Gastroesophageal reflux in asthmatics: A double-blind, placebo- controlled crossover study with omeprazole

Chest

Volumn 116, Issue 5, 1999, Pages 1257-1264

  Kiljander, Toni O ^a   Salomaa, Eija Riitta M ^b   Hietanen, Eino K ^b   Terho, Erkki O ^b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b NONE

Author keywords

Asthma; Gastroesophageal reflux; Omeprazole

Indexed keywords

OMEPRAZOLE;

ADULT; AGED; ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CROSSOVER PROCEDURE; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DYSPNEA; FEMALE; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PEAK EXPIRATORY FLOW; PREVALENCE; PRIORITY JOURNAL; THORAX PAIN; WHEEZING;

EID: 0032743266     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.116.5.1257     Document Type: Article

References (37)

1. 1 Vincent D, Cohen-Jonathan AM, Leport J, et al. Gastro-oesophageal reflux prevalence and relationship with bronchial reactivity in asthma. Eur Respir J 1997; 10:2255-2259
2. 2 Sontag SJ, O'Connel S, Khandelwal S, et al. Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology 1990; 99:613-620
3. 3 Holmes PW, Campbell AM, Barter CE, et al. Changes of lung volumes and lung mechanics in asthma and normal subjects. Thorax 1978; 33:394-400
4. 4 Moote DW, Lloyd DA, McCourtie DR, et al. Increase in gastroesophageal reflux during methacholine-induced bronchospasm. J Allergy Clin Immunol 1986; 78:619-623
5. 5 Tuchman DN, Boyle JT, Pack AI, et al. Comparison of airway responses following tracheal or esophageal acidification in the cat. Gastroenterology 1984; 87:872-881
6. 6 Donnelly RJ, Berrisford RG, Jack CIA, et al. Simultaneous tracheal and esophageal pH monitoring: investigating reflux-associated asthma. Ann Thorac Surg 1993; 56:1029-1034
7. 7 Jack CIA, Calverley PMA, Donnelly RJ, et al. Simultaneous tracheal and oesophageal pH measurements in asthmatic patients with gastro-oesophageal reflux. Thorax 1995; 50:201-204
8. 8 Mansfield LE, Hameister HH, Spaulding HS, et al. The role of the vagus nerve in airway narrowing caused by intraesophageal hydrochloric acid provocation and esophageal distention. Ann Allergy 1981; 47:431-434
9. 9 Schan CA, Harding SM, Haile JM, et al. Gastroesophageal reflux-induced bronchoconstriction: an intraesophageal acid infusion study using state-of-the-art technology. Chest 1994; 106:731-737
10. 10 Harding SM, Schan CA, Guzzo MR, et al. Gastroesophageal reflux-induced bronchoconstriction: is microaspiration a factor? Chest 1995; 108:1220-1227
11. 11 Lodi U, Harding SM, Coghlan HC, et al. Autonomic regulation in asthmatics with gastroesophageal reflux. Chest 1997; 111:65-70
12. 12 Goodall RJR, Earis JE, Cooper DN, et al. Relationship between asthma and gastro-oesophageal reflux. Thorax 1981; 36:116-121
13. 13 Harper PC, Bergner A, Kaye MD. Antireflux treatment for asthma: improvement in patients with associated gastroesophageal reflux. Arch Intern Med 1987; 147:56-60
14. 14 Larrain A, Carrasco E, Galleguillos F, et al. Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux. Chest 1991; 99:1330-1335
15. 15 Harding SM, Richter JE, Guzzo MR, et al. Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome. Am J Med 1996; 100:395-405
16. 16 Ekström T, Lindgren BR, Tibbling L. Effects of ranitidine treatment on patients with asthma and history of gastro-oesophageal reflux: a double blind crossover study. Thorax 1989; 44:19-23
