Dabigatran inhibits Staphylococcus aureus coagulase activity

Journal of Clinical Microbiology

Volumn 48, Issue 11, 2010, Pages 4248-4250

  Vanassche, Thomas ^a   Verhaegen, Jan ^b   Peetermans, Willy E ^b   Hoylaerts, Marc F ^a   Verhamme, Peter ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

COAGULASE; DABIGATRAN ETEXILATE;

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM DETECTION; BLOOD CLOTTING; BLOOD CULTURE; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; FALSE NEGATIVE RESULT; HUMAN; INOCULATION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS;

BENZIMIDAZOLES; BETA-ALANINE; BLOOD COAGULATION; COAGULASE; ENZYME INHIBITORS; HUMANS; STAPHYLOCOCCUS AUREUS;

STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 78049525233     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00896-10     Document Type: Article

References (25)

1. Baddour, L. M., M. M. Tayidi, E. Walker, D. McDevitt, and T. J. Foster. 1994. Virulence of coagulase-deficient mutants of Staphylococcus aureus in experimental endocarditis. J. Med. Microbiol. 41:259-263.
2. Bas, B. M., A. D. Muller, and H. C. Hemker. 1975. Purification and properties of staphylocoagulase. Biochim. Biophys. Acta 379:164-171.
3. Chapman, G. H., C. Berens, A. Peters, and L. Curcio. 1934. Coagulase and hemolysin tests as measures of the pathogenicity of staphylococci. J. Bacteriol. 28:343-363.
4. Connolly, S. J., M. D. Ezekowitz, S. Yusuf, J. Eikelboom, J. Oldgren, A. Parekh, J. Pogue, P. A. Reilly, E. Themeles, J. Varrone, S. Wang, M. Alings, D. Xavier, J. Zhu, R. Diaz, B. S. Lewis, H. Darius, H. C. Diener, C. D. Joyner, and L. Wallentin. 2009. Dabigatran versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. 361:1139-1151.
5. Eriksson, B. I., O. E. Dahl, N. Rosencher, A. A. Kurth, C. N. van Dijk, S. P. Frostick, M. H. Prins, R. Hettiarachchi, S. Hantel, J. Schnee, and H. R. Buller. 2007. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet 370:949-956.
6. Friedrich, R., P. Panizzi, P. Fuentes-Prior, K. Richter, I. Verhamme, P. J. Anderson, S. Kawabata, R. Huber, W. Bode, and P. E. Bock. 2003. Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Nature 425:535-539.
7. Hasegawa, N., I. Kondo, S. Hoshina, K. Kurosaka, and H. Igarashi. 1983. Effect of highly purified coagulase and culture filtrate on virulence and immunity of a coagulase-negative mutant of Staphylococcus aureus BB. Infect. Immun. 39:1236-1242. (Pubitemid 13159967)
8. Hasegawa, N., and C. L. San Clemente. 1978. Virulence and immunity of Staphylococcus aureus BB and certain deficient mutants. Infect. Immun. 22:473-479.
9. Hemker, H. C., B. M. Bas, and A. D. Muller. 1975. Activation of a proenzyme by a stoichiometric reaction with another protein. The reaction between prothrombin and staphylocoagulase. Biochim. Biophys. Acta 379:180-188.
10. Hermsen, E. D., S. S. Shull, D. G. Klepser, P. C. Iwen, A. Armbrust, J. Garrett, A. G. Freifeld, and M. E. Rupp. 2008. Pharmacoeconomic analysis of microbiologic techniques for differentiating staphylococci directly from blood culture bottles. J. Clin. Microbiol. 46:2924-2929.
11. Hijikata-Okunomiya, A., and N. Kataoka. 2003. Argatroban inhibits staphylothrombin. J. Thromb. Haemost. 1:2060-2061.
12. Jonsson, P., M. Lindberg, I. Haraldsson, and T. Wadstrom. 1985. Virulence of Staphylococcus aureus in a mouse mastitis model: studies of alpha hemolysin, coagulase, and protein A as possible virulence determinants with protoplast fusion and gene cloning. Infect. Immun. 49:765-769.
13. McDonald, C. L., and K. Chapin. 1995. Rapid identification of Staphylococcus aureus from blood culture bottles by a classic 2-hour tube coagulase test. J. Clin. Microbiol. 33:50-52.
14. Much, H. 1908. Über eine Vorstufe des Fibrinfermentes in Kulturen von Staphylokokkus aureus. Biochem. Z. 14:143-155.
15. Peters, R. P., P. H. Savelkoul, A. M. Simoons-Smit, S. A. Danner, C. M. Vandenbroucke-Grauls, and M. A. van Agtmael. 2006. Faster identification of pathogens in positive blood cultures by fluorescence in situ hybridization in routine practice. J. Clin. Microbiol. 44:119-123.
16. Qian, Q., K. Eichelberger, and J. E. Kirby. 2007. Rapid identification of Staphylococcus aureus in blood cultures by use of the direct tube coagulase test. J. Clin. Microbiol. 45:2267-2269.
17. Sakai, H., G. W. Procop, N. Kobayashi, D. Togawa, D. A. Wilson, L. Borden, V. Krebs, and T. W. Bauer. 2004. Simultaneous detection of Staphylococcus aureus and coagulase-negative staphylococci in positive blood cultures by real-time PCR with two fluorescence resonance energy transfer probe sets. J. Clin. Microbiol. 42:5739-5744.
18. Sawai, T., K. Tomono, K. Yanagihara, Y. Yamamoto, M. Kaku, Y. Hirakata, H. Koga, T. Tashiro, and S. Kohno. 1997. Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. Infect. Immun. 65:466-471.
19. Schulman, S., C. Kearon, A. K. Kakkar, P. Mismetti, S. Schellong, H. Eriksson, D. Baanstra, J. Schnee, and S. Z. Goldhaber. 2009. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N. Engl. J. Med. 361:2342-2352.
20. Seki, K., M. Ogasawara, J. Sakurada, M. Murai, and S. Masuda. 1989. Altered virulence of a pleiotropic Staphylococcus aureus mutant with a low producibility of coagulase and other factors in mice. Microbiol. Immunol. 33:981-990.
21. Stangier, J., K. Rathgen, H. Stahle, D. Gansser, and W. Roth. 2007. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br. J. Clin. Pharmacol. 64:292-303.
22. Van Ryn, J., J. Stangier, S. Haertter, K. Liesenfeld, W. Wienen, M. Feuring, and A. Clemens. 2010. Dabigatran etexilate - a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb. Haemost. 103:1116-1127.
23. Varettas, K., C. Mukerjee, and P. C. Taylor. 2005. Anticoagulant carryover may influence clot formation in direct tube coagulase tests from blood cultures. J. Clin. Microbiol. 43:4613-4615.
24. Yanagihara, K., M. Tashiro, Y. Fukuda, H. Ohno, Y. Higashiyama, Y. Miyazaki, Y. Hirakata, K. Tomono, Y. Mizuta, K. Tsukamoto, and S. Kohno. 2006. Effects of short interfering RNA against methicillin-resistant Staphylococcus aureus coagulase in vitro and in vivo. J. Antimicrob. Chemother. 57:122-126.
25. Yeh, R. W., and I. K. Jang. 2006. Argatroban: update. Am. Heart J. 151:1131-1138.