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Volumn 392, Issue 1, 2011, Pages 335-342

Surface modification of poly(lactide-co-glycolide) nanoparticles by d-α-tocopheryl polyethylene glycol 1000 succinate as potential carrier for the delivery of drugs to the brain

Author keywords

Brain; Carrier; Drug delivery; PLGA nanoparticles; Surface modification; Vitamin E TPGS

Indexed keywords

BRAIN; CELL CULTURE; DRUG DELIVERY; EMULSIFICATION; GLYCOLS; MORPHOLOGY; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENES; SURFACE TREATMENT; THERMOPLASTICS;

EID: 82855161260     PISSN: 09277757     EISSN: 18734359     Source Type: Journal    
DOI: 10.1016/j.colsurfa.2011.10.012     Document Type: Article
Times cited : (35)

References (56)
  • 1
    • 0030099527 scopus 로고    scopus 로고
    • Transporting therapeutics across the blood-brain barrier
    • Abbott N.J., Romero I.A. Transporting therapeutics across the blood-brain barrier. Mol. Med. Today 1996, 2:106-113.
    • (1996) Mol. Med. Today , vol.2 , pp. 106-113
    • Abbott, N.J.1    Romero, I.A.2
  • 2
    • 33646450620 scopus 로고    scopus 로고
    • Physiology of the blood-brain barrier and its consequences for drug transport to the brain
    • Abbott J. Physiology of the blood-brain barrier and its consequences for drug transport to the brain. Int. Congr. Ser. 2005, 277:3-18.
    • (2005) Int. Congr. Ser. , vol.277 , pp. 3-18
    • Abbott, J.1
  • 3
    • 33845784758 scopus 로고    scopus 로고
    • Blood-brain barrier delivery
    • Pardridge W.M. Blood-brain barrier delivery. Drug Discov. Today 2007, 129(1-2):54-61.
    • (2007) Drug Discov. Today , vol.129 , Issue.1-2 , pp. 54-61
    • Pardridge, W.M.1
  • 4
    • 27744599588 scopus 로고    scopus 로고
    • Targeted Nanoparticles for drug delivery through the blood-brain barrier for Alzheimer's disease
    • Roney C., Kulkarni P., Arora V., Antich P., Bonte F., Wu A., et al. Targeted Nanoparticles for drug delivery through the blood-brain barrier for Alzheimer's disease. J. Control. Release 2005, 108(2-3):193-214.
    • (2005) J. Control. Release , vol.108 , Issue.2-3 , pp. 193-214
    • Roney, C.1    Kulkarni, P.2    Arora, V.3    Antich, P.4    Bonte, F.5    Wu, A.6
  • 5
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 2001, 47(1):65-81.
    • (2001) Adv. Drug Deliv. Rev. , vol.47 , Issue.1 , pp. 65-81
    • Kreuter, J.1
  • 6
    • 70649114473 scopus 로고    scopus 로고
    • Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain
    • Zhao H.W., Zhan Y.W., Chang S.S., Chun Y.W., Tong Y.J., Si L.W. Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain. Biomaterials 2010, 31:908-915.
    • (2010) Biomaterials , vol.31 , pp. 908-915
    • Zhao, H.W.1    Zhan, Y.W.2    Chang, S.S.3    Chun, Y.W.4    Tong, Y.J.5    Si, L.W.6
  • 7
    • 0037161315 scopus 로고    scopus 로고
    • Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxolò)
    • Mu L., Feng S.S. Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxolò). J. Control. Release 2002, 80:129-144.
    • (2002) J. Control. Release , vol.80 , pp. 129-144
    • Mu, L.1    Feng, S.S.2
  • 9
    • 27744488445 scopus 로고    scopus 로고
    • Development of a novel formulation containing poly(d,l-lactide-co-glycolide) microspheres dispersed in PLGA-PEG-PLGA gel for sustained delivery of ganciclovir
    • Duvvuri S., Janoria K.G., Mitra A.K. Development of a novel formulation containing poly(d,l-lactide-co-glycolide) microspheres dispersed in PLGA-PEG-PLGA gel for sustained delivery of ganciclovir. J. Control. Release 2005, 108:282-293.
    • (2005) J. Control. Release , vol.108 , pp. 282-293
    • Duvvuri, S.1    Janoria, K.G.2    Mitra, A.K.3
  • 11
    • 0032867036 scopus 로고    scopus 로고
    • A method for the preparation of polymeric nanocapsules without stabilizer
    • Lu Z., Bei J.Z., Wang S.G. A method for the preparation of polymeric nanocapsules without stabilizer. J. Control. Release 1999, 61:107-112.
