메뉴 건너뛰기




Volumn 6, Issue 12, 2011, Pages

Caffeine acts via A1 adenosine receptors to disrupt embryonic cardiac function

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; CAFFEINE; OXYGEN; RNA;

EID: 82555185637     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028296     Document Type: Article
Times cited : (22)

References (69)
  • 1
    • 0022555622 scopus 로고
    • The effect of heart rate on in utero left ventricular output in the fetal sheep
    • Anderson PA, Glick KL, Killam AP, Mainwaring RD, (1986) The effect of heart rate on in utero left ventricular output in the fetal sheep. J Physiol (Lond) 372: 557-573.
    • (1986) J Physiol (Lond) , vol.372 , pp. 557-573
    • Anderson, P.A.1    Glick, K.L.2    Killam, A.P.3    Mainwaring, R.D.4
  • 2
  • 3
    • 0027412569 scopus 로고
    • Heart rate perturbation in the stage 17-27 chick embryo: effect on stroke volume and aortic flow
    • Cuneo B, Hughes S, Benson DWJ, (1993) Heart rate perturbation in the stage 17-27 chick embryo: effect on stroke volume and aortic flow. Am J Physiol Heart Circ Physiol 264.
    • (1993) Am J Physiol Heart Circ Physiol , vol.264
    • Cuneo, B.1    Hughes, S.2    Benson, D.W.J.3
  • 5
    • 0028805971 scopus 로고
    • The ontogeny of cardiac and neural A1 adenosine receptor expression in rats
    • Rivkees SA, (1995) The ontogeny of cardiac and neural A1 adenosine receptor expression in rats. Brain Res Dev Brain Res 89: 202-213.
    • (1995) Brain Res Dev Brain Res , vol.89 , pp. 202-213
    • Rivkees, S.A.1
  • 7
    • 11144288674 scopus 로고    scopus 로고
    • Prenatal hypoxia and cardiac programming
    • Zhang L, (2005) Prenatal hypoxia and cardiac programming. J Soc Gynecol Investig 12: 2-13.
    • (2005) J Soc Gynecol Investig , vol.12 , pp. 2-13
    • Zhang, L.1
  • 10
    • 0030802218 scopus 로고    scopus 로고
    • The effect of high altitude and other risk factors on birthweight: independent or interactive effects?
    • Jensen GM, Moore LG, (1997) The effect of high altitude and other risk factors on birthweight: independent or interactive effects? Am J Public Health 87: 1003-1007.
    • (1997) Am J Public Health , vol.87 , pp. 1003-1007
    • Jensen, G.M.1    Moore, L.G.2
  • 11
    • 0035142809 scopus 로고    scopus 로고
    • Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development
    • Lee Y, Jeong C, Koo S, Son M, Song H, et al. (2001) Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development. Dev Dyn 220: 175-186.
    • (2001) Dev Dyn , vol.220 , pp. 175-186
    • Lee, Y.1    Jeong, C.2    Koo, S.3    Son, M.4    Song, H.5
  • 12
    • 77957973733 scopus 로고    scopus 로고
    • Hypoxia and fetal heart development
    • Patterson AJ, Zhang L, (2010) Hypoxia and fetal heart development. Curr Mol Med 10: 653-666.
    • (2010) Curr Mol Med , vol.10 , pp. 653-666
    • Patterson, A.J.1    Zhang, L.2
  • 13
    • 71649094085 scopus 로고    scopus 로고
    • The role of hypoxia in development of the Mammalian embryo
    • Dunwoodie SL, (2009) The role of hypoxia in development of the Mammalian embryo. Dev Cell 17: 755-773.
