Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States

Metabolic Syndrome and Related Disorders

Volumn 9, Issue 6, 2011, Pages 475-482

  Vassy, Jason L ^a   Shrader, Peter ^a   Yang, Quanhe ^b   Liu, Tiebin ^b   Yesupriya, Ajay ^b   Chang, Man Huei ^b   Dowling, Nicole F ^b   Ned, Renée M ^b   Dupuis, Josée ^c   Florez, Jose C ^d,e   Khoury, Muin J ^b   Meigs, James B ^a,e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

^c BOSTON UNIVERSITY   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRIACYLGLYCEROL;

ADULT; AFRICAN AMERICAN; ARTICLE; BODY MASS; EFFECT SIZE; EUROPEAN AMERICAN; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; HISPANIC; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES; WAIST CIRCUMFERENCE;

ADULT; ALLELES; CONTINENTAL POPULATION GROUPS; CROSS-SECTIONAL STUDIES; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NUTRITION SURVEYS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; QUANTITATIVE TRAIT, HERITABLE; UNITED STATES;

EID: 82555184957     PISSN: 15404196     EISSN: 15578518     Source Type: Journal    
DOI: 10.1089/met.2011.0021     Document Type: Article

References (42)

1. Wilson PW, D'Agostino RB, Parise H et al. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 2005;112:3066-3072. (Pubitemid 43113437)
2. Franco OH, Massaro JM, Civil J et al. Trajectories of entering the metabolic syndrome: The Framingham Heart Study. Circulation 2009;120:1943-1950.
3. Lin JW, Caffrey JL, Chang MH et al. Sex, menopause, metabolic syndrome, and all-cause and cause-specific mortality-cohort analysis from the Third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab 2010;95:4258-4267.
4. Mozumdar A, Liguori G. Persistent Increase of Prevalence of Metabolic Syndrome Among US adults: NHANES III to NHANES 1999-2006. Diabetes Care 2011;34:216-219.
5. Hivert MF, Grant RW, Shrader P et al. Identifying primary care patients at risk for future diabetes and cardiovascular disease using electronic health records. BMC Health Serv Res 2009;9:170.
6. Newton-Cheh C, Johnson T, Gateva V et al. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genet 2009;41:666-676.
7. Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894. (Pubitemid 46764279)
8. Loos RJ, Lindgren CM, Li S et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genet 2008;40:768-775. (Pubitemid 351748863)
9. Heid IM, Vollmert C, Kronenberg F et al. Association of the MC4R V103I polymorphism with the metabolic syndrome: The KORA Study. Obesity 2008;16:369-376. (Pubitemid 351271918)
10. Speliotes EK, Willer CJ, Berndt SI et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genet 2010;42:937-948.
11. Heid IM, Jackson AU, Randall JC et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics 2010;42:949-60.
12. Dupuis J, Langenberg C, Prokopenko I et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genet 2010;42: 105-116.
13. Kathiresan S, Willer CJ, Peloso GM et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nature Genet 2009;41:56-65.
14. Sabatti C, Service SK, Hartikainen AL et al. Genomewide association analysis of metabolic traits in a birth cohort from a founder population. Nature Genetics 2009;41: 35-46.
15. Chambers JC, Elliott P, Zabaneh D et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nature Genet 2008;40:716-718. (Pubitemid 351748872)
16. Freathy RM, Timpson NJ, Lawlor DA et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes 2008;57:1419-1426.
17. Zeggini E, Scott LJ, Saxena R et al. Meta-analysis of genomewide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nature Genet 2008;40:638-645. (Pubitemid 351601209)
18. Voight BF, Scott LJ, Steinthorsdottir V et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genet 2010;42:579-589.
19. Willer CJ, Speliotes EK, Loos RJ et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genet 2009;41:25-34.
20. Saxena R, Hivert MF, Langenberg C et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genet 2010;42:142-148.
21. Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey: NHANES III. 2010. Available at: www.cdc.gov/nchs/nhanes/ nh3data.htm#1a. Last accessed November 1, 2010.
22. Kosoy R, Nassir R, Tian C et al. Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America. Hum Mutat 2009;30:69-78.
23. National Center for Health S. Plan and Operation of the Third National Health and Nutrition Examination Survey 1988-94: Series 1: Programs and Collection Procedures No. 32. Report; July, 1994.
24. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419. (Pubitemid 15018832)
25. National Heart L, Blood I. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Report: National Institutes of Health; September 2002. Report No.: NIH Publication Number 02-5215.
26. Johnson AD, Handsaker RE, Pulit SL et al. SNAP: A webbased tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics (Oxford, England) 2008;24: 2938-2939.
27. Stolerman ES, Manning AK, McAteer JB et al. Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study. Diabetes 2008;57:1971-1977.
28. Meyre D, Bouatia-Naji N, Tounian A et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nature Genet 2005;37:863-867. (Pubitemid 41077112)
29. McAteer JB, Prudente S, Bacci S et al.; for the ENPP1 Consortium. The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes 2008;57:1125-1130.
30. Orho-Melander M, Melander O, Guiducci C et al. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 2008;57:3112-3121.
31. Gabriel SB, Schaffner SF, Nguyen H et al. The structure of haplotype blocks in the human genome. Science 2002;296: 2225-2229. (Pubitemid 34680308)
32. Lohr SL. Sampling: Design and Analysis. Pacific Grove, CA: Duxbury Press; 1999.
33. Bressler J, Kao WH, Pankow JS et al. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. PloS One 2010;5:e10521.
34. Chang MH, Yesupriya A, Ned RM et al. Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey. BMC Med Genet 2010;11:62.
35. Sjogren M, Lyssenko V, Jonsson A et al. The search for putative unifying genetic factors for components of the metabolic syndrome. Diabetologia 2008;51:2242-2251.
36. Campbell CD, Ogburn EL, Lunetta KL et al. Demonstrating stratification in a European American population. Nature Genet 2005;37:868-872. (Pubitemid 41077113)
37. Chen W, Srinivasan SR, Berenson GS. Path analysis of metabolic syndrome components in black versus white children, adolescents, and adults: The Bogalusa Heart Study. Ann Epidemiol 2008;18:85-91.
38. Haffner SM, D'Agostino R, Saad MF et al. Increased insulin resistance and insulin secretion in nondiabetic African- Americans and Hispanics compared with non-Hispanic whites. The Insulin Resistance Atherosclerosis Study. Diabetes 1996;45:742-748.
39. Norman JE, Bild D, Lewis CE et al. The impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study. Int J Obes Relat Metab Disord 2003;27:369-376. (Pubitemid 36384875)
40. Samani NJ, Erdmann J, Hall AS et al. Genomewide association analysis of coronary artery disease. N Engl J Med 2007;357:443-453. (Pubitemid 47204873)
41. Rung J, Cauchi S, Albrechtsen A et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 2009;41:1110-1115.
42. Doney AS, Dannfald J, Kimber CH et al. The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: A genetics of diabetes audit and research study in tayside scotland (go-DARTS) study. Circ Cardiovasc Genet 2009;2: 255-259.