-
1
-
-
33745515023
-
Tumour microenvironment - TGFβ: The molecular Jekyll and Hyde of cancer
-
DOI 10.1038/nrc1926, PII N1926
-
Bierie, B. and Moses, H. L. (2006) Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer. Nat. Rev. Cancer 6, 506-520 (Pubitemid 43980540)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.7
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
2
-
-
47549090432
-
TGFβ in cancer
-
Massagué, J. (2008) TGFβ in cancer. Cell 134, 215-230
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massagué, J.1
-
3
-
-
68549123472
-
New regulatory mechanisms of TGF-β receptor function
-
Kang, J. S. et al. (2009) New regulatory mechanisms of TGF-β receptor function. Trends Cell Biol. 19, 385-394
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 385-394
-
-
Kang, J.S.1
-
4
-
-
77949903708
-
Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-β responses
-
Daly, A. C. et al. (2010) Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-β responses. J. Biol. Chem. 285, 6489-6497
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 6489-6497
-
-
Daly, A.C.1
-
5
-
-
65249118863
-
Association of v-ErbA with Smad4 disrupts TGF-β signaling
-
Erickson, R. A. and Liu, X. (2009) Association of v-ErbA with Smad4 disrupts TGF-β signaling. Mol. Biol. Cell 20, 1509-1519
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1509-1519
-
-
Erickson, R.A.1
Liu, X.2
-
6
-
-
77956258205
-
Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-β switch from a suppressor to a promoter of cancer cell proliferation
-
Singh, G. et al. (2010) Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-β switch from a suppressor to a promoter of cancer cell proliferation. J. Biol. Chem. 285, 27241-27250
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27241-27250
-
-
Singh, G.1
-
7
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
Thiery, J. P. et al. (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
-
8
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
DOI 10.1016/j.ceb.2005.08.001, PII S0955067405001043
-
Huber, M. A. et al. (2005) Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17, 548-558 (Pubitemid 41267170)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, Issue.5 SPEC. ISS.
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
9
-
-
16344378397
-
TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
-
DOI 10.1091/mbc.E04-08-0658
-
Valcourt, U. et al. (2005) TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial mesenchymal cell transition. Mol. Biol. Cell 16, 1987-2002 (Pubitemid 40471965)
-
(2005)
Molecular Biology of the Cell
, vol.16
, Issue.4
, pp. 1987-2002
-
-
Valcourt, U.1
Kowanetz, M.2
Niimi, H.3
Heldin, C.-H.4
Moustakas, A.5
-
10
-
-
39749157093
-
Sustained TGFβ exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis
-
DOI 10.1038/sj.onc.1210741, PII 1210741
-
Gal, A. et al. (2008) Sustained TGFβ exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene 27, 1218-1230 (Pubitemid 351294691)
-
(2008)
Oncogene
, vol.27
, Issue.9
, pp. 1218-1230
-
-
Gal, A.1
Sjoblom, T.2
Fedorova, L.3
Imreh, S.4
Beug, H.5
Moustakas, A.6
-
11
-
-
3142742249
-
Induction by transforming growth factor-β1 of epithelial to mesenchymal transition is a rare event in vitro
-
Brown, K. A. et al. (2004) Induction by transforming growth factor-β1 of epithelial to mesenchymal transition is a rare event in vitro. Breast Cancer Res. 6, R215-R231
-
(2004)
Breast Cancer Res.
, vol.6
-
-
Brown, K.A.1
-
12
-
-
33745107179
-
A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes
-
DOI 10.1038/sj.onc.1209083, PII 1209083
-
Gotzmann, J. et al. (2006) A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes. Oncogene 25, 3170-3185 (Pubitemid 43881558)
-
(2006)
Oncogene
, vol.25
, Issue.22
, pp. 3170-3185
-
-
Gotzmann, J.1
Fischer, A.N.M.2
Zojer, M.3
Mikula, M.4
Proell, V.5
Huber, H.6
Jechlinger, M.7
Waerner, T.8
Weith, A.9
Beug, H.10
Mikulits, W.11
-
13
-
-
79951813692
-
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition
-
Shirakihara, T. et al. (2011) TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J. 30, 783-795
-
(2011)
EMBO J.