    • (2009) Dev Cell , vol.17 , pp. 755-773
    • Dunwoodie, S.L.1
  • 14
    • 77649109033 scopus 로고    scopus 로고
    • Adenosine A1 receptor activation reduces opening of mitochondrial permeability transition pores in hypoxic cardiomyocytes
    • Xiang F, Huang YS, Zhang DX, Chu ZG, Zhang JP, et al. (2010) Adenosine A1 receptor activation reduces opening of mitochondrial permeability transition pores in hypoxic cardiomyocytes. Clin Exp Pharmacol Physiol 37: 343-349.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 343-349
    • Xiang, F.1    Huang, Y.S.2    Zhang, D.X.3    Chu, Z.G.4    Zhang, J.P.5
  • 15
    • 79955946810 scopus 로고    scopus 로고
    • Regulation of leukocyte function by adenosine receptors
    • Linden J, (2011) Regulation of leukocyte function by adenosine receptors. Adv Pharmacol 61: 95-114.
    • (2011) Adv Pharmacol , vol.61 , pp. 95-114
    • Linden, J.1
  • 17
    • 68849095740 scopus 로고    scopus 로고
    • The adenosinergic immunomodulatory drugs
    • Ohta A, Sitkovsky M, (2009) The adenosinergic immunomodulatory drugs. Curr Opin Pharmacol 9: 501-506.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 501-506
    • Ohta, A.1    Sitkovsky, M.2
  • 18
    • 79952422814 scopus 로고    scopus 로고
    • Adverse and Protective Influences of Adenosine on the Newborn and Embryo: Implications for Preterm White Matter Injury and Embryo Protection
    • Rivkees SA, Wendler CC, (2011) Adverse and Protective Influences of Adenosine on the Newborn and Embryo: Implications for Preterm White Matter Injury and Embryo Protection. Pediatr Res 69: 271-278.
    • (2011) Pediatr Res , vol.69 , pp. 271-278
    • Rivkees, S.A.1    Wendler, C.C.2
  • 20
    • 77952680750 scopus 로고    scopus 로고
    • Identification of the heart as the critical site of adenosine mediated embryo protection
    • Wendler CC, Poulsen RR, Ghatpande S, Greene RW, Rivkees SA, (2010) Identification of the heart as the critical site of adenosine mediated embryo protection. BMC Dev Biol 10: 57.
    • (2010) BMC Dev Biol , vol.10 , pp. 57
    • Wendler, C.C.1    Poulsen, R.R.2    Ghatpande, S.3    Greene, R.W.4    Rivkees, S.A.5
  • 21
    • 80051625243 scopus 로고    scopus 로고
    • Oxygen sensing, homeostasis, and disease
    • Semenza GL, (2011) Oxygen sensing, homeostasis, and disease. N Engl J Med 365: 537-547.
    • (2011) N Engl J Med , vol.365 , pp. 537-547
    • Semenza, G.L.1
  • 22
    • 0028859662 scopus 로고
    • Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine
    • Fredholm BB, (1995) Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol 76: 93-101.
    • (1995) Pharmacol Toxicol , vol.76 , pp. 93-101
    • Fredholm, B.B.1
  • 23
    • 33646773578 scopus 로고    scopus 로고
    • Maternal exposure to caffeine and risk of congenital anomalies: a systematic review
    • Browne ML, (2006) Maternal exposure to caffeine and risk of congenital anomalies: a systematic review. Epidemiology 17: 324-331.
    • (2006) Epidemiology , vol.17 , pp. 324-331
    • Browne, M.L.1
  • 25
    • 0035690863 scopus 로고    scopus 로고
    • Caffeine metabolism and the risk of spontaneous abortion of normal karyotype fetuses
    • Signorello LB, Nordmark A, Granath F, Blot WJ, McLaughlin JK, et al. (2001) Caffeine metabolism and the risk of spontaneous abortion of normal karyotype fetuses. Obstet Gynecol 98: 1059-1066.
    • (2001) Obstet Gynecol , vol.98 , pp. 1059-1066
    • Signorello, L.B.1    Nordmark, A.2    Granath, F.3    Blot, W.J.4    McLaughlin, J.K.5
  • 27
    • 85058204182 scopus 로고    scopus 로고
    • Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study
    • Weng X, Odouli R, Li DK, (2008) Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol 279: e1-e8.
