-
1
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial
-
G.D. Demetri, A.T. van Oosterom, C.R. Garrett, M.E. Blackstein, M.H. Shah, J. Verweij, G. McArthur, I.R. Judson, M.C. Heinrich, J.A. Morgan, J. Desai, C.D. Fletcher, S. George, C.L. Bello, X. Huang, C.M. Baum, and P.G. Casali. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368: 1329-1338 (2006).
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garrett, C.R.3
Blackstein, M.E.4
Shah, M.H.5
Verweij, J.6
McArthur, G.7
Judson, I.R.8
Heinrich, M.C.9
Morgan, J.A.10
Desai, J.11
Fletcher, C.D.12
George, S.13
Bello, C.L.14
Huang, X.15
Baum, C.M.16
Casali, P.G.17
-
2
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
R.J. Motzer, M.D. Michaelson, B.G. Redman, G.R. Hudes, G. Wilding, R.A. Figlin, M.S. Ginsberg, S.T. Kim, C.M. Baum, S.E. DePrimo, J.Z. Li, C.L. Bello, C.P. Theuer, D.J. George, and B.I. Rini. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24: 16-24 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
Ginsberg, M.S.7
Kim, S.T.8
Baum, C.M.9
DePrimo, S.E.10
Li, J.Z.11
Bello, C.L.12
Theuer, C.P.13
George, D.J.14
Rini, B.I.15
-
3
-
-
77953033291
-
Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis
-
B.E. Houk, C.L. Bello, B. Poland, L.S. Rosen, G.D. Demetri, and R.J. Motzer. Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis. Cancer Chemother. Pharmacol. 66: 357-371 (2010).
-
(2010)
Cancer Chemother. Pharmacol.
, vol.66
, pp. 357-371
-
-
Houk, B.E.1
Bello, C.L.2
Poland, B.3
Rosen, L.S.4
Demetri, G.D.5
Motzer, R.J.6
-
4
-
-
2442669093
-
Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer
-
T.J. Abrams, L.J. Murray, E. Pesenti, V.W. Holway, T. Colombo, L.B. Lee, J.M. Cherrington, and N.K. Pryer. Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer. Mol. Cancer Ther. 2: 1011-1021 (2003).
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 1011-1021
-
-
Abrams, T.J.1
Murray, L.J.2
Pesenti, E.3
Holway, V.W.4
Colombo, T.5
Lee, L.B.6
Cherrington, J.M.7
Pryer, N.K.8
-
5
-
-
78650874372
-
SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
-
T.J. Abrams, L.B. Lee, L.J. Murray, N.K. Pryer, and J.M. Cherrington. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol. Cancer Ther. 2: 471-478 (2003).
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 471-478
-
-
Abrams, T.J.1
Lee, L.B.2
Murray, L.J.3
Pryer, N.K.4
Cherrington, J.M.5
-
6
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
S. Faivre, C. Delbaldo, K. Vera, C. Robert, S. Lozahic, N. Lassau, C. Bello, S. Deprimo, N. Brega, G. Massimini, J.P. Armand, P. Scigalla, and E. Raymond. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J. Clin. Oncol. 24: 25-35 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
Robert, C.4
Lozahic, S.5
Lassau, N.6
Bello, C.7
Deprimo, S.8
Brega, N.9
Massimini, G.10
Armand, J.P.11
Scigalla, P.12
Raymond, E.13
-
7
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
-
D.B. Mendel, A.D. Laird, X. Xin, S.G. Louie, J.G. Christensen, G. Li, R.E. Schreck, T.J. Abrams, T.J. Ngai, L.B. Lee, L.J. Murray, J. Carver, E. Chan, K.G. Moss, J.O. Haznedar, J. Sukbuntherng, R.A. Blake, L. Sun, C. Tang, T. Miller, S. Shirazian, G. McMahon, and J.M. Cherrington. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. 9: 327-337 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
8
-
-
9144274970
-
SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model
-
L.J. Murray, T.J. Abrams, K.R. Long, T.J. Ngai, L.M. Olson, W. Hong, P.K. Keast, J.A. Brassard, A.M. O'Farrell, J.M. Cherrington, and N.K. Pryer. SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model. Clin. Exp. Metastasis 20: 757-766 (2003).
