The coronary artery disease-associated 9p21 variant and later life 20-Year survival to cohort extinction

Circulation: Cardiovascular Genetics

Volumn 4, Issue 5, 2011, Pages 542-548

  Dutta, Ambarish ^a,e   Henley, William ^a,e   Lang, Iain A ^a,e   Murray, Anna ^b,e   Guralnik, Jack ^c,e   Wallace, Robert B ^d,e   Melzer, David ^a,e,f  

^a Epidemiology and Public Health Group   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d Centre on Aging   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f PENINSULA MEDICAL SCHOOL   (United Kingdom)

Author keywords

Coronary artery disease; Framingham Risk Score; Genetic variation; Myocardial infarction; Survival

Indexed keywords

AGED; ALLELE; ARTICLE; CHROMOSOME 9P; CORONARY ARTERY DISEASE; DEATH CERTIFICATE; DISEASE CLASSIFICATION; DNA DETERMINATION; FEMALE; FRAMINGHAM RISK SCORE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE; SURVIVAL RATE;

AGED; AGED, 80 AND OVER; ALLELES; CHROMOSOMES, HUMAN, PAIR 9; COHORT STUDIES; CORONARY ARTERY DISEASE; GENETIC VARIATION; HETEROZYGOTE; HOMOZYGOTE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 82955173735     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.111.960146     Document Type: Article

References (33)

1. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H; WTCCC and the Cardiogenics Consortium. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007;357:443-453. (Pubitemid 47204873)
2. Schunkert H, Götz A, Braund P, McGinnis R, Tregouet DA, Mangino M, Linsel-Nitschke P, Cambien F, Hengstenberg C, Stark K, Blankenberg S, Tiret L, Ducimetiere P, Keniry A, Ghori MJ, Schreiber S, El Mokhtari NE, Hall AS, Dixon RJ, Goodall AH, Liptau H, Pollard H, Schwarz DF, Hothorn LA, Wichmann HE, König IR, Fischer M, Meisinger C, Ouwehand W, Deloukas P, Thompson JR, Erdmann J, Ziegler A, Samani NJ, Consortium C. Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation. 2008;117:1675-1684. (Pubitemid 351482592)
3. Samani NJ, Schunkert H. Chromosome 9p21 and cardiovascular disease: the story unfolds. Circ Cardiovasc Genet. 2008;1:81-84.
4. Shen GQ, Li L, Rao S, Abdullah KG, Ban JM, Lee BS, Park JE, Wang QK. Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. Arterioscler Thromb Vasc Biol. 2008; 28:360-365. (Pubitemid 351161212)
5. Bown MJ, Braund PS, Thompson J, London NJM, Samani NJ, Sayers RD. Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm. Circ Cardiovasc Genet. 2008;1:39-42.
6. Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, Rice N, Henley W, Frayling TM, Murray A, Melzer D. The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet. 2009;2:347-353.
7. Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, Ren B, Fu XD, Topol E, Rosenfeld MG, Frazer KA. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011;470:264-268.
8. Broadbent HM, Peden JF, Lorkowski S, Goel A, Ongen H, Green F, Clarke R, Collins R, Franzosi MG, Tognoni G, Seedorf U, Rust S, Eriksson P, Hamsten A, Farrall M, Watkins H. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the anril locus on chromosome 9p. Hum Mol Genet. 2008;17:806-814. (Pubitemid 351359697)
9. Newton-Cheh C, Cook NR, VanDenburgh M, Rimm EB, Ridker PM, Albert CM. A common variant at 9p21 is associated with sudden and arrhythmic cardiac death. Circulation. 2009;120:2062-2068.
10. Buysschaert I, Carruthers KF, Dunbar DR, Peuteman G, Rietzschel E, Belmans A, Hedley A, De Meyer T, Budaj A, Van de Werf F, Lambrechts D, Fox KAA. A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the grace genetics study. Eur Heart J. 2010;31:1132-1141.
11. Zdravkovic S, Wienke A, Pedersen NL, Marenberg ME, Yashin AI, De Faire U. Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins. J Intern Med. 2002;252:247-254.
12. Meng W, Hughes AE, Patterson CC, Belton C, Kee F, McKeown PP. Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population. Dis Markers. 2008;25:81- 85.
13. Emanuele E, Fontana JM, Minoretti P, Geroldi D. Preliminary evidence of a genetic association between chromosome 9p21.3 and human longevity. Rejuvenation Res. 2010;13:23-26.
14. Palomaki GE, Melillo S, Bradley LA. Association between 9p21 genomic markers and heart disease: a meta-analysis. JAMA. 2010;303:648-656.
15. Cornoni-Huntley J, Ostfeld AM, Taylor JO, Wallace RB, Blazer D, Berkman LF, Evans DA, Kohout FJ, Lemke JH, Scherr PA. Established populations for epidemiologic studies of the elderly: study design and methodology. Aging (Milano). 1993;5:27-37. (Pubitemid 23117907)
16. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837-1847. (Pubitemid 28213628)
17. Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J Am Coll Cardiol. 2008;52:378-384. (Pubitemid 352001349)
18. McPherson R, Pertsemlidis A, Kavaslar N, Stewart AFR, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488-1491. (Pubitemid 46906617)
19. Ellis KL, Pilbrow AP, Frampton CM, Doughty RN, Whalley GA, Ellis CJ, Palmer BR, Skelton L, Yandle TG, Palmer SC, Troughton RW, Richards AM, Cameron VA. A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circ Cardiovasc Genet. 2010;3:286-293.
20. Brautbar A, Ballantyne CM, Lawson K, Nambi V, Chambless L, Folsom AR, Willerson JT, Boerwinkle E. Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities study. Circ Cardiovasc Genet. 2009;2: 279-285.
21. Anderson JL, Horne BD, Kolek MJ, Muhlestein JB, Mower CP, Park JJ, May HT, Camp NJ, Carlquist JF. Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility. Am Heart J. 2008;156:1155-1162.e1152.
22. Talmud PJ, Cooper JA, Palmen J, Lovering R, Drenos F, Hingorani AD, Humphries SE. Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men. Clin Chem. 2008;54:467-474. (Pubitemid 351348157)
23. Störk S, Feelders RA, van den Beld AW, Steyerberg EW, Savelkoul HF, Lamberts SW, Grobbee DE, Bots ML. Prediction of mortality risk in the elderly. Am J Med. 2006;119:519-525. (Pubitemid 43795183)
24. Mega JL, Iakoubova OA, Devlin JJ, Qin J, Cannon CP, Braunwald E, Sabatine MS. 9p21 Genetic variant and benefit from intensive statin therapy after an acute coronary syndrome. Circulation. 2009;120: S1144-b.
25. Mangin D. All people over 75 years with a five-year CVD risk of ≥15% should be treated with statins unless specifically contraindicated: no. J Prim Health Care. 2010;2:333-335.
26. Wells S. All people over 75 years with a five-year CVD risk of ≥15% should be treated with statins unless specifically contraindicated: yes. J Prim Health Care. 2010;2:330-332.
27. Johansen CT, Hegele RA. Predictive genetic testing for coronary artery disease. Crit Rev Clin Lab Sci. 2009;46:343-360.
28. Smith JG, Melander O, Lovkvist H, Hedblad B, Engstrom G, Nilsson P, Carlson J, Berglund G, Norrving B, Lindgren A. Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study. Circ Cardiovasc Genet. 2009;2: 159-164.
29. Gschwendtner A, Bevan S, Cole JW, Plourde A, Matarin M, Ross-Adams H, Meitinger T, Wichmann E, Mitchell BD, Furie K, Slowik A, Rich SS, Syme PD, MacLeod MJ, Meschia JF, Rosand J, Kittner SJ, Markus HS, Müller-Myhsok B, Dichgans M, Consortium ISG. Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke. Ann Neurol. 2009;65:531-539.
30. Plant SR, Samsa GP, Shah SH, Goldstein LB. Exploration of a hypothesized independent association of a common 9p21.3 gene variant and ischemic stroke in patients with and without angiographic coronary artery disease. Cerebrovasc Dis. 2011;31:117-122.
31. Anderson CD, Biffi A, Rost NS, Cortellini L, Furie KL, Rosand J. Chromosome 9p21 in ischemic stroke: population structure and meta-analysis. Stroke. 2010;41:1123-1131.
32. Coady SA, Sorlie PD, Cooper LS, Folsom AR, Rosamond WD, Conwill DE. Validation of death certificate diagnosis for coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. J Clin Epidemiol. 2001;54:40-50. (Pubitemid 32106973)
33. Jurek AM, Greenland S, Maldonado G, Church TR. Proper interpretation of non-differential misclassification effects: expectations vs observations. Int J Epidemiol. 2005;34:680-687. (Pubitemid 40852588)