    • (2008) Am J Obstet Gynecol , vol.279
    • Weng, X.1    Odouli, R.2    Li, D.K.3
  • 29
    • 0027289381 scopus 로고
    • Effects of birth weight of alcohol and caffeine consumption during pregnancy
    • Larroque B, Kaminski M, Lelong N, Subtil D, Dehaene P, (1993) Effects of birth weight of alcohol and caffeine consumption during pregnancy. Am J Epidemiol 137: 941-950.
    • (1993) Am J Epidemiol , vol.137 , pp. 941-950
    • Larroque, B.1    Kaminski, M.2    Lelong, N.3    Subtil, D.4    Dehaene, P.5
  • 31
  • 32
    • 0030679660 scopus 로고    scopus 로고
    • A1 adenosine receptors potently regulate heart rate in mammalian embryos
    • Hofman PL, Hiatt K, Yoder MC, Rivkees SA, (1997) A1 adenosine receptors potently regulate heart rate in mammalian embryos. Am J Physiol 273: R1374-1380.
    • (1997) Am J Physiol , vol.273
    • Hofman, P.L.1    Hiatt, K.2    Yoder, M.C.3    Rivkees, S.A.4
  • 33
    • 0029762944 scopus 로고    scopus 로고
    • Doppler echocardiography of normal and abnormal embryonic mouse heart
    • Gui YH, Linask KK, Khowsathit P, Huhta JC, (1996) Doppler echocardiography of normal and abnormal embryonic mouse heart. Pediatr Res 40: 633-642.
    • (1996) Pediatr Res , vol.40 , pp. 633-642
    • Gui, Y.H.1    Linask, K.K.2    Khowsathit, P.3    Huhta, J.C.4
  • 34
    • 0030035598 scopus 로고    scopus 로고
    • In vivo assessment of embryonic cardiovascular dimensions and function in day-10.5 to -14.5 mouse embryos
    • Keller BB, MacLennan MJ, Tinney JP, Yoshigi M, (1996) In vivo assessment of embryonic cardiovascular dimensions and function in day-10.5 to-14.5 mouse embryos. Circ Res 79: 247-255.
    • (1996) Circ Res , vol.79 , pp. 247-255
    • Keller, B.B.1    MacLennan, M.J.2    Tinney, J.P.3    Yoshigi, M.4
  • 35
    • 0033103552 scopus 로고    scopus 로고
    • Umbilical arterial blood flow in the mouse embryo during development and following acutely increased heart rate
    • MacLennan MJ, Keller BB, (1999) Umbilical arterial blood flow in the mouse embryo during development and following acutely increased heart rate. Ultrasound Med Biol 25: 361-370.
    • (1999) Ultrasound Med Biol , vol.25 , pp. 361-370
    • MacLennan, M.J.1    Keller, B.B.2
  • 37
    • 33847714772 scopus 로고    scopus 로고
    • Hemodynamic vulnerability to acute hypoxia in day 10.5-16.5 murine embryos
    • Furukawa S, Tinney JP, Tobita K, Keller BB, (2007) Hemodynamic vulnerability to acute hypoxia in day 10.5-16.5 murine embryos. J Obstet Gynaecol Res 33: 114-127.
    • (2007) J Obstet Gynaecol Res , vol.33 , pp. 114-127
    • Furukawa, S.1    Tinney, J.P.2    Tobita, K.3    Keller, B.B.4
  • 38
    • 69349097606 scopus 로고    scopus 로고
    • The Fetal Heart Rate Response to Hypoxia: Insights from Animal Models
    • Bennet L, Gunn AJ, (2009) The Fetal Heart Rate Response to Hypoxia: Insights from Animal Models. Clin Perinatol 36: 655-672.
