AT1 receptor blockade in experimental myocardial ischemia/reperfusion

Basic Research in Cardiology

Volumn 93, Issue 2 SUPPL., 1998, Pages 85-91

  Jalowy, A ^a   Schulz, R ^a   Heusch, G ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

AT1 receptor; AT2 receptor; Myocardial ischemia; Renin angiotensin system; Reperfusion

Indexed keywords

ANGIOTENSIN RECEPTOR; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BRADYKININ; NITRIC OXIDE; PROSTAGLANDIN; RECEPTOR SUBTYPE;

ANIMAL; DRUG ANTAGONISM; HEART ARRHYTHMIA; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REPERFUSION INJURY; REVIEW; STUNNED HEART MUSCLE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; GUINEA PIG; HEART; HEART INFARCTION SIZE; HEART PROTECTION; HEART VENTRICLE REMODELING; NONHUMAN; PROGNOSIS; RAT; RECEPTOR DENSITY; SWINE;

ANIMALS; ARRHYTHMIA; HUMANS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIAL STUNNING; RECEPTORS, ANGIOTENSIN; RENIN-ANGIOTENSIN SYSTEM;

EID: 0031737086     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s003950050066     Document Type: Article

References (58)

1. Asano K, Dutcher DL, Port D, Minobe WA, Tremmel KD, Roden RL, Bohlmeyer TJ, Bush EW, Jenkin MJ, Abraham WT, Raynolds MV, Zisman LS, Perryman MB, Bristow MR (1997) Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium. Circulation 95: 1193-1200 (Pubitemid 27097830)
2. Azizi M, Chatellier G, Guyene T-T, Murieta- Geoffroy D, Ménard J (1995) Additive effects of combined angiotensin-converting enzyme inhibition and angiotensin II antagonism on blood pressure and renin release in sodium-depleted normotensives. Circulation 92: 825-834
3. Balcells E, Meng QC, Johnson Jr WH, Oparil S, Dell'Italia LJ (1997) Angiotensin II formation from ACE and chymase in human and animal hearts: Methods and species considerations. Am J Physiol 42: H1769-H1774
4. Baumgarten CR, Linz WL, Kunkel G, Schölkens BA, Wiemer G (1993) Ramiprilat increases bradykinin outflow from isolated hearts of rat. Br J Pharmacol 108: 293-295 (Pubitemid 23032527)
5. de Carvalho Frimm C, Sun Y, Weber KT (1997) Angiotensin II receptor blockade and myocardial fibrosis of the infarcted rat heart. J Lab Clin Med 129: 439-446 (Pubitemid 27353845)
6. Diaz RJ, Wilson GJ (1997) Selective blockade of AT1 angiotensin II receptors abolishes ischemic preconditioning in isolated rabbit hearts. J Mol Cell Cardiol 29: 129-139 (Pubitemid 27129137)
7. Ehring T, Baumgart D, Krajcar M, Hümmelgen M, Kompa S, Heusch G (1994) Attenuation of myocardial stunning by the ACE-inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins, but not nitric oxide. Circulation 90: 1368-1385 (Pubitemid 24284460)
8. Ertl G, Kloner RA, Alexander RW, Braunwald E (1982) Limitation of experimental infarct size by an angiotensin-converting enzyme inhibitor. Circulation 65: 40-48 (Pubitemid 12250888)
9. Ford WR, Clanachan AS, Jugdutt BI (1996) Opposite effects of angiotensin AT1 and AT2 receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat hearts. Circulation 94: 3087-30899 (Pubitemid 26427471)
10. Harada K, Komuro I, Hayashi D, Sugaya T, Murakami K, Yazaki Y (1998) Angiotensin II type 1a receptor is involved in the occurrence of reperfusion arrhythmias. Circulation 97: 315-3177 (Pubitemid 28074330)
11. Hartman JC, Hullinger TG, Wall TM, Shebuski RJ (1993) Reduction of myocardial infarct size by ramiprilat is independent of angiotensin II synthesis inhibition. Eur J Pharmacol 234: 229-236 (Pubitemid 23103445)