    • (1999) J. Control. Release , vol.61 , pp. 107-112
    • Lu, Z.1    Bei, J.Z.2    Wang, S.G.3
  • 12
    • 85020563030 scopus 로고    scopus 로고
    • Note
    • Eastman Chemical Company, Vitamin E TPGS NF, Properties and applications, Publication EFC-226A, Kingsport, TN, October 1998.
  • 13
    • 0022982286 scopus 로고
    • Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct-cannulated rats
    • Traber M.G., Kayden H.J., Green J.B., Green M.H. Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct-cannulated rats. Am. J. Clin. Nutr. 1986, 44:914-923.
    • (1986) Am. J. Clin. Nutr. , vol.44 , pp. 914-923
    • Traber, M.G.1    Kayden, H.J.2    Green, J.B.3    Green, M.H.4
  • 14
    • 0025880233 scopus 로고
    • Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E
    • Sokol R.J., Johnson K.E., Karrer F.M., Narkewicz M.R., Kam I., et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991, 338:212-215.
    • (1991) Lancet , vol.338 , pp. 212-215
    • Sokol, R.J.1    Johnson, K.E.2    Karrer, F.M.3    Narkewicz, M.R.4    Kam, I.5
  • 15
    • 0025880233 scopus 로고
    • Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E
    • Sokol R.J., Johnson K.E., Karrer F.M., Narkewicz M.R., Kam I., et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991, 338:697.
    • (1991) Lancet , vol.338 , pp. 697
    • Sokol, R.J.1    Johnson, K.E.2    Karrer, F.M.3    Narkewicz, M.R.4    Kam, I.5
  • 16
    • 0026529119 scopus 로고
    • D-alpha-Tocopheryl polyethylene glycol-1000 succinate enhances the absorption of vitamin D in chronic cholestatic liver disease of infancy and childhood
    • Argao E.A., Heubi J.E., Hollis B.W., Tsang R.C. d-alpha-Tocopheryl polyethylene glycol-1000 succinate enhances the absorption of vitamin D in chronic cholestatic liver disease of infancy and childhood. Pediatr. Res. 1992, 31:146-150.
    • (1992) Pediatr. Res. , vol.31 , pp. 146-150
    • Argao, E.A.1    Heubi, J.E.2    Hollis, B.W.3    Tsang, R.C.4
  • 17
    • 0012471457 scopus 로고    scopus 로고
    • Vitamin E-TPGS enhances the absorption of a model HIV protease inhibitor by inhibiting an apically polarized efflux system
    • Bridgers A., Vickers A., Yu L., Silver I., Coffin M. Vitamin E-TPGS enhances the absorption of a model HIV protease inhibitor by inhibiting an apically polarized efflux system. Pharm. Sci. Suppl. 1998, 1(1):S76.
    • (1998) Pharm. Sci. Suppl. , vol.1 , Issue.1
    • Bridgers, A.1    Vickers, A.2    Yu, L.3    Silver, I.4    Coffin, M.5
  • 18
    • 0029925318 scopus 로고    scopus 로고
    • The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers
    • Chang T., Benet L.Z., Hebert M.F. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin. Pharmacol. Ther. 1996, 59:297-303.
    • (1996) Clin. Pharmacol. Ther. , vol.59 , pp. 297-303
    • Chang, T.1    Benet, L.Z.2    Hebert, M.F.3
  • 19
    • 0028360895 scopus 로고
    • Enhancement of cyclosporin A solubility by d-alpha-tocopherylpolyethylene-glycol-1000 succinate (TPGS)
    • Ismailos G., Reppas C., Macheras P. Enhancement of cyclosporin A solubility by d-alpha-tocopherylpolyethylene-glycol-1000 succinate (TPGS). Eur. J. Pharm. Sci. 1994, 1:269-271.
    • (1994) Eur. J. Pharm. Sci. , vol.1 , pp. 269-271
    • Ismailos, G.1    Reppas, C.2    Macheras, P.3
  • 20
    • 0014174297 scopus 로고
    • Neuromuscular disease in patients with steatorrhoea
    • Binder H.J., Solitare G.B., Spiro H.M. Neuromuscular disease in patients with steatorrhoea. Gut 1967, 8(6):605-611.
    • (1967) Gut , vol.8 , Issue.6 , pp. 605-611
    • Binder, H.J.1    Solitare, G.B.2    Spiro, H.M.3
  • 21
    • 0035895844 scopus 로고    scopus 로고
    • Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence
    • Roghani M., Behzadi G. Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence. Brain Res. 2001, 892:211-217.
