메뉴 건너뛰기




Volumn 25, Issue 4-5, 2011, Pages 495-506

DFMO: Targeted risk reduction therapy for colorectal neoplasia

Author keywords

Chemoprevention; Colorectal cancer; DFMO; Polyamines

Indexed keywords

ACYLTRANSFERASE; CELECOXIB; EFLORNITHINE; NONSTEROID ANTIINFLAMMATORY AGENT; POLYAMINE; SPERMIDINE; SPERMINE ACETYLTRANSFERASE; SULINDAC; UNCLASSIFIED DRUG;

EID: 82455192451     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2011.09.007     Document Type: Article
Times cited : (44)

References (101)
  • 1
    • 0017917570 scopus 로고
    • Analogues of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site
    • P. Bey, C. Danzin, and V. Van Dorsselaer Analogues of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site J Med Chem 21 1 1978 50 55
    • (1978) J Med Chem , vol.21 , Issue.1 , pp. 50-55
    • Bey, P.1    Danzin, C.2    Van Dorsselaer, V.3
  • 2
    • 0345535621 scopus 로고    scopus 로고
    • Development of difluoromethylornithine (DFMO) as a chemoprevention agent
    • F.L. Meyskens Jr., and E.W. Gerner Development of difluoromethylornithine (DFMO) as a chemoprevention agent Clin Cancer Res 5 5 1999 945 951 (Pubitemid 29233206)
    • (1999) Clinical Cancer Research , vol.5 , Issue.5 , pp. 945-951
    • Meyskens Jr., F.L.1    Gerner, E.W.2
  • 3
    • 55549132996 scopus 로고    scopus 로고
    • Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial
    • F.L. Meyskens Jr., C.E. McLaren, and D. Pelot Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial Cancer Prev Res (Phila Pa) 1 1 2008 32 38
    • (2008) Cancer Prev Res (Phila Pa) , vol.1 , Issue.1 , pp. 32-38
    • Meyskens Jr., F.L.1    McLaren, C.E.2    Pelot, D.3
  • 4
    • 13144276360 scopus 로고    scopus 로고
    • Screening of potential cancer-preventing chemicals for inhibition of induction of ornithine decarboxylase in epithelial cells from rat trachea
    • E.L. White, L.J. Ross, and S.M. Schmid Screening of potential cancer-preventing chemicals for inhibition of induction of ornithine decarboxylase in epithelial cells from rat trachea Oncol Rep 5 3 1998 717 722 (Pubitemid 28189335)
    • (1998) Oncology Reports , vol.5 , Issue.3 , pp. 717-722
    • Lucile White, E.1    Ross, L.J.2    Schmid, S.M.3    Kelloff, G.J.4    Steele, V.E.5    Hill, D.L.6
  • 5
    • 0035321503 scopus 로고    scopus 로고
    • Vaniqa-eflornithine 13.9% cream
    • 5
    • J. Shapiro, and H. Lui Vaniqa-eflornithine 13.9% cream Skin Therapy Lett 6 7 2001 1 3 5
    • (2001) Skin Therapy Lett , vol.6 , Issue.7 , pp. 1-3
    • Shapiro, J.1    Lui, H.2
  • 6
    • 0035100870 scopus 로고    scopus 로고
    • Human dermal safety studies with eflornithine HCl 13.9% cream (Vaniqa™), a novel treatment for excessive facial hair
    • DOI 10.1185/030079901750176735
    • J.G. Hickman, F. Huber, and M. Palmisano Human dermal safety studies with eflornithine HCl 13.9% cream (Vaniqa), a novel treatment for excessive facial hair Curr Med Res Opin 16 4 2001 235 244 (Pubitemid 32221480)
    • (2001) Current Medical Research and Opinion , vol.16 , Issue.4 , pp. 235-244
    • Hickman, J.G.1    Huber, F.2    Palmisano, M.3
  • 7
    • 33845955654 scopus 로고    scopus 로고
    • Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair
    • DOI 10.1111/j.1365-4632.2006.03079.x
    • J.E. Wolf Jr., D. Shander, and F. Huber Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair Int J Dermatol 46 1 2007 94 98 (Pubitemid 46029734)
    • (2007) International Journal of Dermatology , vol.46 , Issue.1 , pp. 94-98
    • Wolf Jr., J.E.1    Shander, D.2    Huber, F.3    Jackson, J.4    Lin, C.-S.5    Mathes, B.M.6    Schrode, K.7
  • 9
    • 0023085615 scopus 로고
    • Polyamines in normal and cancer cells
    • G.D. Luk, and R.A. Casero Jr. Polyamines in normal and cancer cells Adv Enzyme Regul 26 1987 91 105
    • (1987) Adv Enzyme Regul , vol.26 , pp. 91-105
    • Luk, G.D.1    Casero Jr., R.A.2
  • 10
    • 0034105197 scopus 로고    scopus 로고
    • Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant min mouse adenomas, and selective toxicity against Apc mutant embryos
