Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia

Stroke

Volumn 36, Issue 6, 2005, Pages 1270-1277

  Petzold, Gabor C ^a   Windmüller, Olaf ^a   Haack, Stephan ^a   Major, Sebastian ^a   Buchheim, Katharina ^a   Megow, Dirk ^a   Gabriel, Siegrun ^a   Lehmann, Thomas Nicolas ^a   Drenckhahn, Christoph ^a   Peters, Oliver ^a   Meierkord, Hartmut ^a   Heinemann, Uwe ^a   Dirnagl, Ulrich ^a   Dreier, Jens P ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Brain injuries; N methyl D aspartate; Spreading cortical depression; Stroke; Subarachnoid hemorrhage; Trauma

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; POTASSIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; DEPOLARIZATION; DOPPLER FLOWMETER; DRUG EFFECT; DRUG EFFICACY; ELECTRODE; EXTRACELLULAR SPACE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MEASUREMENT; NERVE INJURY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SPREADING CORTICAL DEPRESSION; SPREADING CORTICAL ISCHEMIA; STROKE; SUBARACHNOID HEMORRHAGE;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; BODY TEMPERATURE; BRAIN; BRAIN INJURIES; DIZOCILPINE MALEATE; ELECTRODES; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; IONS; ISCHEMIA; LASER-DOPPLER FLOWMETRY; MALE; NEUROPROTECTIVE AGENTS; POTASSIUM; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SPREADING CORTICAL DEPRESSION; SUBARACHNOID HEMORRHAGE;

EID: 20444393947     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000166023.51307.e0     Document Type: Article

References (28)

1. Somjen GG. Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev. 2001;81:1065-1096.
2. Nedergaard M, Hansen AJ. Spreading depression is not associated with neuronal injury in the normal brain. Brain Res. 1988;449:395-398.
3. Strong AJ, Smith SE, Whittington DJ, Meldrum BS, Parsons AA, Krupinski J, Hunter AJ, Patel S, Robertson C. Factors influencing the frequency of fluorescence transients as markers of peri-infarct depolarizations in focal cerebral ischemia. Stroke. 2000;31:214-222.
4. Hartings JA, Rolli ML, Lu XC, Tortella FC. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection. J Neurosci. 2003;23:11602-11610.
5. Nedergaard M, Hansen AJ. Characterization of cortical depolarizations evoked in focal cerebral ischemia. J Cereb Blood Flow Metab. 1993;13:568-574.
6. Müller M, Somjen GG. Na(+) dependence and the role of glutamate receptors and Na(+) channels in ion fluxes during hypoxia of rat hippocampal slices. J Neurophysiol. 2000;84:1869-1880.
7. Busch E, Gyngell ML, Eis M, Hoehn-Berlage M, Hossmann KA. Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging. J Cereb Blood Flow Metab. 1996;16:1090-1099.
8. Dreier JP, Körner K, Ebert N, Görner A, Rubin I, Back, T, Lindauer U, Wolf T, Villringer A, Einhäupl KM, Lauritzen M, Dirnagl U. Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition by N-nitro-L-arginine induces conical spreading ischemia when K+ is increased in the subarachnoid space. J Cereb Blood Flow Metab. 1998;18:978-990.
9. Petzold GC, Einhäupl KM, Dirnagl U, Dreier JP. Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and hemoglobin in the subarachnoid space. Ann Neurol. 2003;54:591-598.
10. Dreier JP, Ebert N, Priller J, Megow D, Lindauer U, Klee R, Reuter U, Imai Y, Einhäupl KM, Victorov I, Dirnagl U. Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage? J Neurosurg. 2000;93:658-666.
11. Dreier JP, Sakowitz OW, Harder A, Zimmer C, Dirnagl U, Valdueza JM, Unterberg AW. Focal laminar cortical MR signal abnormalities after subarachnoid hemorrhage. Ann Neurol. 2002;52:825-829.
12. Dreier JP, Windmüller O, Petzold G, Lindauer U. Einhäupl KM, Dirnagl U. Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats. Neurosurgery. 2002;51:1457-1465.
13. Hernandez-Caceres J, Macias-Gonzalez R, Brozek G, Bures J. Systemic ketamine blocks cortical spreading depression but does not delay the onset of terminal anoxic depolarization in rats. Brain Res. 1987;437:360-364.
14. Lauritzen M, Hansen AJ. The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression. J Cereb Blood Flow Metab. 1992;12:223-229.
15. Ayata C, Shin H, Dunn AK, Boas DA, Moskowitz MA. MK-801 prevents the expansion of blood-flow deficit in acute focal cerebral ischemia by blocking the cerebrovascular effects of ischemic neuroglial depolarization. Abstract 821.2. 2004 Abstract Viewer/Itinerary Planner. Society for Neuroscience; 2004.
16. Iijima T, Mies G, Hossmann KA. Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J Cereb Blood Flow Metab. 1992;12:727-733.
17. Mies G, Kohno K, Hossmann KA. Prevention of periinfarct direct current shifts with glutamate antagonist NBQX following occlusion of the middle cerebral artery in the rat. J Cereb Blood Flow Metab. 1994;14:802-807.
18. Gabriel S, Kivi A, Kovacs R, Lehmann TN, Lanksch WR, Meencke HJ, Heinemann U. Effects of barium on stimulus-induced changes in [K+]o and field potentials in dentate gyrus and area CA1 of human epileptic hippocampus. Neurosci Lett. 1998;249:91-94.
19. Rogatsky GG, Sonn J, Kamenir Y, Zarchin N, Mayevsky A. Relationship between intracranial pressure and cortical spreading depression following fluid percussion brain injury in rats. J Neurotrauma. 2003;20:1315-1325.
20. Busch E, Beaulieu C, de Crespigny A, Moseley ME. Diffusion MR imaging during acute subarachnoid hemorrhage in rats. Stroke. 1998;29:2155-2161.
21. Strong AJ, Fabricius M, Boutelle MG, Hibbins SJ, Hopwood SE, Jones R, Parkin MC, Lauritzen M. Spreading and synchronous depressions of cortical activity in acutely injured human brain. Stroke, 2002;33:2738-2743.
22. Reinert M, Khaldi A, Zauner A, Doppenberg E, Choi S, Bullock R. High level of extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure. J Neurosurg. 2000;93:800-807.
23. Ohta O, Osaka K, Siguma M, Yamamoto M, Shimizu K, Toda N. Cerebral vasospasm following ruptured intracranial aneurysms, especially some contributions of potassium ion released from subarachnoid hematoma to delayed cerebral vasospasm. In: Bevan JA. ed. Vascular Neuroeffector Mechanisms. New York. NY: Raven Press. 1983:353-358.
24. Avoli M, Drapeau C, Louvel J, Pumain R, Olivier A, Villemure JG. Epileptiform activity induced by low extracellular magnesium in the human cortex maintained in vitro. Ann Neurol. 1991;30:589-596.
25. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22:391-397.
26. Chi OZ, Anwar M, Sinha AK, Weiss HR. Effects of MK-801 on cerebral regional oxygen consumption in focal cerebral ischemia in rats. Circ Res. 1991;69:414-420.
27. Anderson TR, Andrew RD. Spreading depression: imaging and blockade in the rat neocortical brain slice. J Neurophysiol. 2002;88:2713-2725.
28. Lauritzen M, Rice ME, Okada Y, Nicholson C. Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum. Brain Res. 1988;475:317-327.