    • (2001) Brain Res. , vol.892 , pp. 211-217
    • Roghani, M.1    Behzadi, G.2
  • 23
    • 0025242960 scopus 로고
    • Oxidation reactions in Parkinson's disease
    • Olanow C.W. Oxidation reactions in Parkinson's disease. Neurology 1990, 40:32-37.
    • (1990) Neurology , vol.40 , pp. 32-37
    • Olanow, C.W.1
  • 24
    • 0027496238 scopus 로고
    • A radical hypothesis for neurodegeneration
    • Olanow C.W. A radical hypothesis for neurodegeneration. Trends Neurosci. 1993, 16:439-444.
    • (1993) Trends Neurosci. , vol.16 , pp. 439-444
    • Olanow, C.W.1
  • 25
    • 0031845040 scopus 로고    scopus 로고
    • Oxidative damage in the central nervous system: protection by melatonin
    • Russel J., Reiter R.J. Oxidative damage in the central nervous system: protection by melatonin. Prog. Neurobiol. 1998, 56:359-384.
    • (1998) Prog. Neurobiol. , vol.56 , pp. 359-384
    • Russel, J.1    Reiter, R.J.2
  • 26
    • 0037735348 scopus 로고    scopus 로고
    • Vitamin E therapy in Parkinson's disease
    • Fariss M.W., Zhang J.G. Vitamin E therapy in Parkinson's disease. Toxicology 2003, 189:129-146.
    • (2003) Toxicology , vol.189 , pp. 129-146
    • Fariss, M.W.1    Zhang, J.G.2
  • 28
    • 0027456581 scopus 로고
    • Mutational analysis of active site residue of human adenosine deaminase
    • Bhumik D., Medin J., Colmenms G. Mutational analysis of active site residue of human adenosine deaminase. J. Biol. Chem. 1993, 8268:5461-5470.
    • (1993) J. Biol. Chem. , vol.8268 , pp. 5461-5470
    • Bhumik, D.1    Medin, J.2    Colmenms, G.3
  • 29
    • 0030001780 scopus 로고    scopus 로고
    • Oxidative stress and anti oxidant therapy in Parkinson's disease
    • Ebadi M., Srinivasan S.K., Baxi M.D. Oxidative stress and anti oxidant therapy in Parkinson's disease. Prog. Neurobiol. 1996, 48:1-19.
    • (1996) Prog. Neurobiol. , vol.48 , pp. 1-19
    • Ebadi, M.1    Srinivasan, S.K.2    Baxi, M.D.3
  • 30
    • 0029936117 scopus 로고    scopus 로고
    • Dopaminergic systems and Parkinson's disease: some latest developments in pathogenetic, diagnostics and pharmacotherapeutic investigations
    • Stoof J.C., Vermeulen R.J., Van royen E.A., Drukarch B., Voorn P., Wolters E.C., Groenewegen H.J. Dopaminergic systems and Parkinson's disease: some latest developments in pathogenetic, diagnostics and pharmacotherapeutic investigations. Neurosci. Res. Commun. 1996, 18:133-141.
    • (1996) Neurosci. Res. Commun. , vol.18 , pp. 133-141
    • Stoof, J.C.1    Vermeulen, R.J.2    Van royen, E.A.3    Drukarch, B.4    Voorn, P.5    Wolters, E.C.6    Groenewegen, H.J.7
  • 31
    • 0028177694 scopus 로고
    • A tocopherol protects against radical-induced injury in cultured neurons
    • Amano S., Ohashi M., Kirihara M., Yang X.H., Hazama F. A tocopherol protects against radical-induced injury in cultured neurons. Neurosci. Lett. 1994, 170:55-58.
    • (1994) Neurosci. Lett. , vol.170 , pp. 55-58
    • Amano, S.1    Ohashi, M.2    Kirihara, M.3    Yang, X.H.4    Hazama, F.5
  • 33
    • 24644459310 scopus 로고    scopus 로고
    • Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release
    • Zhang Z., Feng S.S. Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release. Biomaterials 2006, 27:262-270.
    • (2006) Biomaterials , vol.27 , pp. 262-270
    • Zhang, Z.1    Feng, S.S.2
  • 34
    • 0035848417 scopus 로고    scopus 로고
    • Effects of emulsifiers on the controlled release of paclitaxel (Taxol (R)) from nanospheres of biodegradable polymers
    • Feng S.S, Huang G.F. Effects of emulsifiers on the controlled release of paclitaxel (Taxol (R)) from nanospheres of biodegradable polymers. J. Control. Release 2001, 71:53-69.
