The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: The monoclonal antibody KIM185 to CD18 also binds C4-binding protein

Molecular Immunology

Volumn 49, Issue 1-2, 2011, Pages 38-47

  Gjelstrup, Louise Carstensen ^a   Andersen, Stig Henrik ^a   Petersen, Steen Vang ^a   Enghild, Jan J ^a   Blom, Anna M ^b   Vorup Jensen, Thomas ^a   Thiel, Steffen ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

2 integrin; Antibody cross reactivity; C4 binding protein; Heteroclitic antibodies

Indexed keywords

CD18 ANTIGEN; COMPLEMENT COMPONENT C4 BINDING PROTEIN; GLYCOPROTEIN P 15095; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY KIM185; OLIGOMER; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS REACTION; CRYSTALLOGRAPHY; FLUOROMETRY; GENE DELETION; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; OLIGOMERIZATION; PREDICTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, CD18; BINDING SITES, ANTIBODY; BLOTTING, WESTERN; CROSS REACTIONS; HISTOCOMPATIBILITY ANTIGENS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 82455199178     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.07.018     Document Type: Article

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