ravindranath, Y.A.E.1    Krischer, S.2
  • 80
  • 81
    • 0036153957 scopus 로고    scopus 로고
    • Incidence and treatment of potentially lethal diseases in transient leukemia of Down syndrome: Pediatric Oncology Group Study
    • Jan
    • Al-Kasim F, Doyle JJ, Massey GV, Weinstein HJ, Zipursky A. Incidence and treatment of potentially lethal diseases in transient leukemia of Down syndrome: Pediatric Oncology Group Study. J Pediatr Hematol Oncol. 2002 Jan;24(1):9-13.
    • (2002) J Pediatr Hematol Oncol , vol.24 , Issue.1 , pp. 9-13
    • Al-Kasim, F.1    Doyle, J.J.2    Massey, G.V.3    Weinstein, H.J.4    Zipursky, A.5
  • 82
    • 33646701894 scopus 로고    scopus 로고
    • Long-term results of an ultra low-dose cytarabinebased regimen for the treatment of acute megakaryoblastic leukaemia in children with Down syndrome
    • Jun
    • Al-Ahmari A, Shah N, Sung L, Zipursky A, Hitzler J. Long-term results of an ultra low-dose cytarabinebased regimen for the treatment of acute megakaryoblastic leukaemia in children with Down syndrome. Br J Haematol. 2006 Jun;133(6):646-8.
    • (2006) Br J Haematol , vol.133 , Issue.6 , pp. 646-648
    • Al-Ahmari, A.1    Shah, N.2    Sung, L.3    Zipursky, A.4    Hitzler, J.5
  • 85
    • 0029939156 scopus 로고    scopus 로고
    • Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: A contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia
    • Apr 15
    • Taub JW, Matherly LH, Stout ML, Buck SA, Gurney JG, Ravindranath Y. Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia. Blood. 1996 Apr 15;87(8):3395-403.
    • (1996) Blood , vol.87 , Issue.8 , pp. 3395-3403
    • Taub, J.W.1    Matherly, L.H.2    Stout, M.L.3    Buck, S.A.4    Gurney, J.G.5    Ravindranath, Y.6
  • 86
    • 1642475113 scopus 로고    scopus 로고
    • The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines
    • Jan 15
    • Ge Y, Jensen TL, Stout ML, Flatley RM, Grohar PJ, Ravindranath Y, Matherly LH, Taub JW. The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines. Cancer Res. 2004 Jan 15;64(2):728-35.
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 728-735
    • Ge, Y.1    Jensen, T.L.2    Stout, M.L.3    Flatley, R.M.4    Grohar, P.J.5    Ravindranath, Y.6    Matherly, L.H.7    Taub, J.W.8
  • 87
    • 0035751765 scopus 로고    scopus 로고
    • Distinctive multidrug sensitivity and outcome of acute erythroblastic and megakaryoblastic leukemia in children with Down syndrome
    • Dec
    • Yamada S, Hongo T, Okada S, Watanabe C, Fujii Y, Hori H, Yazaki M, Hanada R, Horikoshi Y. Distinctive multidrug sensitivity and outcome of acute erythroblastic and megakaryoblastic leukemia in children with Down syndrome. Int J Hematol. 2001 Dec;74(4):428-36.
    • (2001) Int J Hematol , vol.74 , Issue.4 , pp. 428-436
    • Yamada, S.1    Hongo, T.2    Okada, S.3    Watanabe, C.4    Fujii, Y.5    Hori, H.6    Yazaki, M.7    Hanada, R.8    Horikoshi, Y.9
  • 88
    • 33750473041 scopus 로고    scopus 로고
    • CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: In vitro drug sensitivity and outcome
    • Oct
    • Savasan S, Buck S, Raimondi SC, Becton DL, Weinstein H, Chang M, Ravindranath Y. CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. Leuk Lymphoma. 2006 Oct;47(10): 2076-83.
    • (2006) Leuk Lymphoma , vol.47 , Issue.10 , pp. 2076-2083
    • Savasan, S.1    Buck, S.2    Raimondi, S.C.3    Becton, D.L.4    Weinstein, H.5    Chang, M.6    Ravindranath, Y.7
  • 89
    • 70350506780 scopus 로고    scopus 로고
    • RUNX1 regulates phosphoinositide 3-kinase/ AKT pathway: Role in chemotherapy sensitivity in acute megakaryocytic leukemia
    • Sep 24
    • Edwards H, Xie C, LaFiura KM, Dombkowski AA, Buck SA, Boerner JL, Taub JW, Matherly LH, Ge Y. RUNX1 regulates phosphoinositide 3-kinase/ AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia. Blood. 2009 Sep 24;114(13):2744-52.
    • (2009) Blood , vol.114 , Issue.13 , pp. 2744-2752
    • Edwards, H.1    Xie, C.2    Lafiura, K.M.3    Dombkowski, A.A.4    Buck, S.A.5    Boerner, J.L.6    Taub, J.W.7    Matherly, L.H.8    Ge, Y.9


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