Azithromycin reduces gastroesophageal reflux and aspiration in lung transplant recipients

Digestive Diseases and Sciences

Volumn 54, Issue 5, 2009, Pages 972-979

  Mertens, V ^a   Blondeau, K ^a   Pauwels, A ^a   Farre, R ^a   Vanaudenaerde, B ^a   Vos, R ^a   Verleden, G ^a,b   Van Raemdonck, D E ^b   Dupont, L J ^a,b   Sifrim, D ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Azithromycin; Bile acids; Gastroesophageal reflux; Lung transplant recipients

Indexed keywords

AZATHIOPRINE; AZITHROMYCIN; BILE ACID; CYCLOSPORIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PEPSIN A; TACROLIMUS;

ACID ASPIRATION; ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ESOPHAGUS; ESOPHAGUS MOTILITY; FEMALE; GASTROESOPHAGEAL REFLUX; GRAFT RECIPIENT; HUMAN; IMPEDANCE; LUNG LAVAGE; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MONITORING; PH; PRIORITY JOURNAL; STOMACH EMPTYING;

ADULT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BILE ACIDS AND SALTS; BRONCHOALVEOLAR LAVAGE FLUID; COHORT STUDIES; CROSS-SECTIONAL STUDIES; ESOPHAGEAL PH MONITORING; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL AGENTS; HUMANS; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; PEPSIN A; RESPIRATORY ASPIRATION;

EID: 63949083201     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-009-0725-4     Document Type: Article

References (59)

