Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage

British Journal of Pharmacology

Volumn 165, Issue 1, 2012, Pages 106-119

  Kameda, Katsuharu ^a   Kikkawa, Yuichiro ^a   Hirano, Mayumi ^a   Matsuo, Satoshi ^a   Sasaki, Tomio ^a   Hirano, Katsuya ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

anticoagulant thrombolytic drugs; antioxidants NO pathways drugs; cardiovascular pharmacology; control of smooth muscle

Indexed keywords

ANGIOTENSIN II; ARGATROBAN; ASCORBIC ACID; G PROTEIN COUPLED RECEPTOR; PROSTAGLANDIN F2 ALPHA; PROTEINASE ACTIVATED RECEPTOR 1; TEMPOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THROMBIN; VASOPRESSIN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BLOOD VESSEL CONTRACTILITY; BLOOD VESSEL REACTIVITY; BRAIN TISSUE; BRAIN VASOSPASM; CONTROLLED STUDY; DRUG EFFECT; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE CONTRACTILITY; SUBARACHNOID HEMORRHAGE;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; DRUG THERAPY, COMBINATION; MALE; PIPECOLIC ACIDS; RABBITS; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; THROMBIN; THROMBOSIS; VASOCONSTRICTION;

EID: 82955189790     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01485.x     Document Type: Article

References (42)