, vol.30
, pp. 783-795
-
-
Shirakihara, T.1
-
14
-
-
33748168727
-
ILEI: A cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
-
DOI 10.1016/j.ccr.2006.07.020, PII S1535610806002510
-
Waerner, T. et al. (2006) ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell 10, 227-239 (Pubitemid 44311068)
-
(2006)
Cancer Cell
, vol.10
, Issue.3
, pp. 227-239
-
-
Waerner, T.1
Alacakaptan, M.2
Tamir, I.3
Oberauer, R.4
Gal, A.5
Brabletz, T.6
Schreiber, M.7
Jechlinger, M.8
Beug, H.9
-
15
-
-
77649261101
-
TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
-
Chaudhury, A. et al. (2010) TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat. Cell Biol. 12, 286-293
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 286-293
-
-
Chaudhury, A.1
-
16
-
-
30644479959
-
Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
-
DOI 10.1128/MCB.26.2.654-667.2006
-
Ju, W. et al. (2006) Deletion of Smad2 in mouse liver reveals novel functionsinhepatocytegrowthand differentiation. Mol. Cell Biol. 26, 654-667 (Pubitemid 43089776)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.2
, pp. 654-667
-
-
Ju, W.1
Ogawa, A.2
Heyer, J.3
Nierhof, D.4
Yu, L.5
Kucherlapati, R.6
Shafritz, D.A.7
Bottinger, E.P.8
-
17
-
-
48749122568
-
Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
-
Hoot, K. E. et al. (2008) Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J. Clin. Invest. 118, 2722-2732
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2722-2732
-
-
Hoot, K.E.1
-
18
-
-
77949265948
-
Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis
-
Petersen, M. et al. (2010) Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis. Oncogene 29, 1351-1361
-
(2010)
Oncogene
, vol.29
, pp. 1351-1361
-
-
Petersen, M.1
-
19
-
-
79952499030
-
Twist1-induced invadopodia formation promotes tumor metastasis
-
Eckert, M. A. et al. (2011) Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 19, 372-386
-
(2011)
Cancer Cell
, vol.19
, pp. 372-386
-
-
Eckert, M.A.1
-
20
-
-
82455209225
-
TGF-β and Smad signaling in transcriptome reprogramming during EMT
-
Jakowlew, S. B., ed., The Human Press Inc
-
Thuault, S. et al. (2008) TGF-β and Smad signaling in transcriptome reprogramming during EMT. In Transforming Growth Factor-β in Cancer Therapy. Basic and Clinical Biology, (Vol. I) (Jakowlew, S. B., ed.), pp. 259-273, The Human Press Inc
-
(2008)
Transforming Growth Factor-β in Cancer Therapy. Basic and Clinical Biology.
, vol.1
, pp. 259-273
-
-
Thuault, S.1
-
21
-
-
78649755556
-
IKKα controls canonical TGFβ-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells
-
Brandl, M. et al. (2010) IKKα controls canonical TGFβ-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells. J. Cell Sci. 123 (Pt 24), 4231-4239
-
(2010)
