Aliskiren and Valsartan reduce myocardial AT1 receptor expression and limit myocardial infarct size in diabetic mice

Cardiovascular Drugs and Therapy

Volumn 25, Issue 6, 2011, Pages 505-515

  Ye, Yumei ^a   Qian, Jinqiao ^a,b   Castillo, Alexander C ^a   Perez Polo, Jose Regino ^a   Birnbaum, Yochai ^a,c  

^a University of Texas Medical Branch School of Medicine   (United States)

^b KUNMING MEDICAL UNIVERSITY   (China)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Angiotensin receptor blocker; Direct renin inhibitor; Infarct size; Ischemia reperfusion injury; Sirt1; Type 2 diabetes mellitus

Indexed keywords

ALISKIREN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; SILENT INFORMATION REGULATOR PROTEIN; VALSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORONARY REPERFUSION; HEART INFARCTION; HEART INFARCTION SIZE; HEART RATE; IMMUNOBLOTTING; LEFT CORONARY ARTERY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SYSTOLIC BLOOD PRESSURE;

ADMINISTRATION, ORAL; AMIDES; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DRUG THERAPY, COMBINATION; FUMARATES; HEMODYNAMICS; IMMUNOBLOTTING; MALE; MICE; MICE, INBRED STRAINS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN; TETRAZOLES; VALINE;

EID: 83055181134     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-011-6339-z     Document Type: Article

References (77)