    • (2009) Clin Perinatol , vol.36 , pp. 655-672
    • Bennet, L.1    Gunn, A.J.2
  • 39
    • 0030911999 scopus 로고    scopus 로고
    • Unilateral Vitelline Vein Ligation Alters Intracardiac Blood Flow Patterns and Morphogenesis in the Chick Embryo
    • Hogers B, DeRuiter MC, Gittenberger-de Groot AC, Poelmann RE, (1997) Unilateral Vitelline Vein Ligation Alters Intracardiac Blood Flow Patterns and Morphogenesis in the Chick Embryo. Circ Res 80: 473-481.
    • (1997) Circ Res , vol.80 , pp. 473-481
    • Hogers, B.1    DeRuiter, M.C.2    Gittenberger-de Groot, A.C.3    Poelmann, R.E.4
  • 40
    • 0142232050 scopus 로고    scopus 로고
    • Pressure overload alters stress-strain properties of the developing chick heart
    • Miller CE, Wong CL, Sedmera D, (2003) Pressure overload alters stress-strain properties of the developing chick heart. Am J Physiol Heart Circ Physiol 285: H1849-H1856.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Miller, C.E.1    Wong, C.L.2    Sedmera, D.3
  • 41
    • 14644399186 scopus 로고    scopus 로고
    • Three-dimensional myofiber architecture of the embryonic left ventricle during normal development and altered mechanical loads
    • Tobita K, Garrison JB, Liu LJ, Tinney JP, Keller BB, (2005) Three-dimensional myofiber architecture of the embryonic left ventricle during normal development and altered mechanical loads. Anat Rec A Discov Mol Cell Evol Biol 283A: 193-201.
    • (2005) Anat Rec A Discov Mol Cell Evol Biol , vol.283 A , pp. 193-201
    • Tobita, K.1    Garrison, J.B.2    Liu, L.J.3    Tinney, J.P.4    Keller, B.B.5
  • 42
    • 0346634892 scopus 로고    scopus 로고
    • Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
    • Hove JR, Koster RW, Forouhar AS, Acevedo-Bolton G, Fraser SE, et al. (2003) Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 421: 172-177.
    • (2003) Nature , vol.421 , pp. 172-177
    • Hove, J.R.1    Koster, R.W.2    Forouhar, A.S.3    Acevedo-Bolton, G.4    Fraser, S.E.5
  • 44
  • 47
    • 0023427233 scopus 로고
    • Effect of heart rate increase on dorsal aortic flow in the stage 24 chick embryo
    • Dunnigan A, Hu N, Benson DWJ, Clark EB, (1987) Effect of heart rate increase on dorsal aortic flow in the stage 24 chick embryo. Pediatr Res 22.
    • (1987) Pediatr Res , vol.22
    • Dunnigan, A.1    Hu, N.2    Benson, D.W.J.3    Clark, E.B.4
  • 49
    • 69449097667 scopus 로고    scopus 로고
    • Selective deletion of A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo
    • Koeppen M, Eckle T, Eltzschig HK, (2009) Selective deletion of A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo. PLoS ONE 4: e6784.
    • (2009) PLoS ONE , vol.4
    • Koeppen, M.1    Eckle, T.2    Eltzschig, H.K.3
  • 50
    • 0021104034 scopus 로고
    • Effects of caffeine on the fetal heart
    • Resch BA, Papp JG, (1983) Effects of caffeine on the fetal heart. Am J Obstet Gynecol 146: 231-232.
    • (1983) Am J Obstet Gynecol , vol.146 , pp. 231-232
    • Resch, B.A.1    Papp, J.G.2
  • 51
    • 0021934280 scopus 로고
    • Effect of caffeine on fetal heart rate and caffeine consumption habits in pregnant patients
    • Resch BA, Papp JG, Gyöngyösi J, Széll SJ, (1985) Effect of caffeine on fetal heart rate and caffeine consumption habits in pregnant patients. Zentralbl Gynakol 107: 1249-1253.