    • R.F. Jacoby, C.E. Cole, and K. Tutsch Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos Cancer Res 60 7 2000 1864 1870 (Pubitemid 30207645)
    • (2000) Cancer Research , vol.60 , Issue.7 , pp. 1864-1870
    • Jacoby, R.F.1    Cole, C.E.2    Tutsch, K.3    Newton, M.A.4    Kelloff, G.5    Hawk, E.T.6    Lubet, R.A.7
  • 11
    • 0025999819 scopus 로고
    • Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination
    • C.V. Rao, K. Tokumo, and J. Rigotty Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha- difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination Cancer Res 51 17 1991 4528 4534
    • (1991) Cancer Res , vol.51 , Issue.17 , pp. 4528-4534
    • Rao, C.V.1    Tokumo, K.2    Rigotty, J.3
  • 12
    • 0032847292 scopus 로고    scopus 로고
    • APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse
    • DOI 10.1093/carcin/20.9.1709
    • S.H. Erdman, N.A. Ignatenko, and M.B. Powell APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse Carcinogenesis 20 9 1999 1709 1713 (Pubitemid 29410548)
    • (1999) Carcinogenesis , vol.20 , Issue.9 , pp. 1709-1713
    • Erdman, S.H.1    Ignatenko, N.A.2    Powell, M.B.3    Blohm-Mangone, K.A.4    Holubec, H.5    Guillen-Rodriguez, J.M.6    Gerner, E.W.7
  • 13
    • 0036880304 scopus 로고    scopus 로고
    • Chemoprevention of prostate carcinogenesis by DFMO and/or finasteride treatment in male Wistar rats
    • A.Y. Esmat, F.M. Refaie, and M.H. Shaheen Chemoprevention of prostate carcinogenesis by DFMO and/or finasteride treatment in male Wistar rats Tumori 88 6 2002 513 521 (Pubitemid 36193903)
    • (2002) Tumori , vol.88 , Issue.6 , pp. 513-521
    • Esmat, A.Y.1    Refaie, F.M.2    Shaheen, M.H.3    Said, M.M.4
  • 14
    • 0034665334 scopus 로고    scopus 로고
    • Chemoprevention of prostate carcinogenesis by alpha- difluoromethylornithine in TRAMP mice
    • S. Gupta, N. Ahmad, and S.R. Marengo Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice Cancer Res 60 18 2000 5125 5133
    • (2000) Cancer Res , vol.60 , Issue.18 , pp. 5125-5133
    • Gupta, S.1    Ahmad, N.2    Marengo, S.R.3
  • 15
    • 0021951646 scopus 로고
    • Effect of concentration of D,L-2-difluoromethylornithine on murine mammary carcinogenesis
    • H.J. Thompson, L.D. Meeker, and E.J. Herbst Effect of concentration of d, l-2-difluoromethylornithine on murine mammary carcinogenesis Cancer Res 45 3 1985 1170 1173 (Pubitemid 15111278)
    • (1985) Cancer Research , vol.45 , Issue.3 , pp. 1170-1173
    • Thompson, H.J.1    Meeker, L.D.2    Herbst, E.J.3
  • 16
    • 1842481509 scopus 로고    scopus 로고
    • The Chemopreventive Agent α-Difluoromethylornithine Blocks Ki-ras-Dependent Tumor Formation and Specific Gene Expression in Caco-2 Cells
    • DOI 10.1002/mc.20008
    • N.A. Ignatenko, H. Zhang, and G.S. Watts The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells Mol Carcinog 39 4 2004 221 233 (Pubitemid 38452242)
    • (2004) Molecular Carcinogenesis , vol.39 , Issue.4 , pp. 221-233
    • Ignatenko, N.A.1    Zhang, H.2    Watts, G.S.3    Skovan, B.A.4    Stringer, D.E.5    Gerner, E.W.6
  • 17
    • 0027997695 scopus 로고
    • Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line
    • DOI 10.1002/mc.2940110304
    • U.M. Wallon, L.R. Shassetz, and A.E. Cress Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line Mol Carcinog 11 3 1994 138 144 (Pubitemid 24372805)
    • (1994) Molecular Carcinogenesis , vol.11 , Issue.3 , pp. 138-144
    • Wallon, U.M.1    Shassetz, L.R.2    Cress, A.E.3    Bowden, G.T.4    Gerner, E.W.5
  • 18
    • 0021363702 scopus 로고
    • Time dependence of the potentiation of 1,3-bis(chloroethyl)-1-nitrosourea cytotoxicity caused by α-difluoromethylornithine-induced polyamine depletion in 9L rat brain tumor cells
    • L. Alhonen-Hongisto, D.F. Deen, and L.J. Marton Time dependence of the potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity caused by alpha-difluoromethylornithine-induced polyamine depletion in 9L rat brain tumor cells Cancer Res 44 5 1984 1819 1822 (Pubitemid 14145720)
    • (1984) Cancer Research , vol.44 , Issue.5 , pp. 1819-1822
