The roles of translation initiation regulation in ultraviolet light-induced apoptosis

Molecular and Cellular Biochemistry

Volumn 293, Issue 1-2, 2006, Pages 173-181

  Parker, Suzanne H ^a   Parker, Todd A ^a   George, Kimberly S ^a   Wu, Shiyong ^a  

^a OHIO UNIVERSITY   (United States)

Author keywords

Apoptosis; EIF2; GCN2; PERK; Ultraviolet light

Indexed keywords

ALANINE; INITIATION FACTOR 2ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SERINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN MCF 7; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SENSITIVITY ANALYSIS; TRANSLATION INITIATION; ULTRAVIOLET RADIATION; WILD TYPE;

ANIMALS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, RADIATION; DOWN-REGULATION; EIF-2 KINASE; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; HUMANS; MICE; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS;

EUKARYOTA;

EID: 33751563020     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9239-y     Document Type: Article

References (43)

1. Gil J, Alcami J, Esteban M: Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. Mol Cell Biol 19: 4653-4663, 1999
2. Balachandran S, Kim CN, Yeh WC, Mak TW, Bhalla K, Barber GN: Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. Embo J 17: 6888-6902, 1998
3. Der SD, Yang YL, Weissmann C, Williams BR: A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A 94: 3279-3283, 1997
4. Srivastava SP, Kumar KU, Kaufman RJ: Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA- dependent protein kinase. J Biol Chem 273: 2416-2423, 1998
5. Harding HP, Zhang Y, Ron D: Protein translation and folding are coupled by an endoplasmic-reticulum- resident kinase [published erratum appears in Nature 1999 Mar 4;398(6722):90] [see comments]. Nature 397: 271-274, 1999
6. Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D: Dynamic interaction of BiP and ER stress transducers in the unfolded- protein response. Nat Cell Biol 2: 326-332, 2000
7. Sood R, Porter AC, Ma K, Quilliam LA, Wek RC: Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem J 346 Pt 2: 281-293, 2000
8. Kumar R, Krause GS, Yoshida H, Mori K, DeGracia DJ: Dysfunction of the unfolded protein response during global brain ischemia and reperfusion. J Cereb Blood Flow Metab 23: 462-471, 2003
9. Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D: Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 7: 1153-1163, 2001
10. Kaufman RJ: The Double-stranded RNA-activated Protein Kinase PKR. In: N Sonenberg, JWB Hershey and MB Mathews (eds). Translational Control of Gene Expression, CSHL Press, Cold Spring Harbor, New York, 2000, pp 503-528
11. Sood R, Porter AC, Olsen D, Cavener DR, Wek RC: A Mammalian Homologue of GCN2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2alpha. Genetics 154: 787-801, 2000
12. Ranu RS: Regulation of protein synthesis in rabbit reticulocyte lysates: the hemeregulated protein kinase (HRI) and double stranded RNA induced protein kinase (dRI) phosphorylate the same site(s) on initiation factor eIF-2. Biochem Biophys Res Commun 91: 1437-1444, 1979
13. Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D: Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 5: 897-904, 2000
14. Fernandez JM, Bode B, Koromilas A, Diehl JA, Krukovets I, Snider MD, Hatzoglou M: Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner. J Biol Chem: 277:11780-11787, 2002
15. Wu S, Hu Y, Wang JL, Chatterjee M, Shi Y, Kaufman RJ: Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum. J Biol Chem 277: 18077-18083, 2002
16. Wu S, Tan M, Hu Y, Wang JL, Scheuner D, Kaufman RJ: Ultraviolet Light Activates NF{kappa}B through Translational Inhibition of I{kappa}B{alpha} Synthesis. J Biol Chem 279: 34898-34902, 2004
17. Kucharczak J, Simmons MJ, Fan Y, Gelinas C: To be, or not to be: NF-kappaB is the answer - role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22: 8961-8982, 2003
18. Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC: Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol 23: 5651-5663, 2003
19. Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ: Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 7: 1165-1176, 2001
20. Wu S, Kaufman RJ: A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR. J Biol Chem 272: 1291-1296, 1997
21. Movsesyan VA, Yakovlev AG, Dabaghyan EA, Stoica BA, Faden AI: Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. Biochem Biophys Res Commun 299: 201-207, 2002
22. Rehemtulla A, Hamilton CA, Chinnaiyan AM, Dixit VM: Ultraviolet radiation-induced apoptosis is mediated by activation of CD- 95 (Fas/ APO-1). J Biol Chem 272: 25783-25786, 1997
23. Aragane Y KD, Metze D, Wilkes G, Poppelmann B, Luger TA, Schwarz T: Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/ APO-1) independently of its ligand CD95L. J Cell Biol 140: 171-182, 1998
24. Wajant H: The Fas sigMaling pathway: more than a paradigm. Science 296: 1635-1636, 2002
25. Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N: Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol 12: 1279-1286, 2002
26. Pain VM: Initiation of protein synthesis in eukaryotic cells. Eur J Biochem 236: 747-771, 1996
27. Price NT, Welsh GI, Proud CG: Phosphorylation of only serine-51 in protein synthesis initiation factor-2 is associated with inhibition of peptide-chain initiation in reticulocyte lysates. Biochem Biophys Res Commun 176: 993-999, 1991
28. Jiang HY, Wek RC: GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation. Biochem J 385: 371-380, 2005
29. DeGracia DJ, Kumar R, Owen CR, Krause GS, White BC: Molecular pathways of protein synthesis inhibition during brain reperfusion: Implications for neuronal survival or death. J Cereb Blood Flow Metab 22: 127-141, 2002
30. Jiang HY, Wek RC: Phosphorylation of the {alpha}-Subunit of the Eukaryotic Initiation Factor-2 (eIF2{alpha}) Reduces Protein Synthesis and Enhances Apoptosis in Response to Proteasome Inhibition. J Biol Chem 280: 14189-14202, 2005
31. Oyadomari S, Araki E, Mori M: Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. Apoptosis 7: 335-345, 2002
32. Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA: Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23: 7198-7209, 2003
33. Marbach I, Licht R, Frohnmeyer H, Engelberg D: Gcn2 mediates Gcn4 activation in response to glucose stimulation or UV radiation not via GCN4 translation. J Biol Chem 276: 16944-16951, 2001
34. Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D: Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 24: 10161-10168, 2004
35. Yun SJ, Lee DJ, Kim MO, Jung B, Kim SO, Sohn NW, Lee EH: Reduction but not cleavage of poly(ADP-ribose) polymerase during stress-mediated cell death in the rat hippocampus. Neuroreport 14: 935-939, 2003
36. Kim JW, Won J, Sohn S, Joe CO: DNA-binding activity of the N-terminal cleavage product of poly(ADP-ribose) polymerase is required for UV mediated apoptosis. J Cell Sci 113 (Pt 6): 955-961, 2000
37. Meli E, Pangallo M, Picca R, Baronti R, Moroni F, Pellegrini-Giampietro DE: Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci 25: 172-180, 2004
38. Munday NA, Vaillancourt JP, Ali A, Casano FJ, Miller DK, Molineaux SM, Yamin TT, Yu VL, Nicholson DW: Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. J Biol Chem 270: 15870-15876, 1995
39. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM: Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81: 801-809, 1995
40. Le Rhun Y, Kirkland JB, Shah GM: Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase. Biochem Biophys Res Commun 245: 1-10, 1998
41. Donze O, Dostie J, Sonenberg N: Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression. Virology 256: 322-329, 1999
42. Takizawa T, Tatematsu C, Nakanishi Y: Double-stranded RNA-activated protein kinase (PKR) fused to green fluorescent protein induces apoptosis of human embryonic kidney cells: Possible role in the Fas signaling pathway. J Biochem (Tokyo) 125: 391-398, 1999
43. Brewer JW, Diehl JA: PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci U S A 97: 12625-12630, 2000