12. Hartman JC, Kurc GM, Hullinger TG, Wall TM, Sheehy RM, Shebuski RJ (1994) Inhibition of nitric oxide synthase prevents myocardial protection by ramipril. J Pharmacol Exp Ther 3: 1071-1076 (Pubitemid 24315222)
13. Hartman JC, Wall TM, Hullinger TG, Shebuski RJ (1993) Reduction of myocardial infarct size in rabbits by ramiprilat: reversal by the bradykinin antagonist HOE 140. J Cardiovasc Pharmacol 21: 996-1003 (Pubitemid 23160691)
14. Hirsch AT, Talsness CE, Schunkert H, Paul M, Dzau VJ (1991) Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. Circ Res 69: 475-482
15. Hohfeld T, Strobach H, Schrör K (1991) Stimulation of prostacyclin synthesis by defibrotide: Improved contractile recovery from myocardial "stunning". J Cardiovasc Pharmacol 17: 108-115
16. Hohlfeld T, Strobach H, Schrör K (1993) Stimulation of endogenous prostacyclin protects the reperfused pig myocardium from ischemic injury. J Pharmacol Exp Ther 264: 397-405 (Pubitemid 23309229)
17. Hübner R, Högemann AM, Sunzel M, Riddell JG (1997) Pharmacokinetics of candesartan after single and repeated doses of candesartan cilexetil in young and elderly healthy volunteers. J Hum Hypertens 11 (Suppl 2): S19-S25 (Pubitemid 27464501)
18. ISIS-4 Collaborative Group (1995) ISIS-4: Arandomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58050 patients with suspected acute myocardial infarction. Lancet 345: 669-685
19. Jalowy A, Schulz R, Dörge H, Behrends M, Heusch G (1998) Infarct size reduction by AT1 receptor blockade through a signal cascade of AT2 receptor activation, bradykinin and prostaglandins in pigs. J Am Coll Cardiol, in press
20. Kitakaze M, Minamino T, Node K, Komamura K, Shinozaki Y, Mori H, Kosaka H, Inoue M, Hori M, Kamada T (1995) Beneficial effects of inhibition of angiotensinconverting enzyme on ischemic myocardium during coronary hypoperfusion in dogs. Circulation 92: 950-961
21. Kohya T, Yokoshiki H, Tohse N, Kanno M, Nakaya H, Saito H, Kitabatake A (1995) Regression of left ventricular hypertrophy prevents ischemia-induced lethal arrhythmias. Beneficial effect of angiotensin II blockade. Circ Res 76: 892-899
22. Kuga T, Mohri M, Egashira K, Hirakawa Y, Tagawa T, Shimokawa H, Takeshita A (1997) Bradykinin-induced vasodilation of human coronary arteries in vivo: Role of nitric oxide and angiotensin-converting enzyme. J Am Coll Cardiol 30: 108-112 (Pubitemid 27357133)
23. Linder C, Heusch G (1990) ACE inhibitors for the treatment of myocardial ischemia? Cardiovasc Drugs Ther 4: 1375-1384
24. Lindpaintner K, Wilhelm MJ, Jin M, Unger T, Lang RE, Schölkens BA, Ganten D (1987) Tissue renin-angiotensin systems: Focus on the heart. J Hypertens 5 (Suppl 2): S33-S38
25. Liu Y-H, Yang X-P, Sharov VG, Nass O, Sabbah HH, Peterson E, Carretero OA (1997) Effects of angiotensin-converting enzyme inhibitorsw and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors. J Clin Invest 99: 1926-1935 (Pubitemid 27175940)
26. Liu Y-H, Yang X-P, Sharov VG, Sigmon DH, Sabbah HN, Carretero OA (1996) Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats. Hypertension 27: 7-13 (Pubitemid 26017674)
27. Liu Y, Tsuchida A, Cohen MV, Downey JM (1995) Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. J Mol Cell Cardiol 27: 883-892
