Coenzyme a binding to the aminoglycoside acetyltransferase (3)-IIIb increases conformational sampling of antibiotic binding site

Biochemistry

Volumn 50, Issue 48, 2011, Pages 10559-10565

  Hu, Xiaohu ^a,b   Norris, Adrianne L ^c   Baudry, Jerome ^a,c   Serpersu, Engin H ^c  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ACETYLTRANSFERASE; ANTIBIOTIC BINDING; APO-ENZYMES; COENZYME A; DYNAMIC PROPERTY; DYNAMIC VARIATIONS; MOLECULAR DYNAMICS SIMULATIONS; STRUCTURAL CHANGE; STRUCTURAL FLEXIBILITIES;

ANTIBIOTICS; DYNAMICS; ENZYMES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

MOLECULAR DYNAMICS;

ACETYLTRANSFERASE IIIB; AMINOGLYCOSIDE; COENZYME A; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG CONFORMATION; DRUG PROTEIN BINDING; HETERONUCLEAR SINGLE QUANTUM COHERENCE; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; THERMODYNAMICS;

ACETYLTRANSFERASES; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; APOPROTEINS; BACILLUS ANTHRACIS; BINDING SITES; COENZYME A; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 82455219022     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201008f     Document Type: Article

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