1. BQ Zhu RE Sievers AE Browne RJ Lee K Chatterjee W Grossman JS Karliner WW Parmley 2003 Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function J Renin Angiotensin Aldosterone Syst 4 31 37 12692751 1:CAS:528:DC%2BD3sXjt1ejsbk%3D (Pubitemid 36443384)
2. ER Schwarz H Montino J Fleischhauer HG Klues J vom Dahl P Hanrath 1997 Angiotensin II receptor antagonist EXP 3174 reduces infarct size comparable with enalaprilat and augments preconditioning in the pig heart Cardiovasc Drugs Ther 11 687 695 9493708 1:CAS:528:DyaK1cXht1Wns7s%3D (Pubitemid 28041042)
3. S Hoshida N Yamashita T Kuzuya M Hori 2000 Differential effects of long-term renin-angiotensin system blockade on limitation of infarct size in cholesterol-fed rabbits Atherosclerosis 149 287 294 10729378 1:CAS:528:DC%2BD3cXhvV2ktrY%3D (Pubitemid 30145538)
4. MK Ozer E Sahna M Birincioglu A Acet 2002 Effects of captopril and losartan on myocardial ischemia-reperfusion induced arrhythmias and necrosis in rats Pharmacol Res 45 257 263 12030787 1:CAS:528:DC%2BD38XjvFOgt7c%3D (Pubitemid 35430519)
5. V Griol-Charhbili E Messadi-Laribi JL Bascands D Heudes P Meneton JF Giudicelli F Alhenc-Gelas C Richer 2005 Role of tissue kallikrein in the cardioprotective effects of ischemic and pharmacological preconditioning in myocardial ischemia FASEB J 19 1172 1174 15860541 1:CAS:528:DC%2BD2MXlvFensrY%3D (Pubitemid 40946455)
6. X Chen S Minatoguchi N Wang M Arai C Lu Y Uno Y Misao G Takemura H Fujiwara 2003 Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits J Cardiovasc Pharmacol 41 938 945 12775974 1:CAS:528:DC%2BD3sXksVGju7o%3D (Pubitemid 36706144)
7. M Kobara T Tatsumi D Kambayashi A Mano S Yamanaka J Shiraishi N Keira S Matoba J Asayama S Fushiki M Nakagawa 2003 Effects of ACE inhibition on myocardial apoptosis in an ischemia-reperfusion rat heart model J Cardiovasc Pharmacol 41 880 889 12775965 1:CAS:528:DC%2BD3sXksVGjtbg%3D (Pubitemid 36706135)
8. HL Lazar Y Bao S Rivers T Colton SA Bernard 2001 High tissue affinity angiotensin-converting enzyme inhibitors improve endothelial function and reduce infarct size Ann Thorac Surg 72 548 553 11515896 1:STN:280: DC%2BD3MvntFartg%3D%3D discussion 553-544 (Pubitemid 32727168)
9. M Kitakaze K Node S Takashima T Minamino T Kuzuya M Hori 2000 Cellular mechanisms of cardioprotection afforded by inhibitors of angiotensin converting enzyme in ischemic hearts: role of bradykinin and nitric oxide Hypertens Res 23 253 259 10821135 1:CAS:528:DC%2BD3cXkt1CnsLw%3D (Pubitemid 30326255)
10. YH Liu XP Yang VG Sharov DH Sigmon HN Sabbath OA Carretero 1996 Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats Hypertension 27 7 13 8591891 (Pubitemid 26017674)
11. JC Hartman 1995 The role of bradykinin and nitric oxide in the cardioprotective action of ACE inhibitors Ann Thorac Surg 60 789 792 7545893 1:STN:280:DyaK2MvgvVSnsQ%3D%3D
12. JC Hartman TG Hullinger TM Wall RJ Shebuski 1993 Reduction of myocardial infarct size by ramiprilat is independent of angiotensin II synthesis inhibition Eur J Pharmacol 234 229 236 8482328 1:CAS:528:DyaK3sXktVSls78%3D (Pubitemid 23103445)
13. JC Hartman TM Wall TG Hullinger RJ Shebuski 1993 Reduction of myocardial infarct size in rabbits by ramiprilat: reversal by the bradykinin antagonist HOE 140 J Cardiovasc Pharmacol 21 996 1003 7687728 1:CAS:528:DyaK3sXltVyks7s%3D (Pubitemid 23160691)
14. R Weidenbach R Schulz P Gres M Behrends H Post G Heusch 2000 Enhanced reduction of myocardial infarct size by combined ACE inhibition and AT(1)-receptor antagonism Br J Pharmacol 131 138 144 10960080 1:CAS:528:DC%2BD3cXmsFKisb8%3D
