Increased oxidative stress and cytotoxicity by hydrogen sulfide in HepG2 cells overexpressing cytochrome P450 2E1

Cell Biology and Toxicology

Volumn 27, Issue 6, 2011, Pages 439-453

  Caro, Andres A ^a   Thompson, Sarah ^a   Tackett, Jonathan ^a  

^a HENDRIX COLLEGE   (United States)

Author keywords

CYP2E1; HepG2 cells; Hydrogen sulfide; Lipid peroxidation; Oxidative stress; Reactive oxygen species

Indexed keywords

ALPHA TOCOPHEROL; CYTOCHROME P450 2E1; CYTOCHROME P450 2E1 INHIBITOR; CYTOCHROME P450 INHIBITOR; DOCOSAHEXAENOIC ACID; HYDROGEN SULFIDE; IRON; IRON CHELATING AGENT; LIPID; TROLOX C; UNCLASSIFIED DRUG;

ARTICLE; CELL SPECIFICITY; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER NECROSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR PROBE; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TIME;

ALPHA-TOCOPHEROL; ANTIOXIDANTS; BLOTTING, WESTERN; CHROMANS; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; GENE EXPRESSION; HEP G2 CELLS; HEPATOCYTES; HUMANS; HYDROGEN SULFIDE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SULFIDES;

EID: 82455199167     PISSN: 07422091     EISSN: 15736822     Source Type: Journal    
DOI: 10.1007/s10565-011-9198-2     Document Type: Article

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