Targeting therapeutic effects: Subcellular location matters. Focus on "Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology"

American Journal of Physiology - Cell Physiology

Volumn 301, Issue 6, 2011, Pages

  Creighton, Judy ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; METFORMIN; PHENFORMIN; RESVERATROL; TAU PROTEIN; THREONINE; UNCLASSIFIED DRUG;

CAVEOLA; CELL COMPARTMENTALIZATION; CELL CYCLE REGULATION; CELL FUNCTION; CELL NUCLEUS; CYTOPLASM; CYTOSKELETON; CYTOSOL; EDITORIAL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; INSULIN SENSITIVITY; MYRISTYLATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

ADENYLATE KINASE; CELL NUCLEUS; CYTOPLASM; ENZYME ACTIVATORS; HUMANS;

EID: 82455166771     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00358.2011     Document Type: Editorial

References (21)

1. Carling D, Mayer FV, Sanders MJ, Gamblin SJ. AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol 7:512-518, 2011.
2. Creighton J, Jian M, Sayner S, Alexeyev M, Insel PA. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J 25:3356-3365, 2011.
3. DiPilato LM, Zhang J. Fluorescent protein-based biosensors: resolving spatiotemporal dynamics of signaling. Curr Opin Chem Biol 14:37-42, 2010.
4. Hardie DG. Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Lett 582:81-89, 2008.
5. Insel PA, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae. Biochem Soc Trans 33: 1131-1134, 2005.
6. Ju TC, Chen HM, Lin JT, Chang CP, Chang WC, Kang JJ, Sun CP, Tao MH, Tu PH, Chang C, Dickson DW, Chern Y. Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J Cell Biol 194:209-227, 2011.
7. Kazgan N, Williams T, Forsberg LJ, Brenman JE. Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase. Mol Biol Cell 21:3433-3442, 2010.
8. Kodiha M, Crampton N, Shrivastava S, Umar R, Stochaj U. Traffic control at the nuclear pore. Nucleus 1:237-244, 2010.
9. Kodiha M, Rassi JG, Brown CM, Stochaj U. Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK->ERK1/2 pathway. Am J Physiol Cell Physiol 293: C1427-C1436, 2007.
10. Kodiha M, Ho-Wo-Cheong D, Stochaj U. Pharmacological AMPkinase activators have compartment-specific effects on cell physiology. Am J Physiol Cell Physiol (September14, 2011).doi:10.1152/ ajpcell.00309.2011.
11. Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, Kemp BE. AMPK is a direct adenylate charge-regulated protein kinase. Science 332:1433-1435, 2011.
12. Patel HH, Murray F, Insel PA. Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol 48:359-391, 2008.
13. Patel KR, Scott E, Brown VA, Gescher AJ, Steward WP, Brown K. Clinical trials of resveratrol. Ann NY Acad Sci 1215:161-169, 2011.
14. Penumathsa SV, Maulik N. Resveratrol: a promising agent in promoting cardioprotection against coronary heart disease. Can J Physiol Pharmacol 87:275-286, 2009.
15. Suzuki A, Okamoto S, Lee S, Saito K, Shiuchi T, Minokoshi Y. Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol 27:4317-4327, 2007.
16. Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D. AMPactivated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure. Biochem J 434:503-512, 2011.
17. Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC. A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metab 13:476-486, 2011.
18. Turnley AM, Stapleton D, Mann RJ, Witters LA, Kemp BE, Bartlett PF. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem 72:1707-1716, 1999.
19. Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M, Andreelli F. Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab 33:395-402, 2007.
20. Wang JW, Imai Y, Lu B. Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1. J Neurosci 27:574-581, 2007.
21. Warden SM, Richardson C, O'Donnell J Jr, Stapleton D, Kemp BE, Witters LA. Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. Biochem J 354: 275-283, 2001.