15. R Schulz G Heusch 2003 AT1-receptor blockade in experimental myocardial ischemia/reperfusion Clin Nephrol 60 S67 S74 12940536 1:CAS:528: DC%2BD3sXnt12msb8%3D (Pubitemid 36896098)
16. M Sato RM Engelman H Otani N Maulik JA Rousou JE Flack 3rd DW Deaton DK Das 2000 Myocardial protection by preconditioning of heart with losartan, an angiotensin II type 1-receptor blocker: implication of bradykinin-dependent and bradykinin-independent mechanisms Circulation 102 III346 III351 11082412 1:STN:280:DC%2BD3M%2FlvFOqtQ%3D%3D
17. A Jalowy R Schulz H Dorge M Behrends G Heusch 1998 Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs J Am Coll Cardiol 32 1787 1796 9822110 1:CAS:528:DyaK1cXnvVymtrw%3D (Pubitemid 28545220)
18. Y Ye KT Keyes CF Zhang JR Perez-Polo Y Lin Y Birnbaum 2010 Additive effect of TAK-491, a new angiotensin receptor blocker, and pioglitazone, in reducing myocardial infarct size Cardiovasc Drugs Ther 24 107 120 20379769 1:CAS:528:DC%2BC3cXns1Crtbk%3D
19. BI Jugdutt M Balghith 2001 Enhanced regional AT(2)-receptor and PKC(epsilon) expression during cardioprotection induced by AT(1)-receptor blockade after reperfused myocardial infarction J Renin Angiotensin Aldosterone Syst 2 134 140 11881113 1:CAS:528:DC%2BD3MXlslart7g%3D
20. BI Jugdutt V Menon 2004 AT2 receptor and apoptosis during AT1 receptor blockade in reperfused myocardial infarction in the rat Mol Cell Biochem 262 203 214 15532725 1:CAS:528:DC%2BD2cXmslWgs7o%3D (Pubitemid 39158070)
21. A Jalowy R Schulz G Heusch 1998 AT1 receptor blockade in experimental myocardial ischemia/reperfusion Basic Res Cardiol 93 85 91 9833169 1:CAS:528:DyaK1cXntlWrtLc%3D (Pubitemid 28498137)
22. BI Jugdutt V Menon 2003 Upregulation of angiotensin II type 2 receptor and limitation of myocardial stunning by angiotensin II type 1 receptor blockers during reperfused myocardial infarction in the rat J Cardiovasc Pharmacol Ther 8 217 226 14506547 1:CAS:528:DC%2BD3sXotl2jur8%3D (Pubitemid 37158968)
23. W Linz BA Scholkens 1992 Role of bradykinin in the cardiac effects of angiotensin-converting enzyme inhibitors J Cardiovasc Pharmacol 20 S83 S90 1282635 1:CAS:528:DyaK3sXpsFSgtQ%3D%3D (Pubitemid 23002818)
24. ST Duggan CM Chwieduk MP Curran 2010 Aliskiren: a review of its use as monotherapy and as combination therapy in the management of hypertension Drugs 70 2011 2049 20883056 1:CAS:528:DC%2BC3cXhsFOntrjO
25. M Azizi 2008 Direct renin inhibition: clinical pharmacology J Mol Med 86 647 654 18368379 1:CAS:528:DC%2BD1cXls1KltL4%3D
26. DJ Hausenloy G Baxter R Bell HE Botker SM Davidson J Downey G Heusch M Kitakaze S Lecour R Mentzer MM Mocanu M Ovize R Schulz R Shannon M Walker G Walkinshaw DM Yellon 2010 Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations Basic Res Cardiol 105 677 686 20865418
27. H Hotta T Miura T Miki N Togashi T Maeda SJ Kim M Tanno T Yano A Kuno T Itoh T Satoh Y Terashima S Ishikawa K Shimamoto 2010 Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts Circ Res 106 129 132 19910577 1:CAS:528:DC%2BD1MXhs1aqt7bE
28. JR Kersten MW Montgomery T Ghassemi ER Gross WG Toller PS Pagel DC Warltier 2001 Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels Am J Physiol Heart Circ Physiol 280 H1744 H1750 11247788 1:CAS:528:DC%2BD3MXjtV2itr0%3D
29. JR Kersten TJ Schmeling KG Orth PS Pagel DC Warltier 1998 Acute hyperglycemia abolishes ischemic preconditioning in vivo Am J Physiol 275 H721 H725 9683464 1:CAS:528:DyaK1cXlsVyjsbs%3D