    • (2001) J. Control. Release , vol.71 , pp. 53-69
    • Feng, S.S.1    Huang, G.F.2
  • 35
    • 0037161315 scopus 로고    scopus 로고
    • Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol (R))
    • Mu L., Feng S.S. Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol (R)). J. Control. Release 2002, 80:129-144.
    • (2002) J. Control. Release , vol.80 , pp. 129-144
    • Mu, L.1    Feng, S.S.2
  • 36
    • 0344083669 scopus 로고    scopus 로고
    • PLGA/TPGS nanoparticles for controlled release of paclitaxel: effects of the emulsifier and drug loading ratio
    • Mu L., Feng S.S. PLGA/TPGS nanoparticles for controlled release of paclitaxel: effects of the emulsifier and drug loading ratio. Pharm. Res. 2003, 20:1864-1872.
    • (2003) Pharm. Res. , vol.20 , pp. 1864-1872
    • Mu, L.1    Feng, S.S.2
  • 37
    • 0037426719 scopus 로고    scopus 로고
    • A novel controlled release formulation for the anticancer drug paclitaxel (Taxol (R)): PLGA nanoparticles containing vitamin E TPGS
    • Mu L., Feng S.S. A novel controlled release formulation for the anticancer drug paclitaxel (Taxol (R)): PLGA nanoparticles containing vitamin E TPGS. J. Control. Release 2003, 86:33-48.
    • (2003) J. Control. Release , vol.86 , pp. 33-48
    • Mu, L.1    Feng, S.S.2
  • 38
    • 0037130209 scopus 로고    scopus 로고
    • Residual polyvinyl alcohol associated with poly(d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
    • Sahoo S.K., Panyam J., Prabha S., Labhasetwar V. Residual polyvinyl alcohol associated with poly(d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J. Control. Release 2002, 82(1):105-114.
    • (2002) J. Control. Release , vol.82 , Issue.1 , pp. 105-114
    • Sahoo, S.K.1    Panyam, J.2    Prabha, S.3    Labhasetwar, V.4
  • 41
    • 33644820138 scopus 로고    scopus 로고
    • The effect of type of organic phase solvents on the particle size of poly(d,l-lactide-co-glycolide) nanoparticles
    • Song K.C., Lee H.S., Choung I.Y., Cho K.I., Ahn Y., Choi E.J. The effect of type of organic phase solvents on the particle size of poly(d,l-lactide-co-glycolide) nanoparticles. Colloids Surf. A: Physicochem. Eng. Aspects 2006, 276:162-167.
    • (2006) Colloids Surf. A: Physicochem. Eng. Aspects , vol.276 , pp. 162-167
    • Song, K.C.1    Lee, H.S.2    Choung, I.Y.3    Cho, K.I.4    Ahn, Y.5    Choi, E.J.6
  • 42
    • 0037122745 scopus 로고    scopus 로고
    • Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells
    • Vinogradov S.V., Bronich T.K., Kabanov A.V. Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells. Adv. Drug Deliv. Rev. 2002, 54:135-147.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 135-147
    • Vinogradov, S.V.1    Bronich, T.K.2    Kabanov, A.V.3
  • 43
    • 0037472066 scopus 로고    scopus 로고
    • Design of a microporous controlled delivery system for theophylline tablets
    • Lin W.J., Lee H.G. Design of a microporous controlled delivery system for theophylline tablets. J. Control. Release 2003, 89:179.
    • (2003) J. Control. Release , vol.89 , pp. 179
    • Lin, W.J.1    Lee, H.G.2
  • 44
    • 40449106025 scopus 로고    scopus 로고
    • Immiscibility with upper-critical-solution-temperature phase diagrams for poly(methyl methacrylate)/polyesters blends
    • Li S.H., Woo E.M. Immiscibility with upper-critical-solution-temperature phase diagrams for poly(methyl methacrylate)/polyesters blends. Colloid Polym. Sci. 2008, 286:253.
    • (2008) Colloid Polym. Sci. , vol.286 , pp. 253
    • Li, S.H.1    Woo, E.M.2
  • 46
    • 0035955170 scopus 로고    scopus 로고
    • FTIR study of degradation products of aliphatic polyesters-carbon fibres composites
    • Pamula E., Blazewicza M.C., Paluszkiewiczb Z., Dobrzynski P. FTIR study of degradation products of aliphatic polyesters-carbon fibres composites. J. Mol. Struct. 2001, 596:69-75.
