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Volumn 301, Issue 6, 2011, Pages

Phosphorylation of eIF2α via the general control kinase, GCN2, modulates the ability of renal medullary cells to survive high urea stress

Author keywords

Activating transcription factor 3; Collecting duct; Osmotic stress

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; GENERAL CONTROL NONDEPRESSIBLE 2 KINASE; HEME REGULATED INHIBITOR KINASE; INITIATION FACTOR 2ALPHA; PANCREATIC ENDOPLASMIC RETICULUM KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE R; UNCLASSIFIED DRUG; UREA;

EID: 82755191649     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00272.2011     Document Type: Article
Times cited : (14)

References (36)
  • 1
    • 43149110398 scopus 로고    scopus 로고
    • Intracellular organic osmolytes: Function and regulation
    • Burg MB, Ferraris JD. Intracellular organic osmolytes: function and regulation. J Biol Chem 283: 7309-7313, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 7309-7313
    • Burg, M.B.1    Ferraris, J.D.2
  • 4
    • 36549062493 scopus 로고    scopus 로고
    • Vasopressin receptor subtype 2 activation increases cell proliferation in the renal medulla of AQP1 null mice
    • Cai Q, McReynolds MR, Keck M, Greer KA, Hoying JB, Brooks HL. Vasopressin receptor subtype 2 activation increases cell proliferation in the renal medulla of AQP1 null mice. Am J Physiol Renal Physiol 293: F1858-F1864, 2007.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Cai, Q.1    McReynolds, M.R.2    Keck, M.3    Greer, K.A.4    Hoying, J.B.5    Brooks, H.L.6
  • 5
    • 77957980916 scopus 로고    scopus 로고
    • Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect
    • Cai Q, Nelson SK, McReynolds MR, Diamond-Stanic MK, Elliott D, Brooks HL. Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect. Am J Physiol Renal Physiol 299: F712-F719, 2010.
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Cai, Q.1    Nelson, S.K.2    McReynolds, M.R.3    Diamond-Stanic, M.K.4    Elliott, D.5    Brooks, H.L.6
  • 7
    • 0033118409 scopus 로고    scopus 로고
    • Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/ enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
    • Fawcett TW, Martindale JL, Guyton KZ, Hai T, Holbrook NJ. Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/ enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. Biochem J 339: 135-141, 1999.
    • (1999) Biochem J , vol.339 , pp. 135-141
    • Fawcett, T.W.1    Martindale, J.L.2    Guyton, K.Z.3    Hai, T.4    Holbrook, N.J.5
  • 8
    • 0026074320 scopus 로고
    • Role of organic osmolytes in adaptation of renal cells to high osmolality
    • Garcia-Perez A, Burg MB. Role of organic osmolytes in adaptation of renal cells to high osmolality. J Membr Biol 119: 1-13, 1991.
    • (1991) J Membr Biol , vol.119 , pp. 1-13
    • Garcia-Perez, A.1    Burg, M.B.2
  • 9
    • 0035903194 scopus 로고    scopus 로고
    • The protein kinase Gcn2p mediates sodium toxicity in yeast
    • Goossens A, Dever TE, Pascual-Ahuir A, Serrano R. The protein kinase Gcn2p mediates sodium toxicity in yeast. J Biol Chem 276: 30753-30760, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 30753-30760
    • Goossens, A.1    Dever, T.E.2    Pascual-Ahuir, A.3    Serrano, R.4
  • 10
    • 0035948624 scopus 로고    scopus 로고
    • The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: Activating transcription factor proteins and homeostasis
    • Hai T, Hartman MG. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 273: 1-11, 2001.
    • (2001) Gene , vol.273 , pp. 1-11
    • Hai, T.1    Hartman, M.G.2
  • 12
    • 0033634654 scopus 로고    scopus 로고
    • Regulated translation initiation controls stress-induced gene expression in mammalian cells
    • Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6: 1099-1108, 2000.
    • (2000) Mol Cell , vol.6 , pp. 1099-1108
    • Harding, H.P.1    Novoa, I.2    Zhang, Y.3    Zeng, H.4    Wek, R.5    Schapira, M.6    Ron, D.7
  • 15
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
    • Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol 22: 7405-7416, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3    Rastani, S.4    Diehl, A.5    Sonenberg, N.6    Koromilas, A.7    Wouters, B.G.8
  • 16
    • 0035166679 scopus 로고    scopus 로고
    • Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses
    • Lu L, Han AP, Chen JJ. Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses. Mol Cell Biol 21: 7971-7980, 2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 7971-7980
    • Lu, L.1    Han, A.P.2    Chen, J.J.3
  • 19
    • 0034726705 scopus 로고    scopus 로고
    • Repression of TNF-alpha-induced E-selectin expression by PPAR activators: Involvement of transcriptional repressor LRF-1/ATF3
    • Nawa T, Nawa MT, Cai Y, Zhang C, Uchimura I, Narumi S, Numano F, Kitajima S. Repression of TNF-alpha-induced E-selectin expression by PPAR activators: involvement of transcriptional repressor LRF-1/ATF3. Biochem Biophys Res Commun 275: 406-411, 2000.
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 406-411
    • Nawa, T.1    Nawa, M.T.2    Cai, Y.3    Zhang, C.4    Uchimura, I.5    Narumi, S.6    Numano, F.7    Kitajima, S.8
  • 20