    • Alhonen-Hongisto, L.1    Deen, D.F.2    Marton, L.J.3
  • 19
    • 13544265296 scopus 로고    scopus 로고
    • 1- acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells
    • DOI 10.1074/jbc.M409930200
    • W. Choi, E.W. Gerner, and L. Ramdas Combination of 5-fluorouracil and N1, N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells J Biol Chem 280 5 2005 3295 3304 (Pubitemid 40223791)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.5 , pp. 3295-3304
    • Choi, W.1    Gerner, E.W.2    Ramdas, L.3    Dupart, J.4    Carew, J.5    Proctor, L.6    Huang, P.7    Zhang, W.8    Hamilton, S.R.9
  • 20
    • 0034650470 scopus 로고    scopus 로고
    • α-Difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model
    • DOI 10.1002/(SICI)1097-0215(20000115)85:2<243::AID-IJC15>3.0.CO;2-2
    • Y. Takahashi, M. Mai, and K. Nishioka alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model Int J Cancer 85 2 2000 243 247 (Pubitemid 30023074)
    • (2000) International Journal of Cancer , vol.85 , Issue.2 , pp. 243-247
    • Takahashi, Y.1    Mai, M.2    Nishioka, K.3
  • 21
    • 0025330360 scopus 로고
    • Tumor angiogenesis and polyamines: α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro
    • M. Takigawa, M. Enomoto, and Y. Nishida Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro Cancer Res 50 13 1990 4131 4138 (Pubitemid 20225641)
    • (1990) Cancer Research , vol.50 , Issue.13 , pp. 4131-4138
    • Takigawa, M.1    Enomoto, M.2    Nishida, Y.3    Pan, H.-O.4    Kinoshita, A.5    Suzuki, F.6
  • 22
    • 0028158044 scopus 로고
    • Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells
    • M.E. Tome, S.M. Fiser, and E.W. Gerner Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells J Cell Physiol 158 2 1994 237 244 (Pubitemid 24063550)
    • (1994) Journal of Cellular Physiology , vol.158 , Issue.2 , pp. 237-244
    • Tome, M.E.1    Fiser, S.M.2    Gerner, E.W.3
  • 23
    • 2642563084 scopus 로고    scopus 로고
    • In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells
    • X.S. Wan, Z. Zhou, and A.R. Kennedy In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells Oncol Rep 10 6 2003 2009 2014
    • (2003) Oncol Rep , vol.10 , Issue.6 , pp. 2009-2014
    • Wan, X.S.1    Zhou, Z.2    Kennedy, A.R.3
  • 24
    • 7044285899 scopus 로고    scopus 로고
    • Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells
    • S. Zaletok, S.N. Alexandrova, and N. Berdynskykh Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells Exp Oncol 26 3 2004 221 225
    • (2004) Exp Oncol , vol.26 , Issue.3 , pp. 221-225
    • Zaletok, S.1    Alexandrova, S.N.2    Berdynskykh, N.3
  • 26
    • 0033755187 scopus 로고    scopus 로고
    • Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N- nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme
    • V.A. Levin, J.M. Uhm, and K.A. Jaeckle Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme Clin Cancer Res 6 10 2000 3878 3884
    • (2000) Clin Cancer Res , vol.6 , Issue.10 , pp. 3878-3884
    • Levin, V.A.1    Uhm, J.M.2    Jaeckle, K.A.3
  • 27
    • 0022999939 scopus 로고
    • A phase II study of α-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma
    • F.L. Meyskens, E.M. Kingsley, and T. Glattke A phase II study of alpha-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma Invest New Drugs 4 3 1986 257 262 (Pubitemid 17205956)
    • (1986) Investigational New Drugs , vol.4 , Issue.3 , pp. 257-262
    • Meyskens, F.L.1    Kingsley, E.M.2    Glattke, T.3
  • 28
    • 0026671825 scopus 로고
    • Ornithine decarboxylase as an enzyme target for therapy
    • P.P. McCann, and A.E. Pegg Ornithine decarboxylase as an enzyme target for therapy Pharmacol Ther 54 2 1992 195 215
    • (1992) Pharmacol Ther , vol.54 , Issue.2 , pp. 195-215
    • McCann, P.P.1    Pegg, A.E.2
  • 29
    • 0033754923 scopus 로고    scopus 로고
    • Phase II study of 6-thioguanine, procarbazine, dibromodulcitol, lomustine, and vincristine chemotherapy with radiotherapy for treating malignant glioma in children