28. Martorana PA, Kettenbach B, Breipohl G, Linz W, Schölkens BA (1990) Reduction of infarct size by local angiotensin-converting enzyme inhibition is abolished by a bradykinin antagonist. Eur J Pharmacol 182: 395-396 (Pubitemid 20225736)
29. Massoudy P, Becker BF, Gerlach E (1994) Bradykinin accounts for improved postischemic function and decreased glutathione release of guinea pig heart treated with the angiotensin-converting enzyme inhibitor ramiprilat. J Cardiovasc Pharmacol 23: 632-639 (Pubitemid 24100150)
30. McAlpine HM, Cobbe SM (1988) Neuroendocrine changes in acute myocardial infarction. Am J Med 84 (suppl 3A): 61-66
31. Mukoyama M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ (1993) Expression cloning of type 2 angiotensin II receptor reveals a unique class of seventransmembrane receptors. J Biol Chem 268: 24539-24542 (Pubitemid 23335456)
32. Muller CA, Opie LH, Peisach M, Pineda CA (1992) Antiarrhythmic effects of the angiotensin converting enzyme inhibitor perindoprilat in a pig model of acute regional myocardial ischemia. J Cardiovasc Pharmacol 19: 748-754
33. Müller DN, Fischli W, Clozel J-P, Hilgers KF, Bohlender J, Ménard J, Busjahn A, Ganten D, Luft FC (1998) Local angiotensin II generation in the rat heart. Role of renin uptake. Circ Res 82: 13-20 (Pubitemid 28074014)
34. Nio Y, Matsubara H, Murasawa S, Kanasaki M, Inada M (1995) Regulation of gene transcription of angiotensin II receptor subtypes. J Clin Invest 95: 46-54
35. Nishikimi T, Yamagishi H, Takeuchi K, Takeda T (1995) An angiotensin II receptor antagonist attenuates left ventricular dilatation after myocardial infarction in hypertensive rats. Cardiovasc Res 29: 856-861
36. Noda K, Sasaguri M, Ideishi M, Ikeda M, Arakawa K (1993) Role of locally formed angiotensin II and bradykinin in the reduction of myocardial infarct size in dogs. Cardiovasc Res 27: 334-340 (Pubitemid 23070349)
37. Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC, Klein M, Lamas GA, Packer M, Rouleau J, Rouleau JL, Rutherford J, Wertheimer JH, Hawkins CM (1992) Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 327: 669-6777
38. Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas I, Deedwania OC, Ney DE, Snavely DB, Chang PI (1997) Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of losartan in the elderly study, ELITE). Lancet 349: 747-752 (Pubitemid 27122456)
39. Richard V, Ghaleh B, Berdeaux A, Giudicelli J-F (1993) Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs. Br J Pharmacol 110: 969-974 (Pubitemid 24005227)
40. Scheuer DA, Perrone MH (1993) Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin. Am J Physiol 33: R917-R923 (Pubitemid 23152573)
41. Schieffer B, Wirger A, Meybrunn M, Seitz S, Holtz J, Riede UN, Drexler H (1994) Comparative effects of chronic angiotensin- converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation 89: 2273- 22822 (Pubitemid 24142808)
42. Schwarz ER, Montino H, Fleischhauer J, Klues HG, vom Dahl J, Hanrath P (1997) Angiotensin II receptor antagonist EXP 3174 reduces infarct size comparable with enalaprilat and augments preconditioning in the pig heart. Cardiovasc Drugs Ther 11: 687-695 (Pubitemid 28041042)
43. Seyedi N, Xu XB, Nasjletti A, Hintze TH (1995) Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension 26: 164-170
44. Sladek T, Sladkova J, Kolar F, Papousek F, Cicutti N, Korecky B, Rakusan K (1996) The effect of AT1 receptor antagonist on chronic cardiac response to coronary artery ligation in rats. Cardiovasc Res 31: 568- 576 (Pubitemid 26140064)