J. Cell Sci.
, vol.123
, Issue.24 PART
, pp. 4231-4239
-
-
Brandl, M.1
-
22
-
-
59649128301
-
A positive role for Myc in TGFβ-induced Snail transcription and epithelial-to-mesenchymal transition
-
Smith, A. P. et al. (2009) A positive role for Myc in TGFβ-induced Snail transcription and epithelial-to-mesenchymal transition. Oncogene 28, 422-430
-
(2009)
Oncogene
, vol.28
, pp. 422-430
-
-
Smith, A.P.1
-
23
-
-
58649097517
-
Role of Ras signaling in the induction of snail by transforming growth factor-β
-
Horiguchi, K. et al. (2009) Role of Ras signaling in the induction of snail by transforming growth factor-β. J. Biol. Chem. 284, 245-253
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 245-253
-
-
Horiguchi, K.1
-
24
-
-
0038756636
-
Transforming growth factor β-1 induces Snail transcription factor in epithelial cell lines. Mechanisms for epithelial mesenchymal transitions
-
DOI 10.1074/jbc.M211304200
-
Peinado, H. et al. (2003) Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J. Biol. Chem. 278, 21113-21123 (Pubitemid 36806424)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.23
, pp. 21113-21123
-
-
Peinado, H.1
Quintanilla, M.2
Cano, A.3
-
25
-
-
43149111275
-
Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-β1
-
DOI 10.1242/jcs.019455
-
Alcorn, J. F. et al. (2008) Jun. N-terminal kinase 1 regulates epithelial-epithelial-to-mesenchymaltransition induced by TGF-β1. J. CellSci. 121 (Pt7), 1036-1045 (Pubitemid 351639422)
-
(2008)
Journal of Cell Science
, vol.121
, Issue.7
, pp. 1036-1045
-
-
Alcorn, J.F.1
Guala, A.S.2
Van Der Velden, J.3
McElhinney, B.4
Irvin, C.G.5
Davis, R.J.6
Janssen-Helninger, Y.M.W.7
-
26
-
-
68249092353
-
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition
-
Vincent, T. et al. (2009) A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition. Nat. Cell Biol. 11, 943-950
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 943-950
-
-
Vincent, T.1
-
27
-
-
44649163918
-
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
-
DOI 10.1038/embor.2008.74, PII EMBOR200874
-
Burk, U. et al. (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 9, 582-589 (Pubitemid 351772923)
-
(2008)
EMBO Reports
, vol.9
, Issue.6
, pp. 582-589
-
-
Burk, U.1
Schubert, J.2
Wellner, U.3
Schmalhofer, O.4
Vincan, E.5
Spaderna, S.6
Brabletz, T.7
-
28
-
-
43049103824
-
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
-
DOI 10.1038/ncb1722, PII NCB1722
-
Gregory, P. A. et al. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 10, 593-601 (Pubitemid 351627379)
-
(2008)
Nature Cell Biology
, vol.10
, Issue.5
, pp. 593-601
-
-
Gregory, P.A.1
Bert, A.G.2
Paterson, E.L.3
Barry, S.C.4
Tsykin, A.5
Farshid, G.6
Vadas, M.A.7
Khew-Goodall, Y.8
Goodall, G.J.9
-
29
-
-
79955954699
-
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
-
Gregory, P. A. et al. (2011) An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol. Biol. Cell 22, 1686-1698
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 1686-1698
-
-
Gregory, P.A.1
-
30
-
-
63049136592
-
A Mutant-p53/Smad complex opposes p63 to empower TGFβ-induced metastasis
-
Adorno, M. et al. (2009) A Mutant-p53/Smad complex opposes p63 to empower TGFβ-induced metastasis. Cell 137, 87-98
-
(2009)
Cell
, vol.137
, pp. 87-98
-
-
Adorno, M.1
-
31
-
-
76249084838
-
Smad signaling is required to maintain epigenetic silencing during breast cancer progression
-
Papageorgis, P. et al. (2010) Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 70, 968-978
-
(2010)
Cancer Res.
, vol.70
, pp. 968-978
-
-
Papageorgis, P.1
-
32
-
-
70449526719
-
Localized and reversible TGFb signalling switches breast cancer cells from cohesive to single cell motility
-
Giampieri, S. et al. (2009) Localized and reversible TGFb signalling switches breast cancer cells from cohesive to single cell motility. Nat. Cell Biol. 11, 1287-1296
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1287-1296
-
-
Giampieri, S.1
-
33
-
-
68349160814
-
Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis
-
Korpal, M. et al. (2009) Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis. Nat. Med. 15, 960-966
-
(2009)
Nat. Med.
