Effects of NMDA receptor antagonists with different subtype selectivities on retinal spreading depression

British Journal of Pharmacology

Volumn 165, Issue 1, 2012, Pages 235-244

  Wang, Minyan ^a   Chazot, Paul L ^b   Ali, Sura ^a   Duckett, Stevens F ^a   Obrenovitch, Tihomir P ^c  

^a UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

chick retina; CP 101606; GluN2A; GluN2A 2B; GluN2B; GluN2D; immunoblotting; NMDA receptor subtypes; NVP AAM077; spreading depression; UBP141

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR SUBTYPE GLUN1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR SUBTYPE GLUN2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR SUBTYPE GLUN2B; NVP AAM 077; POTASSIUM ION; TRAXOPRODIL; UBP 141; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHICK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG TARGETING; IMMUNOBLOTTING; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RETINA; SPREADING CORTICAL DEPRESSION; SPREADING RETINAL DEPRESSION;

ANIMALS; CHICKENS; GENE EXPRESSION REGULATION; MALE; RECEPTORS, N-METHYL-D-ASPARTATE; RETINA; RETINAL DISEASES; STROKE; TISSUE CULTURE TECHNIQUES;

EID: 82955189736     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01553.x     Document Type: Article

References (48)

1. Alexander SPH, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164: S1-S324.
2. Allyson J, Dontigny E, Auberson Y, Cyr M, Massicotte G, (2010). Blockade of NR2A-containing NMDA receptors induces Tau Phosphorylation in rat hippocampal slices. Neural Plast 2010: 340168.
3. Auberson YP, Allgeier H, Bischoff S, Lingenhoehl K, Moretti R, Schmutz M, (2002). 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett 12: 1099-1102. (Pubitemid 34242811)
4. Ayata C, (2010). Cortical spreading depression triggers migraine attack: pro. Headache 50: 725-730.
5. Brothwell SL, Barber JL, Monaghan DT, Jane DE, Gibb AJ, Jones S, (2008). NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol 6: 739-750. (Pubitemid 351194114)
6. Cammarata D, Krusz JC, (2005). Memantine: novel mechanism for migraine and headache prophylaxis. Headache 45: 820.
7. Chazot PL, Lawrence S, Thompson CL, (2002). Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists. Neuropharmacology 42: 319-324. (Pubitemid 34230484)
8. Chen HS, Lipton SA, (2005). Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels. J Pharmacol Exp Ther 314: 961-971. (Pubitemid 41205958)
9. Costa BM, Feng B, Tsintsadze TS, Morley RM, Irvine MW, Tsintsadze V, et al,. (2009). N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. J Pharmacol Exp Ther 331: 618-626.
10. Dahlem MA, Müller SC, (2000). Image processing techniques applied to excitation waves in the chicken retina. Methods 21: 317-323. (Pubitemid 32896738)
11. Dahlem YA, Dahlem MA, Mair T, Braun K, Müller SC, (2003). Extracellular potassium alters frequency and profile of retinal spreading depression waves. Exp Brain Res 152: 221-228. (Pubitemid 37153643)
12. Dingledine R, Borges K, Bowie D, Traynelis SF, (1999). The glutamate receptor ion channels. Pharmacol Rev 51: 7-61. (Pubitemid 29113865)
13. Dohmen C, Sakowitz OW, Fabricius M, Bosche B, Reithmeier T, Ernestus RI, et al,. (2008). Spreading depolarisations occur in human ischemic stroke with high incidence. Ann Neurol 63: 720-728. (Pubitemid 351945531)
14. Dreier JP, Woitzik J, Fabricius M, Bhatia R, Major S, Drenckhahn C, et al,. (2006). Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarisations. Brain 129 (Pt 12): 3224-3237. (Pubitemid 44871438)
15. Dunah AW, Yasuda RP, Luo J, Wang Y, Prybylowski KL, Wolfe BB, (1999). Biochemical studies of the structure and function of the N-methyl-D-aspartate subtype of glutamate receptors. Mol Neurobiol 19: 151-179. (Pubitemid 29246913)
16. Farkas E, Pratt R, Sengpiel F, Obrenovitch TP, (2008). Direct, live imaging of cortical spreading depression and anoxic depolarisation using a fluorescent, voltage-sensitive dye. J Cereb Blood Flow Metab 28: 251-262. (Pubitemid 351161299)
17. Feng B, Tse HW, Skifter DA, Morley R, Jane DE, Monaghan DT, (2004). Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1- (phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid. Br J Pharmacol 141: 508-516. (Pubitemid 38297013)
18. Fischer G, Mutel V, Trube G, Malherbe P, Kew JN, Mohacsi E, et al,. (1997). Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther 283: 1285-1292. (Pubitemid 28016504)
19. Fischer AJ, Seltner RL, Poon J, Stell WK, (1998). Immunocytochemical characterization of quisqualic acid- and N-methyl-D-aspartate-induced excitotoxicity in the retina of chicks. J Comp Neurol 393: 1-15. (Pubitemid 28120061)
20. Fletcher EL, Hack I, Brandstätter JH, Wässle H, (2000). Synaptic localization of NMDA receptor subunits in the rat retina. J Comp Neurol 420: 98-112. (Pubitemid 30207236)
