Severity and outcome of acute stroke in women: Relation to adrenal sex steroid levels

Metabolism: Clinical and Experimental

Volumn 61, Issue 1, 2012, Pages 84-91

  Pappa, Theodora ^a   Vemmos, Konstantinos ^a   Saltiki, Katerina ^a   Mantzou, Emilia ^a   Stamatelopoulos, Kimon ^a   Alevizaki, Maria ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; PRASTERONE SULFATE;

ACUTE STROKE; AGED; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; COMPUTER ASSISTED TOMOGRAPHY; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISABILITY; DISEASE SEVERITY; FEMALE; HEART ATRIUM FIBRILLATION; HORMONE DETERMINATION; HOSPITALIZATION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MORTALITY; NEUROIMAGING; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTMENOPAUSE; PRIORITY JOURNAL; PROGNOSIS; RANKIN SCALE; RISK ASSESSMENT; SMOKING; STROKE; WAIST HIP RATIO;

ADRENAL GLANDS; AGED; ANDROSTENEDIONE; COHORT STUDIES; CONFIDENCE INTERVALS; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; FOLLOW-UP STUDIES; GONADAL STEROID HORMONES; HOSPITALIZATION; HUMANS; LOGISTIC MODELS; MULTIVARIATE ANALYSIS; ODDS RATIO; OUTCOME ASSESSMENT (HEALTH CARE); POSTMENOPAUSE; PROGNOSIS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STROKE;

EID: 82955162697     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.06.003     Document Type: Conference Paper

References (62)