30. A Klamann P Sarfert V Launhardt G Schulte WH Schmiegel MA Nauck 2000 Myocardial infarction in diabetic vs non-diabetic subjects. Survival and infarct size following therapy with sulfonylureas (glibenclamide) Eur Heart J 21 220 229 10639304 1:STN:280:DC%2BD3c7gslShsw%3D%3D (Pubitemid 30137807)
31. A Tsang DJ Hausenloy MM Mocanu RD Carr DM Yellon 2005 Preconditioning the diabetic heart: the importance of Akt phosphorylation Diabetes 54 2360 2364 16046302 1:CAS:528:DC%2BD2MXnt1yntro%3D (Pubitemid 41134263)
32. K Przyklenk M Maynard DL Greiner P Whittaker 2011 Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes Antioxid Redox Signal 14 781 790 20578962 1:CAS:528: DC%2BC3MXht1ykt78%3D
33. N Ghaboura S Tamareille PH Ducluzeau L Grimaud L Loufrani A Croue Y Tourmen D Henrion A Furber F Prunier 2011 Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3beta signaling Basic Res Cardiol 106 147 162 20981553 1:CAS:528:DC%2BC3cXhs1ejtLbE
34. G Heusch K Boengler R Schulz 2008 Cardioprotection: nitric oxide, protein kinases, and mitochondria Circulation 118 1915 1919 18981312
35. AH Chaanine RJ Hajjar 2011 AKT signalling in the failing heart Eur J Heart Fail 13 825 829 21724622 1:CAS:528:DC%2BC3MXps1Ohtrs%3D
36. MB Harris MA Blackstone SG Sood C Li JM Goolsby VJ Venema BE Kemp RC Venema 2004 Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors Am J Physiol Heart Circ Physiol 287 H560 H566 15087285 1:CAS:528:DC%2BD2cXmvFalu7Y%3D (Pubitemid 38955284)
37. RR Alcendor S Gao P Zhai D Zablocki E Holle X Yu B Tian T Wagner SF Vatner J Sadoshima 2007 Sirt1 regulates aging and resistance to oxidative stress in the heart Circ Res 100 1512 1521 17446436 1:CAS:528:DC%2BD2sXltl2nsbY%3D (Pubitemid 46834764)
38. JA Baur KJ Pearson NL Price HA Jamieson C Lerin A Kalra VV Prabhu JS Allard G Lopez-Lluch K Lewis PJ Pistell S Poosala KG Becker O Boss D Gwinn M Wang S Ramaswamy KW Fishbein RG Spencer EG Lakatta D Le Couteur RJ Shaw P Navas P Puigserver DK Ingram R de Cabo DA Sinclair 2006 Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 337 342 17086191 1:CAS:528:DC%2BD28Xht1Sgtb3I (Pubitemid 44764104)
39. MC Haigis DA Sinclair 2010 Mammalian sirtuins: biological insights and disease relevance Annu Rev Pathol 5 253 295 20078221 1:CAS:528: DC%2BC3cXivFekt7c%3D
40. Y Ye KT Keyes C Zhang JR Perez-Polo Y Lin Y Birnbaum 2010 The myocardial infarct size limiting effects of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA Am J Physiol Heart Circ Physiol 285 H1454 H1465
41. Y Ye Y Lin S Atar MH Huang JR Perez-Polo BF Uretsky Y Birnbaum 2006 Myocardial protection by pioglitazone, atorvastatin, and their combination: mechanisms and possible interactions Am J Physiol Heart Circ Physiol 291 H1158 H1169 16603698 1:CAS:528:DC%2BD28XhtVSksrjO (Pubitemid 44343659)
42. FC Luft 2008 Renin inhibition and atherosclerosis Nephrol Dial Transplant 23 2474 2476 18430802
43. JH van Esch E Moltzer R van Veghel IM Garrelds F Leijten AM Bouhuizen AH Danser 2010 Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats J Hypertens 28 2145 2155 20625318
44. F Fyhrquist O Saijonmaa 2008 Renin-angiotensin system revisited J Intern Med 264 224 236 18793332 1:STN:280:DC%2BD1cngsFOmtQ%3D%3D
45. BI Jugdutt V Menon 2004 Valsartan-induced cardioprotection involves angiotensin II type 2 receptor upregulation in dog and rat models of in vivo reperfused myocardial infarction J Card Fail 10 74 82 14966778 1:CAS:528:DC%2BD2cXht1Kit7c%3D (Pubitemid 38880894)
