Monoamine reuptake inhibition and mood-enhancing potential of a specified oregano extract

British Journal of Nutrition

Volumn 105, Issue 8, 2011, Pages 1150-1163

  Mechan, Annis O ^a   Fowler, Ann ^a   Seifert, Nicole ^a   Rieger, Henry ^a   Wöhrle, Tina ^a   Etheve, Stéhane ^a   Wyss, Adrian ^a   Scüler, Göde ^a   Colletto, Biagio ^a   Kilpert, Claus ^a   Aston, James ^b   Elliott, J Martin ^b   Goralczyk, Regina ^a   Mohajeri, M Hasan ^a  

^a DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

^b DE MONTFORT UNIVERSITY   (United Kingdom)

Author keywords

In vivo microdialysis; Monoamine reuptake inhibition; Mood enhancing potential; Oregano extract

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CARVACROL; DOPAMINE TRANSPORTER; MONOAMINE; OREGANO EXTRACT; OREVIDA; PLANT EXTRACT; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG TISSUE LEVEL; FORCED SWIMMING TEST; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; MOOD; MOUSE; NONHUMAN; PLANT LEAF; PROTEIN EXPRESSION; RAT; SEROTONIN BRAIN LEVEL; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; ANXIETY; BEHAVIOR, ANIMAL; BENZOQUINONES; BIOGENIC MONOAMINES; BRAIN; DEPRESSION; DIETARY SUPPLEMENTS; DRUG DISCOVERY; HEK293 CELLS; HUMANS; MALE; MICE; MONOAMINE OXIDASE INHIBITORS; MONOTERPENES; NEUROTRANSMITTER UPTAKE INHIBITORS; ORIGANUM; PLANT EXTRACTS; PLANT LEAVES; RANDOM ALLOCATION; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 82455174071     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510004940     Document Type: Article

References (55)

