An Old NSAID Revisited: Crystal Structure of Aldose Reductase in Complex with Sulindac at 1.0 Å Supports a Novel Mechanism for its Anticancer and Antiproliferative Effects

ChemMedChem

Volumn 6, Issue 12, 2011, Pages 2155-2157

  Steuber, Holger ^a  

^a PROTEROS BIOSTRUCTURES GMBH   (Germany)

Author keywords

Aldose reductase; Antitumor agents; Crystal structures; Enzyme inhibition; Sulindac

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HISTONE; IDD 388; LEUCINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN KINASE C; RANIBIZUMAB; SULINDAC; SULINDAC SULFIDE; SULINDAC SULFONE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; WNT PROTEIN; ZOPOLRESTAT;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; OXIDATIVE STRESS; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ALDEHYDE REDUCTASE; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL PROLIFERATION; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; ENZYME INHIBITORS; HUMANS; PROTEIN STRUCTURE, TERTIARY; SULINDAC;

EID: 82955186898     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100374     Document Type: Article

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