Diagnosis and Management of GERD Before and After Lung Transplantation

Thoracic Surgery Clinics

Volumn 21, Issue 4, 2011, Pages 499-510

  Hoppo, Toshitaka ^a   Jobe, Blair A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Bronchiolitis obliterans syndrome; End stage lung disease; Gastroesophageal reflux disease; Lung transplant

Indexed keywords

AZITHROMYCIN; BILE ACID; BOTULINUM TOXIN; ERYTHROMYCIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 8; METRONIDAZOLE; PEPSIN A; PROTON PUMP INHIBITOR; SIMETHICONE; STEROID; STOMACH SECRETION INHIBITOR; TACROLIMUS; TECHNETIUM 99M;

ABDOMINAL PRESSURE; ANTIBIOTIC PROPHYLAXIS; ANTICOAGULANT THERAPY; BARIUM ESOPHAGRAM; BLOATING; BRONCHIOLITIS OBLITERANS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLOSTRIDIUM DIFFICILE INFECTION; COMPRESSION GARMENT; COUGHING; DIARRHEA; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE FREE SURVIVAL; DRUG USE; DUAL CHANNEL PH MONITORING; END STAGE LUNG DISEASE; ESOPHAGEAL PH MONITORING; ESOPHAGOSCOPY; ESOPHAGUS EXAMINATION; ESOPHAGUS FUNCTION DISORDER; ESOPHAGUS MANOMETRY; FIBROSING ALVEOLITIS; FORCED EXPIRATORY VOLUME; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MOTILITY DISORDER; HUMAN; HYPOPHARYNX; LAPAROSCOPIC SURGERY; LARYNGOPHARYNGEAL REFLUX; LOWER ESOPHAGUS SPHINCTER; LUNG DISEASE; LUNG EMBOLISM; LUNG LAVAGE; LUNG RESECTION; LUNG TRANSPLANTATION; MOBILIZATION; MUCOCILIARY CLEARANCE; MULTICHANNEL INTRALUMINAL IMPEDANCE PH MEASUREMENT; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STOMACH EMPTYING; STOMACH FUNDOPLICATION; STOMACH PARESIS; SWALLOWING; THORAX PRESSURE; THROMBOSIS PREVENTION; UPPER ESOPHAGUS SPHINCTER;

BRONCHIOLITIS OBLITERANS; BRONCHOALVEOLAR LAVAGE FLUID; ELECTRIC IMPEDANCE; ESOPHAGEAL PH MONITORING; GASTRIC EMPTYING; GASTROESOPHAGEAL REFLUX; HUMANS; LUNG DISEASES; LUNG TRANSPLANTATION; MANOMETRY;

EID: 82955220548     PISSN: 15474127     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thorsurg.2011.08.006     Document Type: Review

References (87)