-
(2003)
Clin. Exp. Metastasis
, vol.20
, pp. 757-766
-
-
Murray, L.J.1
Abrams, T.J.2
Long, K.R.3
Ngai, T.J.4
Olson, L.M.5
Hong, W.6
Keast, P.K.7
Brassard, J.A.8
O'Farrell, A.M.9
Cherrington, J.M.10
Pryer, N.K.11
-
9
-
-
44449171930
-
Dermatological reactions to the multitargeted tyrosine kinase inhibitor sunitinib
-
S.E. Rosenbaum, S. Wu, M.A. Newman, D.P. West, T. Kuzel, and M.E. Lacouture. Dermatological reactions to the multitargeted tyrosine kinase inhibitor sunitinib. Support. Care Cancer 16: 557-566 (2008).
-
(2008)
Support. Care Cancer
, vol.16
, pp. 557-566
-
-
Rosenbaum, S.E.1
Wu, S.2
Newman, M.A.3
West, D.P.4
Kuzel, T.5
Lacouture, M.E.6
-
10
-
-
65249140606
-
Risk of hand-foot skin reaction with the multitargeted kinase inhibitor sunitinib in patients with renal cell and non-renal cell carcinoma: a metaanalysis
-
D. Chu, M.E. Lacouture, E. Weiner, and S. Wu. Risk of hand-foot skin reaction with the multitargeted kinase inhibitor sunitinib in patients with renal cell and non-renal cell carcinoma: a metaanalysis. Clin. Genitourin. Cancer 7: 11-19 (2009).
-
(2009)
Clin. Genitourin. Cancer
, vol.7
, pp. 11-19
-
-
Chu, D.1
Lacouture, M.E.2
Weiner, E.3
Wu, S.4
-
11
-
-
52949128348
-
Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib
-
M.E. Lacouture, S. Wu, C. Robert, M.B. Atkins, H.H. Kong, J. Guitart, C. Garbe, A. Hauschild, I. Puzanov, D.T. Alexandrescu, R.T. Anderson, L. Wood, and J.P. Dutcher. Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib. Oncologist 13: 1001-1011 (2008).
-
(2008)
Oncologist
, vol.13
, pp. 1001-1011
-
-
Lacouture, M.E.1
Wu, S.2
Robert, C.3
Atkins, M.B.4
Kong, H.H.5
Guitart, J.6
Garbe, C.7
Hauschild, A.8
Puzanov, I.9
Alexandrescu, D.T.10
Anderson, R.T.11
Wood, L.12
Dutcher, J.P.13
-
12
-
-
52949138886
-
Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib
-
M.E. Lacouture, L.M. Reilly, P. Gerami, and J. Guitart. Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib. Ann. Oncol. 19: 1955-1961 (2008).
-
(2008)
Ann. Oncol.
, vol.19
, pp. 1955-1961
-
-
Lacouture, M.E.1
Reilly, L.M.2
Gerami, P.3
Guitart, J.4
-
13
-
-
25444472043
-
Release of doxorubicin in sweat: first step to induce the palmar-plantar erythrodysesthesia syndrome?
-
U. Jacobi, E. Waibler, P. Schulze, J. Sehouli, G. Oskay-Ozcelik, T. Schmook, W. Sterry, and J. Lademann. Release of doxorubicin in sweat: first step to induce the palmar-plantar erythrodysesthesia syndrome? Ann. Oncol. 16: 1210-1211 (2005).
-
(2005)
Ann. Oncol.
, vol.16
, pp. 1210-1211
-
-
Jacobi, U.1
Waibler, E.2
Schulze, P.3
Sehouli, J.4
Oskay-Ozcelik, G.5
Schmook, T.6
Sterry, W.7
Lademann, J.8
-
14
-
-
70449647041
-
Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): focus on sorafenib and sunitinib
-
A.D. Lipworth, C. Robert, and A.X. Zhu. Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): focus on sorafenib and sunitinib. Oncology 77: 257-271 (2009).
-
(2009)
Oncology
, vol.77
, pp. 257-271
-
-
Lipworth, A.D.1
Robert, C.2
Zhu, A.X.3
-
15
-
-
0033915736
-
Techniques for analytical testing of unconventional samples
-
L. Rivier. Techniques for analytical testing of unconventional samples. Baillieres Best Pract. Res. Clin. Endocrinol. Metab. 14(1): 147-165 (2000).
-
(2000)
Baillieres Best Pract. Res. Clin. Endocrinol. Metab.
, vol.14
, Issue.1
, pp. 147-165
-
-
Rivier, L.1
-
16
-
-
0003484310
-
-
U.S. Food and Drug Administration: Centre for Drug Evaluation an Research. accessed January
-
U.S. Food and Drug Administration: Centre for Drug Evaluation an Research. Guidance for Industry: Bioanalytical Method Validation. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070107.pdf (accessed January 2011).