1. RS Irwin WM Corrao MR Pratter 1981 Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy Am Rev Respir Dis 123 4 Pt 1 413 417
2. D Sifrim L Dupont K Blondeau X Zhang J Tack J Janssens 2005 Weakly acidic reflux in patients with chronic unexplained cough during 24-hour pressure, pH, and impedance monitoring Gut 54 4 449 454 10.1136/gut.2004.055418
3. J Feigelson J Sauvegrain 1975 Letter: Gastro-esophageal reflux in mucoviscidosis Nouv Presse Med 4 38 2729 2730
4. Blondeau K, Dupont L, Mertens V, Verleden G, Malfroot A, Vandenplas Y, Hauser B, Sifrim D. Gastroesophageal reflux and aspiration of gastric contents in adult patients with cystic fibrosis. Gut. 2008;57:1049-1055.
5. A Rosztoczy L Makk F Izbeki R Roka A Somfay T Wittmann 2008 Asthma and gastroesophageal reflux: clinical evaluation of esophago-bronchial reflex and proximal reflux Digestion 77 3-4 218 224 10.1159/000146083
6. SM Harding 2001 The potential role of gastroesophageal reflux in asthma Minerva Gastroenterol Dietol 47 2 75 83
7. K Blondeau V Mertens BA Vanaudenaerde GM Verleden DE Van Raemdonck D Sifrim LJ Dupont 2008 Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection Eur Respir J 31 4 707 713 10.1183/09031936.00064807
8. F D'Ovidio S Keshavjee 2006 Gastroesophageal reflux and lung transplantation Dis Esophagus 19 5 315 320 10.1111/j.1442-2050.2006.00603.x
9. SM Palmer AP Miralles DN Howell SR Brazer VF Tapson RD Davis 2000 Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation Chest 118 4 1214 1217 10.1378/chest.118.4.1214
10. LR Young D Hadjiliadis RD Davis SM Palmer 2003 Lung transplantation exacerbates gastroesophageal reflux disease Chest 124 5 1689 1693 10.1378/chest.124.5.1689
11. K Stordal GB Johannesdottir BS Bentsen PK Knudsen KC Carlsen O Closs M Handeland HK Holm L Sandvik 2005 Acid suppression does not change respiratory symptoms in children with asthma and gastro-oesophageal reflux disease Arch Dis Child 90 9 956 960 10.1136/adc.2004.068890
12. SP Jiang RY Liang ZY Zeng QL Liu YK Liang JG Li 2003 Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease World J Gastroenterol 9 5 1123 1125
13. C Bocskei M Viczian R Bocskei I Horvath 2005 The influence of gastroesophageal reflux disease and its treatment on asthmatic cough Lung 183 1 53 62 10.1007/s00408-004-2526-z
14. TO Kiljander ER Salomaa EK Hietanen EO Terho 2000 Chronic cough and gastro-oesophageal reflux: a double-blind placebo-controlled study with omeprazole Eur Respir J 16 4 633 638 10.1034/j.1399-3003.2000.16d11.x
15. R Tutuian I Mainie A Agrawal D Adams DO Castell 2006 Nonacid reflux in patients with chronic cough on acid-suppressive therapy Chest 130 2 386 391 10.1378/chest.130.2.386
16. I Mainie R Tutuian A Agrawal A Hila KB Highland DB Adams DO Castell 2005 Fundoplication eliminates chronic cough due to non-acid reflux identified by impedance pH monitoring Thorax 60 6 521 523 10.1136/thx.2005.040139
17. RP Boesch JD Acton 2007 Outcomes of fundoplication in children with cystic fibrosis J Pediatr Surg 42 8 1341 1344 10.1016/j.jpedsurg.2007.03.030
18. E Cantu III JZ Appel III MG Hartwig H Woreta C Green R Messier SM Palmer RD Davis Jr 2004 J. Maxwell Chamberlain memorial paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease Ann Thorac Surg 78 4 1142 1151 10.1016/j.athoracsur.2004.04.044
19. MG Hartwig JZ Appel RD Davis 2005 Antireflux surgery in the setting of lung transplantation: strategies for treating gastroesophageal reflux disease in a high-risk population Thorac Surg Clin 15 3 417 427 10.1016/j.thorsurg.2005. 03.001
20. EK O'Halloran JD Reynolds CL Lau RJ Manson RD Davis SM Palmer TN Pappas EM Clary WS Eubanks 2004 Laparoscopic Nissen fundoplication for treating reflux in lung transplant recipients J Gastrointest Surg 8 1 132 137 10.1016/j.gassur.2003.10.1013
21. C Mansi P Borro M Giacomini R Biagini MR Mele N Pandolfo V Savarino 2000 Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis Aliment Pharmacol Ther 14 5 561 569 10.1046/j.1365-2036.2000.00742.x