46. BI Jugdutt V Menon 2004 AT1 receptor blockade limits myocardial injury and upregulates AT2 receptors during reperfused myocardial infarction Mol Cell Biochem 260 111 118 15228092 1:CAS:528:DC%2BD2cXjsFSmtbc%3D (Pubitemid 39127578)
47. G Sawicki V Menon BI Jugdutt 2004 Improved balance between TIMP-3 and MMP-9 after regional myocardial ischemia-reperfusion during AT1 receptor blockade J Card Fail 10 442 449 15470656 1:CAS:528:DC%2BD2cXhtVSgtbjL (Pubitemid 41080226)
48. J Yang H Jiang J Yang JW Ding LH Chen S Li XD Zhang 2009 Valsartan preconditioning protects against myocardial ischemia-reperfusion injury through TLR4/NF-kappaB signaling pathway Mol Cell Biochem 330 39 46 19370315 1:CAS:528:DC%2BD1MXhtlCqurvM
49. JL Zhao YJ Yang SJ You ZC Jing YJ Wu JL Cheng RL Gao 2006 Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion Coron Artery Dis 17 463 469 16845255
50. MM Mocanu DC Field DM Yellon 2006 A potential role for PTEN in the diabetic heart Cardiovasc Drugs Ther 20 319 321 16779530 (Pubitemid 44701164)
51. JH van Esch R van Veghel IM Garrelds F Leijten AM Bouhuizen AH Danser 2011 Handle region peptide counteracts the beneficial effects of the Renin inhibitor aliskiren in spontaneously hypertensive rats Hypertension 57 852 858 21321303
52. G Lastra J Habibi AT Whaley-Connell C Manrique MR Hayden J Rehmer K Patel C Ferrario JR Sowers 2009 Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression Endocrinology 150 2561 2568 19246535 1:CAS:528:DC%2BD1MXmvVCqtL8%3D
53. DJ Hausenloy DM Yellon 2006 Survival kinases in ischemic preconditioning and postconditioning Cardiovasc Res 70 240 253 16545352 1:CAS:528: DC%2BD28XjvVGjurs%3D
54. KH Su JY Tsai YR Kou AN Chiang SH Hsiao YL Wu HH Hou CC Pan SK Shyue TS Lee 2009 Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling Cardiovasc Res 82 468 475 19307231 1:CAS:528:DC%2BD1MXmtFSjtrk%3D
55. MS Zhou IH Schulman L Raij 2009 Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension Am J Physiol Heart Circ Physiol 296 H833 H839 19151253 1:CAS:528:DC%2BD1MXjtFGksbg%3D
56. S Matsuhisa H Otani T Okazaki K Yamashita Y Akita D Sato A Moriguchi T Iwasaka 2008 N-acetylcysteine abolishes the protective effect of losartan against left ventricular remodeling in cardiomyopathy hamster Antioxid Redox Signal 10 1999 2008 18665799 1:CAS:528:DC%2BD1cXhtFKlsL7F
57. K Rusai C Jianxing R Schneider H Struijker-Boudier J Lutz U Heemann M Baumann 2011 Renin inhibition mitigates anti-angiogenesis in spontaneously hypertensive rats J Hypertens 29 266 272 21045736 1:CAS:528:DC%2BC3cXhs1aks7rL
58. J Habibi A Whaley-Connell MR Hayden VG DeMarco R Schneider SD Sowers P Karuparthi CM Ferrario JR Sowers 2008 Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat Endocrinology 149 5643 5653 18653711 1:CAS:528:DC%2BD1cXhtlWnsrnM
59. T Imanishi H Tsujioka H Ikejima A Kuroi S Takarada H Kitabata T Tanimoto Y Muragaki S Mochizuki M Goto K Yoshida T Akasaka 2008 Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes Hypertension 52 563 572 18645051 1:CAS:528: DC%2BD1cXpvFKgs7o%3D
60. D Westermann A Riad O Lettau A Roks K Savvatis PM Becher F Escher AH Jan Danser HP Schultheiss C Tschope 2008 Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure Hypertension 52 1068 1075 18955663 1:CAS:528:DC%2BD1cXhsVWrt7vN
61. A Skyschally P van Caster K Boengler P Gres J Musiolik D Schilawa R Schulz G Heusch 2009 Ischemic postconditioning in pigs: no causal role for RISK activation Circ Res 104 15 18 19038864 1:CAS:528:DC%2BD1cXhsFSmt7%2FJ