    • (1985) Zentralbl Gynakol , vol.107 , pp. 1249-1253
    • Resch, B.A.1    Papp, J.G.2    Gyöngyösi, J.3    Széll, S.J.4
  • 52
    • 0023182687 scopus 로고
    • Effect of caffeine on the contractility of the fetal heart muscle
    • Resch BA, Papp JG, Gyöngyösi J, (1987) Effect of caffeine on the contractility of the fetal heart muscle. Zentralbl Gynakol 109: 945-951.
    • (1987) Zentralbl Gynakol , vol.109 , pp. 945-951
    • Resch, B.A.1    Papp, J.G.2    Gyöngyösi, J.3
  • 53
    • 78650136825 scopus 로고    scopus 로고
    • Foetal response to maternal coffee intake: role of habitual versus non-habitual caffeine consumption
    • Mulder EJ, Tegaldo L, Bruschettini P, Visser GH, (2010) Foetal response to maternal coffee intake: role of habitual versus non-habitual caffeine consumption. J Psychopharmacol 24: 1641-1648.
    • (2010) J Psychopharmacol , vol.24 , pp. 1641-1648
    • Mulder, E.J.1    Tegaldo, L.2    Bruschettini, P.3    Visser, G.H.4
  • 54
    • 0024391144 scopus 로고
    • Effects of regular and decaffeinated coffee on fetal breathing and heart rate
    • Salvador HS, Koos BJ, (1989) Effects of regular and decaffeinated coffee on fetal breathing and heart rate. Am J Obstet Gynecol 160: 1043-1047.
    • (1989) Am J Obstet Gynecol , vol.160 , pp. 1043-1047
    • Salvador, H.S.1    Koos, B.J.2
  • 55
    • 0028351795 scopus 로고
    • Acute maternal and fetal cardiovascular effects of caffeine ingestion
    • Miller RC, Watson WJ, Hackney AC, Seeds JW, (1994) Acute maternal and fetal cardiovascular effects of caffeine ingestion. Am J Perinatol 11: 132-136.
    • (1994) Am J Perinatol , vol.11 , pp. 132-136
    • Miller, R.C.1    Watson, W.J.2    Hackney, A.C.3    Seeds, J.W.4
  • 56
    • 0021042634 scopus 로고
    • The effects of caffeine on placental and fetal blood flow in human pregnancy
    • Kirkinen P, Jouppila P, Koivula A, Vuori J, Puukka M, (1983) The effects of caffeine on placental and fetal blood flow in human pregnancy. Am J Obstet Gynecol 147: 939-942.
    • (1983) Am J Obstet Gynecol , vol.147 , pp. 939-942
    • Kirkinen, P.1    Jouppila, P.2    Koivula, A.3    Vuori, J.4    Puukka, M.5
  • 57
    • 0030683533 scopus 로고    scopus 로고
    • Nicotine and caffeine. Influence on prenatal hemodynamics and behavior in early twin pregnancy
    • Huisman M, Risseeuw B, van Eyck J, Arabin B, (1997) Nicotine and caffeine. Influence on prenatal hemodynamics and behavior in early twin pregnancy. J Reprod Med 42: 731-734.
    • (1997) J Reprod Med , vol.42 , pp. 731-734
    • Huisman, M.1    Risseeuw, B.2    van Eyck, J.3    Arabin, B.4
  • 58
    • 61949343322 scopus 로고    scopus 로고
    • Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine
    • Yang JN, Bjorklund O, Lindstrom-Tornqvist K, Lindgren E, Eriksson TM, et al. (2009) Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine. J Appl Physiol 106: 631-639.
    • (2009) J Appl Physiol , vol.106 , pp. 631-639
    • Yang, J.N.1    Bjorklund, O.2    Lindstrom-Tornqvist, K.3    Lindgren, E.4    Eriksson, T.M.5
  • 60
    • 79954994463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5′-nucleotidase (CD73) and the A2B adenosine receptor
    • Hart ML, Grenz A, Gorzolla IC, Schittenhelm J, Dalton JH, et al. (2011) Hypoxia-inducible factor-1alpha-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5′-nucleotidase (CD73) and the A2B adenosine receptor. J Immunol 186: 4367-4374.