22. SM Fink RC Lange RW McCallum 1983 Effect of metoclopramide on normal and delayed gastric emptying in gastroesophageal reflux patients Dig Dis Sci 28 12 1057 1061 10.1007/BF01295802
23. RW McCallum SM Fink E Lerner DM Berkowitz 1983 Effects of metoclopramide and bethanechol on delayed gastric emptying present in gastroesophageal reflux patients Gastroenterology 84 6 1573 1577
24. T Takeda H Konomi G Naritomi J Yoshida H Matsunaga K Akazawa M Tanaka 1996 Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: an ultrasonographic study J Gastroenterol 31 3 323 328 10.1007/BF02355019
25. S Campo S Morini MA Re D Monno R Lorenzetti B Moscatelli E Bologna 1997 Esophageal dysmotility and gastroesophageal reflux in intrinsic asthma Dig Dis Sci 42 6 1184 1188 10.1023/A:1018841704897
26. YM Fouad PO Katz JG Hatlebakk DO Castell 1999 Ineffective esophageal motility: the most common motility abnormality in patients with GERD-associated respiratory symptoms Am J Gastroenterol 94 6 1464 1467 10.1111/j.1572-0241.1999. 1127-e.x
27. A Malfroot I Dab 1991 New insights on gastro-oesophageal reflux in cystic fibrosis by longitudinal follow up Arch Dis Child 66 11 1339 1345 10.1136/adc.66.11.1339
28. RH Poe MC Kallay 2003 Chronic cough and gastroesophageal reflux disease: experience with specific therapy for diagnosis and treatment Chest 123 3 679 684 10.1378/chest.123.3.679
29. Y Vandenplas 1998 Clinical use of cisapride and its risk-benefit in paediatric patients Eur J Gastroenterol Hepatol 10 10 871 881 10.1097/00042737-199810000-00011
30. CL Chen WC Orr MH Verlinden A Dettmer H Brinkhoff D Riff S Schwartz RD Soloway R Krause F Lanza RJ Mack 2002 Efficacy of a motilin receptor agonist (ABT-229) for the treatment of gastro-oesophageal reflux disease Aliment Pharmacol Ther 16 4 749 757 10.1046/j.1365-2036.2002.01218.x
31. P Netzer B Schmitt W Inauen 2002 Effects of ABT-229, a motilin agonist, on acid reflux, oesophageal motility and gastric emptying in patients with gastro-oesophageal reflux disease Aliment Pharmacol Ther 16 8 1481 1490 10.1046/j.1365-2036.2002.01324.x
32. SG Gerhardt JF McDyer RE Girgis JV Conte SC Yang JB Orens 2003 Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study Am J Respir Crit Care Med 168 1 121 125 10.1164/rccm.200212- 1424BC
33. GM Verleden LJ Dupont 2004 Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation Transplantation 77 9 1465 1467 10.1097/01.TP.0000122412.80864.43
34. B Yates DM Murphy IA Forrest C Ward RM Rutherford AJ Fisher JL Lordan JH Dark PA Corris 2005 Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome Am J Respir Crit Care Med 172 6 772 775 10.1164/rccm.200411-1537OC
35. GM Verleden BM Vanaudenaerde LJ Dupont DE Van Raemdonck 2006 Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome Am J Respir Crit Care Med 174 5 566 570 10.1164/rccm.200601- 071OC
36. M Estenne JR Maurer A Boehler JJ Egan A Frost M Hertz GB Mallory GI Snell S Yousem 2002 Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria J Heart Lung Transplant 21 3 297 310 10.1016/S1053-2498(02) 00398-4
37. D Sifrim D Castell J Dent PJ Kahrilas 2004 Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux Gut 53 7 1024 1031 10.1136/gut.2003.033290
38. F Zerbib SB des Varannes S Roman P Pouderoux F Artigue U Chaput F Mion F Caillol E Verin G Bommelaer P Ducrotte JP Galmiche D Sifrim 2005 Normal values and day-to-day variability of 24-h ambulatory oesophageal impedance-pH monitoring in a Belgian-French cohort of healthy subjects Aliment Pharmacol Ther 22 10 1011 1021 10.1111/j.1365-2036.2005.02677.x
39. S Kudoh A Azuma M Yamamoto T Izumi M Ando 1998 Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin Am J Respir Crit Care Med 157 6 Pt 1 1829 1832
40. A Jaffe A Bush 2001 Anti-inflammatory effects of macrolides in lung disease Pediatr Pulmonol 31 6 464 473 10.1002/ppul.1076