62. R Bolli B Dawn XL Tang Y Qiu P Ping YT Xuan WK Jones H Takano Y Guo J Zhang 1998 The nitric oxide hypothesis of late preconditioning Basic Res Cardiol 93 325 338 9833145 1:CAS:528:DyaK1cXntlWrt7o%3D (Pubitemid 28499453)
63. Y Ye JD Martinez RJ Perez-Polo Y Lin BF Uretsky Y Birnbaum 2008 The role of eNOS, iNOS, and NF-kappaB in upregulation and activation of cyclooxygenase-2 and infarct size reduction by atorvastatin Am J Physiol Heart Circ Physiol 295 H343 H351 18469150 1:CAS:528:DC%2BD1cXoslynsro%3D
64. S Matsuhisa H Otani T Okazaki K Yamashita Y Akita D Sato A Moriguchi H Imamura T Iwasaka 2008 Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart Am J Physiol Heart Circ Physiol 294 H2473 H2479 18390819 1:CAS:528: DC%2BD1cXnsVaksbw%3D
65. JH Oak H Cai 2007 Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice Diabetes 56 118 126 17192473 1:CAS:528:DC%2BD2sXhtVWltrc%3D
66. R Miyazaki T Ichiki T Hashimoto K Inanaga I Imayama J Sadoshima K Sunagawa 2008 SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells Arterioscler Thromb Vasc Biol 28 1263 1269 18420994 1:CAS:528:DC%2BD1cXmvFehsbg%3D
67. M Orimo T Minamino H Miyauchi K Tateno S Okada J Moriya I Komuro 2009 Protective role of SIRT1 in diabetic vascular dysfunction Arterioscler Thromb Vasc Biol 29 889 894 19286634 1:CAS:528:DC%2BD1MXlslCgtbc%3D
68. D Della-Morte KR Dave RA DeFazio YC Bao AP Raval MA Perez-Pinzon 2009 Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway Neuroscience 159 993 1002 19356683 1:CAS:528:DC%2BD1MXjsVKqsrw%3D
69. HR Zhu ZY Wang XL Zhu XX Wu EG Li Y Xu 2010 Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke Neuropharmacology 59 70 76 20381504 1:CAS:528:DC%2BC3cXmslCms7Y%3D
70. CP Hsu P Zhai T Yamamoto Y Maejima S Matsushima N Hariharan D Shao H Takagi S Oka J Sadoshima 2010 Silent information regulator 1 protects the heart from ischemia/reperfusion Circulation 122 2170 2182 21060073
71. NR Sundaresan VB Pillai D Wolfgeher S Samant P Vasudevan V Parekh H Raghuraman JM Cunningham M Gupta MP Gupta 2011 The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy Sci Signal 4 46ra
72. R Amat A Planavila SL Chen R Iglesias M Giralt F Villarroya 2009 SIRT1 controls the transcription of the Peroxisome Proliferator-activated Receptor-{gamma} Co-activator-1{alpha} (PGC-1{alpha}) gene in skeletal muscle through the PGC-1{alpha} autoregulatory loop and interaction with MyoD J Biol Chem 284 21872 21880 19553684 1:CAS:528:DC%2BD1MXpsFymtrw%3D
73. JJ Sheu S Chua CK Sun LT Chang CH Yen CJ Wu M Fu HK Yip 2011 Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction Int J Cardiol 147 79 87 19751953
74. A Skyschally R Schulz G Heusch 2010 Cyclosporine A at reperfusion reduces infarct size in pigs Cardiovasc Drugs Ther 24 85 87 20182781
75. JS Han HS Wang DM Yan ZW Wang HG Han HY Zhu XM Li 2010 Myocardial ischaemic and diazoxide preconditioning both increase PGC-1alpha and reduce mitochondrial damage Acta Cardiol 65 639 644 21302669
76. EG Lynn MV Stevens RP Wong D Carabenciov J Jacobson E Murphy MN Sack 2010 Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1 J Mol Cell Cardiol 49 693 698 20600099 1:CAS:528: DC%2BC3cXhtVyrurjJ
77. KA Rasbach RG Schnellmann 2007 PGC-1alpha over-expression promotes recovery from mitochondrial dysfunction and cell injury Biochem Biophys Res Commun 355 734 739 17307137 1:CAS:528:DC%2BD2sXisVWisr4%3D (Pubitemid 46330214)