21. Frizelle PA, Chen PE, Wyllie DJ, (2006). Equilibrium constants for (R)-[(S)-1-(4-bromo- phenyl)-ethylamino](2,3-dioxo-1,2,3,4-tetrahydroquinoxalin- 5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant GLUN1/NR2A and GLUN1/NR2B N-methyl-D-aspartate receptors: implications for studies of synaptic transmission. Mol Pharmacol 70: 1022-1032. (Pubitemid 44268459)
22. Gill R, Andiné P, Hillered L, Persson L, Hagberg H, (1992). The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischaemia in the rat. J Cereb Blood Flow Metab 12: 371-379.
23. Hanke W, de Lima VM, (2008). Central nervous tissue: an excitable medium. A study using the retinal spreading depression as a tool. Philos Transact A Math Phys Eng Sci 366: 359-368.
24. Hawkins LM, Chazot PL, Stephenson FA, (1999). Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors. J Biol Chem 274: 27211-27218.
25. Kertész S, Kapus G, Gacsályi I, Lévay G, (2010). Deramciclane improves object recognition in rats: potential role of NMDA receptors. Pharmacol Biochem Behav 94: 570-574.
26. Liu L, Wong TP, Pozza MF, Lingenhoehl K, Wang Y, Sheng M, et al,. (2004). Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304: 1021-1024. (Pubitemid 38638102)
27. Lynch DR, Shim SS, Seifert KM, Kurapathi S, Mutel V, Gallagher MJ, et al,. (2001). Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol 416: 185-195. (Pubitemid 32274245)
28. Marrannes R, Willems R, De Prins E, Wauquier A, (1988). Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat. Brain Res 457: 226-240.
29. Menniti FS, Pagnozzi MJ, Butler P, Chenard BL, Jaw-Tsai SS, Frost White W, (2000). CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents. Neuropharmacology 39: 1147-1155. (Pubitemid 30173180)
30. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, et al,. (1992). Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256: 1217-1221.
31. Morley RM, Tse HW, Feng B, Miller JC, Monaghan DT, Jane DE, (2005). Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem 48: 2627-2637. (Pubitemid 40516452)
32. Mott DD, Doherty JJ, Zhang S, Washburn MS, Fendley MJ, Lyuboslavsky P, et al,. (1998). Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition. Nat Neurosci 1: 659-667. (Pubitemid 128406376)
33. Neyton J, Paoletti P, (2006). Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci 26: 1331-1333. (Pubitemid 43237003)
34. Olsen TS, (1995). Pathophysiology of the migraine aura: the spreading depression theory. Brain 118: 307-308.
35. Paoletti P, Neyton J, (2007). NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 7: 39-47. (Pubitemid 46238036)
36. Peeters M, Gunthorpe MJ, Strijbos PJ, Goldsmith P, Upton N, James MF, (2007). Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine. J Pharmacol Exp Ther 321: 564-572. (Pubitemid 46624518)
37. Peixoto NL, Fernandes de Lima VM, Hanke W, (2001). Correlation of the electrical and intrinsic optical signals in the chick spreading depression phenomenon. Neurosci Lett 299: 89-92. (Pubitemid 32146352)
38. Peltz G, Pacific DM, Noviasky JA, Shatla A, Mehalic T, (2005). Seizures associated with memantine use. Am J Health Syst Pharm 62: 420-421. (Pubitemid 40394624)
39. Petzold GC, Windmüller O, Haack S, Major S, Buchheim K, Megow D, et al,. (2005). Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarisations and spreading ischemia. Stroke 36: 1270-1277. (Pubitemid 40798750)
40. Risher WC, Ard D, Yuan J, Kirov SA, (2010). Recurrent spontaneous spreading depolarisations facilitate acute dendritic injury in the ischemic penumbra. J Neurosci 30: 9859-9868.
41. Sakowitz OW, Kiening KL, Krajewski KL, Sarrafzadeh AS, Fabricius M, Strong AJ, et al,. (2009). Preliminary evidence that ketamine inhibits spreading depolarisations in acute human brain injury. Stroke 40: e519-e522.
42. Sheardown MJ, (1993). The triggering of spreading depression in the chick retina: a pharmacological study. Brain Res 607: 189-194. (Pubitemid 23104965)
43. Sun L, Shipley MT, Lidow MS, (2000). Expression of GLUN1, NR2A-D, and NR3 subunits of the NMDA receptor in the cerebral cortex and olfactory bulb of adult rat. Synapse 35: 212-221. (Pubitemid 30056718)
44. Thompson CL, Drewery DL, Atkins HD, Stephenson FA, Chazot PL, (2002). Immunohistochemical localization of N-methyl-D-aspartate receptor subunits in the adult murine hippocampal formation: evidence for a unique role of the NR2D subunit. Brain Res Mol Brain Res 102: 55-61. (Pubitemid 34607742)
45. Van den Maagdenberg AM, Pietrobon D, Pizzorusso T, Kaja S, Broos LA, Cesetti T, et al,. (2004). A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 41: 701-710. (Pubitemid 38326833)
46. Vitanova LA, (2011). Immunocytochemical study of GLUN1, NR2A and NR2B subunits of NMDA receptor in frog retina (Rana ridibunda). Acta Histochem 13: 495-500.
47. Willette RN, Lysko PG, Sauermelch CF, (1994). A comparison of (+)SK&F 10047 and MK-801 on cortical spreading depression. Brain Res 648: 347-351.
48. Yamakura T, Mori H, Masaki H, Shimoji K, Mishina M, (1993). Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists. Neuroreport 4: 687-690. (Pubitemid 23190892)