-
(2011)
Guidance for Industry: Bioanalytical Method Validation
-
-
-
17
-
-
34548550429
-
Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays
-
C.T. Viswanathan, S. Bansal, B. Booth, A.J. DeStefano, M.J. Rose, J. Sailstad, V.P. Shah, J.P. Skelly, P.G. Swann, and R. Weiner. Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays. Pharm. Res. 24: 1962-1973 (2007).
-
(2007)
Pharm. Res.
, vol.24
, pp. 1962-1973
-
-
Viswanathan, C.T.1
Bansal, S.2
Booth, B.3
DeStefano, A.J.4
Rose, M.J.5
Sailstad, J.6
Shah, V.P.7
Skelly, J.P.8
Swann, P.G.9
Weiner, R.10
-
19
-
-
59049090776
-
Liquid chromatography-electrospray ionization mass spectrometry determination of methylphenidate and ritalinic acid in conventional and non-conventional biological matrices
-
E. Marchei, M. Farrè, M. Pellegrini, S. Rossi, O. García-Algar, O. Vall, and S. Pichini. Liquid chromatography-electrospray ionization mass spectrometry determination of methylphenidate and ritalinic acid in conventional and non-conventional biological matrices. J. Pharm. Biomed. Anal. 49: 434-439 (2009).
-
(2009)
J. Pharm. Biomed. Anal.
, vol.49
, pp. 434-439
-
-
Marchei, E.1
Farrè, M.2
Pellegrini, M.3
Rossi, S.4
García-Algar, O.5
Vall, O.6
Pichini, S.7
-
20
-
-
41749111102
-
Determination of fentanyl in sweat and hair of a patient using transdermal patches
-
S. Schneider, Z. Ait-m-bark, C. Schummer, P. Lemmer, M. Yegles, B. Appenzeller, and R. Wennig. Determination of fentanyl in sweat and hair of a patient using transdermal patches. J. Anal. Toxicol. 32: 260-264 (2008).
-
(2008)
J. Anal. Toxicol.
, vol.32
, pp. 260-264
-
-
Schneider, S.1
Ait-m-bark, Z.2
Schummer, C.3
Lemmer, P.4
Yegles, M.5
Appenzeller, B.6
Wennig, R.7
-
21
-
-
67649199034
-
Therapeutic drug monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry
-
A. Haouala, B. Zanolari, B. Rochat, M. Montemurro, K. Zaman, M.A. Duchosal, H.B. Ris, S. Leyvraz, N. Widmer, and L.A. Decosterd. Therapeutic drug monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877: 1982-1996 (2009).
-
(2009)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.877
, pp. 1982-1996
-
-
Haouala, A.1
Zanolari, B.2
Rochat, B.3
Montemurro, M.4
Zaman, K.5
Duchosal, M.A.6
Ris, H.B.7
Leyvraz, S.8
Widmer, N.9
Decosterd, L.A.10
-
22
-
-
28744454447
-
Reversible Z-E isomerism and pharmaceutical implications for SU5416
-
A. Sistla and N. Shenoy. Reversible Z-E isomerism and pharmaceutical implications for SU5416. Drug Dev. Ind. Pharm. 31: 1001-1007 (2005).
-
(2005)
Drug Dev. Ind. Pharm.
, vol.31
, pp. 1001-1007
-
-
Sistla, A.1
Shenoy, N.2
-
23
-
-
70849085455
-
Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma
-
R.W. Sparidans, D. Iusuf, A.H. Schinkel, J.H. Schellens, and J.H. Beijnen. Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877: 4090-4096 (2009).
-
(2009)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.877
, pp. 4090-4096
-
-
Sparidans, R.W.1
Iusuf, D.2
Schinkel, A.H.3
Schellens, J.H.4
Beijnen, J.H.5
-
24
-
-
37249072373
-
A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period
-
C.D. Britten, F. Kabbinavar, J.R. Hecht, C.L. Bello, J. Li, C. Baum, and D. Slamon. A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period. Cancer Chemother. Pharmacol. 61: 515-524 (2008).
-
(2008)
Cancer Chemother. Pharmacol.
, vol.61
, pp. 515-524
-
-
Britten, C.D.1
Kabbinavar, F.2
Hecht, J.R.3
Bello, C.L.4
Li, J.5
Baum, C.6
Slamon, D.7
|