    • V.A. Levin, K. Lamborn, and W. Wara Phase II study of 6-thioguanine, procarbazine, dibromodulcitol, lomustine, and vincristine chemotherapy with radiotherapy for treating malignant glioma in children Neuro Oncol 2 1 2000 22 28
    • (2000) Neuro Oncol , vol.2 , Issue.1 , pp. 22-28
    • Levin, V.A.1    Lamborn, K.2    Wara, W.3
  • 30
    • 0031809858 scopus 로고    scopus 로고
    • The gastrointestinal polyamine source depletion enhances DFMO induced polyamine depletion in MCF-7 human breast cancer cells in vivo
    • J. Leveque, F. Burtin, and V. Catros-Quemener The gastrointestinal polyamine source depletion enhances DFMO induced polyamine depletion in MCF-7 human breast cancer cells in vivo Anticancer Res 18 4A 1998 2663 2668 (Pubitemid 28386564)
    • (1998) Anticancer Research , vol.18 , Issue.4 A , pp. 2663-2668
    • Leveque, J.1    Burtin, F.2    Catros-Quemener, V.3    Havouis, R.4    Moulinoux, J.-P.5
  • 31
    • 0029134770 scopus 로고
    • Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer
    • F.L. Meyskens Jr., and E.W. Gerner Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer J Cell Biochem Suppl 22 1995 126 131
    • (1995) J Cell Biochem Suppl , vol.22 , pp. 126-131
    • Meyskens Jr., F.L.1    Gerner, E.W.2
  • 33
    • 77649195334 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer
    • H.H. Bailey, K. Kim, and A.K. Verma A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}- difluoromethylornithine in subjects with previous history of skin cancer Cancer Prev Res (Phila) 3 1 2010 35 47
    • (2010) Cancer Prev Res (Phila) , vol.3 , Issue.1 , pp. 35-47
    • Bailey, H.H.1    Kim, K.2    Verma, A.K.3
  • 35
    • 11344295619 scopus 로고    scopus 로고
    • Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3
    • A.T. Vlastos, L.A. West, and E.N. Atkinson Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3 Clin Cancer Res 11 1 2005 390 396 (Pubitemid 40075819)
    • (2005) Clinical Cancer Research , vol.11 , Issue.1 , pp. 390-396
    • Vlastos, A.-T.1    West, L.A.2    Atkinson, E.N.3    Boiko, I.4    Malpica, A.5    Hong, W.K.6    Follen, M.7
  • 36
    • 33745463143 scopus 로고    scopus 로고
    • Randomized Prospective Phase III Trial of Difluoromethylornithine vs Placebo in Preventing Recurrence of Completely Resected Low Risk Superficial Bladder Cancer
    • DOI 10.1016/j.juro.2006.03.061, PII S0022534706008305
    • E. Messing, K.M. Kim, and F. Sharkey Randomized prospective phase III trial of difluoromethylornithine vs placebo in preventing recurrence of completely resected low risk superficial bladder cancer J Urol 176 2 2006 500 504 (Pubitemid 43949406)
    • (2006) Journal of Urology , vol.176 , Issue.2 , pp. 500-504
    • Messing, E.1    Kim, K.M.2    Sharkey, F.3    Schultz, M.4    Parnes, H.5    Kim, D.6    Saltzstein, D.7    Wilding, G.8
  • 38
    • 79957810567 scopus 로고    scopus 로고
    • Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia
    • F.A. Sinicrope, R. Broaddus, and N. Joshi Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia Cancer Prev Res (Phila) 4 6 2011 829 839
    • (2011) Cancer Prev Res (Phila) , vol.4 , Issue.6 , pp. 829-839
    • Sinicrope, F.A.1    Broaddus, R.2    Joshi, N.3
  • 39
    • 0026618065 scopus 로고
    • Polyamine contents in rectal and buccal mucosae in humans treated with oral difluoromethylornithine
    • J.O. Boyle, F.L. Meyskens Jr., and H.S. Garewal Polyamine contents in rectal and buccal mucosae in humans treated with oral difluoromethylornithine Cancer Epidemiol Biomarkers Prev 1 2 1992 131 135
    • (1992) Cancer Epidemiol Biomarkers Prev , vol.1 , Issue.2 , pp. 131-135
    • Boyle, J.O.1    Meyskens Jr., F.L.2    Garewal, H.S.3
  • 42
    • 0015255807 scopus 로고
    • Polyamine and nucleic acid concentrations in Ehrlich ascites carcinoma cells and liver of tumor-bearing mice at various stages of tumor growth
    • G. Andersson, and O. Heby Polyamine and nucleic acid concentrations in Ehrlich ascites carcinoma cells and liver of tumor-bearing mice at various stages of tumor growth J Natl Cancer Inst 48 1 1972 165 172
    • (1972) J Natl Cancer Inst , vol.48 , Issue.1 , pp. 165-172
    • Andersson, G.1    Heby, O.2