    • (2001) J. Mol. Struct. , vol.596 , pp. 69-75
    • Pamula, E.1    Blazewicza, M.C.2    Paluszkiewiczb, Z.3    Dobrzynski, P.4
  • 47
    • 8544267215 scopus 로고    scopus 로고
    • Study on surfactant coating of polymeric nanoparticles for controlled delivery of anticancer drug
    • Mu L., Seow P.H., Ang S.N., Feng S.S. Study on surfactant coating of polymeric nanoparticles for controlled delivery of anticancer drug. Colloid Polym. Sci. 2004, 283:58-65.
    • (2004) Colloid Polym. Sci. , vol.283 , pp. 58-65
    • Mu, L.1    Seow, P.H.2    Ang, S.N.3    Feng, S.S.4
  • 48
    • 40349103371 scopus 로고    scopus 로고
    • High-pressure solution blending of polycaprolactone with poly(methyl methacrylate) in acetone plus carbon dioxide
    • Liu K., Kiran E. High-pressure solution blending of polycaprolactone with poly(methyl methacrylate) in acetone plus carbon dioxide. Polymer 2008, 49:1555-1561.
    • (2008) Polymer , vol.49 , pp. 1555-1561
    • Liu, K.1    Kiran, E.2
  • 49
    • 0025937178 scopus 로고
    • Ethanol enhances growth factor-induced neurite formation in PC12 cells
    • Messing R.O., Henteleff M., Park J.J. Ethanol enhances growth factor-induced neurite formation in PC12 cells. Brain Res. 1991, 565:301-311.
    • (1991) Brain Res. , vol.565 , pp. 301-311
    • Messing, R.O.1    Henteleff, M.2    Park, J.J.3
  • 50
    • 0033574518 scopus 로고    scopus 로고
    • Mechanisms mediating somatostatin-induced reduction of cytosolic free calcium in PC12 cells
    • Traina G., Bagnoli P. Mechanisms mediating somatostatin-induced reduction of cytosolic free calcium in PC12 cells. Neurosci. Let. 1999, 265:123-126.
    • (1999) Neurosci. Let. , vol.265 , pp. 123-126
    • Traina, G.1    Bagnoli, P.2
  • 51
    • 0033528443 scopus 로고    scopus 로고
    • Mechanisms of apoptosis in PC12 cells irreversibly differentiated with nerve growth factor and cyclic AMP
    • Lambeng N., Michel P.P., Brugg B., Agid Y., Ruberg M. Mechanisms of apoptosis in PC12 cells irreversibly differentiated with nerve growth factor and cyclic AMP. Brain Res. 1999, 821:60-68.
    • (1999) Brain Res. , vol.821 , pp. 60-68
    • Lambeng, N.1    Michel, P.P.2    Brugg, B.3    Agid, Y.4    Ruberg, M.5
  • 52
    • 0035848417 scopus 로고    scopus 로고
    • Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers
    • Feng S.S., Huang G.F. Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers. J. Control. Release 2001, 71:53-69.
    • (2001) J. Control. Release , vol.71 , pp. 53-69
    • Feng, S.S.1    Huang, G.F.2
  • 54
    • 0032714228 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein by d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)
    • Dintaman J.M., Silverman J.A. Inhibition of P-glycoprotein by d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS). Pharm. Res. 1999, 16:1550-1556.
    • (1999) Pharm. Res. , vol.16 , pp. 1550-1556
    • Dintaman, J.M.1    Silverman, J.A.2
  • 55
    • 0034665061 scopus 로고    scopus 로고
    • The formulation of Halofantrine as either non-solubilising PEG 6000 or solubilising lipid based solid dispersions: physical stability and absolute bioavailability assessment
    • Khoo S.M., Porter C.J.H., Charman W.N. The formulation of Halofantrine as either non-solubilising PEG 6000 or solubilising lipid based solid dispersions: physical stability and absolute bioavailability assessment. Int. J. Pharm. 2000, 205:65-78.
    • (2000) Int. J. Pharm. , vol.205 , pp. 65-78
    • Khoo, S.M.1    Porter, C.J.H.2    Charman, W.N.3
  • 56
    • 0034691813 scopus 로고    scopus 로고
    • Influence of vitamin E TPGS on the properties of hydrophilic films produced by hot-melt extrusion
    • Repka M.A., McGinity J.W. Influence of vitamin E TPGS on the properties of hydrophilic films produced by hot-melt extrusion. Int. J. Pharm. 2000, 202:63-70.
    • (2000) Int. J. Pharm. , vol.202 , pp. 63-70
    • Repka, M.A.1    McGinity, J.W.2


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