    • (2011) J Immunol , vol.186 , pp. 4367-4374
    • Hart, M.L.1    Grenz, A.2    Gorzolla, I.C.3    Schittenhelm, J.4    Dalton, J.H.5
  • 61
    • 0023229420 scopus 로고
    • The effects of long- and short-term maternal caffeine ingestion on human fetal breathing and body movements in term gestations
    • McGowan J, Devoe LD, Searle N, Altman R, (1987) The effects of long- and short-term maternal caffeine ingestion on human fetal breathing and body movements in term gestations. Am J Obstet Gynecol 157: 726-729.
    • (1987) Am J Obstet Gynecol , vol.157 , pp. 726-729
    • McGowan, J.1    Devoe, L.D.2    Searle, N.3    Altman, R.4
  • 62
    • 0027413818 scopus 로고
    • Maternal caffeine consumption and fetal behavior in normal third-trimester pregnancy
    • Devoe LD, Murray C, Youssif A, Arnaud M, (1993) Maternal caffeine consumption and fetal behavior in normal third-trimester pregnancy. Am J Obstet Gynecol 168: 1105-1111.
    • (1993) Am J Obstet Gynecol , vol.168 , pp. 1105-1111
    • Devoe, L.D.1    Murray, C.2    Youssif, A.3    Arnaud, M.4
  • 63
    • 0030907305 scopus 로고    scopus 로고
    • Expression of the cholinergic signal-transduction pathway components during embryonic rat heart development
    • Franco D, Moorman AFM, Lamers WH, (1997) Expression of the cholinergic signal-transduction pathway components during embryonic rat heart development. Anat Rec 248: 110-120.
    • (1997) Anat Rec , vol.248 , pp. 110-120
    • Franco, D.1    Moorman, A.F.M.2    Lamers, W.H.3
  • 64
    • 0017666424 scopus 로고
    • Ontogenetic development of autonomic neuroeffector transmission and transmitter reactivity in embryonic and fetal hearts
    • Pappano AJ, (1977) Ontogenetic development of autonomic neuroeffector transmission and transmitter reactivity in embryonic and fetal hearts. Pharmacological Reviews 29: 3-33.
    • (1977) Pharmacological Reviews , vol.29 , pp. 3-33
    • Pappano, A.J.1
  • 65
    • 0035979311 scopus 로고    scopus 로고
    • Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor
    • Johansson B, Halldner L, Dunwiddie TV, Masino SA, Poelchen W, et al. (2001) Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci USA 98: 9407-9412.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9407-9412
    • Johansson, B.1    Halldner, L.2    Dunwiddie, T.V.3    Masino, S.A.4    Poelchen, W.5
  • 66
    • 0141816729 scopus 로고    scopus 로고
    • A1 adenosine receptors mediate hypoxia-induced ventriculomegaly
    • Turner CP, Seli M, Ment L, Stewart W, Yan H, et al. (2003) A1 adenosine receptors mediate hypoxia-induced ventriculomegaly. Proc Natl Acad Sci U S A 100: 11718-11722.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11718-11722
    • Turner, C.P.1    Seli, M.2    Ment, L.3    Stewart, W.4    Yan, H.5
  • 68
    • 0031833150 scopus 로고    scopus 로고
    • Adenosine receptors: new opportunities for future drugs
    • Poulsen SA, Quinn R, (1998) Adenosine receptors: new opportunities for future drugs. Bioorg Med Chem 6: 619-641.
    • (1998) Bioorg Med Chem , vol.6 , pp. 619-641
    • Poulsen, S.A.1    Quinn, R.2
  • 69
    • 33644984200 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development
    • Wendler CC, Rivkees SA, (2006) Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. Dev Biol 291: 264-277.
    • (2006) Dev Biol , vol.291 , pp. 264-277
    • Wendler, C.C.1    Rivkees, S.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.