1. Button B.M., Roberts S., Kotsimbos T.C., et al. Gastroesophageal reflux (symptomatic and silent): a potentially significant problem in patients with cystic fibrosis before and after lung transplantation. J Heart Lung Transplant 2005, 24(10):1522-1529.
2. el-Serag H.B., Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology 1997, 113(3):755-760.
3. Napierkowski J., Wong R.K. Extraesophageal manifestations of GERD. Am J Med Sci 2003, 326(5):285-299.
4. Raghu G., Freudenberger T.D., Yang S., et al. High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J 2006, 27(1):136-142.
5. Christie J.D., Edwards L.B., Kucheryavaya A.Y., et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplant report-2010. J Heart Lung Transplant 2010, 29(10):1104-1118.
6. Palmer S.M., Miralles A.P., Howell D.N., et al. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest 2000, 118(4):1214-1217.
7. Riise G.C., Williams A., Kjellstrom C., et al. Bronchiolitis obliterans syndrome in lung transplant recipients is associated with increased neutrophil activity and decreased antioxidant status in the lung. Eur Respir J 1998, 12(1):82-88.
8. Shilling R.A., Wilkes D.S. Immunobiology of chronic lung allograft dysfunction: new insights from the bench and beyond. Am J Transplant 2009, 9(8):1714-1718.
9. Belcher J.R. The pulmonary complications of dysphagia. Thorax 1949, 4(1):44-56.
10. Salvioli B., Belmonte G., Stanghellini V., et al. Gastro-oesophageal reflux and interstitial lung disease. Dig Liver Dis 2006, 38(12):879-884.
11. Tobin R.W., Pope C.E., Pellegrini C.A., et al. Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998, 158(6):1804-1808.
12. Sweet M.P., Patti M.G., Leard L.E., et al. Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation. J Thorac Cardiovasc Surg 2007, 133(4):1078-1084.
13. D'Ovidio F., Singer L.G., Hadjiliadis D., et al. Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Ann Thorac Surg 2005, 80(4):1254-1260.
14. Ledson M.J., Tran J., Walshaw M.J. Prevalence and mechanisms of gastro-oesophageal reflux in adult cystic fibrosis patients. J R Soc Med 1998, 91(1):7-9.
15. Sweet M.P., Herbella F.A., Leard L., et al. The prevalence of distal and proximal gastroesophageal reflux in patients awaiting lung transplantation. Ann Surg 2006, 244(4):491-497.
16. Casanova C., Baudet J.S., del Valle Velasco M., et al. Increased gastro-oesophageal reflux disease in patients with severe COPD. Eur Respir J 2004, 23(6):841-845.
17. Rascon-Aguilar I.E., Pamer M., Wludyka P., et al. Role of gastroesophageal reflux symptoms in exacerbations of COPD. Chest 2006, 130(4):1096-1101.
18. Harding S.M., Guzzo M.R., Richter J.E. 24-h esophageal pH testing in asthmatics: respiratory symptom correlation with esophageal acid events. Chest 1999, 115(3):654-659.
19. Harding S.M., Guzzo M.R., Richter J.E. The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms. Am J Respir Crit Care Med 2000, 162(1):34-39.
20. Kiljander T.O., Salomaa E.R., Hietanen E.K., et al. Gastroesophageal reflux in asthmatics: a double-blind, placebo-controlled crossover study with omeprazole. Chest 1999, 116(5):1257-1264.
21. Sontag S.J., O'Connell S., Khandelwal S., et al. Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology 1990, 99(3):613-620.
22. Ntoumazios S.K., Voulgari P.V., Potsis K., et al. Esophageal involvement in scleroderma: gastroesophageal reflux, the common problem. Semin Arthritis Rheum 2006, 36(3):173-181.
23. Savarino E., Bazzica M., Zentilin P., et al. Gastroesophageal reflux and pulmonary fibrosis in scleroderma: a study using pH-impedance monitoring. Am J Respir Crit Care Med 2009, 179(5):408-413.
24. Harari S., Caminati A. Idiopathic pulmonary fibrosis. Allergy 2005, 60(4):421-435.
25. Bodet-Milin C., Querellou S., Oudoux A., et al. Delayed gastric emptying scintigraphy in cystic fibrosis patients before and after lung transplantation. J Heart Lung Transplant 2006, 25(9):1077-1083.
26. Stewart S. Pathology of lung transplantation. Semin Diagn Pathol 1992, 9(3):210-219.
27. Estenne M., Maurer J.R., Boehler A., et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant 2002, 21(3):297-310.
28. DiGiovine B., Lynch J.P., Martinez F.J., et al. Bronchoalveolar lavage neutrophilia is associated with obliterative bronchiolitis after lung transplantation: role of IL-8. J Immunol 1996, 157(9):4194-4202.
29. Verleden G.M., Vos R., De Vleeschauwer S.I., et al. Obliterative bronchiolitis following lung transplantation: from old to new concepts?. Transpl Int 2009, 22(8):771-779.
30. Snell G.I., Westall G.P. The contribution of airway ischemia and vascular remodelling to the pathophysiology of bronchiolitis obliterans syndrome and chronic lung allograft dysfunction. Curr Opin Organ Transplant 2010, 15(5):558-562.
31. Sato M., Keshavjee S. Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling. Semin Thorac Cardiovasc Surg 2008, 20(2):173-182.