1. Food and Health Forum (2008) The links between diet and behaviour: the influence of nutrition on mental health: Associate Parliamentary Food and Health Forum. http://www.fhf.org.uk/
2. Cornah D (2006) Feeding Minds: the Impact of Food on Mental Health. London: Mental Health Foundation. http://www.mentalhealth.org.uk
3. Van de Weyer C (2005) Changing Diets, Changing Minds: How Food Affects Mental Well Being and Behaviour. London: Sustain.
4. Fernstrom JD (1990) Aromatic amino acids and monoamine synthesis in the central nervous system: influence of the diet. J Nutr Biochem 1, 508-517.
5. Wurtman RJ & Fernstrom JD (1975) Control of brain monoamine synthesis by diet and plasma amino acids. Am J Clin Nutr 28, 638-647.
6. Frederick AL & Stanwood GD (2009) Drugs, biogenic amine targets and the developing brain. Dev Neurosci 31, 7-22.
7. Jayanthi LD & Ramamoorthy S (2005) Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. AAPS J 7, E728-E738.
8. Lucki I (1998) The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44, 151-162.
9. Missale C, Nash SR, Robinson SW, et al. (1998) Dopamine receptors: from structure to function. Physiol Rev 78, 189-225.
10. Haskell CF, Scholey AB, Jackson PA, et al. (2008) Cognitive and mood effects in healthy children during 12 weeks' supplementation with multi-vitamin/minerals. Br J Nutr 100, 1086-1096.
11. Kennedy DO, Scholey AB, Tildesley NT, et al. (2002) Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 72, 953-964.
12. Tildesley NT, Kennedy DO, Perry EK, et al. (2005) Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol Behav 83, 699-709.
13. Tildesley NT, Kennedy DO, Perry EK, et al. (2003) Salvia lavandulaefolia (Spanish sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav 75, 669-674.
14. Scholey AB, Tildesley NT, Ballard CG, et al. (2008) An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology (Berlin) 198, 127-139.
15. Ofir R, Tamir S, Khatib S, et al. (2003) Inhibition of serotonin re-uptake by licorice constituents. J Mol Neurosci 20, 135-140.
16. Yáñez M, Fraiz N, Cano E, et al. (2006) Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity. Biochem Biophys Res Commun 344, 688-695.
17. Dhingra D & Sharma A (2006) Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Prog Neuropsychopharmacol Biol Psychiatry 30, 449-454.
18. Dhingra D, Parle M & Kulkarni SK (2004) Memory enhancing activity of Glycyrrhiza glabra in mice. J Ethnopharmacol 91, 361-365.
19. de Moraes Pultrini A, Galindo LA & Costa M (2006) Effects of the essential oil from Citrus aurantium L. in experimental anxiety models in mice. Life Sci 78, 1720-1725.
20. Bergström LS & Lynöe N (2008) Enhancing concentration, mood and memory in healthy individuals: an empirical study of attitudes among general practitioners and the general population. Scand J Public Health 36, 532-537.
21. Fowler A, Seifert N, Acker V, et al. (2006) A nonradioactive high-throughput/high-content assay for measurement of the human serotonin reuptake transporter function in vitro. J Biomol Screen 11, 1027-1034.
22. Qian Y, Galli A, Ramamoorthy S, et al. (1997) Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J Neurosci 17, 45-57.
23. Holt A, Sharman DF, Baker GB, et al. (1997) A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates. Anal Biochem 244, 384-392.
24. White HL, Scates PW & Cooper BR (1996) Extracts of Ginkgo biloba leaves inhibit monoamine oxidase. Life Sci 58, 1315-1321.
25. Yamada M & Yasuhara H (2004) Clinical pharmacology of MAO inhibitors: safety and future. Neurotoxicology 25, 215-221.
26. Lucki I, Dalvi A & Mayorga AJ (2001) Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology (Berl) 155, 315-322.
27. Porsolt RD, Bertin A & Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229, 327-336.
28. Njung'e K & Handley SL (1991) Evaluation of marble-burying behavior as a model of anxiety. Pharmacol Biochem Behav 38, 63-67.
29. Njung'e K & Handley SL (1991) Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents. Br J Pharmacol 104, 105-112.
30. Londei T, Valentini AMV & Leone VG (1998) Investigative burying by laboratory mice may involve non-functional, compulsive, behaviour. Behav Brain Res 94, 249-254.
31. Broekkamp CL, Rijk HW, Joly-Gelouin D, et al. (1986) Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swiminduced grooming in mice. Eur J Pharmacol 126, 223-229.
32. Crawley JN (1981) Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines. Pharmacol Biochem Behav 15, 695-699.
33. Kreiss DS, Wieland S & Lucki I (1993) The presence of a serotonin uptake inhibitor alters pharmacological manipulations of serotonin release. Neuroscience 52, 295-301.
34. Malagié I, Trillat AC, Jacquot C, et al. (1995) Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study. Eur J Pharmacol 286, 213-217.
35. Felton TM, Kang TB, Hjorth S, et al. (2003) Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex. Naunyn Schmiedebergs Arch Pharmacol 367, 297-305.
36. Maione S, Palazzo E, Pallotta M, et al. (1997) Effects of imipramine on raphe nuclei and prefrontal cortex extracellular serotonin levels in the rat. Psychopharmacology (Berl) 134, 401-405.
37. Rutter JJ & Auerbach SB (1993) Acute uptake inhibition increases extracellular serotonin in the rat forebrain. J Pharmacol Exp Ther 265, 1319-1324.
38. Paxinos G & Watson C (1986) The Rat Brain in Stereotaxic Coordinates. London: Academic Press.
39. Carlier PR, Lo MM, Lo PC, et al. (1998) Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopaminereuptake inhibitor (SNDRI) and a species-selective dopamine- reuptake inhibitor based on the gamma-amino alcohol functional group. Bioorg Med Chem Lett 8, 487-492.
40. Skolnick P, Popik P, Janowsky A, et al. (2003) Antidepressant- like actions of DOV 21,947: a "triple" reuptake inhibitor. Eur J Pharmacol 461, 99-104.
41. Skolnick P, Popik P, Janowsky A, et al. (2003) "Broad spectrum" antidepressants: is more better for the treatment of depression? Life Sci 73, 3175-3179.
42. Nutt DJ (2008) Relationship of neurotransmitters to the symptoms of major depressive disorder. J Clin Psychiatry 69, Suppl. E1, 4-7.
43. Cryan JF, Valentino RJ & Lucki I (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 29, 547-569.
44. Sillaber I, Panhuysen M, Henniger MS, et al. (2008) Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine. Psychopharmacology (Berl) 200, 557-572.
45. Hirano K, Kimura R, Sugimoto Y, et al. (2005) Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. Br J Pharmacol 144, 695-702.
46. Hascoët M, Bourin M & Nic Dhonnchadha BA (2000) The influence of buspirone, and its metabolite 1-PP, on the activity of paroxetine in the mouse light/dark paradigm and four plates test. Pharmacol Biochem Behav 67, 45-53.
47. Bourin M, Redrobe JP, Hascoët M, et al. (1996) A schematic representation of the psychopharmacological profile of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 20, 1389-1402.
48. Mason SS, Baker KB, Davis KW, et al. (2009) Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains. Eur J Pharmacol 602, 306-315.
49. Kulkarni SK & Dhir A (2007) Effect of various classes of antidepressants in behavioral paradigms of despair. Prog Neuropsychopharmacol Biol Psychiatry 31, 1248-1254.
50. Nicolas LB, Kolb Y & Prinssen EP (2006) A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants. Eur J Pharmacol 547, 106-115.
51. Kobayashi T, Hayashi E, Shimamura M, et al. (2008) Neurochemical responses to antidepressants in the prefrontal cortex of mice and their efficacy in preclinical models of anxiety-like and depression-like behavior: a comparative and correlational study. Psychopharmacology (Berl) 197, 567-580.
52. Li X, Morrow D & Witkin JM (2006) Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying. Life Sci 78, 1933-1939.
53. Bourin M & Hascoët M (2003) The mouse light/dark box test. Eur J Pharmacol 463, 55-65.
54. Melo FHC, Venâncio ET, de Sousa DP, et al. (2010) Anxiolytic- like effect of carvacrol (5-isopropyl-2-methylphenol) in mice: involvement with GABAergic transmission. Fundam Clin Pharmacol 24, 437-443.
55. Machado DG, Bettio LE, Cunha MP, et al. (2009) Antidepressant- like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. Prog Neuropsychopharmacol Biol Psychiatry 33, 642-650.