1. Alexander SPH, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164: S1-S324.
2. Asano T, Sasaki T, Koide T, Takakura K, Sano K, (1984). Experimental evaluation of the beneficial effect of an antioxidant on cerebral vasospasm. Neurol Res 6: 49-53. (Pubitemid 14031307)
3. Blackhart BD, Ruslim-Litrus L, Lu CC, Alves VL, Teng W, Scarborough RM, et al,. (2000). Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide. Mol Pharmacol 58: 1178-1187.
4. Booden MA, Eckert LB, Der CJ, Trejo J, (2004). Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol 24: 1990-1999. (Pubitemid 38248939)
5. Carr AC, Zhu BZ, Frei B, (2000). Potential antiatherogenic mechanisms of ascorbate (vitamin C) and α-tocopherol (vitamin E). Circ Res 87: 349-354.
6. Choi SH, Lee DY, Kim SU, Jin BK, (2005). Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase. J Neurosci 25: 4082-4090.
7. Cobelens PM, Kavelaars A, Heijnen CJ, Ribas C, Mayor F Jr, Penela P, (2007). Hydrogen peroxide impairs GRK2 translation via a calpain-dependent and cdk1-mediated pathway. Cell Signal 19: 269-277. (Pubitemid 44969973)
8. Coughlin SR, (2000). Thrombin signaling and protease-activated receptors. Nature 407: 258-264.
9. Fisher CM, Kistler JP, Davis JM, (1980). Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 6: 1-9. (Pubitemid 10159923)
10. phox-containing NADPH oxidase. Circ Res 89: 47-54. (Pubitemid 34135491)
11. Hirano K, (2007). The roles of proteinase-activated receptors in the vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol 27: 27-36. (Pubitemid 46370476)
12. Hirano K, Hirano M, (2010). Current perspective on the role of the thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage. J Pharmacol Sci 114: 127-133.
13. Hollenberg MD, (2005). Physiology and pathophysiology of proteinase-activated receptors (PARs): proteinases as hormone-like signal messengers: PARs and more. J Pharmacol Sci 97: 8-13. (Pubitemid 40313093)
14. Inagawa T, Yamamoto M, Kamiya K, (1990). Effect of clot removal on cerebral vasospasm. J Neurosurg 72: 224-230. (Pubitemid 20087711)
15. Kai Y, Hirano K, Maeda Y, Nishimura J, Sasaki T, Kanaide H, (2007). Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage. Stroke 38: 3259-3265. (Pubitemid 350175746)
16. Kai Y, Maeda Y, Sasaki T, Kanaide H, Hirano K, (2008). Basic and translational research on proteinase-activated receptors: the role of thrombin receptor in cerebral vasospasm in subarachnoid hemorrhage. J Pharmacol Sci 108: 426-432.
17. Kassell NF, Sasaki T, Colohan AR, Nazar G, (1985). Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 16: 562-572. (Pubitemid 15007226)
18. Kasuya H, Shimizu T, Takakura K, (1998). Thrombin activity in CSF after SAH is correlated with the degree of SAH the persistence of subarachnoid clot and the development of vasospasm. Acta Neurochir (Wien) 140: 579-584. (Pubitemid 28345060)
19. Kawakami M, Kodama N, Toda N, (1991). Suppression of the cerebral vasospastic actions of oxyhemoglobin by ascorbic acid. Neurosurgery 28: 33-39; discussion 39-40.
20. Kellogg EW 3rd, Fridovich I, (1977). Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide. J Biol Chem 252: 6721-6728. (Pubitemid 8200429)
21. 2+ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage. J Cereb Blood Flow Metab 30: 1637-1650.
22. 2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl) sulfonyl]-L-arginyl]-2- piperidinecarboxylic acid. Biochemistry 23: 85-90. (Pubitemid 14181541)
23. Kodama N, Sasaki T, Kawakami M, Sato M, Asari J, (2000). Cisternal irrigation therapy with urokinase and ascorbic acid for prevention of vasospasm after aneurysmal subarachnoid hemorrhage. Outcome in 217 patients. Surg Neurol 53: 110-117; discussion 117-118.
24. Kolias AG, Sen J, Belli A, (2009). Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: putative mechanisms and novel approaches. J Neurosci Res 87: 1-11.
25. Luo Z, Harada T, London S, Gajdusek C, Mayberg MR, (1995). Antioxidant and iron-chelating agents in cerebral vasospasm. Neurosurgery 37: 1154-1158; discussion 1158-1159.
26. Maeda Y, Hirano K, Kai Y, Hirano M, Suzuki SO, Sasaki T, et al,. (2007). Up-regulation of proteinase-activated receptor 1 and increased contractile responses to thrombin after subarachnoid haemorrhage. Br J Pharmacol 152: 1131-1139. (Pubitemid 350166042)
27. McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE, (2005). Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem 280: 25048-25059. (Pubitemid 40934596)
28. Misra HP, Fridovich I, (1972). The generation of superoxide radical during the autoxidation of hemoglobin. J Biol Chem 247: 6960-6962.
29. Monti E, Cova D, Guido E, Morelli R, Oliva C, (1996). Protective effect of the nitroxide tempol against the cardiotoxicity of adriamycin. Free Radic Biol Med 21: 463-470. (Pubitemid 26313942)
30. Ohkawa H, Ohishi N, Yagi K, (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358. (Pubitemid 9194347)
31. phox may participate in forming this oxidase in vitro and in vivo. J Biol Chem 274: 19814-19822.
32. Sano K, Asano T, Tanishima T, Sasaki T, (1980). Lipid peroxidation as a cause of cerebral vasospasm. Neurol Res 2: 253-272. (Pubitemid 11101229)
33. Sasaki T, Kassell NF, (1990). The role of endothelium in cerebral vasospasm. Neurosurg Clin N Am 1: 451-463.
34. Sasaki T, Wakai S, Asano T, Watanabe T, Kirino T, Sano K, (1981). The effect of a lipid hydroperoxide of arachidonic acid on the canine basilar artery. An experimental study on cerebral vasospasm. J Neurosurg 54: 357-365. (Pubitemid 11135945)
35. Sato M, (1987). Prevention of cerebral vasospasm: experimental studies on the degradation of oxyhemoglobin by ascorbic acid. Fukushima J Med Sci 33: 55-70.
36. Smirnova IV, Salazar A, Arnold PM, Glatt S, Handler M, Festoff BW, (1997). Thrombin and its precursor in human cerebrospinal fluid. Thromb Haemost 78: 1473-1479. (Pubitemid 27519392)
37. Soh UJ, Dores MR, Chen B, Trejo J, (2010). Signal transduction by protease-activated receptors. Br J Pharmacol 160: 191-203.
38. Sugawara T, Jadhav V, Ayer R, Chen W, Suzuki H, Zhang JH, (2009). Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats. Stroke 40: 1530-1532.
39. Trejo J, (2003). Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking. J Pharmacol Exp Ther 307: 437-442. (Pubitemid 37310654)
40. Tsurutani H, Ohkuma H, Suzuki S, (2003). Effects of thrombin inhibitor on thrombin-related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model. Stroke 34: 1497-1500. (Pubitemid 36693524)
41. White RP, Robertson JT, (1985). Role of plasmin, thrombin, and antithrombin III as etiological factors in delayed cerebral vasospasm. Neurosurgery 16: 27-35. (Pubitemid 15154198)
42. Zhang Z, Nagata I, Kikuchi H, Xue JH, Sakai N, Sakai H, et al,. (2001). Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage: vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB. Stroke 32: 1665-1672. (Pubitemid 32631922)