41. J Gottlieb J Szangolies T Koehnlein H Golpon A Simon T Welte 2008 Long-term azithromycin for bronchiolitis obliterans syndrome after lung transplantation Transplantation 85 1 36 41
42. F D'Ovidio M Mura M Tsang TK Waddell MA Hutcheon LG Singer D Hadjiliadis C Chaparro C Gutierrez A Pierre G Darling M Liu S Keshavjee 2005 Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation J Thorac Cardiovasc Surg 129 5 1144 1152 10.1016/j.jtcvs.2004. 10.035
43. F D'Ovidio M Mura R Ridsdale H Takahashi TK Waddell M Hutcheon D Hadjiliadis LG Singer A Pierre C Chaparro C Gutierrez L Miller G Darling M Liu M Post S Keshavjee 2006 The effect of reflux and bile acid aspiration on the lung allograft and its surfactant and innate immunity molecules SP-A and SP-D Am J Transplant 6 8 1930 1938 10.1111/j.1600-6143.2006.01357.x
44. D Hadjiliadis DR Duane MP Steele RH Messier CL Lau SS Eubanks SM Palmer 2003 Gastroesophageal reflux disease in lung transplant recipients Clin Transplant 17 4 363 368 10.1034/j.1399-0012.2003.00060.x
45. SM Palmer 2006 Reflux of bile acids: an innate problem of lung transplantation Am J Transplant 6 8 1757 1758 10.1111/j.1600-6143.2006.01425.x
46. RD Davis Jr CL Lau S Eubanks RH Messier D Hadjiliadis MP Steele SM Palmer 2003 Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation J Thorac Cardiovasc Surg 125 3 533 542 10.1067/mtc.2003.166
47. TL Peeters 1993 Erythromycin and other macrolides as prokinetic agents Gastroenterology 105 6 1886 1899
48. L Thielemans I Depoortere J Perret P Robberecht Y Liu T Thijs C Carreras E Burgeon TL Peeters 2005 Desensitization of the human motilin receptor by motilides J Pharmacol Exp Ther 313 3 1397 1405 10.1124/jpet.104.081497
49. D Sifrim K Blondeau 2006 Technology insight: the role of impedance testing for esophageal disorders Nat Clin Pract Gastroenterol Hepatol 3 4 210 219 10.1038/ncpgasthep0446
50. I Bala K Prasad I Bhukal D Nakra M Pratap 2008 Effect of preoperative oral erythromycin, erythromycin-ranitidine, and ranitidine-metoclopramide on gastric fluid pH and volume J Clin Anesth 20 1 30 34 10.1016/j.jclinane.2007.08. 002
51. T Asai K Murao K Shingu 2000 Pre-operative oral erythromycin reduces residual gastric volume and acidity Br J Anaesth 85 6 861 864 10.1093/bja/85.6.861
52. D Memis A Turan B Karamanlioglu T Guler A Yurdakoc Z Pamukcu N Turan 2002 Effect of preoperative oral use of erythromycin and nizatidine on gastric pH and volume Anaesth Intensive Care 30 4 428 432
53. AT Clarke AA Wirz JJ Manning SA Ballantyne DJ Alcorn KE McColl 2008 Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket Gut 57 3 292 297 10.1136/gut.2006.109421
54. Bisschops R, Sifrim D, Vos R, Janssens J, Tack J. Influence of gastric motility modifying drugs on the postprandial acid and bile pockets at the gastro-esophageal junction. Gastroenterology (in press).
55. D Sifrim H Matsuo J Janssens G Vantrappen 1994 Comparison of the effects of midecamycin acetate and azithromycin on gastrointestinal motility in man Drugs Exp Clin Res 20 3 121 126
56. C Ward IA Forrest IA Brownlee GE Johnson DM Murphy JP Pearson JH Dark PA Corris 2005 Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts Thorax 60 10 872 874 10.1136/thx.2004.036426
57. V Mertens K Blondeau BM Vanaudenaerde R Vos DE Van Raemdonck GM Verleden D Sifrim LJ Dupont 2008 Pepsin or bile acids: what is the best marker of gastric aspiration in lung transplant recipients? J Heart Lung Transplant 27 2 S125 S126 10.1016/j.healun.2007.11.188
58. GH Koek R Vos D Sifrim R Cuomo J Janssens J Tack 2005 Mechanisms underlying duodeno-gastric reflux in man Neurogastroenterol Motil 17 2 191 199 10.1111/j.1365-2982.2004.00633.x
59. A Fountos E Chrysos J Tsiaoussis N Karkavitsas OJ Zoras A Katsamouris E Xynos 2003 Duodenogastric reflux after biliary surgery: scintigraphic quantification and improvement with erythromycin ANZ J Surg 73 6 400 403 10.1046/j.1445-2197.2003.t01-1-02654.x