, vol.15
, pp. 960-966
-
-
Korpal, M.1
-
34
-
-
0030024536
-
High levels of transforming growth factor in patients with colorectal cancer: Association with disease progression
-
DOI 10.1053/gast.1996.v110.pm8566583
-
Tsushima, H. et al. (1996) High levels of transforming growth factor β 1 in patients with colorectal cancer: association with disease progression. Gastroenterology 110, 375-382 (Pubitemid 26043869)
-
(1996)
Gastroenterology
, vol.110
, Issue.2
, pp. 375-382
-
-
Tsushima, H.1
Kawata, S.2
Tamura, S.3
Ito, N.4
Shirai, Y.5
Kiso, S.6
Imai, Y.7
Shimomukai, H.8
Nomura, Y.9
Matsuda, Y.10
Matsuzawa, Y.11
-
35
-
-
70349213381
-
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling
-
Micalizzi, D. S. et al. (2009) The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling. J. Clin. Invest. 119, 2678-2690
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 2678-2690
-
-
Micalizzi, D.S.1
-
36
-
-
69549128378
-
A role for the TGFβ-Par6 polarity pathway in breast cancer progression
-
Viloria-Petit, A. M. et al. (2009) A role for the TGFβ-Par6 polarity pathway in breast cancer progression. Proc. Natl. Acad. Sci. U. S. A. 106, 14028-14033
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 14028-14033
-
-
Viloria-Petit, A.M.1
-
37
-
-
43049165453
-
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
-
DOI 10.1016/j.cell.2008.03.027, PII S0092867408004443
-
Mani, S. A. et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (Pubitemid 351636299)
-
(2008)
Cell
, vol.133
, Issue.4
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.-J.3
Eaton, E.Ng.4
Ayyanan, A.5
Zhou, A.Y.6
Brooks, M.7
Reinhard, F.8
Zhang, C.C.9
Shipitsin, M.10
Campbell, L.L.11
Polyak, K.12
Brisken, C.13
Yang, J.14
Weinberg, R.A.15
-
38
-
-
70349205537
-
Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition
-
McCoy, E. L. et al. (2009) Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. J. Clin. Invest. 119, 2663-2677
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 2663-2677
-
-
McCoy, E.L.1
-
39
-
-
33847419142
-
Molecular Definition of Breast Tumor Heterogeneity
-
DOI 10.1016/j.ccr.2007.01.013, PII S1535610807000293
-
Shipitsin, M. et al. (2007) Molecular definition of breast tumor heterogeneity. Cancer Cell 11, 259-273 (Pubitemid 46349843)
-
(2007)
Cancer Cell
, vol.11
, Issue.3
, pp. 259-273
-
-
Shipitsin, M.1
Campbell, L.L.2
Argani, P.3
Weremowicz, S.4
Bloushtain-Qimron, N.5
Yao, J.6
Nikolskaya, T.7
Serebryiskaya, T.8
Beroukhim, R.9
Hu, M.10
Halushka, M.K.11
Sukumar, S.12
Parker, L.M.13
Anderson, K.S.14
Harris, L.N.15
Garber, J.E.16
Richardson, A.L.17
Schnitt, S.J.18
Nikolsky, Y.19
Gelman, R.S.20
Polyak, K.21
more..
-
40
-
-
41149157649
-
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
-
DOI 10.1016/j.cell.2008.01.046, PII S0092867408002110
-
Padua, D. et al. (2008) TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133, 66-77 (Pubitemid 351442989)
-
(2008)
Cell
, vol.133
, Issue.1
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.-F.2
Wang, Q.3
Nadal, C.4
Gerald, W.L.5
Gomis, R.R.6
Massague, J.7
-
41
-
-
77955295090
-
Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter
-
Hannigan, A. et al. (2010) Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter. J. Clin. Invest. 120, 2842-2857
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2842-2857
-
-
Hannigan, A.1
-
42
-
-
0035887461
-
Inducible expression of transforming growth factor β1 in papillomas causes rapid metastasis
-
Weeks, B. H. et al. (2001) Inducible expression of transforming growth factor β1 in papillomas causes rapid metastasis. Cancer Res 61, 7435-7443 (Pubitemid 32995031)
-
(2001)
Cancer Research
, vol.61
, Issue.20
, pp. 7435-7443
-
-
Weeks, B.H.1
He, W.2
Olson, K.L.3
Wang, X.-J.4
-
43
-
-
67651005826
-
Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer
-
Bierie, B. et al. (2009) Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer. J. Clin. Invest. 119, 1571-1582
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1571-1582
-
-
Bierie, B.1
-
44
-
-
45549085803
-
An anti-transforming growth factor β antibody suppresses metastasis via cooperative effects on multiple cell compartments
-
Nam, J. S. et al. (2008) An anti-transforming growth factor β antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res. 68, 3835-3843
-
(2008)
Cancer Res.
