Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2

Assay and Drug Development Technologies

Volumn 9, Issue 6, 2011, Pages 628-634

  Liu, Yi ^a   Beck, Edward J ^a   Flores, Christopher M ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIDOCAINE; PHENYTOIN; SODIUM CHANNEL NAV1.2; TETRODOTOXIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BIOLOGICAL ACTIVITY; CELL DENSITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPOLARIZATION; DRUG DETERMINATION; DRUG POTENCY; DRUG PROTEIN BINDING; ELECTROPHYSIOLOGY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PATCH CLAMP; PROTEIN EXPRESSION; RAT; STEADY STATE; STRUCTURE ACTIVITY RELATION; VALIDATION STUDY;

ACTION POTENTIALS; ANIMALS; CELL LINE; ION CHANNEL GATING; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TIME FACTORS;

EID: 83055198523     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2011.0375     Document Type: Article

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