Cucurbitane-type triterpenoids from momordica charantia

Planta Medica

Volumn 76, Issue 15, 2010, Pages 1758-1761

  Ma, Jun ^a   Whittaker, Paul ^a   Keller, Amy C ^b   Mazzola, Eugene P ^a   Pawar, Rahul S ^a   White, Kevin D ^a   Callahan, John H ^a   Kennelly, Edward J ^b   Krynitsky, Alexander J ^a   Rader, Jeanne I ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Cucurbitaceae; cucurbitanetype triterpenoid; Momordica charantia; momordicoside U

Indexed keywords

3 HYDROXYCUCURBITA 5,24 DIEN 19 AL 7,23 DI O BETA GLUCOPYRANOSIDE; 3BETA,7BETA,25-TRIHYDROXYCUCURBITA 5,23 DIEN 19 AL; CUCURBITANE; GLYCOSIDE; KUGUAGLYCOSIDE G; MOMORDICA CHARANTIA EXTRACT; MOMORDICINE I; MOMORDICINE II; MOMORDICOSIDE U; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; INSULIN RELEASE; MOMORDICA CHARANTIA; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ROENTGEN SPECTROSCOPY;

ANIMALS; CELL LINE; GLYCOSIDES; INSULIN; INSULIN-SECRETING CELLS; MICE; MOMORDICA CHARANTIA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SAPONINS; TRITERPENES;

CUCURBITACEAE; MOMORDICA CHARANTIA;

EID: 77958556086     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1249807     Document Type: Article

References (20)

1. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003 60 356-359
2. Li Q Y., Chen H B., Liu Z M., Wang B, Zhao Y Y. Cucurbitane triterpenoids from Momordica charantia. Magn Reson Chem 2007 45 451-456
3. Akihisa T, Higo N, Tokuda H, Ukiya M, Akazawa H, Tochigi Y, Kimura Y, Suzuki T, Nishino H. Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects. J Nat Prod 2007 70 1233-1239
4. Wang Y H., Avula B, Liu Y, Khan I A. Determination and quantitation of five cucurbitane triterpenoids in Momordica charantia by reversed-phase high-performance liquid chromatography with evaporative light scattering detection. J Chromatogr Sci 2008 46 133-136
5. Liu Y, Ali Z, Khan I A. Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia. Planta Med 2008 74 1291-1294
6. Okabe H, Miyahara Y, Yamaguchi T, Miyahara K, Kawasaki T. Studies on the constituents of Momordica charantia L. I. Isolation and characterization of momordicosides A and B, glycosides of a pentahydroxy-cucurbitane triterpene. Chem Pharm Bull 1980 28 2753-2762
7. Miyahara Y, Okabe H, Yamaguchi T. Studies on the constituents of Momordica charantia L. II. Isolation and characterization of minor seed glycosides, momordicosides C, D and E. Chem Pharm Bull 1981 29 1561-1566
8. Yasuda M, Iwamoto M, Okabe H, Yamaguchi T. Structures of momordicines I, II and III, the bitter principles in the leaves and vines of Momordica charantia. Chem Pharm Bull 1984 32 2044-2047
9. Fatope M O., Takeda Y, Yamashita H, Okabe H, Yamaguchi T. New cucurbitane triterpenoids from Momordica charantia. J Nat Prod 1990 53 1491-1497
10. Chang C I., Chen C R., Liao Y W., Cheng H L., Chen Y C., Chou C H. Cucurbitane-type tripterpenoids from Momordica charantia. J Nat Prod 2006 69 1168-1171
11. Chang C I., Chen C R., Liao Y W., Cheng H L., Chen Y C., Chou C H. Cucurbitane-type triterpenoids from the stems of Momordica charantia. J Nat Prod 2008 71 1327-1330
12. Chen J, Tian R, Qiu M, Lu L, Zheng Y, Zhang Z. Trinocucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry 2008 69 1043-1048
13. Chen J C., Lu L, Zhang X M., Zhou L, Li Z R., Qiu M H. Eight new cucurbitane glycosides, kuguaglycosides AH, from the root of Momordica charantia L. Helv Chim Acta 2008 91 920-929
14. Harinantenaina L, Tanaka M, Takaoka S, Oda M, Mogami O, Uchida M, Asakawa Y. Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem Pharm Bull 2006 54 1017-1021
15. Tan M J., Ye J M., Turner N, Hohnen-Behrens C, Ke C Q., Tang C P., Chen T, Weiss H C., Gesing E R., Rowland A, James D E., Ye Y. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol 2008 15 263-273
16. Mekuria D B., Kashiwagi T, Tebayashi S, Kim C S. Cucurbitane triterpenoid oviposition deterrent from Momordica charantia to the leafminer, Liriomyza trifolii. Biosci Biotechnol Biochem 2005 69 1706-1710
17. Yasui H, Kato A, Yazawa M J. Antifeedants to armyworms, Spodoptera litura and Pseudaletia separate, from bitter gourd leaves, Momordica charantia. Chem Ecol 1998 24 803-813
18. Kashiwagi T, Mekuria D B., Dekebo A, Sato K, Tebayashi S, Kim C S. A new oviposition deterrent to the leafminer, Liriomyza trifolii: cucurbitane glucoside from Momordica charantia. Z Naturforsch C 2007 62C 603-607
19. Zhao J, Pawar R S., Ali Z, Khan I A. Phytochemical investigation of Turnera diffusa. J Nat Prod 2007 70 289-292
20. Persaud S J., Al-Majed H, Raman A, Jones P M. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol 1999 163 207-212