L-arginine plus drospirenone-ethinyl estradiol in the treatment of patients with PCOS: A prospective, placebo controlled, randomised, pilot study

Gynecological Endocrinology

Volumn 26, Issue 12, 2010, Pages 861-868

  Battaglia, Cesare ^a   Mancini, Fulvia ^b   Battaglia, Bruno ^a   Facchinetti, Fabio ^c   Artini, Paolo G ^d   Venturoli, Stefano ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b INSTITUT UNIVERSITARI DEXEUS   (Spain)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

drospirenone; l arginine; nitric oxide; Polycystic ovary syndrome; ultrasound

Indexed keywords

ARGININE; DROSPIRENONE PLUS ETHINYLESTRADIOL; NITRATE; NITRITE; PLACEBO;

ADULT; ARTERY BLOOD FLOW; ARTICLE; BLOOD ANALYSIS; BLOOD PRESSURE MONITORING; BRACHIAL ARTERY; CHEMICAL ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; COLOR ULTRASOUND FLOWMETRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; HUMAN; LOW DRUG DOSE; MEDICAL EXAMINATION; OPHTHALMIC ARTERY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASODILATATION;

ADULT; ANDROSTENEDIONE; ANDROSTENES; ARGININE; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; ESTRADIOL; ETHINYL ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; LUTEINIZING HORMONE; OVARY; PILOT PROJECTS; POLYCYSTIC OVARY SYNDROME; PROSPECTIVE STUDIES; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; ULTRASONOGRAPHY, DOPPLER, COLOR; UTERUS; YOUNG ADULT;

EID: 78149424436     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2010.501882     Document Type: Article

References (23)

1. Meyer C, McGrath BP, Teede HJ. Overweight women with polycistic ovary syndrome have evidence of subclinical cardiovascular disease. J Clin Endocrinol Metab 2005;90: 5711-5716. (Pubitemid 41415480)
2. Baillargeon JP, McClish DK, Essah PA, Nestler GE. Associa-tion between the current use of low-dose oral contraceptives and cardiovascular arterial disease: a meta-analysis. J Clin Endocrinol Metab 2005;90:3863-3870.
3. WHO collaborative study of cardiovascular disease and steroid hormone contraception. Acute myocardial infar-ction and combined oral contraceptives: results of an international multicentre case-control study. Lancet 1997; 349:1202-1209. (Pubitemid 27190043)
4. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophisiology, and pharmacology. Pharmaco Rev 1991;43: 109-142.
5. Battaglia C, Mancini F, Cianciosi A, Busacchi P, Facchinetti F, Marchesini Reggiani, G, Marzocchi R, de Aloysio D. Vascular risk in young women with polycystic ovary and polycystic ovary syndrome. Obstet Gynecol 2008;111:385-395. (Pubitemid 351653430)
6. Battaglia C, Artini PG, D'Ambrogio G, Genazzani AD, Genazzani AR. The role of color Doppler imaging in the diagnosis ofpolycystic ovary syndrome. Am J Obstet Gynecol 1995;172:108-113.
7. Battaglia C, Artini PG, Salvatori M, Giulini S, Petraglia F, Maxia N, Volpe A. Ultrasonographic patterns of polycystic ovaries: color Doppler and hormonal correlations. Ultrasound Obstet Gynecol 1998;11:332-336. (Pubitemid 28282407)
8. Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol 1971;21:1440-1447.
9. Battaglia C, Mancini F, Regnani G, Persico N, Volpe A, de Aloysio D. Hormone therapy and ophthalmic artery blood flow changes in women with primary open-angle glaucoma. Menopause 2004;11:69-77. (Pubitemid 40362201)
10. Gosling RG, Lo PTS, Taylor MG. Interpretation ofpulsatility index in feeder arteries to low-impedance vascular beds. Ultrasound ObstetGynecol 1991;1:175-179.
11. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R. International brachial artery reactivity task force. Guide-lines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery. J Am Coll Cardiol 2002;39:257-265. (Pubitemid 34084631)
12. Staessen JA, Fagard R, Thijs L, Amery A, and the Participants in The Fourth International Consensus Con-ference on the 24-Hour Ambulatory Blood Pressure Monitoring. A consensus view on the technique of ambulatory blood pressure monitoring. Hypertension 1995;26:912-918.
13. Facchinetti F, De Martis S, Neri I, Caputo A, Volpe A. Effects of transdermal glyceryltrinitrate on 24-h blood pressure changes in patients with gestational hypertension. Prenat Neonat Med 1997;2:22-28. (Pubitemid 127498889)
14. Battaglia C, Regnani G, Marsella T, Facchinetti F, Volpe A, Venturoli S, Flamigni C. Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: a double-blind, randomized study. Hum Reprod 2002; 17:659-665. (Pubitemid 34232436)
15. Battaglia C, Cianciosi A, Mancini F, Persico N, Sisti G, Facchinetti F, Busacchi P. Angeliq versus Activelle in normotensive postmenopausal women: a prospective, rando-mized pilot study. Menopause 2009;16:803-809.
16. Diamanti-Kandarakis E, Baillargeon JP, Iuorno MJ, Jakubowicz DJ, Nestler JE. A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pill. J Clin Endocrinol Metab 2003;88:1927-1932.
17. Oelkers WHK. Drospirenone in combination with estrogens: for contraception and hormone replacement therapy. Climac-teric 2005;8:19-27. (Pubitemid 41608060)
18. Muhn P, Krattenmacher R, Beier S, Elger W, Schillinger E. Drospirenone: a novel progestogen with antimineral corticoid and antiandrogenic activity: pharmacological characterization in animal models. Contraception 1995;51:99-110.
19. Guido M, Romualdi D, Giuliani M, Suriano S, Selvaggi L, Apa R, Lanzone A. Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: a clinical, endocrinological, metabolic pilot study. J Clin Endocrinol Metab 2004;89:2817-2823. (Pubitemid 38766371)
20. Anderson TJ. Assessment and treatment of endothelial dysfunction in humans. J Am Coll Cardiol 1999;34:631-638. (Pubitemid 29436165)
21. Anderson EA, Mark AL. Flow-mediated and reflex changes in large peripheral artery tone in humans. Circulation 1989;79: 93-100.
22. Gerasimovska-Kitanovska B, Zafirovska K, Bogdanovska S, Lozance L, Severova-Andreevska G. Decreased nitric oxide in women with essential hypertension in prehypertensive phase. Croat Med J 2005;46:889-893. (Pubitemid 43175542)
23. Powers WJ, Press GA, Grubb RL Jr, Gado M, Raichle ME. The effect of hemodynamically significant carotid artery disease on the hemodynamic status of the cerebral circulation. Ann Intern Med 1987;106:27-34.