  • 43
    • 0015027247 scopus 로고
    • Polyamine accumulation and biosynthesis in a mouse L1210 leukemia
    • D.H. Russell, and C.C. Levy Polyamine accumulation and biosynthesis in a mouse L1210 leukemia Cancer Res 31 3 1971 248 251
    • (1971) Cancer Res , vol.31 , Issue.3 , pp. 248-251
    • Russell, D.H.1    Levy, C.C.2
  • 44
    • 32944470417 scopus 로고    scopus 로고
    • Emerging concepts in targeting the polyamine metabolic pathway in epithelial cancer chemoprevention and chemotherapy
    • DOI 10.1093/jb/mvj022
    • U.K. Basuroy, and E.W. Gerner Emerging concepts in targeting the polyamine metabolic pathway in epithelial cancer chemoprevention and chemotherapy J Biochem 139 1 2006 27 33 (Pubitemid 43258843)
    • (2006) Journal of Biochemistry , vol.139 , Issue.1 , pp. 27-33
    • Basuroy, U.K.1    Gerner, E.W.2
  • 46
    • 0346850853 scopus 로고    scopus 로고
    • Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer
    • DOI 10.1074/jbc.M307265200
    • N. Babbar, N.A. Ignatenko, and R.A. Casero Jr. Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer J Biol Chem 278 48 2003 47762 47775 (Pubitemid 37523223)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.48 , pp. 47762-47775
    • Babbar, N.1    Ignatenko, N.A.2    Casero Jr., R.A.3    Gerner, E.W.4
  • 47
    • 32944475762 scopus 로고    scopus 로고
    • 1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells
    • DOI 10.1042/BJ20051298
    • N. Babbar, E.W. Gerner, and R.A. Casero Jr. Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells Biochem J 394 Pt 1 2006 317 324 (Pubitemid 43259681)
    • (2006) Biochemical Journal , vol.394 , Issue.1 , pp. 317-324
    • Babbar, N.1    Gerner, E.W.2    Casero Jr., R.A.3
  • 49
    • 55949129367 scopus 로고    scopus 로고
    • Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis
    • N.A. Ignatenko, D.G. Besselsen, and D.E. Stringer Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis Nutr Cancer 60 Suppl. 1 2008 30 35
    • (2008) Nutr Cancer , vol.60 , Issue.SUPPL. 1 , pp. 30-35
    • Ignatenko, N.A.1    Besselsen, D.G.2    Stringer, D.E.3
  • 50
    • 0037396409 scopus 로고    scopus 로고
    • Polyamines as modifiers of genetic risk factors in human intestinal cancers
    • DOI 10.1042/BST0310388
    • N. Babbar, and E.W. Gerner Polyamines as modifiers of genetic risk factors in human intestinal cancers Biochem Soc Trans 31 2 2003 388 392 (Pubitemid 36520683)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.2 , pp. 388-392
    • Babbar, N.1    Gerner, E.W.2
  • 51
    • 4944242891 scopus 로고    scopus 로고
    • Polyamines and cancer: Old molecules, new understanding
    • DOI 10.1038/nrc1454
    • E.W. Gerner, and F.L. Meyskens Jr. Polyamines and cancer: old molecules, new understanding Nat Rev Cancer 4 10 2004 781 792 (Pubitemid 39331150)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 781-792
    • Gerner, E.W.1    Meyskens Jr., F.L.2
  • 55
    • 0031733015 scopus 로고    scopus 로고
    • Polyamine metabolism as target for cancer chemoprevention (Review)
    • N. Seiler, C.L. Atanassov, and F. Raul Polyamine metabolism as target for cancer chemoprevention (review) Int J Oncol 13 5 1998 993 1006 (Pubitemid 28506070)
    • (1998) International Journal of Oncology , vol.13 , Issue.5 , pp. 993-1006
    • Seiler, N.1    Atanassov, C.L.2    Raul, F.3
  • 56
    • 0028358206 scopus 로고
    • Gastrointestinal tissue polyamine contents of patients with Barrett's esophagus treated with α-difluoromethylornithine
    • E.W. Gerner, H.S. Garewal, and S.S. Emerson Gastrointestinal tissue polyamine contents of patients with Barrett's esophagus treated with alpha-difluoromethylornithine Cancer Epidemiol Biomarkers Prev 3 4 1994 325 330 (Pubitemid 24181577)
    • (1994) Cancer Epidemiology Biomarkers and Prevention , vol.3 , Issue.4 , pp. 325-330
    • Gerner, E.W.1    Garewal, H.S.2    Emerson, S.S.3    Sampliner, R.E.4
  • 57
  • 58
    • 0026683752 scopus 로고
    • Ornithine decarboxylase activity is critical for cell transformation
    • DOI 10.1038/360355a0
