Neuroinflammation in Alzheimer's disease wanes with age

Journal of Neuroinflammation

Volumn 8, Issue , 2011, Pages

  Hoozemans, Jeroen J M ^a   Rozemuller, Annemieke J M ^a   van Haastert, Elise S ^a   Eikelenboom, Piet ^a,b   van Gool, Willem A ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Aging; Alzheimer's disease; Astrocyte; Microglia

Indexed keywords

BIOLOGICAL MARKER; CD68 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; HLA ANTIGEN CLASS 2;

ADULT; AGE; AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; PATIENT ASSESSMENT; PHENOTYPE; TEMPORAL CORTEX; AGING; ANIMAL; ENCEPHALITIS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; ANIMALS; BIOLOGICAL MARKERS; ENCEPHALITIS; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 82755162460     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-8-171     Document Type: Article

References (34)

1. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000, 21:383-421. 10.1016/S0197-4580(00)00124-X, 10858586.
2. Arends YM, Duyckaerts C, Rozemuller JM, Eikelenboom P, Hauw JJ. Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiol Aging 2000, 21:39-47.
3. Vehmas AK, Kawas CH, Stewart WF, Troncoso JC. Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiol Aging 2003, 24:321-31. 10.1016/S0197-4580(02)00090-8, 12498966.
4. Hoozemans JJ, Van Haastert ES, Veerhuis R, Arendt T, Scheper W, Eikelenboom P, Rozemuller AJ. Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J Neuroinflammation 2005, 2:27. 10.1186/1742-2094-2-27, 1308853, 16300681.
5. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009, 41:1088-1093. 10.1038/ng.440, 2845877, 19734902.
6. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009, 41:1094-1099. 10.1038/ng.439, 19734903.
7. Mrak RE, Griffin WST. Glia and their cytokines in progression of neurodegeneration. Neurobiology of Aging 2005, 26:349-354. 10.1016/j.neurobiolaging.2004.05.010, 15639313.
8. Hoozemans JJ, Veerhuis R, Rozemuller JM, Eikelenboom P. Soothing the inflamed brain: effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology. CNS Neurol Disord Drug Targets 2011, 10:57-67. 10.2174/187152711794488665, 21143138.
9. Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB. In-vivo measurement of activated microglia in dementia. Lancet 2001, 358:461-7. 10.1016/S0140-6736(01)05625-2, 11513911.
10. Okello A, Edison P, Archer HA, Turkheimer FE, Kennedy J, Bullock R, Walker Z, Kennedy A, Fox N, Rossor M, et al. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology 2009, 72:56-62. 10.1212/01.wnl.0000338622.27876.0d, 2817573, 19122031.
11. Franceschi C, Bonafe M. Centenarians as a model for healthy aging. Biochem Soc Trans 2003, 31:457-461. 10.1042/BST0310457, 12653662.
12. Streit WJ, Braak H, Xue QS, Bechmann I. Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol 2009, 118:475-485. 10.1007/s00401-009-0556-6, 2737117, 19513731.
13. Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 1982, 139:1136-9.
14. Yamaguchi H, Haga C, Hirai S, Nakazato Y, Kosaka K. Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain. Acta Neuropathol (Berl) 1990, 79:569-72.
15. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 1991, 82:239-259.
16. Vitek MP, Brown CM, Colton CA. APOE genotype-specific differences in the innate immune response. Neurobiol Aging 2009, 30:1350-1360. 10.1016/j.neurobiolaging.2007.11.014, 2782461, 18155324.
17. Meyer MR, Tschanz JT, Norton MC, Welsh-Bohmer KA, Steffens DC, Wyse BW, Breitner JC. APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease. Nat Genet 1998, 19:321-322. 10.1038/1206, 9697689.
18. Sheng JG, Mrak RE, Griffin WS. Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol 1998, 95:229-234. 10.1007/s004010050792, 9542587.
19. Schuitemaker A, van der Doef TF, Boellaard R, van der Flier WM, Yaqub M, Windhorst AD, Barkhof F, Jonker C, Kloet RW, Lammertsma AA, et al. Microglial activation in healthy aging. Neurobiol Aging 2010,
20. Beach TG, Walker R, McGeer EG. Patterns of gliosis in Alzheimer's disease and aging cerebrum. Glia 1989, 2:420-436. 10.1002/glia.440020605, 2531723.
21. Streit WJ. Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res Brain Res Rev 2005, 48:234-239.
22. Pont-Lezica L, Bechade C, Belarif-Cantaut Y, Pascual O, Bessis A. Physiological roles of microglia during development. J Neurochem 2011, 119:901-908. 10.1111/j.1471-4159.2011.07504.x, 21951310.
23. Hoozemans JJ, Veerhuis R, Rozemuller JM, Eikelenboom P. Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology. Int J Dev Neurosci 2006, 24:157-165. 10.1016/j.ijdevneu.2005.11.001, 16384684.
24. Streit WJ, Sammons NW, Kuhns AJ, Sparks DL. Dystrophic microglia in the aging human brain. Glia 2004, 45:208-212. 10.1002/glia.10319, 14730714.
25. Ramprasad MP, Terpstra V, Kondratenko N, Quehenberger O, Steinberg D. Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc Natl Acad Sci USA 1996, 93:14833-14838. 10.1073/pnas.93.25.14833, 26222, 8962141.
26. Deininger MH, Pater S, Strik H, Meyermann R. Macrophage/microglial cell subpopulations in glioblastoma multiforme relapses are differentially altered by radiochemotherapy. J Neurooncol 2001, 55:141-147. 10.1023/A:1013805915224, 11859968.
27. Caffo M, Caruso G, Germano A, Galatioto S, Meli F, Tomasello F. CD68 and CR3/43 immunohistochemical expression in secretory meningiomas. Neurosurgery 2005, 57:551-557. 10.1227/01.NEU.0000170440.32720.77, 16145535.
28. Kim SU, de Vellis J. Microglia in health and disease. J Neurosci Res 2005, 81:302-313. 10.1002/jnr.20562, 15954124.
29. Colton CA, Wilcock DM. Assessing activation states in microglia. CNS Neurol Disord Drug Targets 2010, 9:174-191.
30. Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease--a double-edged sword. Neuron 2002, 35:419-32. 10.1016/S0896-6273(02)00794-8, 12165466.
31. van der Flier WM, Pijnenburg YA, Fox NC, Scheltens P. Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE varepsilon4 allele. Lancet Neurol 2011, 10:280-288. 10.1016/S1474-4422(10)70306-9, 21185234.
32. van Gool WA, Aisen PS, Eikelenboom P. Anti-inflammatory therapy in Alzheimer's disease: is hope still alive?. J Neurol 2003, 250:788-92. 10.1007/s00415-003-1146-5, 12883918.
33. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C. Age, neuropathology, and dementia. N Engl J Med 2009, 360:2302-2309. 10.1056/NEJMoa0806142, 19474427.
34. van Gool WA, Eikelenboom P. The two faces of Alzheimer's disease. J Neurol 2000, 247:500-505. 10.1007/s004150070147, 10993489.