    • 35648985077 scopus 로고    scopus 로고
    • Activation of the integrated stress response regulates lovastatin-induced apoptosis
    • Niknejad N, Morley M, Dimitroulakos J. Activation of the integrated stress response regulates lovastatin-induced apoptosis. J Biol Chem 282: 29748-29756, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 29748-29756
    • Niknejad, N.1    Morley, M.2    Dimitroulakos, J.3
  • 21
    • 33751563020 scopus 로고    scopus 로고
    • The roles of translation initiation regulation in ultraviolet light-induced apoptosis
    • Parker SH, Parker TA, George KS, Wu S. The roles of translation initiation regulation in ultraviolet light-induced apoptosis. Mol Cell Biochem 293: 173-181, 2006.
    • (2006) Mol Cell Biochem , vol.293 , pp. 173-181
    • Parker, S.H.1    Parker, T.A.2    George, K.S.3    Wu, S.4
  • 22
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 23
    • 0037344146 scopus 로고    scopus 로고
    • The renal medullary interstitium: Focus on osmotic hypertonicity
    • Sadowski J, Dobrowolski L. The renal medullary interstitium: focus on osmotic hypertonicity. Clin Exp Pharmacol Physiol 30: 119-126, 2003.
    • (2003) Clin Exp Pharmacol Physiol , vol.30 , pp. 119-126
    • Sadowski, J.1    Dobrowolski, L.2
  • 24
    • 0034163483 scopus 로고    scopus 로고
    • Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
    • Sood R, Porter AC, Ma K, Quilliam LA, Wek RC. Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem J 346: 281-293, 2000.
    • (2000) Biochem J , vol.346 , pp. 281-293
    • Sood, R.1    Porter, A.C.2    Ma, K.3    Quilliam, L.A.4    Wek, R.C.5
  • 25
    • 0034011182 scopus 로고    scopus 로고
    • Ras signaling in the inner medullary cell response to urea and NaCl
    • Tian W, Boss GR, Cohen DM. Ras signaling in the inner medullary cell response to urea and NaCl. Am J Physiol Cell Physiol 278: C372-C380, 2000.
    • (2000) Am J Physiol Cell Physiol , vol.278
    • Tian, W.1    Boss, G.R.2    Cohen, D.M.3
  • 26
    • 0034797395 scopus 로고    scopus 로고
    • Signaling and gene regulation by urea in cells of the mammalian kidney medulla
    • Tian W, Cohen DM. Signaling and gene regulation by urea in cells of the mammalian kidney medulla. Comp Biochem Physiol A Mol Integr Physiol 130: 429-436, 2001.
    • (2001) Comp Biochem Physiol a Mol Integr Physiol , vol.130 , pp. 429-436
    • Tian, W.1    Cohen, D.M.2
  • 27
    • 0036721288 scopus 로고    scopus 로고
    • Urea stress is more akin to EGF exposure than to hypertonic stress in renal medullary cells
    • Tian W, Cohen DM. Urea stress is more akin to EGF exposure than to hypertonic stress in renal medullary cells. Am J Physiol Renal Physiol 283: F388-F398, 2002.
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Tian, W.1    Cohen, D.M.2
  • 28
    • 35848935017 scopus 로고    scopus 로고
    • Translational control and the unfolded protein response
    • Wek RC, Cavener DR. Translational control and the unfolded protein response. Antioxid Redox Signal 9: 2357-2371, 2007.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 2357-2371
    • Wek, R.C.1    Cavener, D.R.2
  • 29
    • 0024381444 scopus 로고
    • Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability
    • Wek RC, Jackson BM, Hinnebusch AG. Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability. Proc Natl Acad Sci USA 86: 4579-4583, 1989.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 4579-4583
    • Wek, R.C.1    Jackson, B.M.2    Hinnebusch, A.G.3
  • 30
    • 0029006391 scopus 로고
    • The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
    • Wek SA, Zhu S, Wek RC. The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol 15: 4497-4506, 1995.
    • (1995) Mol Cell Biol , vol.15 , pp. 4497-4506
    • Wek, S.A.1    Zhu, S.2    Wek, R.C.3
  • 31
    • 22744442218 scopus 로고    scopus 로고
    • Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination
    • Yan C, Lu D, Hai T, Boyd DD. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J 24: 2425-2435, 2005.
    • (2005) EMBO J , vol.24 , pp. 2425-2435
    • Yan, C.1    Lu, D.2    Hai, T.3    Boyd, D.D.4
  • 34
    • 0033848559 scopus 로고    scopus 로고
    • Urea protects from the proapoptotic effect of NaCl in renal medullary cells
    • Zhang Z, Tian W, Cohen DM. Urea protects from the proapoptotic effect of NaCl in renal medullary cells. Am J Physiol Renal Physiol 279: F345-F352, 2000.
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Zhang, Z.1    Tian, W.2    Cohen, D.M.3
  • 35
    • 0033042674 scopus 로고    scopus 로고
    • Urea-associated oxidative stress and Gadd153/CHOP induction
    • Zhang Z, Yang XY, Cohen DM. Urea-associated oxidative stress and Gadd153/CHOP induction. Am J Physiol Renal Physiol 276: F786-F793, 1999.
    • (1999) Am J Physiol Renal Physiol , vol.276
    • Zhang, Z.1    Yang, X.Y.2    Cohen, D.M.3
  • 36
    • 0029785485 scopus 로고    scopus 로고
    • Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2
    • Zhu S, Sobolev AY, Wek RC. Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2. J Biol Chem 271: 24989-24994, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 24989-24994
    • Zhu, S.1    Sobolev, A.Y.2    Wek, R.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.