1. W.L. Miller, and R.J. Auchus The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders Endocr Rev 32 2011 81 151
2. N. Orentreich, J.L. Brind, and R.L. Rizer Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood J Clin Endocrinol Metab 59 1984 551 555 (Pubitemid 14031806)
3. G.A. Laughlin, and E. Barrett-Connor Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study J Clin Endocrinol Metab 85 2000 3561 3568
4. C.H. Liu, G.A. Laughlin, and U.G. Fischer Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20-desmolase enzymatic activity J Clin Endocrinol Metab 71 1990 900 906
5. C.R. Parker Jr, R.L. Mixon, and R.M. Brissie Aging alters zonation in the adrenal cortex of men J Clin Endocrinol Metab 82 1997 3898 3901 (Pubitemid 27509391)
6. J.L. Sanders, R.M. Boudreau, and A.R. Cappola Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study J Am Geriatr Soc 58 2010 421 426
7. M. Fukui, H. Ose, and Y. Kitagawa Relationship between low serum endogenous androgen concentrations and arterial stiffness in men with type 2 diabetes mellitus Metabolism 56 2007 1167 1173 (Pubitemid 47223255)
8. G.P. Bernini, M. Sgro', and A. Moretti Endogenous androgens and carotid intimal-medial thickness in women J Clin Endocrinol Metab 84 1999 2008 2012 (Pubitemid 30647026)
9. A. Vryonidou, A. Papatheodorou, and A. Tavridou Association of hyperandrogenemic and metabolic phenotype with carotid intima-media thickness in young women with polycystic ovary syndrome J Clin Endocrinol Metab 90 2005 2740 2746 (Pubitemid 40686318)
10. A. Dagre, J. Lekakis, and C. Mihas Association of dehydroepiandrosterone- sulfate with endothelial function in young women with polycystic ovary syndrome Eur J Endocrinol 154 2006 883 890 (Pubitemid 43997728)
11. S. Yoshida, K. Aihara, and H. Azuma Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function Atherosclerosis 212 2010 310 315
12. M. Luque-Ramírez, C. Mendieta-Azcona, and F. Alvarez-Blasco Androgen excess is associated with the increased carotid intima-media thickness observed in young women with polycystic ovary syndrome Hum Reprod 22 2007 3197 3203 (Pubitemid 351696785)
13. M. Szathmári, A. Treszl, and B. Vásárhelyi Left ventricular mass index and ventricular septum thickness are associated with serum dehydroepiandrosterone-sulphate levels in hypertensive women Clin Endocrinol (Oxf) 59 2003 110 114 (Pubitemid 36774116)
14. Y. Moriyama, H. Yasue, and M. Yoshimura The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity J Clin Endocrinol Metab 85 2000 1834 1840 (Pubitemid 32269285)
15. A.E. Hak, J.C. Witteman, and F.H. de Jong Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study J Clin Endocrinol Metab 87 2002 3632 3639 (Pubitemid 34879505)
16. E. Debing, E. Peeters, and W. Duquet Endogenous sex hormone levels in postmenopausal women undergoing carotid artery endarterectomy Eur J Endocrinol 156 2007 687 693 (Pubitemid 46952539)
17. A. Khatibi, C.D. Agardh, and Y.A. Shakir Could androgens protect middle-aged women from cardiovascular events? A population-based study of Swedish women: The Women's Health in the Lund Area (WHILA) Study Climacteric 10 2007 386 392 (Pubitemid 47402940)
18. F. Iellamo, M. Volterrani, and G. Caminiti Testosterone therapy in women with chronic heart failure: a pilot double-blind, randomized, placebo-controlled study J Am Coll Cardiol 56 2010 1310 1316
19. W. Rosamond, K. Flegal, and G. Friday Heart disease and stroke statistics-2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation 115 2007 e69 e171
20. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI) Arch Intern Med 157 1997 2413 2446
21. World Health Organisation Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. Part 1. Diabetes mellitus-diagnosis 2006 World Health Organisation/ International Diabetes Federation Geneva
22. Third report of the National Cholesterol Education Program(NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report Circulation 106 2002 3143
23. S. Hatano Experience from a multicentre stroke register: a preliminary report Bull World Health Organisation 54 1976 541 553 (Pubitemid 8114220)
24. T. Brott, H.P. Adams Jr, and C.P. Olinger Measurements of acute cerebral infarction: a clinical examination scale Stroke 20 1989 864 870 (Pubitemid 19188240)
25. J. Rankin Cerebral vascular accidents in patient over the age of 60. II. Prognosis Scott Med J 2 1957 200 215
26. European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee Guidelines for management of ischaemic stroke and transient ischaemic attack 2008 Cerebrovasc Dis 25 2008 457 507
27. E. Barrett-Connor, and D. Goodman-Gruen Dehydroepiandrosterone sulfate does not predict cardiovascular death in postmenopausal women. The Rancho Bernardo Study Circulation 91 1995 1757 1760
28. A.P. Van Beek, F.C. de Ruijter-Heijstek, and H. Jansen Sex steroids and plasma lipoprotein levels in healthy women: the importance of androgens in the estrogen-deficient state Metabolism 53 2004 187 192 (Pubitemid 38168890)
29. M.T. Korytkowski, E.I. Krug, and M.A. Daly Does androgen excess contribute to the cardiovascular risk profile in postmenopausal women with type 2 diabetes? Metabolism 54 2005 1626 1631 (Pubitemid 41728155)
30. M.E. Weinberg, J.E. Manson, and J.E. Buring Bottom of form low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women Metabolism 55 2006 1473 1480 (Pubitemid 44537344)