32. D'Ovidio F., Keshavjee S. Gastroesophageal reflux and lung transplantation. Dis Esophagus 2006, 19(5):315-320.
33. Davis R.D., Lau C.L., Eubanks S., et al. Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. J Thorac Cardiovasc Surg 2003, 125(3):533-542.
34. Hadjiliadis D., Duane Davis R., Steele M.P., et al. Gastroesophageal reflux disease in lung transplant recipients. Clin Transplant 2003, 17(4):363-368.
35. Stovold R., Forrest I.A., Corris P.A., et al. Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection. Am J Respir Crit Care Med 2007, 175(12):1298-1303.
36. Shah N., Force S.D., Mitchell P.O., et al. Gastroesophageal reflux disease is associated with an increased rate of acute rejection in lung transplant allografts. Transplant Proc 2010, 42(7):2702-2706.
37. Herve P., Silbert D., Cerrina J., et al. Impairment of bronchial mucociliary clearance in long-term survivors of heart/lung and double-lung transplantation. The Paris-Sud Lung Transplant Group. Chest 1993, 103(1):59-63.
38. Suen H.C., Hendrix H., Patterson G.A. Special article: physiologic consequences of pneumonectomy. Consequences on the esophageal function. 1999. Chest Surg Clin N Am 2002, 12(3):587-595.
39. Dougenis D., Morrit G.N., Vagianos C., et al. Motility disorders of the esophagus before and after pneumonectomy for lung carcinoma. Eur Surg Res 1996, 28(6):461-465.
40. D'Ovidio F., Mura M., Ridsdale R., et al. The effect of reflux and bile acid aspiration on the lung allograft and its surfactant and innate immunity molecules SP-A and SP-D. Am J Transplant 2006, 6(8):1930-1938.
41. Parkman H.P., Hasler W.L., Fisher R.S. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology 2004, 127(5):1592-1622.
42. Blondeau K., Mertens V., Vanaudenaerde B.A., et al. Nocturnal weakly acidic reflux promotes aspiration of bile acids in lung transplant recipients. J Heart Lung Transplant 2009, 28(2):141-148.
43. Vos R., Blondeau K., Vanaudenaerde B.M., et al. Airway colonization and gastric aspiration after lung transplantation: do birds of a feather flock together?. J Heart Lung Transplant 2008, 27(8):843-849.
44. Andersen L.I., Jensen G. Prevalence of benign oesophageal disease in the Danish population with special reference to pulmonary disease. J Intern Med 1989, 225(6):393-402.
45. Lang I.M., Haworth S.T., Medda B.K., et al. Airway responses to esophageal acidification. Am J Physiol Regul Integr Comp Physiol 2008, 294(1):R211-R219.
46. Barry D.W., Vaezi M.F. Laryngopharyngeal reflux: more questions than answers. Cleve Clin J Med 2010, 77(5):327-334.
47. Hoppo T, Jarido V, Pennathur A, et al. Antireflux surgery preserves lung function in patients with GERD and end-stage lung disease before and after lung transplantation. Arch Surg, in press.
48. Narayani R.I., Burton M.P., Young G.S. Utility of esophageal biopsy in the diagnosis of nonerosive reflux disease. Dis Esophagus 2003, 16(3):187-192.
49. Hill L.D., Kozarek R.A., Kraemer S.J., et al. The gastroesophageal flap valve: in vitro and in vivo observations. Gastrointest Endosc 1996, 44(5):541-547.
50. Ward C., Forrest I.A., Brownlee I.A., et al. Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 2005, 60(10):872-874.
51. D'Ovidio F., Mura M., Tsang M., et al. Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation. J Thorac Cardiovasc Surg 2005, 129(5):1144-1152.
52. Blondeau K., Mertens V., Vanaudenaerde B.A., et al. Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection. Eur Respir J 2008, 31(4):707-713.
53. Patti M.G., Debas H.T., Pellegrini C.A. Clinical and functional characterization of high gastroesophageal reflux. Am J Surg 1993, 165(1):163-166. [discussion: 166-8].
54. Patti M.G., Arcerito M., Tamburini A., et al. Effect of laparoscopic fundoplication on gastroesophageal reflux disease-induced respiratory symptoms. J Gastrointest Surg 2000, 4(2):143-149.
55. Koufman J.A., Aviv J.E., Casiano R.R., et al. Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg 2002, 127(1):32-35.
56. Lee B.E., Kim G.H., Ryu D.Y., et al. Combined dual channel impedance/pH-metry in patients with suspected laryngopharyngeal reflux. J Neurogastroenterol Motil 2010, 16(2):157-165.
57. Oelschlager B.K., Chang L., Pope C.E., et al. Typical GERD symptoms and esophageal pH monitoring are not enough to diagnose pharyngeal reflux. J Surg Res 2005, 128(1):55-60.
58. Hirano I., Richter J.E. ACG practice guidelines: esophageal reflux testing. Am J Gastroenterol 2007, 102(3):668-685.
59. Fass J., Silny J., Braun J., et al. Measuring esophageal motility with a new intraluminal impedance device. First clinical results in reflux patients. Scand J Gastroenterol 1994, 29(8):693-702.
60. Srinivasan R., Vela M.F., Katz P.O., et al. Esophageal function testing using multichannel intraluminal impedance. Am J Physiol Gastrointest Liver Physiol 2001, 280(3):G457-G462.
