Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence

Journal of Thrombosis and Haemostasis

Volumn 9, Issue 12, 2011, Pages 2436-2446

  Vanassche, T ^a   Verhaegen, J ^b   Peetermans, W E ^b   Van Ryn, J ^c   Cheng, A ^d   Schneewind, O ^d   Hoylaerts, M F ^a   Verhamme, P ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Dabigatran; Direct thrombin inhibitor; Staphylocoagulase; Staphylococcus aureus; Staphylothrombin; Von Willebrand binding protein

Indexed keywords

ARGATROBAN; BACTERIAL ENZYME; COAGULASE; DABIGATRAN; DABIGATRAN ETEXILATE; FIBRIN; FIBRINOGEN; LEPIRUDIN; PLACEBO; POLYSTYRENE; PROTHROMBIN; THROMBIN;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BACTERIUM ADHERENCE; BACTERIUM MUTANT; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

ANIMALS; BACTERIAL ADHESION; BENZIMIDAZOLES; BETA-ALANINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRINOGEN; IMMUNOHISTOCHEMISTRY; MICE; PLACEBOS; STAPHYLOCOCCUS AUREUS; THROMBIN; VIRULENCE;

EID: 82755189076     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2011.04529.x     Document Type: Article

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