Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine

Toxicology in Vitro

Volumn 25, Issue 8, 2011, Pages 1581-1587

  Funakoshi, Takeshi ^a   Aki, Toshihiko ^a   Nakayama, Haruka ^a   Watanuki, Yumi ^a   Imori, Satoko ^a   Uemura, Koichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Caspase; Chelerythrine; H9c2; Mitochondria; Reactive oxygen species

Indexed keywords

CASPASE 3; CASPASE 9; CHELERYTHRINE; MALONIC ACID; REACTIVE OXYGEN METABOLITE; ROTENONE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; GRANULAR CELL TUMOR; HEART MITOCHONDRION; HEART MUSCLE CELL; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; NONHUMAN; PROTEIN DEGRADATION; RAT; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOPHENANTHRIDINES; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; HEART NEOPLASMS; MALONATES; MITOCHONDRIA; NEOPLASMS, MUSCLE TISSUE; RATS; REACTIVE OXYGEN SPECIES; ROTENONE; UNCOUPLING AGENTS;

EID: 82655174017     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.05.028     Document Type: Article

References (29)

1. Bai L.-P., Zhao Z.-Z., Cai Z., Jiang Z.-H. Site-specific binding of chelerythrine to single cytosine and thymine bulges in DNA hairpins. Nucleic Acid Symp. Ser. 2006, 50:197-198.
2. Barreto M.C., Pinto R.E., Arrabaça J.D., Pavão M.L. Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids. Toxicol. Lett. 2003, 146:37-47.
3. Batandier C., Guigas B., Detaille D., El-Mir M., Fontaine E., Rigoulet M., Leverve X. The ROS production induced by a reverse-electron flux at respiratory-chain complex1 is hampered by metformin. J. Bioenergy Biomembr. 2006, 38:33-42.
4. Benov L., Sztejnberg L., Fridovich I. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic. Biol. Med. 1998, 25:826-831.
5. Chan S.L., Lee M.C., Tan K.O., Yang L.K., Lee A.S., Flotow H., Fu N.Y., Butler M.S., Soejarto D.D., Buss A.D., Yu V.C. Identification of chelerythrine as an inhibitor of Bcl XL function. J. Biol. Chem. 2003, 278:20453-20456.
6. Chen Q., Vazquez E.J., Moghaddas S., Hoppel C.L., Lesnefsky E.J. Production of reactive oxygen species by mitochondria: central role of complex III. J. Biol. Chem. 2003, 278:36027-36031.
7. Chen Y., McMillan-Ward E., Kong J., Israels S.J., Gibson S.B. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J. Cell Sci. 2007, 120:4155-4166.
8. Colombo M.L., Bosisio E. Pharmacological activities of Chelidonium majus L. (Papaveraceae). Pharmacol. Res. 1996, 33:127-134.
9. Crow M.T., Mani K., Nam Y.J., Kitsis R.N. The mitochondrial death pathway and cardiac myocyte apoptosis. Circ. Res. 2004, 95:957-970.
10. Dröge W. Free radicals in the physiological control of cell function. Physiol. Rev. 2002, 82:47-95.
11. Gustafsson A.B., Gottlieb R.A. Heart mitochondria: gates of life and death. Cardiovasc. Res. 2008, 77:334-343.
12. Herbert J.M., Augereau J.M., Gleye J., Maffrand J.P. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 1990, 172:993-999.
13. Kaminskyy V., Kulachkovskyy O., Stoika R. A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids. Toxicol. Lett. 2008, 177:168-181.
14. Kaminskyy V., Lin K.W., Filyak Y., Stoika R. Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells. Cell Biol. Int. 2008, 32:271-277.
15. Kuznetsov, A.V., Kehrer, I., Kozlov, A.V., Haller, M., Redl, H., Hermann, M., Grimm, M., Tropppmair, J., 2011. Mitochondrial ROS production under cellular stress: comparison of different detection methods. Anal. Bioanal. Chem. doi:10.1007/s00216-011-4764-2.
16. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
17. Liu Y., Fiskum G., Schubert D. Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 2002, 80:780-787.
18. Matkar S.S., Wrischnik L.A., Hellmann-Blumberg U. Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis. Arch. Biochem. Biophys. 2008, 477:43-52.
19. Orrenius S., Gogvadze V., Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu. Rev. Pharmacol. Toxicol. 2007, 47:143-183.
20. Shanker G., Syversen T., Aschner J., Aschner M. Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes. Mol. Brain Res. 2005, 137:11-22.
21. Slunská Z., Gelnarová E., Hammerová J., Táborská E., Slaninová I. Effect of quaternary benzo[c]phenanthridine alkaloids sanguilutine and chelilutine on normal and cancer cells. Toxicol. In Vitro 2010, 24:697-706.
22. Uemura K., Adachi-Akahane S., Shintani-Ishida K., Yoshida K. Carbon monoxide protects cardiomyogenic cells against ischemic death through L-type Ca2+ channel inhibition. Biochem. Biophysic. Res. Commun. 2005, 334:661-668.
23. Vallejos R.H., Rizzotto M.G. Effect of chelerythrine on mitochondrial energy coupling. FEBS Lett. 1972, 21:195-198.
24. Vogler M., Weber K., Dinsdale D., Schmitz I., Schulze-Osthoff K., Dyer M.J., Cohen G.M. Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ. 2009, 16:1030-1039.
25. Vrba J., Dolezel P., Vicar J., Modrianský M., Ulrichová J. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells. Toxicol. In Vitro 2008, 22:1008-1017.
26. Wan K.F., Chan S.L., Sukumaran S.K., Lee M.C., Yu V.C. Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. J. Biol. Chem. 2008, 283:8423-8433.
27. Xiong J.W., Zhu L., Jiao X., Liu S.S. Evidence for ΔpH surface component (ΔpHS) of proton motive force in ATP synthesis of mitochondria. Biochim. Biophys. Acta 2010, 1800:213-222.
28. Yamamoto S., Seta K., Morisco C., Vatner S.F., Sadoshima J. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J. Mol. Cell. Cardiol. 2001, 33:1829-1848.
29. Yang R., Piperdi S., Gorlick R. Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma. Clin. Cancer Res. 2008, 14:6396-6404.