45. Spinale FG, de Gasparo M, Whitebread S, Hebbar L, Clair MJ, Melton M, Krombach S, Mukherjee R, Iannini JP, O S-J (1997) Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure I. Effects on left ventricular performance and neurohormonal systems. Circulation 96: 2385-2396
46. Stoll M, Steckelings UM, Bottari SP, Metzger R, Unger T (1995) The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 95: 651-657
47. The Acute Infarction Ramipril Efficacy (AIRE) Investigators (1993) Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 342: 821-828
48. Thomas GP, Ferrier GR, Howlett SE (1996) Losartan exerts antiarrhythmic activity independent of angiotensin II receptor blockade in simulated ventricular ischemia and reperfusion. J Pharmacol Exp Ther 278: 1090-1097 (Pubitemid 27166957)
49. Timmermans PBMWM, Wong PC, Chiu AT, Herblin WF, Benefield P, Carini DJ, Lee RJ, Wexler RR, Saye JAM, Smith RD (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 45: 205-251 (Pubitemid 23191415)
50. van Gilst WH, de Graeff PA, Wesseling H, de Langen CDJ (1986) Reduction of reperfusion arrhythmias in the ischemic isolated rat heart by angiotensin converting enzyme inhibitors: A comparison of captopril, enalapril, and HOE 498. J Cardiovasc Pharmacol 8: 722-728 (Pubitemid 16061306)
51. Webster MWI, Fitzpatrick MA, Nicholls MG, Ikram H, Wells JE (1985) Effect of enalapril on ventricular arrhythmias in congestive heart failure. Am J Cardiol 56: 566-56
52. Werrmann JG, Cohen SM (1994) Comparison of effects of angiotensin-converting enzyme inhibition with those of angiotensin II receptor antagonism on functional and metabolic recovery in postischemic working rat heart as studied by [31P] nuclear magnetic resonance. J Cardiovasc Pharmacol 24: 573-586 (Pubitemid 24303157)
53. Werrmann JG, Cohen SM (1996) Use of losartan to examine the role of the cardiac renin-angiotensin system in myocardial dysfunction during ischemia and reperfusion. J Cardiovasc Pharmacol 27: 177-182 (Pubitemid 26041494)
54. Wharton J, Morgan K, Rutherford RAD, Catravas JD, Chester A, Whitehead BF, de Leval MR, Yacoub MH, Polak JM (1998) Differential distribution of angiotensin AT2 receptors in the normal and failing human heart. J Pharmacol Exp Ther 284: 323-336 (Pubitemid 28109563)
55. Wiemer G, Schölkens BA, Busse R, Wagner A, Heitsch H, Linz W(1993) The functional role of angiotensin II-subtype AT2- receptors in endothelial cells and isolated ischemic rat hearts. Pharm Pharmacol Lett 3: 24-27
56. Yamagishi H, Kim S, Nishikimi T, Takeuchi K, Takeda T (1993) Contribution of cardiac renin-angiotensin system to ventricular remodelling in myocardialinfarcted rats. J Mol Cell Cardiol 25: 1369-1380 (Pubitemid 24003843)
57. Yang C-H, Shyr M-H, Tan PPC, Chan SHH (1996) Participation of AT1 and AT2 receptors in the differential interaction between angiotensin II or III and alpha-2 adrenoceptors in the nucleus reticularis gigantocellularis in cardiovascular regulation and antinociception in rats. J Pharmacol Exp Ther 279: 795-802
58. Yoshiyama M, Kim S, Yamagishi H, Omura T, Tani T, Yanagi S, Toda I, Teragaki M, Akioka K, Takeuchi K, Takeda T (1994) Cardioprotective effect of the angiotensin II type 1 receptor antagonist TCV-116 on ischemia-reperfusion injury. Am Heart J 128: 1-6 (Pubitemid 24227128)