Analysis of mitochondrial genome revealed a rare 50bp deletion and substitutions in a family with hypertension

Mitochondrion

Volumn 11, Issue 6, 2011, Pages 878-885

  Elango, Santhini ^a   Govindaraj, Periyasamy ^b   Vishwanadha, Vijaya Padma ^a   Reddy, Alla Govardhana ^b   Tamang, Rakesh ^b   Muthusami, Uthiralingam ^c   Kunnoth, Sreejith ^c   Koyilil, Vijaya Kumar ^d   Lakshman, MohanaKrishnan ^d   Shanmugasundharam, N ^d   Singh, Lalji ^b,e   Thangaraj, Kumarasamy ^b  

^a BHARATHIAR UNIVERSITY   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c LOYOLA COLLEGE   (India)

^d Sri Ramakrishna Hospital   (India)

^e Genome Foundation   (India)

Author keywords

Coronary artery disease; Hypertension; MtDNA; Mutation; POLG; Type 2 diabetes

Indexed keywords

ISOLEUCINE; POLYMERASE GAMMA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CSB 2; TRANSCRIPTION FACTOR CSB 3; TRANSCRIPTION FACTOR HPR; TRANSCRIPTION FACTOR TFY; UNCLASSIFIED DRUG; VALINE;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ARTICLE; CODON; COMPUTER MODEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DNA SEQUENCE; ETHNICITY; EXON; FAMILY STUDY; GENE; GENE DELETION; GENE MUTATION; GENE PRODUCT; GENETIC VARIABILITY; GEOGRAPHY; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; HYPERTENSION; INDIA; INDIAN; INTRON; MISSENSE MUTATION; MITOCHONDRIAL GENOME; ND1 GENE; ND5 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PEDIGREE ANALYSIS; PHENOTYPE; POLYMERASE GAMMA GENE; PREVALENCE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; FAMILY HEALTH; FEMALE; GENOME, MITOCHONDRIAL; HUMANS; HYPERTENSION; INDIA; MALE; MIDDLE AGED; POINT MUTATION; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION;

EID: 82755182828     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2011.07.002     Document Type: Article

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