Laryngopharyngeal reflux: More questions than answers

Cleveland Clinic Journal of Medicine

Volumn 77, Issue 5, 2010, Pages 327-334

  Barry, David W ^a   Vaezi, Michael F ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GASTROESOPHAGEAL REFLUX; PATHOPHYSIOLOGY; REVIEW;

REGURGITATION, GASTRIC;

EID: 77954667127     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.77a.09121     Document Type: Review

References (40)

1. Nebel OT, Fornes MF, Castell DO. Symptomatic gastroesophageal reflux: incidence and precipitating factors. Am J Dig Dis 1976; 21:953-956.
2. Kahrilas PJ, Shaheen NJ, Vaezi MF; American Gastroenterological Association Institute; Clinical Practice and Quality Management Committee. American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease. Gastroenterology 2008; 135:1392-1413.
3. Jonaitis L, Pribuisiene R, Kupcinskas L, Uloza V. Laryngeal examination is superior to endoscopy in the diagnosis of the laryngopharyngeal form of gastroesophageal reflux disease. Scand J Gastroenterol 2006; 41:131-137.
4. Vaezi MF, Hicks DM, Abelson TI, Richter JE. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect association. Clin Gastroenterol Hepatol 2003; 1:333-344.
5. Jaspersen D, Kulig M, Labenz J, et al. Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD study. Aliment Pharmacol Ther 2003; 17:1515-1520.
6. Karkos PD, Benton J, Leong SC, et al. Trends in laryngopharyngeal reflux: a British ENT survey. Eur Arch Otorhinolaryngol 2007; 264:513-517.
7. Dent J, Dodds WJ, Friedman RH, et al. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest 1980; 65:256-267.
8. Schreiber S, Garten D, Sudhoff H, et al. Pathophysiological mechanisms of extraesophageal reflux in otolaryngeal disorders. Eur Arch Otorhinolaryngol 2009; 266:17-24.
9. Adhami T, Goldblum JR, Richter JE, Vaezi MF. The role of gastric and duodenal agents in laryngeal injury: an experimental canine model. Am J Gastroenterol 2004; 99:2098-2106.
10. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991; 101(4 pt 2 suppl 53):1-78.
11. Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J. Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 2004; 114:2129-2134.
12. Vaezi MF. Therapy insight: gastroesophageal reflux disease and laryngopharyngeal reflux. Nat Clin Pract Gastroenterol Hepatol 2005; 2:595-603.
13. Farrokhi F, Vaezi MF. Extra-esophageal manifestations of gastroesophageal reflux. Oral Dis 2007; 13:349-359.
14. Koufman JA. Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear Nose Throat J 2002; 81(9 suppl 2):7-9.
15. Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg 2000; 123:385-388.
16. Milstein CF, Charbel S, Hicks DM, Abelson TI, Richter JE, Vaezi MF. Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs flexible scope). Laryngoscope 2005; 115;2256-2261.
17. Branski RC, Bhattacharyya N, Shapiro J. The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyn geal reflux disease. Laryngoscope 2002; 112;1019-1024.
18. Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001; 111:1313-1317.
19. Gupta R, Sataloff RT. Laryngopharyngeal reflux: current concepts and questions. Curr Opin Otolaryngol Head Neck Surg 2009; 17:143-148.
20. Jamieson JR, Stein HJ, DeMeester TR, et al. Ambulatory 24-h esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility. Am J Gastroenterol 1992; 87:1102-1111.
21. Reichel O, Issing WJ. Impact of different pH thresholds for 24-h dual probe pH monitoring in patients with suspected laryngopharyngeal reflux. J Laryngol Otol 2008; 122:485-489.
22. Shaker R, Milbrath M, Ren J, et al. Esophagopharyngeal distribution of refluxed gastric acid in patients with reflux laryngitis. Gastroenterology 1995; 109:1575-1582.
23. Jacob P, Kahrilas PJ, Herzon G. Proximal esophageal pH-metry in patients with "reflux laryngitis." Gastroenterology 1991; 100:305-310.
24. Eubanks TR, Omelanczuk PE, Maronian N, Hillel A, Pope CE 2nd, Pellegrini CA. Pharyngeal pH monitoring in 222 patients with suspected laryngeal reflux. J Gastrointest Surg 2001; 5:183-190.
25. Vaezi MF. Gastroesophageal reflux disease and the larynx. J Clin Gastroenterol 2003; 36:198-203.
26. Ulualp SO, Toohill RJ, Shaker R. Outcomes of acid suppressive therapy in patients with posterior laryngitis. Otolaryngol Head Neck Surg 2001; 124:16-22.
27. Pritchett JM, Aslam M, Slaughter JC, Ness RM, Garrett CG, Vaezi MF. Efficacy of esophageal impedance/pH monitoring in patients with refractory gastroesophageal reflux disease, on and off therapy. Clin Gastroenterol Hepatol 2009; 7:743-748.
28. Vaezi MF, Richter JE, Stasney CR, et al. Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope 2006; 116;254-260.
29. Qadeer MA, Phillips CO, Lopez AR, et al. Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta analysis of randomized controlled trials. Am J Gastroenterol 2006; 101:2646-2654.
30. Eherer AJ, Habermann W, Hammer HF, et al. Effect of pantoprazole on the course of reflux-associated laryngitis: a placebo-controlled double-blind crossover study. Scand J Gastroenterol 2003; 38:462-467.
31. El-Serag HB, Lee P, Buchner A, et al. Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. Am J Gastroenterol 2001; 96:979-983.
32. Noordzij JP, Khidr A, Evans BA, et al. Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study. Laryngoscope 2001; 111:2147-2151.
33. Langevin S, Hanh N. GERD-induced ENT symptoms: a prospective placebo controlled study with omeprazole 40 mg a day. Gastroenterology 2001; 120:A-16.
34. Havas T, Huang S, Levy M, et al. Posterior pharyngolaryngitis. Double blind randomized placebo-controlled trial of proton pump inhibitor therapy. Aust J Otolaryng 1999; 3:243-246.
35. Vaezi MF, Richter JE, Stasney CR, et al. Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope 2006; 116:254-260.
36. Wo JM, Koopman JI, Harrell SP, et al. Double-blind placebo-controlled trial with single-dose pantoprazole for laryngopharyngeal reflux. Am J Gastroenterol 2006; 101:1972-1978.
37. Steward DL, Wilson KM, Kelly DH, et al. Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial. Otolaryngol Head Neck Surg 2004; 131:342-350.
38. Fackler WK, Ours TM, Vaezi MF, Richter JE. Long term effect of H2RA therapy on nocturnal gastric acid breakthrough. Gastroenterology 2002; 122:625-632.
39. Swoger J, Ponsky J, Hicks DM, et al. Surgical fundoplication in laryngeal reflux unresponsive to aggressive acid suppression: a controlled study. Clin Gastroenterol Hepatol 2006; 4:433-441.
40. So JB, Zeitels SM, Rattner DW. Outcome of atypical symptoms attributed to gastroesophageal reflux treated by laparoscopic fundoplication. Surgery 1998; 124:28-32.