    • M. Auvinen, A. Paasinen, and L.C. Andersson Ornithine decarboxylase activity is critical for cell transformation Nature 360 6402 1992 355 358 (Pubitemid 23000675)
    • (1992) Nature , vol.360 , Issue.6402 , pp. 355-358
    • Auvinen, M.1    Paasinen, A.2    Andersson, L.C.3    Holtta, E.4
  • 59
    • 0032861554 scopus 로고    scopus 로고
    • Role of polyamines in mediating malignant transformation and oncogene expression
    • DOI 10.1016/S1357-2725(99)00098-9, PII S1357272599000989
    • A. Tabib, and U. Bachrach Role of polyamines in mediating malignant transformation and oncogene expression Int J Biochem Cell Biol 31 11 1999 1289 1295 (Pubitemid 29486710)
    • (1999) International Journal of Biochemistry and Cell Biology , vol.31 , Issue.11 , pp. 1289-1295
    • Tabib, A.1    Bachrach, U.2
  • 60
    • 0027631049 scopus 로고
    • Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa
    • L.J. Hixson, H.S. Garewal, and D.L. McGee Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa Cancer Epidemiol Biomarkers Prev 2 4 1993 369 374
    • (1993) Cancer Epidemiol Biomarkers Prev , vol.2 , Issue.4 , pp. 369-374
    • Hixson, L.J.1    Garewal, H.S.2    McGee, D.L.3
  • 61
    • 0026606164 scopus 로고
    • Polyamine levels, ornithine decarboxylase (ODC) activity, and ODC-mRNA expression in normal and cancerous human colonocytes
    • Y. Elitsur, J.A. Moshier, and R. Murthy Polyamine levels, ornithine decarboxylase (ODC) activity, and ODC-mRNA expression in normal and cancerous human colonocytes Life Sci 50 19 1992 1417 1424
    • (1992) Life Sci , vol.50 , Issue.19 , pp. 1417-1424
    • Elitsur, Y.1    Moshier, J.A.2    Murthy, R.3
  • 63
    • 0026485433 scopus 로고
    • Polyamines as markers of malignancy
    • U. Bachrach Polyamines as markers of malignancy Prog Drug Res 39 1992 9 33
    • (1992) Prog Drug Res , vol.39 , pp. 9-33
    • Bachrach, U.1
  • 64
    • 0023881236 scopus 로고
    • Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy
    • A.E. Pegg Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy Cancer Res 48 4 1988 759 774 (Pubitemid 18061860)
    • (1988) Cancer Research , vol.48 , Issue.4 , pp. 759-774
    • Pegg, A.E.1
  • 65
    • 0142020885 scopus 로고    scopus 로고
    • Regulation of adherens junctions and epithelial paracellular permeability: A novel function for polyamines
    • X. Guo, J.N. Rao, and L. Liu Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines Am J Physiol Cell Physiol 285 5 2003 C1174 C1187
    • (2003) Am J Physiol Cell Physiol , vol.285 , Issue.5
    • Guo, X.1    Rao, J.N.2    Liu, L.3
  • 66
    • 0018422701 scopus 로고
    • Effects of α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated rats
    • C. Danzin, M.J. Jung, and N. Claverie Effects of alpha- difluoromethylornithine, an enzyme-activated irreversible inhibitor or ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated rats Biochem J 180 3 1979 507 513 (Pubitemid 9208283)
    • (1979) Biochemical Journal , vol.180 , Issue.3 , pp. 507-513
    • Danzin, C.1    Jung, M.J.2    Claverie, N.3
  • 67
    • 0018372884 scopus 로고
    • Effect of α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues
    • C. Danzin, M.J. Jung, and J. Grove Effect of alpha- difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues Life Sci 24 6 1979 519 524 (Pubitemid 9123397)
    • (1979) Life Sciences , vol.24 , Issue.6 , pp. 519-524
    • Danzin, C.1    Jung, M.J.2    Grove, J.3    Bey, P.4
  • 68
    • 0025700682 scopus 로고
    • Implications for a reduced DNA-elongation rate in polyamine-depleted cells
    • S.M. Oredsson, B. Nicander, and O. Heby Implications for a reduced DNA-elongation rate in polyamine-depleted cells Eur J Biochem 190 3 1990 483 489
    • (1990) Eur J Biochem , vol.190 , Issue.3 , pp. 483-489
    • Oredsson, S.M.1    Nicander, B.2    Heby, O.3
  • 71
    • 0023880427 scopus 로고
    • Effect of polyamine depletion on c-myc expression in human colon carcinoma cells
    • P. Celano, S.B. Baylin, and F.M. Giardiello Effect of polyamine depletion on c-myc expression in human colon carcinoma cells J Biol Chem 263 12 1988 5491 5494