17. 17 Gustafsson PM, Kjellman N-IM, Tibbling L. A trial of ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux. Eur Respir J 1992; 5:201-206
18. 18 Meier JH, McNally PR, Punja M, et al. Does omeprazole (Prilosec) improve respiratory function in asthmatics with gastroesophageal reflux? A double-blind, placebo-controlled crossover study. Dig Dis Sci 1994; 39:2127-2133
19. 19 Teichtal H, Kronborg IJ, Yeomans ND, et al. Adult asthma and gastro-oesophageal reflux: the effects of omeprazole therapy on asthma. Aust N Z J Med 1996; 26:671-676
20. 20 Sontag S, O'Connel S, Greenlee H, et al. Is gastroesophageal reflux a factor in some asthmatics? Am J Gastroenterol 1987; 82:119-126
21. 21 Nagel RA, Brown P, Perks WH, et al. Ambulatory pH monitoring of gastro-oesophageal reflux in "morning dipper" asthmatics. BMJ 1988; 297:1371-1373
22. 22 Ford GA, Oliver PS, Prior JS, et al. Omeprazole in the treatment of asthmatics with nocturnal symptoms and gastro-oesophageal reflux: a placebo-controlled crossover study. Postgrad Med J 1994; 70:350-354
23. 23 Boeree MJ, Peters FTM, Postma DS, et al. No effects of high-dose omeprazole in patients with severe airway hyperresponsiveness and (a)symptomatic gastro-oesophageal reflux. Eur Respir J 1998; 11:1070-1074
24. 24 American Thoracic Society. Definitions and classification of chronic bronchitis, asthma and pulmonary emphysema. Am Rev Respir Dis 1962; 85:762-768
25. 25 Klauser AG, Schindlbeck NE, Muller-Lissner SA. Esophageal 24-h pH monitoring: is prior manometry necessary for correct positioning of the electrode? Am J Gastroenterol 1990; 85:1463-1467
26. 26 Johnson LF, DeMeester TR. Twenty-four-hour pH monitoring of the distal esophagus: a quantitative measure of gastroesophageal reflux. Am J Gastroenterol 1974; 62:325-332
27. 27 Jamieson JR, Stein HJ, DeMeester TR, et al. Ambulatory 24-h esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility. Am J Gastroenterol 1992; 87:1102-1111
28. 28 Viljanen A. Reference values for spirometric, pulmonary diffusing capacity and body plethysmographic studies. Scand J Clin Invest 1982; 159(Suppl42):5-20
29. 29 Jones B, Kenward MG. Design and analysis of crossover trials. London, UK: Chapman and Hall, 1990
30. 30 Grizzle JE. The two-period change-over design and its use in clinical trials. Biometrics 1965; 21:467-480
31. 31 Irwin RS, Curley FJ, French CL. Difficult-to-control asthma: contributing factors and outcome of a systematic management protocol. Chest 1993; 103:1662-1669
32. 32 Stein MR, Towner TG, Weber RW, et al. The effect on theophylline on the lower esophageal sphincter pressure. Ann Allergy 1980; 45:238-241
33. 33 Levin TR, Sperling RM, McQuaid KR. Omeprazole improves peak expiratory flow rate and quality of life in asthmatics with gastroesophageal reflux. Am J Gastroenterol 1998; 93:1060-1063
34. 34 Ekström T, Tibbling L. Gastro-oesophageal reflux and nocturnal asthma. Eur Respir J 1988; 1:636-638
35. 35 Perrin-Fayolle M, Gormand F, Braillon G, et al. Long-term results of surgical treatment for gastroesophageal reflux in asthmatic patients. Chest 1989; 96:40-45
36. 36 Schnatz PF, Castell JA, Castell DO. Pulmonary symptoms associated with gastroesophageal reflux: use of ambulatory pH monitoring to diagnose and to direct therapy. Am J Gastroenterol 1996; 91:1715-1718
37. 37 Gastal OL, Castell JA, Castell DO. Frequency and site of gastroesophageal reflux in patients with chest symptoms: studies using proximal and distal pH monitoring. Chest 1994; 106:1793-1796