31. Y.M. Rolland, H.M. Perry 3rd, and P. Patrick Leptin and adiponectin levels in middle-aged postmenopausal women: associations with lifestyle habits, hormones, and inflammatory markers-a cross-sectional study Metabolism 55 2006 1630 1636 (Pubitemid 44834406)
32. M.A. Maturana, V. Breda, and F. Lhullier Relationship between endogenous testosterone and cardiovascular risk in early postmenopausal women Metabolism 57 2008 961 965 (Pubitemid 351814689)
33. G.B. Phillips, T. Jing, and S.B. Heymsfield Does insulin resistance, visceral adiposity, or a sex hormone alteration underlie the metabolic syndrome? Studies in women Metabolism 57 2008 838 844 (Pubitemid 351697914)
34. G.S. Merki-Feld, B. Imthurn, and M. Rosselli Serum concentrations of high-molecular weight adiponectin and their association with sex steroids in premenopausal women Metabolism 60 2011 180 185
35. E. Barrett-Connor, and D. Goodman-Gruen Prospective study of endogenous sex hormones and fatal cardiovascular disease in postmenopausal women BMJ 311 1995 1193 1196
36. C. Sievers, J. Klotsche, and L. Pieper Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients Eur J Endocrinol 163 2010 699 708
37. T. Naessen, U. Sjogren, and J. Bergquist Endogenous steroids measured by high-specificity liquid chromatography-tandem mass spectrometry and prevalent cardiovascular disease in 70-year-old men and women J Clin Endocrinol Metab 95 2010 1889 1897
38. L.J. Shaw, C.N. Bairey Merz, and R. Azziz Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health-National Heart, Lung, and Blood Institute sponsored Women's Ischemia Syndrome Evaluation J Clin Endocrinol Metab 93 2008 1276 1284 (Pubitemid 351519721)
39. N.J. Alkayed, I. Harukuni, and A.S. Kimes Gender-linked brain injury in experimental stroke Stroke 29 1998 159 165
40. D.N. Krause, S.P. Duckles, and D.A. Pelligrino Influence of sex steroid hormones on cerebrovascular function J Appl Physiol 101 2006 1252 1261 (Pubitemid 44497571)
41. L.D. McCullough, K. Blizzard, and E.R. Simpson Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection J Neurosci 23 2003 8701 8705 (Pubitemid 37176650)
42. E. Barrett-Connor, K.T. Khaw, and S.S. Yen A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease N Engl J Med 315 1986 1519 1524 (Pubitemid 17052150)
43. A.Z. LaCroix, K. Yano, and D.M. Reed Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men Circulation 86 1992 1529 1535
44. D.P. Trivedi, and K.T. Khaw Dehydroepiandrosterone sulfate and mortality in elderly men and women J Clin Endocrinol Metab 86 2001 4171 4177 (Pubitemid 32848531)
45. A. Philips, D. Carroll, and C. Gale Cortisol, dehydroepiandrosterone sulphate, their ratio and all-cause and cause-specific mortality in the Vietnam Experience Study Eur J Endocrinol 163 2010 285 292
46. C. Ohlsson, F. Labrie, and E. Barrett-Connor Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men J Clin Endocrinol Metab 95 2010 4406 4414
47. A.R. Cappola, Q.L. Xue, and J.D. Walston DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I J Gerontol A Biol Sci Med Sci 61 2006 957 962 (Pubitemid 44413935)
48. C. Shufelt, P. Bretsky, and C.M. Almeida DHEA-S levels and cardiovascular disease mortality in postmenopausal women: results from the National Institutes of Health-National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE) J Clin Endocrinol Metab 95 2010 4985 4992
49. M. Enomoto, H. Adachi, and A. Fukami Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow-up study in a community-based cohort (Tanushimaru study) J Am Geriatr Soc 56 2008 994 998 (Pubitemid 351782716)
50. H. Kawano, H. Yasue, and A. Kitagawa Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men J Clin Endocrinol Metab 88 2003 3190 3195 (Pubitemid 36877493)
51. W. Arlt, F. Callies, and J.C. van Vlijmen Dehydroepiandrosterone replacement in women with adrenal insufficiency N Engl J Med 341 1999 1013 1020 (Pubitemid 29451796)
52. P.J. Hunt, E.M. Gurnell, and F.A. Huppert Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial J Clin Endocrinol Metab 85 2000 4650 4656 (Pubitemid 32157648)
53. R.S. Boxer, A. Kleppinger, and J. Brindisi Effects of dehydroepiandrosterone (DHEA) on cardiovascular risk factors in older women with frailty characteristics Age Ageing 39 2010 451 458
54. T. Simoncini, P. Mannella, and L. Fornari Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms Endocrinology 144 2003 3449 3455 (Pubitemid 36904421)
55. D. Liu, H. Si, and K.A. Reynolds Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression Endocrinology 148 2007 3068 3076 (Pubitemid 46996987)
56. P.A. Lapchak, D.F. Chapman, and S.Y. Nunez Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors Stroke 31 2000 1953 1956
57. N.A. Compagnone, and S.H. Mellon Neurosteroids: biosynthesis and function of these novel neuromodulators Front Neuroendocrinol 21 2000 1 56 (Pubitemid 30105920)
58. V.G. Kimonides, N.H. Khatibi, and C.N. Svendsen Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity Proc Natl Acad Sci USA 95 1998 1852 1857 (Pubitemid 28103483)
59. G. Apostolova, R.A. Schweizer, and Z. Balazs Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue Am J Physiol Endocrinol Metab 288 2005 E957 964
60. H. Li, G. Klein, and P. Sun Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia Brain Res 888 2001 263 266 (Pubitemid 32058791)
61. Z. Li, S. Cui, and Z. Zhang DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats J Cereb Blood Flow Metab 29 2009 287 296
62. N. Marklund, M. Peltonen, and T.K. Nilsson Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke J Intern Med 256 2004 15 21 (Pubitemid 38813615)