    • (1988) J Biol Chem , vol.263 , Issue.12 , pp. 5491-5494
    • Celano, P.1    Baylin, S.B.2    Giardiello, F.M.3
  • 72
    • 0033754970 scopus 로고    scopus 로고
    • Bioavailability study of oral liquid and tablet forms of alpha-difluoromethylornithine
    • P.P. Carbone, J.A. Douglas, and J. Thomas Bioavailability study of oral liquid and tablet forms of alpha-difluoromethylornithine Clin Cancer Res 6 10 2000 3850 3854
    • (2000) Clin Cancer Res , vol.6 , Issue.10 , pp. 3850-3854
    • Carbone, P.P.1    Douglas, J.A.2    Thomas, J.3
  • 73
    • 4143049044 scopus 로고    scopus 로고
    • Inhibitors of polyamine metabolism: Review article
    • H.M. Wallace, and A.V. Fraser Inhibitors of polyamine metabolism: review article Amino Acids 26 4 2004 353 365 (Pubitemid 39093138)
    • (2004) Amino Acids , vol.26 , Issue.4 , pp. 353-365
    • Wallace, H.M.1    Fraser, A.V.2
  • 74
    • 0345688128 scopus 로고    scopus 로고
    • A perspective of polyamine metabolism
    • DOI 10.1042/BJ20031327
    • H.M. Wallace, A.V. Fraser, and A. Hughes A perspective of polyamine metabolism Biochem J 376 Pt 1 2003 1 14 (Pubitemid 37487199)
    • (2003) Biochemical Journal , vol.376 , Issue.1 , pp. 1-14
    • Wallace, H.M.1    Fraser, A.V.2    Hughes, A.3
  • 77
    • 0030968757 scopus 로고    scopus 로고
    • Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction
    • G.A. Piazza, A.K. Rahm, and T.S. Finn Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction Cancer Res 57 12 1997 2452 2459 (Pubitemid 27255906)
    • (1997) Cancer Research , vol.57 , Issue.12 , pp. 2452-2459
    • Piazza, G.A.1    Rahm, A.K.2    Finn, T.S.3    Fryer, B.H.4    Li, H.5    Stoumen, A.L.6    Pamukcu, R.7    Ahnen, D.J.8
  • 79
    • 0030894288 scopus 로고    scopus 로고
    • Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer
    • G.N. Levy Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer Faseb J 11 4 1997 234 247 (Pubitemid 27118324)
    • (1997) FASEB Journal , vol.11 , Issue.4 , pp. 234-247
    • Levy, G.N.1
  • 82
    • 3242721547 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva
    • DOI 10.1016/j.ygyno.2004.03.018, PII S0090825804001891
    • B.M. Cracchiolo, D.S. Heller, and P.M. Clement Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva Gynecol Oncol 94 1 2004 217 222 (Pubitemid 38950524)
    • (2004) Gynecologic Oncology , vol.94 , Issue.1 , pp. 217-222
    • Cracchiolo, B.M.1    Heller, D.S.2    Clement, P.M.J.3    Wolff, E.C.4    Park, M.-H.5    Hanauske-Abel, H.M.6
  • 84
    • 0028343678 scopus 로고
    • Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: A randomized trial
    • F.L. Meyskens Jr., E. Surwit, and T.E. Moon Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial J Natl Cancer Inst 86 7 1994 539 543
    • (1994) J Natl Cancer Inst , vol.86 , Issue.7 , pp. 539-543
    • Meyskens Jr., F.L.1    Surwit, E.2    Moon, T.E.3
  • 85
    • 0036894435 scopus 로고    scopus 로고
    • Modifiable risk factors for colon cancer
    • DOI 10.1016/S0889-8553(02)00057-2, PII S0889855302000572
    • E. Giovannucci Modifiable risk factors for colon cancer Gastroenterol Clin North Am 31 4 2002 925 943 (Pubitemid 35403506)
    • (2002) Gastroenterology Clinics of North America , vol.31 , Issue.4 , pp. 925-943
    • Giovannucci, E.1
  • 86
    • 0036073327 scopus 로고    scopus 로고
    • Obesity, gender, and colon cancer
    • DOI 10.1136/gut.51.2.147
    • E. Giovannucci Obesity, gender, and colon cancer Gut 51 2 2002 147 (Pubitemid 34791434)
    • (2002) Gut , vol.51 , Issue.2 , pp. 147
    • Giovannucci, E.1
  • 88
    • 34248157118 scopus 로고    scopus 로고
    • Effect of aspirin on long-term risk of colorectal cancer: Consistent evidence from randomised and observational studies
    • DOI 10.1016/S0140-6736(07)60747-8, PII S0140673607607478
    • E. Flossmann, and P.M. Rothwell Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies Lancet 369 9573 2007 1603 1613 (Pubitemid 46710123)
    • (2007) Lancet , vol.369 , Issue.9573 , pp. 1603-1613
    • Flossmann, E.1    Rothwell, P.M.2
  • 89
    • 37949049850 scopus 로고