, vol.68
, pp. 3835-3843
-
-
Nam, J.S.1
-
45
-
-
37349100945
-
Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis
-
DOI 10.1016/j.ccr.2007.12.004, PII S153561080700373X
-
Yang, L. et al. (2008) Abrogation of TGF β signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13, 23-35 (Pubitemid 350309741)
-
(2008)
Cancer Cell
, vol.13
, Issue.1
, pp. 23-35
-
-
Yang, L.1
Huang, J.2
Ren, X.3
Gorska, A.E.4
Chytil, A.5
Aakre, M.6
Carbone, D.P.7
Matrisian, LynnM.8
Richmond, A.9
Lin, P.C.10
Moses, H.L.11
-
46
-
-
78651399324
-
TGF-β-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases
-
Mohammad, K. S. et al. (2011) TGF-β-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases. Cancer Res. 71, 175-184
-
(2011)
Cancer Res.
, vol.71
, pp. 175-184
-
-
Mohammad, K.S.1
-
47
-
-
34248185926
-
Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression
-
DOI 10.1172/JCI30740
-
Biswas, S. et al. (2007) Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J. Clin. Invest. 117, 1305-1313 (Pubitemid 46718418)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.5
, pp. 1305-1313
-
-
Biswas, S.1
Guix, M.2
Rinehart, C.3
Dugger, T.C.4
Chytil, A.5
Moses, H.L.6
Freeman, M.L.7
Arteaga, C.L.8
-
48
-
-
42249099019
-
LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
-
DOI 10.1158/1535-7163.MCT-07-0337
-
Melisi, D. et al. (2008) LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol. Cancer Ther. 7, 829-840 (Pubitemid 351551036)
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.4
, pp. 829-840
-
-
Melisi, D.1
Ishiyama, S.2
Sclabas, G.M.3
Fleming, J.B.4
Xia, Q.5
Tortora, G.6
Abbruzzese, J.L.7
Chiao, P.J.8
-
49
-
-
0036087521
-
Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects
-
Yang, Y. A. et al. (2002) Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects. J. Clin. Invest. 109, 1607-1615
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1607-1615
-
-
Yang, Y.A.1
-
50
-
-
35148832173
-
Loss of TGFβ Signaling Destabilizes Homeostasis and Promotes Squamous Cell Carcinomas in Stratified Epithelia
-
DOI 10.1016/j.ccr.2007.08.020, PII S1535610807002395
-
Guasch, G. et al. (2007) Loss of TGFβ signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 12, 313-327 (Pubitemid 47539305)
-
(2007)
Cancer Cell
, vol.12
, Issue.4
, pp. 313-327
-
-
Guasch, G.1
Schober, M.2
Pasolli, H.A.3
Conn, E.B.4
Polak, L.5
Fuchs, E.6
-
51
-
-
33751247898
-
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression
-
DOI 10.1101/gad.1475506
-
Ijichi, H. et al. (2006) Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor- β signaling in cooperation with active Kras expression. Genes Dev. 20, 3147-3160 (Pubitemid 44790629)
-
(2006)
Genes and Development
, vol.20
, Issue.22
, pp. 3147-3160
-
-
Ijichi, H.1
Chytil, A.2
Gorska, A.E.3
Aakre, M.E.4
Fujitani, Y.5
Fujitani, S.6
Wright, C.V.E.7
Moses, H.L.8
-
52
-
-
33646537475
-
Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma
-
Lu, S. L. et al. (2006) Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev. 20, 1331-1342
-
(2006)
Genes Dev.
, vol.20
, pp. 1331-1342
-
-
Lu, S.L.1
|