61. Anandasabapathy S., Jaffin B.W. Multichannel intraluminal impedance in the evaluation of patients with persistent globus on proton pump inhibitor therapy. Ann Otol Rhinol Laryngol 2006, 115(8):563-570.
62. Mainie I., Tutuian R., Agrawal A., et al. Combined multichannel intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg 2006, 93(12):1483-1487.
63. Wu J.C. Combined multichannel intraluminal impedance and pH monitoring for patients with suspected laryngopharyngeal reflux: is it ready to use?. J Neurogastroenterol Motil 2010, 16(2):108-109.
64. Oelschlager B.K., Quiroga E., Isch J.A., et al. Gastroesophageal and pharyngeal reflux detection using impedance and 24-hour pH monitoring in asymptomatic subjects: defining the normal environment. J Gastrointest Surg 2006, 10(1):54-62.
65. Hoppo T, Sanz AF, Nason KS, et al. How much pharyngeal exposure is " normal?" Normative data for laryngopharyngeal reflux events using hypopharyngeal multichannel intraluminal impedance (HMII). J Gastrointest Surg 2011. [Epub ahead of print].
66. Farrell T.M., Richardson W.S., Halkar R., et al. Nissen fundoplication improves gastric motility in patients with delayed gastric emptying. Surg Endosc 2001, 15(3):271-274.
67. Van Sickle K.R., McClusky D.A., Swafford V.A., et al. Delayed gastric emptying in patients undergoing antireflux surgery: analysis of a treatment algorithm. J Laparoendosc Adv Surg Tech A 2007, 17(1):7-11.
68. Filichia L.A., Cendan J.C. Small case series of gastric stimulation for the management of transplant-induced gastroparesis. J Surg Res 2008, 148(1):90-93.
69. Yiannopoulos A., Shafazand S., Ziedalski T., et al. Gastric pacing for severe gastroparesis in a heart-lung transplant recipient. J Heart Lung Transplant 2004, 23(3):371-374.
70. Castell D.O., Kahrilas P.J., Richter J.E., et al. Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis. Am J Gastroenterol 2002, 97(3):575-583.
71. Tamhankar A.P., Peters J.H., Portale G., et al. Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel intraluminal impedance technology. J Gastrointest Surg 2004, 8(7):890-897. [discussion: 897-8].
72. Edelbroek M.A., Horowitz M., Wishart J.M., et al. Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects. J Nucl Med 1993, 34(4):582-588.
73. Peeters T.L. Erythromycin and other macrolides as prokinetic agents. Gastroenterology 1993, 105(6):1886-1899.
74. Mertens V., Blondeau K., Pauwels A., et al. Azithromycin reduces gastroesophageal reflux and aspiration in lung transplant recipients. Dig Dis Sci 2009, 54(5):972-979.
75. Koek G.H., Vos R., Sifrim D., et al. Mechanisms underlying duodeno-gastric reflux in man. Neurogastroenterol Motil 2005, 17(2):191-199.
76. Verleden G.M., Dupont L.J. Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation. Transplantation 2004, 77(9):1465-1467.
77. Verleden G.M., Vanaudenaerde B.M., Dupont L.J., et al. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2006, 174(5):566-570.
78. Yates B., Murphy D.M., Forrest I.A., et al. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2005, 172(6):772-775.
79. Vos R., Vanaudenaerde B.M., Verleden S.E., et al. A randomised controlled trial of azithromycin to prevent chronic rejection after lung transplantation. Eur Respir J 2011, 37(1):164-172.
80. Cantu E., Appel J.Z., Hartwig M.G., et al. J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease. Ann Thorac Surg 2004, 78(4):1142-1151. [discussion: 1142-51].
81. Burton P.R., Button B., Brown W., et al. Medium-term outcome of fundoplication after lung transplantation. Dis Esophagus 2009, 22(8):642-648.
82. Balsara K.P., Shah C.R., Hussain M. Laparoscopic fundoplication for gastro-esophageal reflux disease: an 8 year experience. J Minim Access Surg 2008, 4(4):99-103.
83. Linden P.A., Gilbert R.J., Yeap B.Y., et al. Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation. J Thorac Cardiovasc Surg 2006, 131(2):438-446.
84. Booth M.I., Stratford J., Jones L., et al. Randomized clinical trial of laparoscopic total (Nissen) versus posterior partial (Toupet) fundoplication for gastro-oesophageal reflux disease based on preoperative oesophageal manometry. Br J Surg 2008, 95(1):57-63.
85. Robertson A.G., Dunn L.J., Shenfine J., et al. Randomized clinical trial of laparoscopic total (Nissen) versus posterior partial (Toupet) fundoplication for gastro-oesophageal reflux disease based on preoperative oesophageal manometry (Br J Surg 2008; 95: 57-63). Br J Surg 2008, 95(6):799. [author reply: 799-800].
86. Strate U., Emmermann A., Fibbe C., et al. Laparoscopic fundoplication: Nissen versus Toupet two-year outcome of a prospective randomized study of 200 patients regarding preoperative esophageal motility. Surg Endosc 2008, 22(1):21-30.
87. Jobe B.A., Kahrilas P.J., Vernon A.H., et al. Endoscopic appraisal of the gastroesophageal valve after antireflux surgery. Am J Gastroenterol 2004, 99(2):233-243.