    • The evolution of cancer of the colon and rectum
    • T. Muto, H.J. Bussey, and B.C. Morson The evolution of cancer of the colon and rectum Cancer 36 6 1975 2251 2270
    • (1975) Cancer , vol.36 , Issue.6 , pp. 2251-2270
    • Muto, T.1    Bussey, H.J.2    Morson, B.C.3
  • 90
    • 0027601440 scopus 로고
    • Evaluation of alpha-difluoromethylornithine as a potential chemopreventive agent: Tolerance to daily oral administration in humans
    • P.J. Creaven, L. Pendyala, and N.J. Petrelli Evaluation of alpha-difluoromethylornithine as a potential chemopreventive agent: tolerance to daily oral administration in humans Cancer Epidemiol Biomarkers Prev 2 3 1993 243 247
    • (1993) Cancer Epidemiol Biomarkers Prev , vol.2 , Issue.3 , pp. 243-247
    • Creaven, P.J.1    Pendyala, L.2    Petrelli, N.J.3
  • 91
    • 0025868407 scopus 로고
    • Dose-related alpha-difluoromethylornithine ototoxicity
    • M.K. Croghan, M.G. Aickin, and F.L. Meyskens Dose-related alpha-difluoromethylornithine ototoxicity Am J Clin Oncol 14 4 1991 331 335
    • (1991) Am J Clin Oncol , vol.14 , Issue.4 , pp. 331-335
    • Croghan, M.K.1    Aickin, M.G.2    Meyskens, F.L.3
  • 94
    • 0031454230 scopus 로고    scopus 로고
    • α-Difluoromethylornithine ototoxicity: Chemoprevention clinical trial results
    • T.R. Pasic, D. Heisey, and R.R. Love alpha-difluoromethylornithine ototoxicity. Chemoprevention clinical trial results Arch Otolaryngol Head Neck Surg 123 12 1997 1281 1286 (Pubitemid 28007375)
    • (1997) Archives of Otolaryngology - Head and Neck Surgery , vol.123 , Issue.12 , pp. 1281-1286
    • Pasic, T.R.1    Heisey, D.2    Love, R.R.3
  • 95
    • 61349138323 scopus 로고    scopus 로고
    • Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas
    • C.E. McLaren, S. Fujikawa-Brooks, and W.P. Chen Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas Cancer Prev Res (Phila) 1 7 2008 514 521
    • (2008) Cancer Prev Res (Phila) , vol.1 , Issue.7 , pp. 514-521
    • McLaren, C.E.1    Fujikawa-Brooks, S.2    Chen, W.P.3
  • 96
    • 70349673598 scopus 로고    scopus 로고
    • Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival
    • J.A. Zell, A. Ziogas, and N. Ignatenko Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival Clin Cancer Res 15 19 2009 6208 6216
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6208-6216
    • Zell, J.A.1    Ziogas, A.2    Ignatenko, N.3
  • 97
    • 68349123550 scopus 로고    scopus 로고
    • Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas
    • J.A. Zell, D. Pelot, and W.P. Chen Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas Cancer Prev Res (Phila Pa) 2 3 2009 209 212
    • (2009) Cancer Prev Res (Phila Pa) , vol.2 , Issue.3 , pp. 209-212
    • Zell, J.A.1    Pelot, D.2    Chen, W.P.3
  • 99
    • 77957824343 scopus 로고    scopus 로고
    • Ornithine Decarboxylase-1 polymorphism, chemoprevention with Eflornithine and sulindac, and outcomes among colorectal adenoma patients
    • [epub ahead of print]
    • J.A. Zell, C.E. McLaren, and W.P. Chen Ornithine Decarboxylase-1 polymorphism, chemoprevention with Eflornithine and sulindac, and outcomes among colorectal adenoma patients J Natl Cancer Inst 2010 [epub ahead of print]
    • (2010) J Natl Cancer Inst
    • Zell, J.A.1    McLaren, C.E.2    Chen, W.P.3
  • 100
    • 33750575970 scopus 로고    scopus 로고
    • The dilemma and promise of cancer chemoprevention
    • DOI 10.1038/ncponc0609, PII NCPONC0609
    • S.M. Lippman The dilemma and promise of cancer chemoprevention Nat Clin Pract Oncol 3 10 2006 523 (Pubitemid 44781718)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.10 , pp. 523
    • Lippman, S.M.1
  • 101
    • 33748160584 scopus 로고    scopus 로고
    • Risks and benefits of celecoxib to prevent recurrent adenomas
    • DOI 10.1056/NEJMe068158
    • B.M. Psaty, and J.D. Potter Risks and benefits of celecoxib to prevent recurrent adenomas N Engl J Med 355 9 2006 950 952 (Pubitemid 44315987)
    • (2006) New England Journal of Medicine , vol.355 , Issue.9 , pp. 950-952
    • Psaty, B.M.1    Potter, J.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.